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Performance Products Make Horsepower As the technology used on 4x4s has progressed, things have changed drastically. Gone are the good old days of sitting around chewing the fat about what [...]

Think back more than a decade ago and try to remember the very first time you laid eyes on the then-brand-new '90 Ford Explorer. At the time, you may have [...]

INSTALLING A GRANATELLI MOTORSPORTS MASS AIR SENSOR OK, here's the scenario: You own a '95-'99 Chevrolet small-block 5.7L Vortec engine and you want more power. Let's face it, what self-respecting [...]

Tumor-associated macrophages (TAMs) are integral to the development of complex tumor microenvironments (TMEs) and can execute disparate cellular programs in response to extracellular cues. However, upstream signaling processes underpinning this phenotypic plasticity remain to be elucidated. Here, we report that concordant AXL-STAT3 signaling in TAMs is triggered by lung cancer cells or cancer-associated fibroblasts in the cytokine milieu. This paracrine action drives TAM differentiation toward a tumor-promoting “M2-like” phenotype with upregulation of CD163 and putative mesenchymal markers, contributing to TAM heterogeneity and diverse cellular functions. One of the upregulated markers, CD44, mediated by AXL-IL-11-pSTAT3 signaling cascade, enhances macrophage ability to interact with endothelial cells and facilitate formation of primitive vascular networks. We also found that AXL-STAT3 inhibition can impede the recruitment of TAMs in a xenograft mouse model, thereby suppressing tumor growth. These findings suggest the potential application of AXL-STAT3-related markers to quantitatively assess metastatic potential and inform therapeutic strategies in lung cancer.

WITH A LITTLE HELP FROM BASSANI MANUFACTURING We often talk of relatively inexpensive ways to increase horsepower and torque while at the same time maintaining complete driveability, reliability, and functionality [...]

Did We Make Our Goal? Last month, we chronicled the buildup of a small-block 383 Chevy using a cast 400 small-block crankshaft, all with the goal of making 500 lb-ft [...]

Summit Racing Builds a Stump-Puller Sitting around the office and brainstorming ideas is often the best way that any magazine staff comes up with new ideas to help keep the [...]

Among off-road enthusiasts, there is a tendency to allow the visions that we have for our custom trucks to get a bit out of hand. Jeff Fandrick is one such [...]

Several letters to the editor are presented in response to articles in the August 2015 issue, including "The Most Invasive Species of All" by Curtis W. Marean, "Hidden Hearing Loss" by M. Charles Liberman, and "Space Cowboys" by Linda Billings.

The signs are all there. The wallpaper is starting to peel, there are not enough exam rooms, and the waiting room is standing room only. There is no doubt about [...]

The article offers information on the design and construction of the 2012 Ram 3500 truck from Chrysler of Ken Philippe.

The article evaluates a 27-Daytona cat hull and a 2007 Chevy Silverado pickup truck.

The article provides information on the customization of a Cadillac Escalade sport utility vehicle (SUV) by Jason Plotke of Innovative Automotive Group IAG based in Scottsdale, Arizona under parameters established by General Motors. A ProCharger centrifugal supercharger was added to transform the V-8 engine. A McGaughy's 2/4 suspension drop was installed under the front and rear of the vehicle to improve the suspension system. Rockford Fosgate speakers were used to enhance the audio system.

AbstractWe show that under Martin's Axiom, the cofinality cf(Aut(G)) of the automorphism group of the random graph G is 2?.

Discusses the design changes in the 2002 Ford Explorer. Drivetrain of the sport utility vehicle; Interior design; Safety features.

The soft segment of poly (polyamide-polytetramethylene glycol) esters crystallize at strains beginning at about 500%, raising the observed crys tal melting temperature from about 7 to 38°C. Accompanying the strain- induced crystallization, the polymer hardens, changing from elastic to plastic. Upon melting of the PTMO crystallites, Pebax reasserts its elastic character.

Focuses on the '88 Chevy pickup truck of Jeff Fandrick, an off-road enthusiast. Description of the truck's paint design; Information on the truck's suspension lift; Other changes made on the truck.

The article focuses on the use of Bully Dog tuners for truck engine performance by snowboarder Tony Jenkins for his truck with 350 horsepower. It explores how the snowboarder solved his problem with driving through a mountainous terrain with the tuner. It offers information on the Triple Dog GT tuner from Bully Dog. The quality of being user-friendly of Bully Dog tuner is described.

The article offers step-by-step instructions for installing a tow hitch by Valley Industries on a 2006 Ford F-150 pickup truck.

Introduces the Excursion automobile from Boyd Coddington Jr. in La Habra, California. Automobile features; Design of the automobile; Experience of the company in automotive modification.

The article focuses on the preparation of the magazine "Truckin'" on the Specialty Equipment Market Association (SEMA) Show where the 2009 Dodge Arm will be debuting. It also introduces the article in the issue which features the annual "Truckin'" magazine 2009 Truck of the Year Award. The issue also includes a fullsize truck competition testing several trucks which include Chevrolet Silverado, Dodge Arm and Toyota Tundra.

The author discusses the 28-day production schedule of the staff of "Truckin'" to produce the magazine.

The article presents a discussion about the author's first sound system installed in his first car. The sound system consists of a headunit and 6x9 speakers for the car rear deck. The author mentioned that his friend introduced him to sub woofers. An introduction to his issue, focused on sound systems in trucks, is presented.

The article pays tribute to which the author considers as his heroes. These people include Wally Parks, National Hot Rod Association (NHRA) founder, Boyd Coddington Sr., founder of Boyds Wheels and Hot Rods by Boyds, and Robert Petersen, founder of Petersen Publishing. The author states that these people made an impact on his life and he knew these people long before entering his career path of automotive publishing.

The author suggests a positive approach to dealing with the economic downturn in the U.S. in 2008. According to the author, the stock market, automobile sales and computer companies are among those affected by the slowing economy. He says the unfavorable housing market and the all-time high gasoline prices are prevalent on the daily discussion among people. He also emphasizes that legislators might need to seek advice and news sources should provide positive information.

The author comments on using high-fuel consumption pickup trucks and increasing oil price. According to the author, many have traded their pickup trucks for cars with better fuel efficiency however, some of the felt the need for their trucks after trading them. He asserted that fuel prices will not go down to the same level as before.

The author focuses on the improvements within the web-based publication truckinweb.com. He notes that the website has been improved with new content, a lot of editor blogs and technology forum sections that invite readers to participate. He mentions that the website features sections for downloadable wallpapers. He adds that readers who intend to purchase a new truck or a sport utility vehicle (SUV) may place the model and make of the truck they are interested for the local auto dealers to see.

A preface for the June 3, 2008 issue of the magazine "Truckin'" is presented.

The article introduces an annual wheel and tire issue featuring the latest rolling stocks for new and old classic trucks.

A letter to the editor is presented in response to the September 25, 2007, 40th Anniversary issue of the periodical.

The article reflects on the importance for a physician group to own their own medical office building. The author explains that this initiative allows the group to fully determine the make up of the space, and permits the group to recruit and select the other tenants of the building. He suggests that Indiana is blessed with developers and health care advisors who can help physicians in their buy-versus-lease decisions.

Several letters to the editor are presented in response to previously published article including "It's Vegas, Baby," in the November 23, 2006 issue, another "L.A. Shanti R.I.P," in the October 10, 2006 issue which highlight the initiatives of many organizations in dealing with the medical issues of AIDS and another which commends the publication for its articles and topics.