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Your search keyword '"Syn, Christopher"' showing total 4 results
Start Over Author "Syn, Christopher" Publication Type Magazines
4 results on '"Syn, Christopher"'

1. Population study of 11 Y-chromosomal STR loci in Singapore Chinese.

Author

Tang, June Sheau Wei, Wong, Hang Yee, Syn, Christopher Kiu Choong, Tan-Siew, Wai Fun, Chow, Shui Tse, and Budowle, Bruce

Subjects
Haplotypes -- Research -- Genetic aspects -- Analysis, Chinese -- Genetic aspects -- Research -- Analysis, Human population genetics -- Research -- Genetic aspects -- Analysis, Y chromosome -- Analysis -- Research -- Genetic aspects
Abstract

Abstract In this study of 212 unrelated Singapore Chinese males, allelic frequencies and gene diversities of 11 Y-chromosome specific STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS438 [...]

Published
2006

2. An isothermal primer extension method for whole genome amplification of fresh and degraded DNA: applications in comparative genomic hybridization, genotyping and mutation screening

Author

Lee, Cheryl I P, Leong, Siew Hong, Png, Adrian E H, Choo, Keng Wah, Syn, Christopher, Lim, Dennis T H, Law, Hai Yang, and Kon, Oi Lian

Abstract

We describe a protocol that uses a bioinformatically optimized primer in an isothermal whole genome amplification (WGA) reaction. Overnight incubation at 37 °C efficiently generates several hundred- to several thousand-fold increases in input DNA. The amplified product retains reasonably faithful quantitative representation of unamplified whole genomic DNA (gDNA). We provide protocols for applying this isothermal primer extension WGA protocol in three different techniques of genomic analysis: comparative genomic hybridization (CGH), genotyping at simple tandem repeat (STR) loci and screening for single base mutations in a common monogenic disorder, β-thalassemia. gDNA extracted from formalin-fixed paraffin-embedded (FFPE) tissues can also be amplified with this protocol.

Published
2006
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