94 results on '"Sun, Yuanyuan"'
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2. Lysozyme-(-)-epigallocatechin gallate covalent conjugates: preparation, structure and functional properties
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Yin, Yongpeng, Luo, Denglin, Jin, Weiping, Sun, Yuanyuan, Yue, Mengge, Li, Penglin, and Xu, Wei
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The development of multi-functional preservatives is a promising solution to food waste caused by microbial spoilage. Therefore, in the present study, lysozyme - (-)-epigallocatechin gallate (Ly-EGCG) covalent conjugates were prepared by a free radical grafting approach. The effects of EGCG concentration on the physicochemical, structural, antioxidant, and antibacterial properties of Ly-EGCG conjugates were investigated. The covalent coupling of Ly with EGCG was confirmed by the generation of new bands in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) profiles, the decrease in fluorescence intensity (> 85%) shown by multispectral techniques, and the shift of the amide I band in the Fourier transform infrared (FTIR) spectra. Compared to Ly, after adding 0.7 mM EGCG, the thermal denaturation temperature of the Ly-EGCG conjugates was decreased to 68.84 °C, whereas the DPPH scavenging capacity (88.84 ± 0.42%) and total antioxidant capacity (0.94 ± 0.06 U/mL) were remarkably enhanced. The inhibitory effect of Ly-EGCG conjugates on E. coliand S. aureuscould be effectively regulated by modifying the EGCG concentration. Furthermore, Pearson correlation analysis revealed a correlation between the structural and functional properties of Ly-EGCG conjugates. These results provide potential strategies for the development of food-grade, multi-functional preservatives.
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- 2024
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3. Thioredoxin Reductase-Mediated Reaction Evokes In SituSurface Polarization Effect on BiOIO3: Toward a New Sensing Strategy for Cathodic Photoelectrochemistry
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Gu, Mengmeng, Yu, Zhangcong, Wu, Xiuming, Sun, Yuanyuan, Hu, Jiangwei, Dong, Yuming, and Wang, Guang-Li
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We have witnessed the fast progress of cathodic photoelectrochemistry over the past decades, though its signal transduction tactic still lacks diversity. Exploring new sensing strategies for cathodic photoelectrochemistry is extremely demanding yet hugely challenging. This article puts forward a unique idea to incorporate an enzymatic reaction-invoked surface polarization effect (SPE) on the surface of BiOIO3to implement an innovative cathodic photoelectrochemical (PEC) bioanalysis. Specifically, the thioredoxin reductase (TrxR)-mediated reaction produced the polar glutathione (GSH), which spontaneously coordinated to the surface of BiOIO3and induced SPE by forming a polarized electric field, resulting in improved electron (e–) and hole (h+) pair separation efficiency and an enhanced photocurrent output. Correlating this phenomenon with the detection of TrxR exhibited a high performance in terms of sensitivity and selectivity, achieving a linear range of 0.007–0.5 μM and a low detection limit of 2.0 nM (S/N = 3). This study brings refreshing inspiration for the cathodic PEC signal transduction tactic through enzyme-mediated in situreaction to introduce SPE, which enriches the diversity of available signaling molecules. Moreover, this study unveils the potential of in situgenerated SPE for extended and futuristic applications.
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- 2024
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4. Near telomere-to-telomere genome of the model plant Physcomitrium patens
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Bi, Guiqi, Zhao, Shijun, Yao, Jiawei, Wang, Huan, Zhao, Mengkai, Sun, Yuanyuan, Hou, Xueren, Haas, Fabian B., Varshney, Deepti, Prigge, Michael, Rensing, Stefan A., Jiao, Yuling, Ma, Yingxin, Yan, Jianbin, and Dai, Junbiao
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The model plant Physcomitrium patenshas played a pivotal role in enhancing our comprehension of plant evolution and development. However, the current genome harbours numerous regions that remain unfinished and erroneous. To address these issues, we generated an assembly using Oxford Nanopore reads and Hi-C mapping. The assembly incorporates telomeric and centromeric regions, thereby establishing it as a near telomere-to-telomere genome except a region in chromosome 1 that is not fully assembled due to its highly repetitive nature. This near telomere-to-telomere genome resolves the chromosome number at 26 and provides a gap-free genome assembly as well as updated gene models to aid future studies using this model organism.
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- 2024
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5. Mechanism and Stereoselectivity Control of Terminal Alkyne Dimerization Activated by a Zr/Co Heterobimetallic Complex: A DFT Study
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Sun, Yuanyuan, Zhang, Jinying, Zeng, Yanli, Meng, Lingpeng, and Li, Xiaoyan
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Heterobimetallic complexes have recently garnered considerable attention in organic synthesis owing to their high activity and selectivity, which surpass those of monometallic complexes. In this study, the detailed mechanisms of terminal alkyne dimerization activated by the heterobimetallic Zr/Co complex, as well as the different stereoselectivities of Me3SiC≡CH and PhC≡CH dimerization, were investigated and elucidated by using density functional theory calculations. After excluding the three-molecule reaction and outer-sphere mechanisms, the inner-sphere mechanism was determined as the most optimal process. The inner-sphere mechanism involves four processes: THF dissociation and coordination of the first alkyne; ligand migration and C–H activation; N2dissociation and insertion of the second alkyne; and reductive elimination. The stereoselectivity between the E-/Z- and gem-isomers is determined by the C–C coupling mode of the two alkynes and that of the E- and Z-isomers is determined by the sequence of the C–C coupling and hydrogen migration in the reductive elimination process. Me3SiC≡CH dimerization yields only an E-isomer owing to the large differences in the distortion and interaction energies, whereas PhC≡CH dimerization produces an E-, Z-, and gem-isomers owing to the reduced interaction energy differences.
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- 2024
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6. Multi-Stage Planning of Distribution Network With High Penetration Renewable Energy Considering Reliability Index
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Liu, Jie, Sun, Kaiqi, Ding, Zhaohao, Li, Ke-Jun, and Sun, Yuanyuan
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In this study, a multi-stage planning model of the distribution network with high photovoltaic (PV) penetration considering operational reliability is presented. The operation reliability cost consisting of three modified reliability indices is imposed in the objective function in the proposed distribution systems planning model. Additionally, the distribution network reconfiguration including microgrid is considered at the operation level to improve system operation reliability. Nonlinear expressions of modified reliability indices aggravate the complexity of the proposed planning model. To address the computational burden, the planning model is simplified as a mixed integer linear programming (MILP) model, which have an efficient computational behavior with exiting MILP solvers. The benefits of imposing operation reliability cost in the objective function and network reconfiguration including microgrid as operation strategies, are discussed. The effectiveness of the proposed model is tested by numerical results.
