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The geodesic graph of Riemannian spaces all geodesics of which are orbits of 1-parameter isometry groups was constructed by J. Szenthe in 1976 and it became a basic tool for studying such spaces, called g.o.\ spaces. This infinitesimal structure corresponds to the reductive complement ]]>\mathfrak m$ in the case of naturally reductive spaces. The systematic study of Riemannian g.o. spaces was started by O. Kowalski and L.~Vanhecke in 1991, when they introduced the most important definitions, classified the low-dimensional examples and described the basic constructions of this theory. The aim of this paper is to investigate a connection theoretical analogue of the concept of the geodesic graph.The geodesic graph of Riemannian spaces all geodesics of which are orbits of 1-parameter isometry groups was constructed by J. Szenthe in 1976 and it became a basic tool for studying such spaces, called g.o.\ spaces. This infinitesimal structure corresponds to the reductive complement ]]>\mathfrak m$ in the case of naturally reductive spaces. The systematic study of Riemannian g.o. spaces was started by O. Kowalski and L.~Vanhecke in 1991, when they introduced the most important definitions, classified the low-dimensional examples and described the basic constructions of this theory. The aim of this paper is to investigate a connection theoretical analogue of the concept of the geodesic graph.

Three of the four independently induced Ketel(D) dominantnegative female sterile mutations that identify the Drosophila importin-beta gene, originated from a C4114--> T transition and the concurrent replacement of Pro446 by Leu (P446L). CD spectroscopy of representative peptides with Pro or Leu in the crucial position revealed that upon the Pro-->Leu exchange the P446L mutant protein loses flexibility and attains most likely an open conformation. The P446L mutation abolishes RanGTP binding of the P446L mutant form of importin-beta protein and results in increased RanGDP binding ability. Notably, the P446L mutant importin-beta does not exert its dominant-negative effect on nuclear protein import and has no effect on mitotic spindle-related functions and chromosome segregation. However, it interferes with nuclear envelope formation during mitosis-to-interphase transition, revealing a novel function of importin-beta.