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Recently, slippery liquid-infused porous surfaces (SLIPS) have attracted extensive attention due to their excellent anti-icing performance. However, the unsatisfactory durability resulting from the loss of lubricant hinders its practical application. Here, a micro/nanointegrated lubricant-infused surface combining microcone hole array and TiO2porous nanostructure (P-SLIPS) was fabricated, where its inverted pyramid-shaped microgroove can protect the nanoporous structure from being damaged. Experimental results show that with the aid of microcone hole array, the sanding repelling properties of P-SLIPS have dramatically improved with the significantly decreased ice adhesion strength after 7 sanding cycles. In the process of droplet scouring and dynamic icing, the icing phenomenon in P-SLIPS did not occur even after 10 sanding cycles, while this value is 3 sanding cycles in SLIPS. All of these could be attributed to the introduction of microcone array structure, which makes the coating not be completely damaged during the icing/deicing and sanding polishing processes. Thus, the anti-icing durability of the P-SLIPS can be greatly improved.

The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can provide neuroprotective benefits. Here, we report the discovery and development of a class of potent activators (NATs) of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway. We obtained the crystal structure of NAMPT in complex with the NAT, which defined the allosteric action of NAT near the enzyme active site. The optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT activity. NATs effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional reprogramming. Importantly, NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN) without any overt toxicity. These findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline.

All-inorganic CsPbCl3perovskite in ultraviolet (UV) detection is drawing increasing interest owing to its UV-matchable optical band gap, ultrahigh UV stability, and superior inherent optoelectronic properties. Almost all of the reported CsPbCl3photodetectors employ CsPbCl3nano- or microstructures as sensitive components, while CsPbCl3polycrystalline film-based self-powered photodetectors are rarely studied on account of the terrible precursor solubility. Herein, a novel sequential vapor-deposition technique is demonstrated to fabricate CsPbCl3polycrystalline film for the first time. High-quality CsPbCl3films with excellent optical, electronic, and morphological features are obtained. A self-powered photodetector based on the CsPbCl3film is constructed without any charge transport layer, showing a high UV detection performance. A thin p-type PbS buffer layer is further introduced to passivate the surface defects of the CsPbCl3layer and decrease the interfacial energy barrier by forming a type-II heterojunction, contributing to a faster hole extraction rate and a suppressed dark current level. The best-performing device achieves an ultrafast response time of 1.92 μs, an ultrahigh on/off ratio of 2.22 × 105, and a responsivity of 0.22 A/W upon 375 nm UV illumination at 0 V bias. This comprehensive performance is the best among all of the CsPbCl3photodetectors reported to date. The as-prepared photodetectors also present an eminent UV irradiation and long-term durability in ambient air. Furthermore, a large-area and uniform 625-pixel UV image sensor is fabricated and attains a prominent imaging capability. Our work opens a new avenue for the scalable production of CsPbCl3-based optoelectronics.

Polyvinylpolymethylsiloxane (PVPMS)/polydimethylsiloxane (PDMS) copolymer aerogels were synthesized via consecutive radical polymerization and cohydrolytic polycondensation of vinylmethyldimethoxysilane and dimethyldimethoxysilane, followed by supercritical drying or ambient pressure drying. The resultant PVPMS/PDMS copolymer aerogels exhibit a highly porous, tunable triple-network structure consisting of interlinked hydrocarbon polymers, PVPMS and PDMS. These aerogels display superhydrophobicity (151°), low density (109 mg cm–3), low thermal conductivity (29.8 mW m–1K–1), and adjustable pore structure. The combination of good machinability, low thermal conductivity, excellent compressive elasticity and bending flexibility, and efficient organic solvent adsorption gives these aerogels broad application prospects in thermal insulation and oil–water separation. In addition, PVPMS/PDMS/carbon nanotube (CNT) composite aerogels were obtained by incorporating the conductive CNTs, followed by vacuum drying. The resultant PVPMS/PDMS/CNT composite aerogel exhibits high sensitivity with a broad pressure sensing range in strain and pressure sensing applications.

ABSTRACTLong noncoding RNAs (lncRNAs) are important regulators of the biological functions and underlying molecular mechanisms of colorectal cancer (CRC). However, the role of the lncRNA ZEB1-AS1 in CRC is not thoroughly understood. In this study, we found that ZEB1-AS1 was markedly upregulated in CRC. ZEB1-AS1 knockdown significantly suppressed CRC cell proliferation and induced apoptosis, whereas enhanced expression of ZEB1-AS1 had the opposite effect. Bioinformatics analysis identified miR-181a-5p as a candidate target of ZEB1-AS1. Moreover, we found an inverse correlation between ZEB1-AS1 and miR-181a-5p expression in CRC tissue. Inhibition of miR-181a-5p significantly upregulated ZEB1-AS1, whereas overexpression of miR-181a-5p had the opposite effect, suggesting that ZEB1-AS1 is negatively regulated by miR-181a-5p. Using luciferase reporter and RIP assays, we found that miR-181a-5p directly targets ZEB1-AS1. Importantly, ZEB1-AS1 may act as an endogenous ‘sponge’ to regulate miRNA targets by competing for miR-181a-5p binding. In summary, our findings provide the evidence supporting the role of ZEB1-AS1 as an oncogene in CRC. Our study also demonstrates that miR-181a-5p targets not only protein-coding genes but also the lncRNA ZEB1-AS1.

