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Background: The emergence of multidrug resistance among enterococci makes effective treatment of enterococcalinfections more challenging. Giant pandas (Ailuropoda melanoleuca) are vulnerable to oral trauma and lesions as they feast on bamboo. Enterococcimay contaminate such oral lesions and cause infection necessitating treatment with antibiotics. However, few studies have focused on the virulence and drug resistance of oral-derived enterococci, including Enterococcus faecium, in giant pandas. In this study, we analyzed the prevalence of 8 virulence genes and 14 drug resistance genes in E. faeciumisolates isolated from saliva samples of giant pandas held in captivity in China and examined the antimicrobial drug susceptibility patterns of the E. faeciumisolates. Results: Twenty-eight isolates of E. faeciumwere successfully isolated from the saliva samples. Four virulence genes were detected, with the acmgene showing the highest prevalence (89%). The cylA, cpd, esp, and hylgenes were not detected. The isolated E. faeciumisolates possessed strong resistance to a variety of drugs; however, they were sensitive to high concentrations of aminoglycosides. The resistance rates to vancomycin, linezolid, and nitrofurantoin were higher than those previously revealed by similar studies in China and other countries. Conclusions: The findings of the present study indicate the drugs of choice for treatment of oral E. faeciuminfection in the giant panda.

The hydrochemistry of alpine lakes reflects water characteristic and its response to climatic change. Over 300 water samples had been collected from 52 sites of 5 lakes and 7 inflowing rivers in the Yamzhog Yumco Basin, South Tibet, during 2009–2014, basing which the hydrochemical regime and its mechanism were analyzed along with the adoption of hydrological investigations in 1979 and 1984 as well. Results revealed that the waters were hard with weak alkalinity for the Yamzhog Yumco Basin. Most of them were fresh, and the rest were slightly saline. The hydrochemical types of 5 lakes (i.e., Lake Yamzhog Yum Co, Puma Yum Co, Bajiu Co, Kongmu Co, and Chen Co) were SO42––HCO3––Mg2+–Na+, HCO3––SO42––Mg2+–Ca2+, SO42––Mg2+–Na+, SO42––HCO3––Ca2+, and SO42––Na+–Mg2+–Ca2+, respectively. As for rivers, HCO3–and SO42–were the major anions, and Ca2+was the dominant cation. Lake Yamzhog Yum Co, the largest lake in the basin, exhibited remarkable spatial variations in hydrochemistry at its surface but irregular changes with depth. The weathering of evaporates and carbonates, together with evaporation and crystallization, were the major mechanisms controlling the hydrochemistry of waters in the Yamzhog Yumco Basin. Global warming also had significant impacts on hydrochemical variations.

A review is presented of the occurrence of 24 abnormal hemoglobins (13 a-chain variants and 11 ß-chain variants) in populations in the Silk Road area of Northwestern China. Most frequently occurring were Hb D-Punjab [ß21(GH4)Glu?Gln] in Uygurs, Kazaks, and Khalkhas, Hb G-Taipei [ß22(B4)Glu?Gly] in persons of the Han nationality, and Hb G-Coushatta [ß22 (B4)Glu?Ala] in the Uygurs, Kazaks, Hans, and related nationalities. The data suggest that these variants likely originated in Central Asia, in the Han nationality of China, and in the minorities of northern China, respectively. Other variants occurred at considerably lower frequencies and were imported from other countries or arose as independent mutations. Two variants [Hb Tashikuergan or a19(AB1)Ala?Glu; Hb Tianshui or ß39(C5) Gln?Arg] were observed for the first time. The data from this study of the many variants support the movements of various populations in this area, as reported in numerous historical documents.

Based on the research of existing air monitoring and the research of APP products, the author is based on experience design and emotional design, from the perspective of human-computer interaction design, to explore better communication between users and intelligent products at emotional level. Through the analysis of the emotional design of products, we completed a set of persuasive APP design based on IOS flat system. Based on DOAS's working principle, we can get real-time data from environment and connect with mobile's APP, it is convenient for users to choose their own travel, to solve a series of health problems caused by environmental problems and people are concerned about their own health.

This paper studies how the new training mode of mechanical industry design promotes the transformation and upgrading of China's manufacturing industry. Through the analysis of the status quo of China's manufacturing industry design, the degree of industrial design engineering is adjusted to the mechanical category policy, and then from the perspective of the new model background, the industrial design complements the mechanical professional ability, the mechanical perfection of the industrial design professional ability, the complementary relationship between industrial design and mechanical skills, and analyzes the new model by improving the design ability of the new composite talents - improve market thinking, improve innovation capabilities, enrich professional skills, master technical theory, and enhance logical thinking to promote iterative upgrading of manufacturing products, thereby promoting the transformation and upgrading of China's manufacturing industry.

This paper studies how to design tourism culture creative products with Henan regional cultural characteristics and spiritual connotations. By analysing the advantages of Henan tourism product development and the main problems existing at present, summarize innovative ways to create distinctive brands, international, and sustainable design. Combining with actual cases of deepening design, trying to study Henan's regional tourism culture and creative products that have practical value, artistic value and cultural connotation value from various angles of design methods. I hope this article can be used as a reference for the innovative design of cultural and creative products.