1. Cardioprotective effects of timosaponin B-II isolated from Anemarrhenarhizome in a zebrafish model
- Author
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Du, Meng-Jiao, Chen, Jian-Ping, Lian, Bo-Wen, Mei, Wen-Jie, Yu, Jia-Xian, Chen, Li-Shi, Deng, Shan-Bin, Zhong, Yan-Mei, and Yu, Chu-Qin
- Abstract
Timosaponin B-II (TB-II; (25S)-26-(β-D-glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl) oxy]-5β-furostan-22-ol is extracted fromAnemarrhena. Its anti-inflammation, anti-oxidation, and anti-asthma properties have been widely explored. However, its effect on the heart has not been reported. In this study, we used zebrafish as a research model to determine the effects of TB-II on the heart and its toxic and anti-inflammatory effects. To explore the cause of cardioprotective effects of TB-II, we used transgenic zebrafish with macrophages and neutrophils labeled with fluorescent protein. We found for the first time that TB-II had a protective effect on the zebrafish heart. It did not affect the survival and hatching rates of zebrafish embryos, indicating its low toxicity. Results showed that TB-II may have cardioprotective effects, which might be related to its anti-inflammatory effects.
- Published
- 2020
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