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The three new triterpenes (1−3) and five known triterpenes and a sterol were isolated from the acetone extract of a Turkish collection of Salvia kronenburgii. The structures of the new triterpenes were established as 1β,2α-dihydroxy-3β-acetoxy-11-oxours-12-ene (1), 2α,20β-dihydroxy-3β-acetoxyurs-9(11),12-diene (2), and 1β,2α-dihydroxy-3β-acetoxyurs-9(11),12-diene (3) on the basis of spectral analyses, including 1D and 2D NMR and mass spectroscopy. It is probable that compounds 2 and 3 are artifacts from dehydration of the corresponding allylic alcohols. 1β,2α,3β,11α-Tetrahydroxyurs-12-ene (5), the most abundant compound in the extract, was found to be highly cytotoxic to renal, non-small cell lung, and breast cancer cell lines.

Four new sesquiterpenes, (8R*)-8-bromo-10-epi-β-snyderol (1), (8S*)-8-bromo-β-snyderol (2), 5-bromo-3-(3‘-hydroxy-3‘-methylpent-4‘-enylidene)-2,4,4-trimethylcyclohexanone (3), and the epoxide 4, have been isolated from the chloroform−methanol extract of Laurencia obtusa, together with the three known compounds α-snyderol (5), α-snyderol acetate (6), and stigmasterol. The structures of the isolated compounds were elucidated through spectroscopic analyses. Compound 1 showed antimalarial activity, with IC50 values of 2700 and 4000 ng/mL against the D6 and W2 clones of Plasmodium falciparum, respectively.

A new norditerpenoid and six new triterpenoids were isolated from the roots of Salvia kronenburgii. The new diterpenoid was kronenquinone (1). The new triterpenoids were 1β,2α,3β,11α-tetrahydroxy-olean-12-ene (2), 1β,2α,3β,11α-tetrahydroxy-urs-12-ene (3), 2α-acetoxy-urs-5,12-diene-3β,11α-diol (4), 3α-acetoxy-urs-12-ene-1β,11α-diol (5), 1β,3α,11α-trihydroxy-urs-12-ene (6), 2α,3β,11α-trihydroxy-urs-12-ene (7), and the known triterpenes 3β-acetoxy-urs-12-ene-1β,2α,11α-triol (8) and 3β-acetoxyolean-12-ene-1β,2α,11α-triol (9). Structures were determined by NMR and MS techniques.

From the roots of Salvia multicaulis, four new aromatic norditerpenoids, multicaulin (1), 12-demethylmulticauline (2), multiorthoquinone (3), and 12-demethylmultiorthoquinone (4), two new abietane diterpenoids, 12-methyl-5-dehydrohorminone (5) and 12-methyl-5-dehydroacetylhorminone (6), as well as a new pimarane diterpenoid, salvipimarone (7), were isolated. Also obtained in this investigation were the known compounds α-amyrin, hinokione, horminone, lupeol, manool, 1-oxoferruginol, 18-oxoferruginol, pisiferal, and sempervirol. The structures of compounds 1−7 were established by 1D and 2D NMR techniques and by chemical methods. The antituberculous activity of 1−7 was tested against Mycobacterium tuberculosis strain H37Rv, and all compounds were found to be significantly active, with 2 and 4−6 being the most potent substances. Six of these novel compounds were evaluated against a number of additional bacterial cultures.

The aerial parts of Salvia yosgadensis afforded five new terpenes with unusual skeletons, together with two known norditerpenes, ambreinolide and norambreinolide. The new compounds were elucidated as 6α-hydroxyambreinolide, 6α-hydroxynorambreinolide, 6α-hydroxy-8α-acetoxy-13,14,15,16-tetranorlabdan-12-oic acid, and two 19,20-dinorsesterterpenes, named as yosgadensonol and 13-epi-yosgadensonol. Their structures were determined by spectroscopic means, particularly by extensive 1D and 2D NMR studies.

From the roots of Salvia montbretii six new diterpenoids were isolated in addition to eleven known compounds. The new compounds were established as salvibretol (1), 1-oxosalvibretol (4), 6-hydroxysalvinolone (5), 7-hydroxytaxodione (6), 7,7‘-bistaxodione (7), and 11,11‘-didehydroxy-7,7‘-dihydroxytaxodione (8), using 1D and 2D NMR techniques.

The roots of Salvia blepharochlaena have yielded two new diterpenoids, blephaein (1) and O-methylpisiferic acid methyl ester (2), together with eight known diterpenoids. The structures of the new compounds were established by spectroscopic analysis and by some chemical reactions. Potent antibacterial activity was exhibited by the known compounds horminone (9) and 7-acetylhorminone (10) against Staphylococcus aureus ATCC 6538 P, Staphylococcus epidermidis ATCC 12226, and Bacillus subtilis ATCC 6633. Horminone was also found to be active against Enterococcus faecalis ATCC 29212.

The acetone extract of Nepeta caesarea yielded four new nepetalic acid derivatives, 3‘α-[β-sitosteryl-3β-oxy]dihydronepetalactone (1), 3‘β-[5α-stigmast-7-ene-3β-oxy]dihydronepetalactone (2), 3‘α-[olean-12-ene-28-oyl-3β-oxy]dihydronepetalactone (3), and 3‘α-[lup-20(29)-ene-28-ol-3β-oxy]dihydronepetalactone (4). The structures were elucidated by NMR and MS techniques.

Two new rearranged neo-clerodane diterpenoids, alysines D (1) and E (2), were isolated from the aerial parts of Teucrium alyssifolium. Their structures were established by spectral methods including 1D and 2D NMR techniques.

A new noricetexane diterpene, salvimultine, has been isolated from the polar fractions of Salvia multicaulis. Its structure was established as 1(10)-seco-2(10)-cyclo-icetexane by using 1D and 2D NMR spectral methods, including COSY, HETCOR, COLOC, and NOESY experiments as well as HRMS.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.