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- 2024
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7. An Integration Scheme for Highway Rest Area Integrating the Distributed Photovoltaic Generation and Energy Storage
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Li, Bowen, Sun, Huiru, Lou, Jie, Sun, Kaiqi, Zhang, Zhengfa, and Sun, Yuanyuan
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With the large-scale expansionary of electric vehicles (EVs), charging facilities on highway have also been developed rapidly as supporting services, providing convenient and fast charging services for electric vehicle users. Due to the limited number and capacity of charging facilities, it is difficult to meet diverse queue waiting time needs of EV users during peak charging periods. Meanwhile, considering the integration of distributed photovoltaic and distributed energy storage system (DPV-DESS) on highway, this paper aims at proposing a strategy for the highway to coordinate multiple resources and meet the diverse charging demand of EVs. In this paper, a highway integration scheme with DPV-DESS is established to maximize the EV charging simultaneity and EV users’ satisfaction while achieving the efficient utilization of DPV-DESS. Firstly, based on the DPV-DESS configuration, the model of photovoltaic (PV), energy storage and EV charging parameters are built. Secondly, considering PV output characteristics and the diverse charging needs, a two-layer optimization model is put forward. In the upper layer, multi-source coordination optimization model is proposed to realize efficient utilization. In the lower layer, an orderly charging strategy is raised for EVs senseless charging. Finally, case studies have been conducted on a self-sustained DPV-DESS consisting of a modified test system with 20 charging piles. Numerical results indicate that the proposed scheme can maximize the EV users’ satisfaction while minimizing the operating cost on the premise of the self-sustained highway transportation energy system operation.
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- 2024
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8. A Measurement-Based Dynamic Harmonic Model for Single-Phase Diode Bridge Rectifier-Type Devices
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Xie, Xiangmin, Zhang, Jinghui, Sun, Yuanyuan, and Fan, Jianhua
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Home appliances with single-phase diode bridge rectifiers (SDBRs) are widely used due to the rapid development of power electronics technology. This article proposes a dynamic harmonic model based on measured data for SDBR-type devices. First, the SDBR-type devices are categorized into two types by identifying the current waveform difference diagram. Second, the harmonic coupled models are established for two types of devices, and the circuit parameters are estimated using the
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- 2024
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9. Aperiodically Intermittent Control of Switched Stochastic Nonlinear Systems Based on Discrete-Time Observation
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Sun, Yuanyuan, Deng, Feiqi, Yu, Peilin, and Huang, Yongjia
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The brief focuses on stabilizing aperiodically intermittent control (AIC) for switched stochastic nonlinear systems (SSNSs) based on discrete-time observation. The relationship between switched and discrete-time observation points under controller rest and activation intervals is analyzed. Three states are considered for running the controlled system, namely synchronous control, asynchronous control, and open-loop operation. Sufficient conditions are provided for the stabilization of SSNSs, allowing the Lyapunov function to increase within the asynchronous control interval. In addition, the method can be extended to SSNSs based on discrete-time observations without AIC. Finally, a tunnel diode circuit model (TDCM) with noise effects is provided to illustrate the validity of theoretical conclusions.
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- 2024
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10. Transforming growth factor-β and bone morphogenetic protein signaling pathways in pathological cardiac hypertrophy
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Wen, Jing, Liu, Guixiang, Liu, Mingjie, Wang, Huarui, Wan, Yunyan, Yao, Zhouhong, Gao, Nannan, Sun, Yuanyuan, and Zhu, Ling
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ABSTRACTPathological cardiac hypertrophy (referred to as cardiac hypertrophy) is a maladaptive response of the heart to a variety of pathological stimuli, and cardiac hypertrophy is an independent risk factor for heart failure and sudden death. Currently, the treatments for cardiac hypertrophy are limited to improving symptoms and have little effect. Elucidation of the developmental process of cardiac hypertrophy at the molecular level and the identification of new targets for the treatment of cardiac hypertrophy are crucial. In this review, we summarize the research on multiple active substances related to the pathogenesis of cardiac hypertrophy and the signaling pathways involved and focus on the role of transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signaling in the development of cardiac hypertrophy and the identification of potential targets for molecular intervention. We aim to identify important signaling molecules with clinical value and hope to help promote the precise treatment of cardiac hypertrophy and thus improve patient outcomes.
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- 2023
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11. Mechanism and Selectivity Investigation of [Cu]/[Pd] Synergistic Catalyzed Borylfluoroallylation of Alkyne: A DFT Study
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Liu, Qing, Sun, Yuanyuan, Zeng, Yanli, and Li, Xiaoyan
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Transition-metal-catalyzed fluorination of organic compounds is the most effective method to obtain high-value fluorinated compounds that are widely used in the fields of medicine and materials science. In this work, the synergistically catalyzed mechanism of borylfluoroallylation of acetylene catalyzed by [Cu]/[Pd] bimetallic catalysts as well as the chemoselectivity and regioselectivity of the reactions were investigated by means of density functional theory calculations. The results showed that the whole reaction involves three processes: [Cu]-catalyzed borylcuprization of alkynes and [Pd]-catalyzed open-loop coupling of difluorocyclopropane, followed by transmetalation and reduction elimination of the two intermediates to yield the final product. For the title reaction, the mode of Cu–B bond insertion into the alkyne determines the regioselectivity, while the modes of open-loop coupling of difluorocyclopropane and β-F elimination control the chemoselectivity. The reduction elimination process is the rate-determining step, yielding cis-a-Pro as the major product. Our work clarifies the catalytic mechanism responsible for acetylene borylfluoroenylation catalyzed by [Cu]/[Pd] catalysts, providing a detailed explanation for reported experimental results and valuable information for acetylene functionalization.
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- 2023
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12. Mechanistic Insights into Oxazolone Synthesis by Bimetallic Au–Pd-Catalyzed Catalysis and Catalyst Design: DFT Investigations
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Wu, Xueju, Sun, Yuanyuan, Zeng, Yanli, and Li, Xiaoyan
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Bimetallic synergistic catalysis is one of the most effective and powerful strategies for the synthesis of oxazolones, an important species in organic synthesis. In this work, the mechanism of AuCl(PMe3)/AgOTf-Pd(0) ([Au–Pd]) bimetallic catalyst-catalyzed oxazolone synthesis using N-alkynyl carbamates as precursors was studied in detail by DFT calculations and the catalytic performances of a series of bimetallic catalysts were evaluated. The results show that the reaction begins from the [Au]-catalyzed cycloisomerization of N-alkynyl carbamates. After the five-membered intermediate is formed, the [Pd(0)]-catalyzed cycle starts, which contains three steps: oxidation addition, transmetalation, and reductive elimination. The whole reaction belongs to a catalyzed catalysis, and the reductive elimination is the rate-determining step. In the transmetalation process, both the [Pd(0)] catalyst and the ionic bridge are necessary. For the [Au–Pd]-catalyzed process, it is Cl–as the bridge, not OTf–. The cheaper metal compound, AgCl(PMe3), can serve as the alternative of AuCl(PMe3) to co-catalyze with the [Pd(0)] catalyst for the title reaction.
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- 2023
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13. Enhancing Size-Selective Adsorption of CO2/CH4on ETS-4 via Ion-Exchange Coupled with Thermal Treatment
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Peng, Qilong, Chen, Yu, Fang, Diyi, Liu, Chuanlei, Wu, Kongguo, Chen, Yuxiang, Jiang, Hao, Sun, Yuanyuan, Wu, Qiumin, Wu, Di, and Sun, Hui
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ETS-4 shows great potential to achieve effective separation of challenging mixtures due to its promising tunability of pores. However, the regulation of pore size is largely limited by its low thermal stability. Here, Na-ETS-4 was synthesized by the hydrothermal method and additionally modified via ion exchange coupled with thermal treatment. Structures of all synthesized samples were examined using a variety of characterization techniques. Both adsorption equilibrium and kinetics of CO2and CH4on these adsorbents were evaluated on custom-made adsorption units. In addition, the mechanism of CO2adsorption on different structural models of ETS-4 was revealed via combining with the molecular dynamics (MD) simulations. Ion exchange largely improves the thermal stability of ETS-4 and its adsorption capacities for CO2and CH4. Ba-ETS-4-350 exhibits the largest equilibrium selectivity of 12.42 and the greatest Henry’s selectivity of 2178.51. The radial distribution function (RDF) results reveal the main adsorption sites of CO2in different ETS-4 structures.
