In Multiplexed MPC, the control variables of a MIMO plant are moved asynchronously, following a pre-planned periodic sequence. The advantage of Multiplexed MPC lies in its reduced computational complexity, leading to faster response to disturbances, which may result in improved performance, despite finding sub-optimal solution to the original problem. This paper extends the original Multiplexed MPC in a way such that the control inputs are no longer restricted to a pre-planned periodic sequence. Instead, the most appropriate control input channel would be optimised and selected to counter the disturbances, hence the name ‘Channel-Hopping'. In addition, the proposed algorithm is suitable for execution on modern computing platforms such as FPGA or GPU, exploits multi-core, parallel and pipeline computing techniques. The algorithm for the proposed Channel-hopping MPC (CH-MPC) will be described and its stability established. Illustrative examples are given to demonstrate the behaviour of the proposed Channel-Hopping MPC algorithm.