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'Hillary Clinton likens Trump to Hitler and warns he would end democracy.' --The Guardian, November 9, 2023 'Trump's ramped-up rhetoric raises new concerns about violence and authoritarianism' --PBS News Hour, [...]

The world we inhabit is a dangerous place. From common criminals to hostile regimes, threats and enemies (foreign and domestic) abound. Human history will dispose the prudent man to protect [...]

If Pope Francis expects that his banishment of Archbishop Carlo Maria Vigano will rid him of a troublesome thorn in his side, he is likely to be disappointed. The former [...]

General Michael Flynn was targeted for destruction by the Deep State, which torpedoed his appointment as national security advisor. He is now fighting back. He was an innocent man who [...]

Lieutenant General Michael Thomas Flynn is a man on a mission. During April and May of this year, he crisscrossed the country on a national bus tour premiering his new [...]

Are multiple planned 'crises' just around the corner? Maybe 'emergencies' serious enough to throw the election? Maybe postpone the election? Even cancel the election? How about a new pandemic? (Fears [...]

Since the 2020 presidential election, Joe Biden, congressional Democrats, and their usual allies in the major media have relentlessly hammered as 'baseless' every reasonable concern about the vulnerabilities of electronic [...]

The unprecedented flood of illegal immigrants into the United States is not happenstance. The Biden administration and United Nations have engineered the deluge. The invasion is not stopping; it is [...]

Indoctrinating Our Children to Death: Government Schools' War on Faith, Family & Freedom--And How to Stop It, by Alex Newman, Pinecrest, Florida: Liberty Sentinel Press, 2024, 237 pages, paperback. (To [...]

Worldwide Catholic opposition to the Vatican's pre-Christmas declaration allowing blessings for same-sex couples has continued to escalate since the revolutionary papal document was issued. Fiducia Supplicans ('Supplicating Trust') was released [...]

Dr. Douglas G. Frank is a physicist, chemist, mathematician, author, inventor, science consultant, computer builder, teacher--and election expert. He is the author/ co-author of 60 peer-reviewed articles in scientific publications, [...]

The 2024 presidential and general elections are now less than a year away. Will they be the last genuine elections under our constitutional system? They could well be. Communist regimes [...]

In July 2016, Professor Jin Canrong, one of the Chinese Communist Party's (CCP) top advisors, gave a two-day seminar to party and business leaders at the Southern Club Hotel in [...]

If you thought you were going to get a break from the orgy of environmental hysteria when the UN Sustainable Development Goals (SDG) Summit concluded last month, think again. That [...]

Since we are three-quarters of the way through 2023, maybe we should pause and assess what we think about 'Year One' of a New World Order. What's this, you say? [...]

'History is a set of lies agreed upon.' So, supposedly, said Napoleon Bonaparte. Well, the liars have certainly gotten the upper hand since Napoleon's day. Our 'history industry' has been [...]

IN BRIEF The accounting profession continues to suffer from the barrier to entry caused by the 150-hour CPA licensure requirement and is struggling to find ways to ensure a greater [...]

KGB. Gestapo. Stasi. DGI. We all know the names. Every totalitarian regime has its enforcement arm, its dreaded police apparatus. These evil entities exist to strike terror into the hearts [...]

The competitive nature of ObGyn recruiting is reflected in rising starting salaries. It remains one of the most recruited specialties. Starting salaries have increased in recent years. Here, considerations about [...]

Does it make sense to make investment decisions based on woke ESG standards, as opposed to doing what is in the best interest of the investors? It does, if the [...]

High-flying pedophile Jeffrey Epstein may be dead, but his convenient demise by jailhouse 'suicide' will not stop the continuing release of evidence incriminating many of the world's richest and most [...]

Headlines: 'What War With China Would Look Like.' 'How War With China Begins.' 'The Coming War With China.' 'Is War With China Inevitable?' 'China Will Go to War With the [...]

The recently concluded United Nations Biodiversity conference in Montreal (a two-week marathon that ran December 7-19) ended with the signing of the Kunming-Montreal Global Biodiversity Framework. The new UN agreement [...]

IN BRIEF The PCAOB inspects audits of registered public accounting firms and identifies deficiencies in gathering audit evidence and internal controls over financial reporting and the failure to comply with [...]

Polygamy? Blessing homosexual unions? 'Radical inclusion' of LGBT people? Holy Communion for those living in adulterous relationships? Ordination of women? Is the Roman Catholic Church really about to flip on [...]