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- 2023
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14. HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells
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Qiu, Qiang, yang, Linyu, Feng, Yunyu, Zhu, Zejiang, Li, Ning, Zheng, Li, Sun, Yuanyuan, Pan, Cong, Qiu, Huandi, Cui, Xue, He, Wei, Wang, Fang, Yi, Yuyao, Tang, Minghai, Yang, Zhuang, Yang, Yunfan, Li, Zhihui, Chen, Lijuan, and Hu, Yiguo
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Purinostat Mesylate (PM) is a novel highly selective and active HDAC I/IIb inhibitor, and the injectable formulation of PM (PMF) based on the compound prescription containing cyclodextrin completely can overcome PM's poor solubility and improves its stability and pharmacokinetic properties. Here, we showed that PM effectively repressed the survival of Ph+leukemia cells and CD34+leukemia cells from CML patients in vitro. In vivostudies demonstrated that PMF significantly prevented BCR-ABL(T315I) induced CML progression by restraining leukemia stem cells (LSCs), which are insensitive to chemotherapy and responsible for CML relapse. Mechanism studies revealed that targeting HDAC I/IIb repressed several important factors for LSCs survival including c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR, as well as interrupted some critical biologic processes. Additionally, PMF increased glutamate metabolism in LSCs by increasing GLS1. The combination of PMF and glutaminase inhibitor BPTES synergistically eradicated LSCs by altering multiple key proteins and signaling pathways which are critical for LSC survival and self-renewal. Overall, our findings represent a new therapeutic strategy for eliminating LSCs by targeting HDAC I/IIb and glutaminolysis, which potentially provides a guidance for PMF clinical trials in the future for TKI resistance CML patients.
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- 2023
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15. Sampled-Data Stabilization for Stochastic Systems Subject to Input Saturation and Its Application to Synchronization of Two Chua’s Circuits
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Huang, Yongjia, Deng, Feiqi, Wan, Fangzhe, Yu, Peilin, and Sun, Yuanyuan
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In this brief, we focus on the stabilization problem of a class of stochastic nonlinear systems under periodic sampled-data state feedback subject to input saturation. An auxiliary variable is introduced to handle the saturation nonlinearity as well as to characterize the estimate of the region of attraction of the origin (RAO). After discretizing the continuous-time systems and obtaining the iterative relations of sampling instants, sufficient stabilization criteria are established in the form of parametric conditions. Both mean square exponential stability and almost sure stability are considered. Based on our results, the relations among the estimate of RAO and controller gain, sampling period can be analysed clearly, which is demonstrated in the example. An application for synchronization of two Chua’s Circuits is presented to illustrate the effectiveness of our results.
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- 2023
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16. Non-Minimum Phase Behavior Analysis of the Weak Grid-Tied VSC's Q-Axis Current Control Dynamics
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Yin, Rui, Sun, Huadong, Sun, Yuanyuan, Zhao, Bing, Wang, Shanshan, Wu, Guanglu, and Sun, Kaiqi
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In this letter, the phenomenon is found that there are non-minimum phase and “undershoot” behavior in grid-tied VSC, even if the outer loop is not applied. Based on the small-signal model, the mechanism that q-axis-related non-minimum phase behavior reduces VSC's stability and the “undershoot” behavior are analyzed in the letter. It is found that the q-axis current control dynamics of weak grid-tied VSC introduce an open-loop unstable zero when the reactive power is supplied from the AC system, which is the key factor for the non-minimum phase behavior.
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- 2023
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17. CuO nanoparticles modify bioaccumulation of perfluorooctanoic acid in radish (Raphanus sativusL.)
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Xu, Yang, Du, Wenchao, Yin, Ying, Sun, Yuanyuan, Ji, Rong, He, Huan, Yang, Shaogui, Li, Shiyin, Wu, Jichun, and Guo, Hongyan
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ABSTRACTResearch on combined phytotoxicity of perfluorooctanoic acid (PFOA) and nanoparticles is very important for the remediation of PFOA contaminated soil and further assessment for the potential of nano-enhanced phytoremediation. Here, joint effects of PFOA and CuO nanoparticles (nCuO) in plants were studied by exposing radish (Raphanus sativusL.) to PFOA (4 mg/kg) and nCuO (200 and 400 mg/kg) for 30 days, and measuring for contaminant accumulation, radish biomass, photosynthesis profiles and nutrient contents. Results showed that PFOA accumulated highly in radish organs but showed limited effects on radish biomass. nCuO could increase the transfer rate of PFOA from root to shoot and reduce PFOA accumulation in edible root part, but higher nCuO lead to decreased radish biomass. Reversely, PFOA alleviated the adverse effects of nCuO on leaf photosynthesis and root metabolism of vitamins and amino acids. These results provided basics for exploring possibility of nano-enhanced phytoremediation for PFOA soil pollution.
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- 2022
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18. FDG Uptake Caused by Right Varicocele
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Deng, Jia, Sun, Yuanyuan, He, Renjie, Cai, Liang, and Chen, Yue
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A 67-year-old man underwent 18F-FDG PET/CT for lung cancer staging. Interestingly, the PET scan revealed strip-shaped FDG uptake in the right inguinal contoured area, which was later confirmed as a right varicocele through ultrasound imaging.
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- 2024
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19. A High-Rate, Durable Cathode for Sodium-Ion Batteries: Sb-Doped O3-Type Ni/Mn-Based Layered Oxides
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Yuan, Tao, Li, Siqing, Sun, Yuanyuan, Wang, Jeng-Han, Chen, An-Jie, Zheng, Qinfeng, Zhang, Yixiao, Chen, Liwei, Nam, Gyutae, Che, Haiying, Yang, Junhe, Zheng, Shiyou, Ma, Zi-Feng, and Liu, Meilin
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O3-Type layered oxides are widely studied as cathodes for sodium-ion batteries (SIBs) due to their high theoretical capacities. However, their rate capability and durability are limited by tortuous Na+diffusion channels and complicated phase evolution during Na+extraction/insertion. Here we report our findings in unravelling the mechanism for dramatically enhancing the stability and rate capability of O3-NaNi0.5Mn0.5–xSbxO2(NaNMS) by substitutional Sb doping, which can alter the coordination environment and chemical bonds of the transition metal (TM) ions in the structure, resulting in a more stable structure with wider Na+transport channels. Furthermore, NaNMS nanoparticles are obtained by surface energy regulation during grain growth. The synergistic effect of Sb doping and nanostructuring greatly reduces the ionic migration energy barrier while increasing the reversibility of the structural evolution during repeated Na+extraction/insertion. An optimized NaNMS-1 electrode delivers a reversible capacity of 212.3 mAh g–1at 0.2 C and 74.5 mAh g–1at 50 C with minimal capacity loss after 100 cycles at a low temperature of −20 °C. Such electrochemical performance is superior to most of the reported layered oxide cathodes used in rechargeable SIBs.
