1. Male behavior by knockout.
- Author
-
Spors H and Sobel N
- Subjects
- Animals, Female, Humans, Male, Mice, Sex Characteristics, Sex Differentiation physiology, Smell physiology, TRPC Cation Channels genetics, Testosterone metabolism, Mice, Knockout physiology, Olfactory Bulb physiology, Sex Attractants physiology, Sexual Behavior, Animal physiology, Vomeronasal Organ physiology
- Abstract
A recent paper published by Kimchi, Xu, and Dulac in Nature describes the emergence of male-type sexual behavior in female mice following incapacitation of the accessory olfactory system. The authors argue that this implies a default male-type behavioral pattern that is otherwise constantly inhibited in the female brain by chemical signals transduced in the accessory olfactory system. In addition to reviewing these findings, we suggest in this Preview how these findings in the mouse could have relevance for human behavior.
- Published
- 2007
- Full Text
- View/download PDF