Rechargeable aqueous Zn‐MnO2batteries are potential candidates for electrochemical energy storage systems due to their easy fabrication, nontoxicity, and low‐cost features. However, the practical application of the MnO2‐based cathode is impeded by its low electrical conductivity and poor stability during cycling. Herein, the Ti3C2/MnO2composite cathode is elaborately designed and fabricated via a simple mechanical grinding method. Benefiting from the high conductivity of Ti3C2MXene along with the abundant active sites of nano‐MnO2, the obtained Ti3C2/MnO2electrode shows fast ion transfer and enhanced structural stability. Therefore, Ti3C2/MnO2composite as the cathode of zinc ion battery exhibits superior charge storage performance (354 mAh g−1at 0.2 A g−1, which is 30% higher than that of pure MnO2cathode), high cycling stability (85% capacitance retention along with about 100% columbic efficiency after 850 cycles at l A g−1), excellent energy density (467.33 Wh kg−lat 260 W kg−1), and impressive long‐term lifespan (65.1 mAh g−1over 900 h at 0.1 A g−1). Furthermore, the mechanism related is elucidated via comprehensive characterizations. Herein, it provides a convenient and efficient method to fabricate high‐performance Mn‐based cathode for Zinc‐ion batteries. Ti3C2/MnO2cathode of zinc ion battery is elaborately designed and fabricated via a simple mechanical grinding method, which shows superior charge storage performance, high cycling stability, excellent energy density, and impressive long‐term lifespan due to the high conductivity of Ti3C2MXene along with the abundant active sites of nano‐MnO2.

ABSTRACTIntroducing cow manure compost as an amendment in landfill-leachate-contaminated soils is proved to be an effective technique for the immobilization of Cd in this study. Landfill-leachate-contaminated soil was collected from an unlined landfill in China and amended with a different blending quantity of cow manure compost (0, 12, 24, 36, and 48 g per 200 g soil), which was made by mixing cow manure and chaff at a ratio of 1/1 and maturing for 6 months. pH values of five different blending quantity mixtures increased by 0.2–0.4, and the organic matter levels increased by 2.5–7%, during a remediation period of 5 weeks. Four fractions of Cd named exchangeable Cd, reducible Cd, oxidizable Cd, and residual Cd in soil were respectively analyzed by a sequential extraction procedure. Introducing the cow manure compost application resulted in more than 40% lower exchangeable Cd but a higher concentration of oxidizable Cd in soils, and mass balance results showed nearly no Cd absorption by applied material, indicating that transformation of exchangeable Cd into oxidization forms was the main mechanism of Cd immobilization when cow manure compost was used as an amendment. The Pearson correlation showed that increasing of pH values significantly improved the efficiency of Cd immobilization, with a correlation coefficiency of 0.940 (p< 0.05). This is the first attempt at heavy metal immobilization in landfill-leachate-contaminated soil by cow manure compost, and findings of this work can be integrated to guide the application.Implications: Addition of cow manure compost (CMC) was effective in reducing exchangeable Cd in landfill-leachate-contaminated soils (LLCS). The immobilization effect of Cd was mainly assigned to the redistribution of labile soil Cd. Organic matter (OM) and pH value increased with CMC application. The pH values were more sensitive to Cd immobilization efficiency. It was proved that CMC can be safely and effectively used for the restoration of LLCS.

This study investigated the alleviating effects of hydrogen sulfide (H2S), derived from sodium hydrosulfide (NaHS), on inflammation induced by dextran sulfate sodium (DSS) in both in vivo and in vitro models. We found that NaHS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NaHS (20 µmol/L) reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-κB (NF-κB) signaling pathway. In conclusion, our results demonstrated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-κB signaling pathway.

Light steel houses are widely applied to low-rise industrial buildings for lightweight, easy industrialization and fast construction. But under the condition of strong wind, there often occurs wind-induced damages to light steel houses because they are sensitive to wind loads, causing huge economic losses. This paper offers a wind-resistant design for a steel structure warehouse which may suffer from force-14 super typhoon with maximum wind speed of 150 km/h. The main factors affecting the wind-resistant capacity of steel structure plants as well as the attacking characteristics and failure mechanism of typhoon on low-rise buildings are fully analyzed. Opinions on the design of low-rise steel structure warehouses against typhoon have been proposed by discussing different wind directions. Considering conceptual design, we also provide some concrete measures of wind-resistance for low-rise buildings in coast areas.

