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The fate of mesenchymal stem cells (MSCs) is regulated by biological, physical and chemical signals. Developments in biotechnology and materials science promoted the occurrence of bioactive materials which can provide physical and chemical signals for MSCs to regulate their fate. In order to design and synthesize materials that can precisely regulate the fate of MSCs, the relationship between the properties of materials and the fate of mesenchymal stem cells need to be clarified, in which the detection of the fate of mesenchymal stem cells plays an important role. In the past 30 years, a series of detection technologies have been developed to detect the fate of MSCs regulated by bioactive materials, among which high-throughput technology has shown great advantages due to its ability to detect large amounts of data at one time. In this review, the latest research progresses of detecting the fate of MSCs regulated by bone bioactive materials (BBMs) are systematically reviewed from traditional technology to high-throughput technology which is emphasized especially. Moreover, current problems and the future development direction of detection technologies of the MSCs fate regulated by BBMs are prospected. The aim of this review is to provide a detection technical framework for researchers to establish the relationship between the properties of BMMs and the fate of MSCs, so as to help researchers to design and synthesize BBMs better which can precisely regulate the fate of MSCs.

In this paper, we discuss the application of the ABS algorithm to the simplex method, the dual simplex method, the linear complementary problem. We consider the ABS formulation of the stopping criterion, the search direction, the minimal rule to determine the vectors entering and leaving the basis matrix and the updating of the Abaffian matrix after a basis vector exchange. The Lemke algorithm for the LCP problem is reformulated in terms of the ABS procedure

We present a scheme for a compact rubidium cold-atom clock which performs diffuse light cooling, microwave interrogation, and detection of the clock signal in a cylindrical microwave cavity. The diffuse light is produced by laser light reflection at the inner surface of the microwave cavity. The pattern of the injected laser beams is specially designed to accumulate the majority of the cold atoms in the center of the microwave cavity. Microwave interrogation of the cold atoms in the cavity leads to Ramsey fringes, which have a linewidth of 24.5 Hz with a contrast of 95.6% when the free evolution time is 20 ms. Recently, a frequency stability of 7.3 x 10-13 τ-l/2 has been achieved. The scheme of this physical package can largely reduce the cold-atom clock complexity and increase clock performance. [ABSTRACT FROM AUTHOR]