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1. The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin

Author

Su, Haochen, Yuan, Yue, Tang, Jiatong, Zhang, Yixuan, Wu, Hao, Zhang, Yin, Liang, Jiawei, Wang, Lei, Zou, Xiaoping, Huang, Shuling, Zhang, Shu, and Lv, Ying

Abstract

•Organoids are excellent preclinical models that retain genome stability and the tumor microenvironment.•GC organoids are of great value in basic life science research and clinical research such as organ development and drug susceptibility screening.•Cisplatin resistance worsens the prognosis of gastric cancer patients.•ATR inhibition can sensitize cisplatin in vivoand in vitroby inhibiting DDR.

Published
2023
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