Climate alarmists are shametully exploiting fires, hurricanes, and other natural disasters to advance their global green agenda. They're ba-a-a-ack! The Climate Calamity Cult is back in megafright mode, prepping us [...]

In the two years since his inauguration, Joe Biden's administration has sent federal SWAT teams into homes and offices to drag nearly 1,000 Americans off to a Soviet-style gulag. Hundreds [...]

This article first appeared in the July 13, 1992 issue of The New American. Environmental militants are moaning that the Earth Summit was sabotaged by President [George H.W.] Bush's election-year [...]

The United Nations' 27th Conference of Parties (COP27), which took place November 6-20 in Sharm El Sheikh, Egypt, has been yet another predictable exhibition of political, corporate, and bureaucratic elites [...]

Is it possible to be more Catholic than the pope? In the case of the current pope, simply remaining faithful to the religion's tenets would make one more Catholic. Francis [...]

The most striking feature of every totalitarian state (whether communist, fascist, or Islamist) is the dreaded police-state apparatus, the iron fist that enforces the will of the Party, the State, [...]

The dramatic jump in crime in America's major urban areas is a result of policies that handcuff police and make crime pay. Those policies can--and must--be changed. It was 1:30 [...]

Is the Biden administration hellbent on destroying America's food-producing capabilities and making food increasingly unaffordable for the average American family? A reality check of federal policies points directly toward that [...]

The 'green' global elites are aiming for total food control. Their power grab, which is now most evident in Holland, threatens the entire planet--including the United States. Dutch farmers are [...]

The nation's population is quickly diversifying, making racial/ethnic disparities in health care outcomes even more apparent. Minority and non-English-speaking populations have grown and may become a majority in the next [...]

Biden's pursuit of a 'new world order' did not originate with him, but has been the goal of globalists for generations. And now this goal is close to fruition. In [...]

People in third-world countries are no stranger to food shortages and famine, but could such a thing happen here in America? If so, what can we do about it? Is [...]

The recent dramatic increase in food prices, together with food shortages, points to a looming food crisis, and even the prospect of famine. In certain parts of the world, famine [...]

Over the past two decades, while the elite media cartel has been promoting every sort of degeneracy in America and the West, it also has falsely promoted Putin as the [...]

As the first anniversary of the January 6 Capitol riot approached, the New York Times Editorial Board, in a January 1, 2022 opinion piece, declared, 'Truly grappling with the threat [...]

On January 5, the day before the giant Stop the Steal rally on the Ellipse in Washington, D.C., a tall, middle-aged man dressed in tan military-style clothing and sporting a [...]

On January 6, 2021, President Donald Trump held a Stop the Steal rally on the Ellipse near the White House, as Congress gathered at the Capitol to count the electoral [...]

Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity1. In this study, we investigated the evolution of genomic signatures caused by endogenous and external mutagenic processes and their interplay with complex structural variants (SVs). We superimposed mutational signatures and phylogenetic analyses of matched serial tumours from patients with urothelial cancer to define the evolutionary dynamics of these processes. We show that APOBEC3-induced mutations are clonal and early, whereas chemotherapy induces mutational bursts of hundreds of late subclonal mutations. Using a genome graph computational tool2, we observed frequent high copy-number circular amplicons characteristic of extrachromosomal DNA (ecDNA)-forming SVs. We characterized the distinct temporal patterns of APOBEC3-induced and chemotherapy-induced mutations within ecDNA-forming SVs, gaining new insights into the timing of these mutagenic processes relative to ecDNA biogenesis. We discovered that most CCND1amplifications in urothelial cancer arise within circular ecDNA-forming SVs. ecDNA-forming SVs persisted and increased in complexity, incorporating additional DNA segments and contributing to the evolution of treatment resistance. Oxford Nanopore Technologies long-read whole-genome sequencing followed by de novo assembly mapped out CCND1ecDNA structure. Experimental modelling of CCND1ecDNA confirmed its role as a driver of treatment resistance. Our findings define fundamental mechanisms that drive urothelial cancer evolution and have important therapeutic implications.

Respiratory syncytial virus vaccines first recommended for use during 2023 were efficacious against lower respiratory tract disease in clinical trials. Limited real-world data regarding respiratory syncytial virus vaccine effectiveness are available. To inform vaccine policy and address gaps in evidence from the clinical trials, we aimed to assess the effectiveness against respiratory syncytial virus-associated hospitalisations and emergency department encounters among adults aged at least 60 years.

