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A highly enantioselective Michael addition of nitro esters to 2-enoyl-pyridine N-oxides was developed by using chiral copper catalysts. The Michael addition products can be obtained in high yields and with up to 96% ee.

Henry reaction is one of the most classical reactions to construct synthetically useful product nitro alcohol, which as a privileged skeleton is widely distributed in various pharmaceuticals. This review summarizes the recent progress of copper-catalyzed asymmetric Henry reaction from 2011 to 2016. The significant progress that has been made in this area will be highlighted and some of challenges that the author believes may be hindering further progress will be revealed.

•A novel composite PCM of LA@Cu/Attapulgite was successfully prepared.•LA@Cu with 2 wt.% of Cu has the best dispersion and high thermal conductivity of 0.33 W/(m•K)).•Thermal conductivity of composite PCM of LA@Cu/Attapulgite reached 0.46 W/(m•K).•Cu particles and attapulgite have the synergistically enhancing effect on thermal conductivity of LA.