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Introduction Spondylitis is an infectious process involving the vertebral body. Often there is a concurrent involvement of the intervertebral disk (spondylodiskitis). In most cases the causative agent is identified (mainly [...]

La neurocisticercosi è l'infestazione del SNC da parte delle larve della taenia solium: l'uomo funge in questo caso da ospite intermedio; le larve si distribuiscono attraverso il torrente circolatorio e successivamente si incistano in varie sedi. A livello encefalico si distinguono forme meningee, parenchimali, endoventricolari e forme miste, con espressione clinica assai variabile.Gli autori descrivono il caso clinico di un bambino affetto da una grave forma di neurocisticercosi con localizzazioni multiple meningee, parenchimali ed endoventricolari. L'evoluzione della malattia è stata seguita principalmente con esami di risonanza magnetica lungo un arco di tempo di otto mesi. Gli autori descrivono gli aspetti semeiologici più tipici di questa malattia studiata con tomografia RM.

Background: The role of growth factors/receptors in the etiopathology and/or development of gastric cancer has recently come under scrutiny, since overexpression or amplification of the EGF system has been found in many intestinal type gastric cancers and related to a more aggressive behavior. Since these gastric carcinomas appear to develop from intestinal metaplasia, a study was planned to investigate whether overexpression of the EGF-receptor gene also occurred in intestinal metaplastic mucosa. Methods: Patients underwent upper GL endoscopy. Gastric biopsies for routine histology, Helicobacter pylori detection, quantification of intestinal metaplasia and EGF-R expression analysis were performed. A 30mer EGF-R specific oligonucleotide was end-labeled and used to probe a dot blot filter containing the RNA from the bioptic samples. Results: Though all the gastric samples transcribed the EGF-R gene to a detectable level, overexpression of the EGF-R gene was found in the metaplastic mucosa in a minority of patients. Conclusions: These preliminary findings suggest that overexpression of the EGF-R gene is infrequent in the metaplastic gastric mucosa.