The US Kidney Allocation System (KAS) prioritizes candidates with a≤20% estimated posttransplant survival (EPTS) to receive high-longevity kidneys defined by a≤20% Kidney Donor Profile Index (KDPI). Use of EPTS in the KAS deprioritizes candidates with older age, diabetes, and longer dialysis durations. We assessed whether this use also disadvantages race and ethnicity minority candidates, who are younger but more likely to have diabetes and longer durations of kidney failure requiring dialysis.

The given text provides an overview of various aspects of Donald Trump's presidency. It mentions his efforts to engage Christian voters, his response to the Charlottesville incident, and the media's alleged bias against him. The text also discusses a book that outlines strategies for Democrats to combat Trump and speculates on the fears of his opponents. It concludes by suggesting that holding political criminals accountable is important for justice and advises caution when considering Trump's promises. [Extracted from the article]

The article explores the historical significance and risks associated with intelligence services, emphasizing their crucial role in national defense and threat detection. It also discusses the evolution of intelligence agencies, the use of false-flag operations, and the contemporary issues related to surveillance and manipulation by modern intelligence organizations.

Proximity-enhanced chemical cross-linking is an invaluable tool for probing protein–protein interactions and enhancing the potency of potential peptide and protein drugs. Here, we extend this approach to covalently stabilize large macromolecular assemblies. We used SuFEx chemistry to covalently stabilize an 18-subunit pore-forming complex, CsgG:CsgF, consisting of nine CsgG membrane protein subunits that noncovalently associate with nine CsgF peptides. Derivatives of the CsgG:CsgF pore have been used for DNA sequencing, which places high demands on the structural stability and homogeneity of the complex. To increase the robustness of the pore, we designed and synthesized derivatives of CsgF-bearing sulfonyl fluorides, which react with CsgG in very high yield to form a covalently stabilized CsgG:CsgF complex. The resulting pores formed highly homogeneous channels when added to artificial membranes. The high yield and rapid reaction rate of the SuFEx reaction prompted molecular dynamics simulations, which revealed that the SO2F groups in the initially formed complex are poised for nucleophilic reaction with a targeted Tyr. These results demonstrate the utility of SuFEx chemistry to structurally stabilize very large (here, 280 kDa) assemblies.

Giant cell arteritis (GCA) is characterized by granulomatous inflammation of the medium‐ and large‐sized arteries accompanied by remodeling of the vessel wall. Fibroblast activation protein alpha (FAP) is a serine protease that promotes both inflammation and fibrosis. Here, we investigated the plasma levels and vascular expression of FAP in GCA. Plasma FAP levels were measured with enzyme‐linked immunosorbent assay in treatment‐naive patients with GCA (n = 60) and polymyalgia rheumatica (PMR) (n = 63) compared with age‐ and sex‐matched healthy controls (HCs) (n = 42) and during follow‐up, including treatment‐free remission (TFR). Inflamed temporal artery biopsies (TABs) of patients with GCA (n = 9), noninflamed TABs (n = 14), and aorta samples from GCA‐related (n = 9) and atherosclerosis‐related aneurysm (n = 11) were stained for FAP using immunohistochemistry. Immunofluorescence staining was performed for fibroblasts (CD90), macrophages (CD68/CD206/folate receptor beta), vascular smooth muscle cells (desmin), myofibroblasts (α‐smooth muscle actin), interleukin‐6 (IL‐6), and matrix metalloproteinase‐9 (MMP‐9). Baseline plasma FAP levels were significantly lower in patients with GCA compared with patients with PMR and HCs and inversely correlated with systemic markers of inflammation and angiogenesis. FAP levels decreased even further at 3 months on remission in patients with GCA and gradually increased to the level of HCs in TFR. FAP expression was increased in inflamed TABs and aorta of patients with GCA compared with control tissues. FAP was abundantly expressed in fibroblasts and macrophages. Some of the FAP+fibroblasts expressed IL‐6 and MMP‐9. FAP expression in GCA is clearly modulated both in plasma and in vessels. FAP may be involved in the inflammatory and remodeling processes in GCA and have utility as a target for imaging and therapeutic intervention.

The progressive growth of the hospitalist model of practice over the past 20 years has solidified the role of the obstetrics and gynecology (ob/gyn) hospitalists as an essential component of quality inpatient care. The ob/gyn hospitalist as an educator is proving to be an important role in the future of hospitalist practice. The role as an educator has long-term benefits and implications for the standardization of education and evidence-based patient care both in community-based and academic practice settings.