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- 2022
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20. Macromolecular Dexamethasone Prodrug Ameliorates Neuroinflammation and Prevents Bone Loss Associated with Traumatic Brain Injury
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Wei, Xin, Zhao, Gang, Jia, Zhenshan, Zhao, Zhifeng, Chen, Ningrong, Sun, Yuanyuan, Kelso, Matthew, Rathore, Geetanjali, and Wang, Dong
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Traumatic brain injury (TBI) is one of the leading causes of death and disability among children and young adults in the United States. In this manuscript, we assessed the utility of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-based dexamethasone (Dex) prodrug (P-Dex) in the treatment of TBI. Using a controlled cortical impact TBI mouse model, P-Dex was found to passively target and sustain at the traumatic/inflammatory brain tissue for over 14 days after systemic administration. The histological evidence supports P-Dex’s therapeutic potential in ameliorating neuroinflammation and mitigating neurodegeneration. Behaviorally, the P-Dex-treated animals showed statistically significant improvement in balance recovery. A trend of neurological severity score improvement at the early time point post-TBI was also noted but did not achieve statistical significance. While probing the potential glucocorticoid side effects that may associate with P-Dex treatment, we discovered that the TBI mice develop osteopenia. Interestingly, the P-Dex-treated TBI mice demonstrated higher bone mineral density and better bone microarchitecture parameters when compared to free Dex and the saline control, revealing the osteoprotective effect of P-Dex in addition to its neuronal protection benefits post-TBI.
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- 2022
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21. Research on coordinated control of AC/DC system considering energy storage power limitation
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Li, Bowen, Sun, Yuanyuan, Li, Yahui, Lu, Tong, Yu, Tao, and Pang, Yanqing
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Energy storage can effectively alleviate the power fluctuation caused by high permeability distributed new energy in AC/DC system. However, due to the state of charge (SOC) of energy storage, AC/DC system is difficult to give full play to the power complementary. Thus, a coordinated control strategy of AC/DC system considering the state of charge of energy storage is proposed in the paper. Firstly, the power balance between subnets of AC/DC system is analyzed to achieve the balance of supply and demand. Then, according to the power control strategy, the AC/DC coordinated control strategy based on energy storage SOC is studied. In order to improve the stable operation ability of the system, the technology of virtual synchronous generator (VSG) is applied. Finally, the validation model is built based on MATLAB/ Simulink platform. The simulation results show that the strategy can effectively coordinate the power interaction between the subnet power supply and the interconnected converter and improve the system stability.
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- 2022
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22. FeOx@FeP heterostructure: Surface phosphorization toward efficient photocatalytic Fenton-like norfloxacin removal
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Zhu, Yukun, Sikandaier, Abiduweili, Zhang, Yifei, Wang, Xiaoxia, Du, Baoyin, Xue, Jingfei, Sun, Yuanyuan, Lu, Ping, and Yang, Dongjiang
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The residues of daily-used antibiotics are difficult to be removed and very harmful to the environment. Herein, FeOx@FeP heterostructure was constructed by surface phosphorization of hematite (α-Fe2O3) synthesized viaa facile hydrothermal method for efficient photo-Fenton degradation of antibiotic norfloxacin (NOR). Compared with the bare α-Fe2O3, the FeOx@FeP heterostructure exhibits much-enhanced photocatalytic Fenton-like performance, with NOR degraded by 75% within 5 min by sunlight-driven photo-Fenton reactions. It was suggested that the surface phosphorization-derived metallic FeP overlayer could accelerate the separation and migration of photogenerated charge carriers in α-Fe2O3, which benefits the generation of •OH and O2•−reactive radicals from photo-Fenton reaction and thus give rise to the great enhancement in NOR degradation activity. This study displays an alternative strategy of surface engineering to design novel heterostructured materials for the efficient photo-Fenton treatment of wastewater containing antibiotic residues as well as other organic pollutants.
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- 2022
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23. GelMA hydrogel: A game-changer in 3D tumor modeling
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Jiao, Weijie, Shan, Jingxin, Gong, Xue, Sun, Yuanyuan, Sang, Lin, Ding, Xiaoying, Zhou, Huihui, and Yu, Ming
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Currently, researchers have increasingly focused on 3D in vitro tumor models as they possess the capacity to replicate tissue-like characteristics and cell-cell interactions within the tumor microenvironment. Hydrogel, a hydrophilic polymer network that crosslinks in a 3D structure, has emerged as a prominent cynosure due to its ability to absorb water, swell, and provide attachment sites for cells. By mimicking the extracellular matrix, hydrogel facilitates the investigation of cell growth and cell-cell interaction. The gelatin methacrylate (GelMA) hydrogel has garnered significant interest in the scientific community due to its ability to be mechanically adjusted and its exceptional biocompatibility. This review primarily focuses on the recent advancements in the construction methodology of 3D tumor models utilizing GelMA hydrogel, including the preparation procedures, tumor attributes, and performance enhancements. Furthermore, we offer insights into the prospective directions for the advancement of GelMA hydrogels. It is anticipated that GelMA hydrogels will find extensive application in the near future for the precise fabrication of tumor models with diverse geometries. These models are poised to become the preferred option for investigating the tumor microenvironment, tumorigenesis, tumor metastasis, and related mechanisms.
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- 2024
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24. Reaction Mixtures Rich in [γ-Glu](n≥1)-Arg Derived from Enzymatic Synthesis as Potential Salt and Umami Enhancers
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Wu, Jing, Sun, Yuanyuan, Huan, Xiang, and Cui, Chun
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Some arginyl dipeptides and γ-glutamyl peptides have been identified as salt and umami enhancers. These compounds provide an operable approach for reducing sodium uptake without losing the palatability of foods. γ-Glu-Arg was hinted to have a taste-enhancing effect in the past, but few research studies have focused on it. In the present study, a series of γ-glutamyl peptides containing Arg such as γ-Glu-Arg, [γ-Glu](n=2)-Arg, [γ-Glu](n=3)-Arg, [γ-Glu](n=4)-Arg, [γ-Glu](n=5)-Arg, [γ-Glu](n=6)-Arg, [γ-Glu](n=7)-Arg, and [γ-Glu](n=8)-Arg were synthesized using glutaminase from Bacillus amyloliquefaciensin the presence of Gln and Arg. A high solid concentration of 30% was found to increase the production of [γ-Glu](1≤n≤4)-Arg. Sensory evaluation revealed that individual [γ-Glu](n=1,2,3,4)-Arg has a slightly bitter and astringent taste. [γ-Glu](n=1,2)-Arg (1.0 mg/mL) significantly increased the umaminess in the mixture of salt and sodium glutamate but showed no significant effect on saltiness in the salt solution, whereas [γ-Glu](n=3,4)-Arg and postenzymatic reaction mixtures (1.0 mg/mL) significantly increased both saltiness and umaminess. [γ-Glu](n=3,4)-Arg and postenzymatic mixtures in the system with 30% solid concentrations showed a high and similar taste-enhancing effect. Moreover, umaminess and saltiness increased 1.9 and 2.4 times in the simulated broth, respectively, while saltiness increased 1.5 times in the salt solution by the addition of postenzymatic reaction mixtures in the system with 30% solid concentrations at 20.0 mg/mL. These results indicated that [γ-Glu](n=1,2,3,4)-Arg and postenzymatic reaction mixtures rich in [γ-Glu](n≥1)-Arg were potential salt or umami enhancers.
