Search

Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and “pre-necrotic” biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.

This paper proposes an effective methodology to decrease the unstable fluid load on the plug of a poppet valve. The aim is to minimize the impact of the sudden fluid load on the control performance and reduce the failure rate of the valve by compensating the output torque of the actuator in real time. The total load superimposed with the unstable fluid load acting on the plug was derived and the relationship among the fluid load, flow parameters and plug displacement was established. Based on the principle of the current loop in the control system of the permanent magnet synchronous motor, the method and strategy of compensating the maximum output torque of the actuator on demand were presented. The co-simulation model of the poppet valve system and load compensation module was built applying AMESim and Matlab/Simulink, and the compensation effect of the valve under sudden change conditions was analyzed. Simulation results show that the unstable fluid load acting on the compensated plug was significantly reduced, and the time for the valve to achieve the equilibrium was shortened by 38.5%. To address implementation concerns, simulation results with different abrupt loads and compensation coefficients were also studied.