Hierarchical tin oxide(SnO2) architectures were synthesized with a facile hydrothermal method. In the hydrothermal synthesis, sodium dodecyl benzene sulfonate(SDBS) surfactant plays an important role as structure-directing reagent. The synthesized samples were characterized by powder X-ray diffraction(XRD), field emission scanning electron microscopy(FESEM), transmission electron microscopy(TEM) and high-resolution transmission electron microscopy(HRTEM). The results clearly reveal that the hierarchical architectures of SnO2were composed of aggregated nanosheets with a thickness of about 100 nm. A possible mechanism for the formation of the SnO2hierarchical architectures was proposed. In addition, the gas sensing properties of the as-prepared products were investigated and it was found that the sensor based on the special SnO2hierarchical architectures exhibited a high response and good selectivity to NO2at the optimal working temperature of 160 °C.

In this work, NASICON-type disks with the formula, Na3Zr2Si2PO12 were prepared by non-aqueous tape casting method. The effect of the dispersant on the slurry viscosity was investigated, triethanolamine was found to be an effective dispersant for NASICON slurry. The correlation between the overall conductivity and the sintering conditions (temperature and time) for the NASICON disk was also studied. Green tapes were calcined at 900°C, 1000°C, 1100°C for 6h and 12h, respectively. Results revealed that the overall conductivity increased with the increasing of the sintering temperature and decreased with the increasing of the sintering time. The segregation of resistive monoclinic ZrO2 phase was examined to have a negative effect on the overall conductivity. The CO2 sensor using NASICON disk and Li2CO3-BaCO3 complex thick film was fabricated and evaluated, the sensitivity was about 82.9 mV/decade at 450°C.

In order to reduce the steel consumption for one of the steel structure residence, a kind of effective approach of optimization design to the original design is given. In this paper, steel consumption of H-section steel beams are taken as objective function, which have relatively larger proportions than others. Design variables are the beam height, web thickness, flange width and flange thickness. The strength, stiffness and stability of the steel beam are taken as constraint condition under the relevant Building Code. By using the sequential quadratic programming method, we set up optimization mathematical model for optimizing the steel structure residence, and then obtain the optimal section size of the steel beams. After the structural optimization design, the steel consumption of GL1 was reduced by 8.24%, compared with those of the original design. Relative to the original design, optimized total steel consumption was reduced by 3.29%. The approach proposed in this paper is an effective method for the optimization design of steel structure residence.

We describe a woman with flank pain and hydronephrosis. Computed tomography (CT) urography and maximum intensity projection (MIP) reformatted images clearly showed that a long finger-like intraluminal filling defects mass in the left middle ureter. The pathologic biopsy by ureteroscopy revealed that the lesion mainly consists of benign fibrinoid necrosis. A large soft smooth, spindle-like, dark brown mass (approximately 13.5 cm in length) was identified in left middle ureter when open surgery was performed. The segment of the ureter part attached to the stalk of the polyp was excised, then a dismembered ureteroplasty was performed. Pathologic examination revealed that the total polyp was an ischemic infarction, characteristic of cellular swelling, tissue degeneration, fibrinoid necrosis, and thrombosis in its vessels. The surface of the polyp was hardly covered with urothelium, but fibroepithelial polyp was still diagnosed. There was no recurrence during the 3 years of follow-up.

We describe a woman with flank pain and hydronephrosis. Computed tomography (CT) urography and maximum intensity projection (MIP) reformatted images clearly showed that a long finger‐like intraluminal filling defects mass in the left middle ureter. The pathologic biopsy by ureteroscopy revealed that the lesion mainly consists of benign fibrinoid necrosis. A large soft smooth, spindle‐like, dark brown mass (approximately 13.5 cm in length) was identified in left middle ureter when open surgery was performed. The segment of the ureter part attached to the stalk of the polyp was excised, then a dismembered ureteroplasty was performed. Pathologic examination revealed that the total polyp was an ischemic infarction, characteristic of cellular swelling, tissue degeneration, fibrinoid necrosis, and thrombosis in its vessels. The surface of the polyp was hardly covered with urothelium, but fibroepithelial polyp was still diagnosed. There was no recurrence during the 3 years of follow‐up.

The differential GPS navigation and positioning technique, multi-channel shallow seismic exploration and high resolution single channel seismic technique were used for the geophysical exploration of the shallow stratum in Jiangshidi nuclear power plant site and its surrounding areas. Based on seismic data post processing results, the seismic section interpretation was performed, combined with regional geological background, borehole data and shallow anatomy data. Five main seismic reflection surfaces were recognized by using seismic stratigraphic method, and eight breakpoints were found according to the active fault discrimination criteria. Then the distribution and activity characteristics of main faults were obtained. The results show that any fault and marked deformation in the quaternary sediments has not been observed in the range of 5 km away from Jiangshidi nuclear power plant site. So the stability analysis results of shallow stratum in target area can meet the requirement of nuclear power plant site selection code.

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