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- 2022
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25. Stereo- and Regioselectivity of Hydrogenation of a Recently Synthesized Carboncone and Its Predictive Models
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Chen, Xuyang, Sun, Yuanyuan, and Wang, Yang
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Since its atomically precise synthesis in recent experiments, the carboncone molecule presents a novel example of discrete nanocarbons with promising applications, but little is known yet about its chemical properties. In this work, we present a comprehensive computational study on the hydrogenation of carboncone with a varying number of added H atoms (from 1 to 12). Unlike planar benzenoid hydrocarbons, carboncone prefers that all H atoms be added to its external, convex surface. The previous topology-based model for hydrogenated fullerenes and benzenoid hydrocarbons is shown to be no longer valid for carboncone. We here propose an extended model capable of predicting the hydrogenation regioselectivity for carboncone, which is largely governed by π delocalization. Yet the H···H repulsion at rim sites also plays an important role in adduct stability. Interestingly, some preferred addition patterns can be understood by counting the size of intact π rings upon H addition. These findings may provide insightful guidance to the functionalization of carboncones and related nanocarbons.
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- 2022
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26. Influence of dead time on harmonic of electric energy router and its compensation strategy
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Wang, Lidan, Cen, Mengyi (Milly), Yin, Shulin, Sun, Yuanyuan, Liu, Zhen, Xu, Qingshen, Yu, Tao, and Pang, Yanqing
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- 2022
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27. Research on suppression of power angle oscillation by series compensation
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Jiang, Tongjun, Zhang, Xueran, Duan, Zhi, Li, Chao, Sun, Yuanyuan, and Chen, Yuan
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In this paper, the advantages and disadvantages of fixed series complement (FSC) and controllable series complement (TCSC) in long-distance transmission are analyzed in detail: FSC has the characteristics of improving line transmission capacity and increasing transient stability, but the control is not flexible enough, which may cause sub-synchronous oscillation and insufficient damping. TCSC has the characteristics of suppressing power Angle oscillation and improving transmission power limit. Considering the two factors of economy and efficiency, a method combining FSC and TCSC is proposed. Taking a typical single-machine infinite system as an example, TCSC adopts the linear control plus bang-Bang control strategy in BPA of China Electric Power Research Institute. According to the research, the transmission capacity of the line can be effectively improved by configuring series complement under different conditions, such as no series complement, only FSC and mutual supplement between FSC and TCSC, and with the increase of TCSC comparison, It is more obvious to resist functional oscillation.
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- 2022
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28. Single-site catalysis in heterogeneous electro-Fenton reaction for wastewater remediation
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Sun, Yuanyuan, Cai, Pengcheng, Yang, Dongjiang, and Yao, Xiangdong
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The heterogeneous electro-Fenton (Hetero-EF) system is characterized by in situgeneration of hydrogen peroxide (H2O2). Then, the hydroxyl radicals (•OH) formed by activization of H2O2can strongly oxidize and mineralize pollutants in wastewater. Single-site heterogeneous catalysts (SSHCs) have the essence of isolated active single sites anchored on and coordinated with the atoms of a suitable substrate. They can bridge the understanding and performance gaps between homogeneous and heterogeneous catalysis, guiding the rational design of next-generation catalysts. They also provide a feasible approach to adjusting the catalytic activity and selectivity of a particular reaction, showing great potential for high Hetero-EF catalysis. However, the research on SSHCs as Hetero-EF catalysts is still in its infancy. More exploration and a universal principle for SSHC design are needed. Here, design principles of high-performance SSHCs toward electro-Fenton field are proposed, aiming to provide general guidance toward development of high-performance SSHCs in Hetero-EF.
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- 2022
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29. Metabolic Dysfunction-associated Fatty Liver Disease and Mortality Among Chinese Adults: a Prospective Cohort Study
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Wang, Xiaomo, Wu, Shouling, Yuan, Xiaojie, Chen, Shuohua, Fu, Qingjiang, Sun, Yuanyuan, Lan, Yanqi, Hu, Shiqi, Wang, Yanhong, Lu, Ying, Qu, Shunxi, and Wang, Li
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- 2022
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30. Circ_HECTD1 regulates cerebral ischemia injury via mechanisms involving the regulation of let-7c-5p/ROCK1 axis
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Guo, Qian, Guo, Tingting, Sun, Yuanyuan, and Chen, Tianrong
- Abstract
Supplemental Digital Content is available in the text.
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- 2022
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31. Light-driven carbon dioxide reduction over the Ag-decorated modified TS-1 zeoliteElectronic supplementary information (ESI) available. See DOI: 10.1039/d1cy02126e
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Li, Guohui, Wang, Min, Shao, Hengyang, Liu, Wenqing, Yang, Sicong, Sun, Wei, Ishihara, Tatsumi, Sun, Yuanyuan, and Zhou, Xiaoxia
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Light-driven reduction of CO2to high value-added fuel has shown great potential in reducing CO2emissions and solving the energy crisis. Herein, a Cu ion-exchanged mesoporous TS-1 zeolite (Cu-TS-1) with rich Ti3+–VOdefects was successfully prepared for the first time. Subsequently, Ag nanoparticles (2–10 nm) are highly dispersed on the surface of the zeolite by a photoreduction process, which greatly improves visible light absorption ability due to the localized surface plasmon resonance of Ag. Under UV-visible light irradiation, the Ag/Cu-TS-1 sample exhibits high and stable CO2reduction performance. The yield of CO reaches 6.93 μmol g−1while the competitive hydrogen evolution can be effectively inhibited. Interestingly, Ag/Cu-TS-1 as a photocathode can convert CO2into CH3OH and C2H5OH, giving a rate of 5.64 and 2.62 μmol cm−2h−1at −0.6 V vs.RHE, respectively. In situRaman tests reveal that the existence of intermediates containing C–H bonds, especially *CO intermediates, plays a key role in C–C coupling, thus promoting the formation of C2 products, indicating that the Ag cocatalyst-loaded Cu-modified zeolite can jointly accelerate the conversion of CO2into a hydrocarbon compound.
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- 2022
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32. A review on nanoconfinement engineering of red phosphorus for enhanced Li/Na/K-ion storage performances
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Sun, Yuanyuan, Zeng, Fanyou, Zhu, Yukun, Lu, Ping, and Yang, Dongjiang
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The strategies used to achieve high reversible capacity, good rate capability and super stability in cycling experiments of red phosphorus confinement into carbon matrix anode materials in Li/Na/K-ion batteries have been reviewed.
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- 2021
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33. Color polarization demosaicking by a convolutional neural network
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Sun, Yuanyuan, Zhang, Junchao, and Liang, Rongguang
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To address color polarization demosaicking problems in polarization imaging with a color polarization camera, we propose a color polarization demosaicking convolutional neural network (CPDCNN), which has a two-branch structure to ensure the fidelity of polarization signatures and enhance image resolution. To train the network, we built a unique dual-camera system and captured a pairwise color polarization image dataset. Experimental results show that CPDCNN outperformances other methods by a large margin in contrast and resolution.
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- 2021
34. Crystal Morphology Modeling of Solvates and Hydrates of Organic Molecular Crystals: Olanzapine Solvate and Dihydrate
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Sun, Yuanyuan, Reutzel-Edens, Susan M., Bhardwaj, Rajni M., and Doherty, Michael F.
