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Investigates the determination of arginine and asymmetric dimethylarginine in human plasma by liquid chromatography/mass spectroscopy with the isotope dilution technique. Detection of the analytes with an electrospray ionization ion trap instrument working in the full-scan single mass spectrometry mode; Assessment of the corresponding values for end-stage chronic renal failure patients; Connection of the elevated concentration levels of asymmetric dimethylarginine to a range of cardiovascular disease.