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Nano-hydroxyapatite/polyamide66/chitosan composite (n-HA/PA66/CS) was prepared by a co-precipitation method and porous scaffolds from n-HA/PA66/CS composite were prepared by means of porogen–leaching method and were characterized by SEM, IR, XRD and universal mechanical testing machine. IR and XRD analyses showed that some chemical bonds existed between n-HA and polymers. Furthermore, macroporous structure of the scaffolds and mechanical strength were tested with a changed ratio of porogens (PVP/NaCl). When the ratio of PVP and NaCl is1: 6, the scaffold processed highly porosity and the pores were interconnected. The compressive strength of the scaffold, can meet the requirement of tissue regeneration.

Nano-hydroxyapatite/polyamide66/chitosan composite (n-HA/PA66/CS) was prepared by a co-precipitation method, and was characterized by TG/DTG, TEM, IR, XRD and Universal mechanical testing machine. TEM test showed that some rod like crystals were formed and distributed uniformly into polymer matrix, with a size of about Φ30nm×80nm. IR and XRD analysis showed that some chemical bonds and electrostatic interaction existed between n-HA and polymers. TG/DTG curves indicated that the composites possessed a talent of high heat-resistance. The compressive strength of composite changed with different content of three compounds, the maximum compressive strength of composite (70MPa) could be acquired.

Using nano-hydroxyapatite/polyamide66 composite (n-HA/PA66) and a special foamer as start materials, a porous species for bone defect repair was successfully developed by thermal-pressing method. The resulting material presented: (1) high compressive strength which reached 13~46MPa; (2) excellent porous structure, the average diameter of pores in the matrix was in range of 280μm to 500μm and porosity of 36% to 57%. The porous architecture could be adjusted by the combination of processing parameters such as the weight of start mixture used per mold and the ratio of composite to foamer as well as n-HA content in the composite. No apparent change in composition and structure of n-HA/PA66 composite was found by XRD and IR determination before and after formation of porous species. According to Sherrer equation, the value of D(002) of n-HA crystals in porous material and start powder were about 70nm, indicating no occurrence of change in size of n-HA during the thermal-pressing procedure. Additionally, no foamer residual was detected in porous species.