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Crystal morphology modeling of organic molecular solvates and hydrates remains largely unexplored due to the complex intermolecular interactions and growth units involved in the attachment at surface sites. In this paper, we present a mechanistic model to predict the crystal morphology of olanzapine–methanol solvate and olanzapine dihydrate. This study provides mechanistic insight into predicting the crystal habits of solvates and hydrates for broader classes of organic molecules. In this model, we assume that olanzapine incorporated into the solid state as a cluster consists of a solute together with a stoichiometric number of solvent molecules. Binding energy calculations are used to identify the most probable growth unit clusters, which is an olanzapine–methanol tetramer for the methanol solvate crystal, and olanzapine–water hexamer for the dihydrate crystal. The close agreement between the experimentally observed and the predicted morphologies lends support to the utility of the model.
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- 2021
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35. Unsupervised learning for hyperspectral recovery based on a single RGB image
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Zhang, Junchao, Zhao, Dangjun, Chen, Jianlai, Sun, Yuanyuan, Yang, Degui, and Liang, Rongguang
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Hyperspectral imagery often suffers from the degradation of spatial, spectral, or temporal resolution due to the limitations of hyperspectral imaging devices. To address this problem, hyperspectral recovery from a single red-green-blue (RGB) image has recently achieved significant progress via deep learning. However, current deep learning-based methods are all learned in a supervised way under the availability of RGB and correspondingly hyperspectral images, which is unrealistic for practical applications. Hence, we propose to recover hyperspectral images from a single RGB image in an unsupervised way. Moreover, based on the statistical property of hyperspectral images, a customized loss function is proposed to boost the performance. Extensive experiments on the BGU iCVL Hyperspectral Image Dataset demonstrate the effectiveness of the proposed method.
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- 2021
36. Evaluating the fractionation of ion-adsorption rare earths for in-situleaching and metallogenic mechanism
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Xu, Qiuhua, Yang, Lifeng, Wang, Dashan, Hou, Xiao, Sun, Yuanyuan, Zhou, Xuezhen, Zhou, Xinmu, and Li, Yongxiu
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The fractionation of ion adsorption rare earths (IAREs) along the depth in a shaft of a deposit at Dajishan, Jiangxi, China was comparatively evaluated using the partition values (PVs) and relative fractionation values (RFVs) of the leached rare earths (REs). It is found that both PVs and RFVs can objectively reflect the migration and fractionation of REs, but RE content and abrasion pH could not. However, the RFVs can provide more information to quantitatively evaluating the migration and fractionation characteristics of REs along the selected direction and region than PVs could, which is of significance for designing the optimal procedures of in-situleaching based on the determined flow direction of injecting solution. It is demonstrated that the migration of Ce, Pr, and Nd along the depth direction is inert, and that of REs post Sm and Y is active. Meanwhile, the migration of La shows region characteristics which is active in the upper and inert in lower region. More interesting, the dependence of RFVs on atomic number of REs displays a tetrad group variation trend. However, the fractionation of REs among clay minerals with different particle sizes is not evident, especially for the clay in the bottom region. These results indicate that the migration and fractionation of REs not only are dominated by the adsorption of their hydrated ions, but also rely on their hydrolysis tendency, which provide information for understanding the metallogenic mechanism of IAREs.
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- 2024
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37. Discovery of Novel N-(Anthracen-9-ylmethyl) Benzamide Derivatives as ZNF207 Inhibitors Promising in Treating Glioma
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Zhang, Menghan, Ding, Yushi, Gao, Mengkang, Lu, Xiaolin, Tan, Jun, Yu, Fei, Gu, Congying, Gu, Lujun, Ren, Xiameng, Hao, Chenyan, Ming, Liqin, Xu, Kang, Mao, Wenhao, Jin, Yuqing, Zhang, Min, You, Linjun, Wang, Zhanbo, Sun, Yuanyuan, Jiang, Jingwei, Yang, Yong, Zhang, Dayong, and Tang, Xinying
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Targeting tumor stemness is an innovative approach to cancer treatment. Zinc Finger Protein 207 (ZNF207) is a promising target for weakening the stemness of glioma cells. Here, a series of novel N-(anthracen-9-ylmethyl) benzamide derivatives against ZNF207 were rationally designed and synthesized. The inhibitory activity was evaluated, and their structure–activity relationships were summarized. Among them, C16exhibited the most potent inhibitory activity, as evidenced by its IC50values ranging from 0.5–2.5 μM for inhibiting sphere formation and 0.5–15 μM for cytotoxicity. Furthermore, we found that C16could hinder tumorigenesis and migration and promote apoptosis in vitro. These effects were attributed to the downregulation of stem-related genes. The in vivoevaluation demonstrated that C16exhibited efficient permeability across the blood–brain barrier and potent efficacy in both subcutaneous and orthotopic glioma tumor models. Hence, C16may serve as a potential lead compound targeting ZNF207 and has promising therapeutic potential for glioma.
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- 2024
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38. Three‐Component 1,4‐Addition through Ugi‐Type Reaction, an Oxidative Dearomatization Strategy
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Chen, Zhihao, Liu, Yuqing, Gao, Xing, Sun, Yuanyuan, Lei, Lingyu, Zhao, Xia, and Lu, Kui
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A three‐component 1,4‐addition variant of the Ugi reaction involving carboxylic acids, isocyanides, and cyclic α,β‐unsaturated imines is presented in this study. The cyclic α,β‐unsaturated imines were conveniently prepared through the oxidative dearomatization of N‐substituted anilines. The reaction proceeded successfully to produce a sole diastereomer, and the relative configuration was determined through 2D NMR and X‐ray diffraction analysis. A three‐component 1,4‐addition Ugi reaction using cyclic α,β‐unsaturated imines as substrates was developed by using an oxidative dearomatization strategy.
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- 2024
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39. Suitable Weir Heights to Improve the Provision of Environmental Flows in Urban Rivers
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Sun, Yuanyuan, Yin, Xin'an, Mao, Xianqiang, Zhang, Enze, and Zhao, Yanwei
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•Improper design of weir heights is one cause of e-flow shortages in rivers.•Measures for satisfying e-flows should be extended to the channel design stage.•Old weir design methods specify too-high weir height to meet e-flow requirements.
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- 2021
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40. Enhanced degradation of norfloxacin by Ce-mediated Fe-MIL-101: catalytic mechanism, degradation pathways, and potential applications in wastewater treatmentElectronic supplementary information (ESI) available. See DOI: 10.1039/d1en00250c
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Bao, Chaosheng, Zhao, Jian, Sun, Yuanyuan, Zhao, Xiaoliang, Zhang, Xiaohui, Zhu, Yukun, She, Xilin, Yang, Dongjiang, and Xing, Baoshan
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Novel Ce-mediated Fe-MIL-101 (Fe/Ce-MIL-101) Fenton catalysts were synthesized to efficiently remove norfloxacin (NOR). The substitution of Ce remarkably enhanced the catalytic performance of Fe-MIL-101, and the degradation efficiency of NOR (10 mg L−1) increased from 50.1% to 94.8% within 60 min. NOR could be completely degraded by Fe/Ce-MIL-101 after 180 min. Moreover, Fe/Ce-MIL-101 showed excellent stability and reusability in simulated and actual wastewater samples. Density functional theory (DFT) calculations revealed that the introduction of Ce(iii) and formation of hetero-coordinated Fe–O–Ce moieties in the secondary building units (SBUs) of Fe-MIL-101 could induce electronic distribution asymmetry, benefit the interaction between the metal sites and H2O2, accelerate electron transfer, and further facilitate H2O2activation. The degradation pathways of NOR were identified based on liquid chromatography-mass spectrometry (LC-MS) analysis and Fukui function calculation. Nine benzene ring-containing intermediates were initially detected after 20 min of degradation, and only two byproducts (“harmless” category) were preserved after 180 min. The opening of the piperazine ring and transformation of the quinolone group were mainly caused by the formed hydroxyl free radicals (OH). This work demonstrates a new strategy to enhance the performance of Fe-based Fenton-like catalysts by mediating the asymmetrical electronic distribution of coordinated Fe sites.
