1. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
- Author
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Stucki, David, Brites, Daniela, Jeljeli, Leïla, Coscolla, Mireia, Liu, Qingyun, Trauner, Andrej, Fenner, Lukas, Rutaihwa, Liliana, Borrell, Sonia, Luo, Tao, Gao, Qian, Kato-Maeda, Midori, Ballif, Marie, Egger, Matthias, Macedo, Rita, Mardassi, Helmi, Moreno, Milagros, Vilanova, Griselda Tudo, Fyfe, Janet, Globan, Maria, Thomas, Jackson, Jamieson, Frances, Guthrie, Jennifer L, Asante-Poku, Adwoa, Yeboah-Manu, Dorothy, Wampande, Eddie, Ssengooba, Willy, Joloba, Moses, Boom, W Henry, Basu, Indira, Bower, James, Saraiva, Margarida, Vasconcellos, Sidra E G, Suffys, Philip, Koch, Anastasia, Wilkinson, Robert, Gail-Bekker, Linda, Malla, Bijaya, Ley, Serej D, Beck, Hans-Peter, de Jong, Bouke C, Toit, Kadri, Sanchez-Padilla, Elisabeth, Bonnet, Maryline, Gil-Brusola, Ana, Frank, Matthias, Penlap Beng, Veronique N, Eisenach, Kathleen, Alani, Issam, Ndung'u, Perpetual Wangui, Revathi, Gunturu, Gehre, Florian, Akter, Suriya, Ntoumi, Francine, Stewart-Isherwood, Lynsey, Ntinginya, Nyanda E, Rachow, Andrea, Hoelscher, Michael, Cirillo, Daniela Maria, Skenders, Girts, Hoffner, Sven, Bakonyte, Daiva, Stakenas, Petras, Diel, Roland, Crudu, Valeriu, Moldovan, Olga, Al-Hajoj, Sahal, Otero, Larissa, Barletta, Francesca, Carter, E Jane, Diero, Lameck, Supply, Philip, Comas, Iñaki, Niemann, Stefan, and Gagneux, Sebastien
- Abstract
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
- Published
- 2016
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