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Metal complexes of the type [M(L)2] 1–3, (M = Co(II), Ni(II) and Cu(II)) of ligand (LH = 2-benzo[d]thiazol-6-ylimino)methyl)benzene-1,4-diol, have been synthesized and characterized by elemental analysis, NMR, Infrared, UV–Visible, ESI-Mass, magnetic moments and ESR spectroscopic methods. Based on spectral data a square planar geometry has been proposed for all the complexes. The interaction of metal complexes with CT-DNA was investigated using UV–Vis absorption and fluorescence spectroscopy. The absorption and fluorescence spectral studies indicate a non-covalent interaction between the metal complexes and DNA base pairs. The competitive studies revealed that the complexes could interact the DNA through an intercalative mode and induce oxidative and photolytic DNA cleavage mediated by reactive oxygen species (ROS), and it is found that the Cu(II) complex cleaved DNA more effectively compared to Co(II) and Ni(II) complexes. In addition, antimicrobial activity of all the complexes was also examined.

A series of binary metal complexes [M(L1)2] and [M(L2)2], (where M = Cu(II), Co(II), Ni(II)) of Schiff bases, HL1 = 2-((E)-(4-(trifluoromethoxy)phenylimino)methyl)-4-methylphenol, HL2 = 2-((E)-(4-(trifluoromethoxy)phenylimino)methyl)-5-methoxyphenol, were synthesized and characterized by different analytical and spectral techniques. The spectral studies revealed that the complexes possess a square planar arrangement around the metal ions. DNA binding studies were investigated against calf thymus DNA and found that the compounds bound to DNA through an intercalation mode. The role of compounds in oxidative and photolytic cleavage of supercoiled pBR322 DNA was considered and emphasized that the complexes can cleave the DNA efficiently. The antioxidant activity of ligands and their complexes was evaluated by DPPH assay method and observed that the complexes found to be potent free radical scavengers. Finally, the in vitro antimicrobial activities by paper disc methods have shown that the complexes are more biocidally active than the free Schiff base ligands.