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- 2021
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41. A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma
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Song, Jiahang, Sun, Yuanyuan, Cao, Hui, Liu, Zhengcheng, Xi, Lei, Dong, Changqing, Yang, Rusong, and Shi, Ye
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ABSTRACTLung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and has a poor prognosis. Pyroptosis is regulated via the activation of inflammasomes and participates in tumorigenesis. However, the effects of pyroptosis-related lncRNAs (PRlncRNAs) on LUAD have not yet been completely elucidated. Therefore, we attempted to systematically explore patterns of cell pyroptosis to establish a novel signature for predicting LUAD survival. Based on TCGA database, we set up a prognostic model by incorporating PRlncRNAs with differential expression using Cox regression and LASSO regression. Kaplan–Meier analysis was conducted to compare the survival of LUAD patients. We further simplified the risk model and created a nomogram to enhance the prediction of LUAD prognosis. Altogether, 84 PRlncRNAs with differential expression were discovered. Subsequently, a new risk model was constructed based on five PRlncRNAs, GSEC, FAM83A-AS1, AL606489.1, AL034397.3 and AC010980.2. The proposed signature exhibited good performance in prognostic prediction and was related to immunocyte infiltration. The nomogram exactly forecasted the overall survival of patients and had excellent clinical utility. In the present study, the five-lncRNA prognostic risk signature and nomogram are trustworthy and effective indicators for predicting the prognosis of LUAD.
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- 2021
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42. Deep-learning-based hyperspectral recovery from a single RGB image
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Zhang, Junchao, Sun, Yuanyuan, Chen, Jianlai, Yang, Degui, and Liang, Rongguang
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Commercial hyperspectral imaging devices are expensive and tend to suffer from the degradation of spatial, spectral, or temporal resolution. To address these problems, we propose a deep-learning-based method to recover hyperspectral images from a single RGB image. The proposed method learns an end-to-end mapping between an RGB image and corresponding hyperspectral images. Moreover, a customized loss function is proposed to boost the performance. Experimental results on a variety of hyperspectral datasets demonstrate that our proposed method outperforms several state-of-the-art methods in terms of both quantitative measurements and perceptual quality.
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- 2020
43. Influence of Size and Phase on the Biodegradation, Excretion, and Phytotoxicity Persistence of Single-Layer Molybdenum Disulfide
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Zou, Wei, Li, Xinyu, Li, Chonghao, Sun, Yuanyuan, Zhang, Xingli, Jin, Caixia, Jiang, Kai, Zhou, Qixing, and Hu, Xiangang
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The increasing applications of single-layer molybdenum disulfide (SLMoS2) pose great potential risks associated with environmental exposure. This study found that metallic-phase SLMoS2with nanoscale (N-1T-SLMoS2, ∼400 nm) and microscale (M-1T-SLMoS2, ∼3.6 μm) diameters at 10–25 mg/L induced significant algal growth inhibition (maximum 72.7 and 74.6%, respectively), plasmolysis, and oxidative damage, but these alterations were recoverable. Nevertheless, membrane permeability, chloroplast damage, and chlorophyll biosynthesis reduction were persistent. By contrast, the growth inhibition (maximum 55.3%) and adverse effects of nano-sized semiconductive-phase SLMoS2(N-2H-SLMoS2, ∼400 nm) were weak and easily alleviated after 96 h of recovery. N-1T-SLMoS2(0.011 μg/h) and N-2H-SLMoS2(0.008 μg/h) were quickly biodegraded to soluble Mo compared with M-1T-SLMoS2(0.004 μg/h) and excreted by algae. Incomplete biodegradation of SLMoS2(26.8–43.9%) did not significantly mitigate its toxicity. Proteomics and metabolomics indicated that the downregulation of proteins (50.7–99.2%) related to antioxidants and photosynthesis and inhibition of carbon fixation and carbohydrate metabolism contributed to the persistent phytotoxicity. These findings highlight the roles and mechanisms of the size and phase in the persistent phytotoxicity of SLMoS2, which has potential implications for risk assessment and environmental applications of nanomaterials.
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- 2020
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44. Three-Dimensional Porous Alginate Fiber Membrane Reinforced PEO-Based Solid Polymer Electrolyte for Safe and High-Performance Lithium Ion Batteries
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Zeng, Fanyou, Sun, Yuanyuan, Hui, Bin, Xia, Yanzhi, Zou, Yihui, Zhang, Xiaoli, and Yang, Dongjiang
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The rational design and optimization of solid polymer electrolytes (SPEs) are critical for the application of safety and high efficiency lithium ion batteries (LIBs). Herein, we synthesized a novel poly(ethylene oxide) (PEO)-based SPE (PEO@AF SPE) with a cross-linking network by the introduction of alginate fiber (AF) membranes. Depending on the high-strength supporting AF skeleton and the cross-linking network formed by hydrogen bonds between the PEO matrix and AF skeleton, the obtained PEO@AF SPE exhibits an excellent tensile strength of 3.71 MPa, favorable heat resistance (close to 120 °C), and wide electrochemical stability window (5.2 V vs Li/Li+). Meanwhile, the abundant oxygen-containing groups in alginate macromolecular and the three-dimensional (3D) porous structure of the AF membrane can greatly increase Li+anchor points and provide more Li+migration pathways, leading to the enhancement of Li+conduction and interfacial stability between the SPE and Li anode. Furthermore, the assembled LiFePO4/PEO@AF SPE/Li cells also exhibit satisfactory electrochemical performance. These results reveal that PEO incorporating with AFs can boost the mechanical strength, thermostability, and electrochemical properties of the SPE simultaneously. Furthermore, one will expect that the newly designed PEO@AF SPE with cross-linked networks thus provides the possibility for future applications of safety and high-performance LIBs.
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- 2020
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45. Morphology, ultrastructure, and molecular phylogeny of the unarmoured dinoflagellate Kirithra sigma sp. nov. (Ceratoperidiniaceae, Dinophyceae)
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Hu, Zhangxi, Li, Zhun, Deng, Yunyan, Iwataki, Mitsunori, Luo, Zhaohe, Wang, Jinxiu, Sun, Yuanyuan, Zhao, Zengxia, Gu, Haifeng, Shin, Hyeon Ho, and Tang, Ying Zhong
- Abstract
ABSTRACTA Gymnodinium-like dinoflagellate, Kirithra sigma sp. nov., was isolated from Jiaozhou Bay, China, and the southern coast of Korea, and examined by light, scanning, and transmission electron microscopy. Pigment composition and nuclear-encoded partial large subunit ribosomal RNA (LSU rRNA) gene were determined. Cells were oval-shaped (26.4‒36.4 μm long and 17.7‒27.2 μm wide), with a conical epicone and hemispherical hypocone. Its cingulum and sulcus were deep and wide. The cingulum encircled the cell completely, its ends slightly overlapping and displaced one to two cingular widths; the sulcus and sulcal extension formed a sigmoid curve. The anterior sulcal extension contacted the apical structure complex (ASC). The ASC formed a complete circle, consisting of three parallel series of vesicles, and the amphiesmal vesicles within ASC were arranged with one central vesicle (sometimes two) encircled by approximately three rows of polygonal amphiesmal vesicles. Polygonal amphiesmal vesicles of different sizes covered the whole cell surface. The subspherical nucleus was located in the hypocone. Pigment analysis showed that peridinin was the main accessory pigment. The present species is morphologically similar to Kirithra asteribut differs in numbers and rows of amphiesmal vesicles within the ASC, absence of ventral pore, and a sigmoid curve formed by the sulcus and sulcal extension. The partial LSU rRNA gene sequence (c. 1400 bases) of K. sigmadiffered by c. 5.3% from that of K. asteri. Molecular phylogeny revealed that K. sigmaformed an independent sister clade to K. asteri, indicating they are congeneric but different species.
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- 2020
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46. A New Software Framework for Implementing Crystal Growth Models to Materials of Any Crystallographic Complexity
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Zhao, Yongsheng, Tilbury, Carl J., Landis, Steven, Sun, Yuanyuan, Li, Jinjin, Zhu, Peng, and Doherty, Michael F.
- Abstract
To continue the realization of new therapeutics, a more diverse range of solid forms is being considered. Synthetic modalities are broadening beyond simple organic molecules to more complicated structures, including organic salts, cocrystals, and solvates. As in all crystalline applications, engineering the morphology of such systems remains an important consideration, but traditional in silico approaches require further development to become capable of accurately describing these systems. A necessary, but not sufficient, condition to enact mechanistic crystal growth models is to calculate and organize solid-state interactions between growth units. The typical software framework for acquiring this information is to apply crystallographic symmetry operations to generate a unit cell from the asymmetric unit. While this approach is feasible for systems where the asymmetric unit corresponds to the growth unit itself, many systems do not satisfy this criterion, particularly the emerging therapeutic solid forms. By redesigning the input preparation software framework, we can build a description of the solid-state interactions that is independent of the asymmetric unit and applicable to any crystallographic complexity. We demonstrate the application of this method to three organic molecular crystals with crystallography of varying degrees of complexicty. The studied systems are naphthalene (Z′ = 0.5), benzoic acid (Z′ = 1), and tazofelone (Z′ = 2), respectively (where Z′ is the number of molecules in the asymmetric unit). This new software framework lays the groundwork for rapid in silico habit predictions of organic salts, cocrystals, and solvates.
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- 2020
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47. Highly specific quantification of mRNA mutation in single cells based on RNase H cleavage-assisted reverse transcription (RT)-PCR
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Yang, Dandan, Sun, Yuanyuan, Chang, Fu, Tian, Hui, Liu, Chenghui, and Li, Zhengping
- Abstract
An RNase H cleavage-assisted RT-PCR strategy was developed for ultra-selective detection of site-specific mRNA mutation at the single-cell level.
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- 2020
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48. Dok-3 deficient mice display different immune clustering and Tim-3 expression
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Yan, Wenjiang, Tian, Yijia, Sun, Peng, Yang, Jingjing, Li, Na, Sun, Yuanyuan, Wang, Shuangxi, and Zhang, Cheng
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Dok-3 has been shown to play an important role in immune system. Tim-3 also has been recognized as an important immune regulator which involves in many diseases. The relationship of them is still unclear. We detected the expression of Tim-3 on spleen immune cells from Dok-3 deficient mice and control mice by flow cytometry. In this article, we found that Dok-3−/−mice display almost entirely different immune clustering characteristics compared with wild type 129 mice. The CD4 T cells and CD8 T cells decreased and DC cells, macrophages, MDSCs increased when the Dok-3 gene knocked-out. The Tim-3 expression on CD4 T cells, CD8 T cells, NK cells, DC cells increased when the Dok-3 gene knocked-out. The macrophages and MDSCs just display the opposite results. Although Dok-3−/−mice display different immune clustering and Tim-3 expression, the mechanism still needs further study.
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- 2019
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49. Research and development of mAb drugs in China: a look from policy perspectives
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Jiang, Rong, Sun, Yuanyuan, Ung, Carolina, Dong, Xinyue, Kong, Xiangjun, Hu, Yuanjia, and Shao, Rong
- Abstract
ABSTRACTBackground: Monoclonal antibody (mAb) drugs are increasingly important for the pharmaceutical industry across the globe. In China, mAb drug developments face many challenges. Multiple policies have been implemented recently to reinforce support in various areas. This study aims to investigate the latest landscape of mAb drugs in China from policy perspectives encompassing R&D, clinical trials, marketing approval, and talent pools.Methods: Information about mAb drugs approved in the United States, the European Union, Japan, and China by 2017 and mAb-related policies in China were retrieved from government websites and third-party statistical databases for descriptive, statistical, and comparative analysis.Results and discussion: In China, 21 mAb drugs (10 locally-developed and 11 imported) have so far been approved. For the 11 imported mAb drugs in China, the median drug lag in the marketing approval was estimated at 87.1 months, compared with the U.S. (0 months), the EU (8.9 months), and Japan (43.4 months). However, as far as the dramatically changing innovation supporting system in China is concerned, emergence of new biopharmaceutical companies, transformation of the current drug companies and their shift to antibody therapy, and the pooling of high-level talent contribute to mAb development in China. The number of clinical trials and marketing applications and approvals involving mAb drugs is also growing. Favorable policies will continue to play a role in the sustainable development of mAb drugs in China.Conclusion: The research showed that the reform of multiple policies and incentives for attracting/retaining high-level talent has evidently been effective in addressing the drug lag of mAb drugs in China. In future development, China should actively monitor the global R&D outcomes and industrial development trends of mAb drugs and make the policy environment more attractive to enable more mAb drugs to be marketed in China as soon as possible.
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- 2019
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50. Input-to-state stability analysis of stochastic delayed switching systems
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Yu, Peilin, Deng, Feiqi, Zhao, Xueyan, and Sun, Yuanyuan
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In this paper, the issues regarding the input-to-state stability (ISS) and integral input-to-state stability (iISS) of the stochastic delayed switching systems with Lévy noise and input control (SDSS-LN-IC) are proposed by employing the comparison theorem approach, mode-dependent average dwell time (MDADT) method, delay integral inequality (DII), and Lyapunov-Razumikhin (L-R) technique. Two switching situations, namely, synchronous switching and asynchronous switching, are considered. Applying integral inequalities, sufficient stability conditions in both cases are given. Moreover, the sequences of this paper allow for the coefficients for the upper-bound expectation estimation of the infinitesimal operator to be mode-dependent, regardless of the sign and time-varying function rather than a constant, as is the case in certain existing results, which manifests the condition of the Lyapunov-Razumikhin technique in this paper is looser and less conservative. Finally, the validity and correctness of the theoretical results are verified by two examples and some simulations.
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- 2023
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