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Background: This study aimed to compare the clinical effect of modified anterolateral and traditional acromioplasty in arthroscopic rotator cuff repair. Methods: The clinical data of 92 patients with total rotator cuff tears admitted to the Department of Joint Surgery of Jinhua Central Hospital from January 2016 to December 2019 were retrospectively analyzed. Among them, 42 patients underwent traditional acromioplasty during arthroscopic rotator cuff repair, and 50 underwent modified anterolateral acromioplasty. Patients were evaluated for preoperative and postoperative shoulder function, pain and critical shoulder angle, and incidence of rotator cuff re-tear at 12 months postoperatively. Results: The preoperative general data of patients in the classic and modified anterolateral acromioplasty groups did not differ significantly (P > 0.05) and were comparable. The UCLA, ASES, and Constant shoulder joint scores were significantly improved in both groups. The VAS score was significantly decreased at 12 months postoperative than preoperative, with a statistically significant difference (P ≤ 0.05). Shoulder function and pain scores did not differ significantly between the two groups at 12 months postoperatively (P > 0.05). The CSA did not differ significantly between preoperative and postoperative 12 months in the traditional acromioplasty group (P > 0.05). However, 12 months postoperative CSA in the modified anterolateral acromioplasty group was significantly smaller than the preoperative CSA, with a statistically significant difference (P ≤ 0.05). The rates of rotator cuff re-tears were 16.67% (7/42) and 4% (2/50) in the two groups at 12 months postoperatively, respectively, with statistically significant differences (P ≤ 0.05). Conclusions: Traditional and modified anterolateral acromioplasty while treating total rotator cuff tears using arthroscopic rotator cuff repair significantly improves shoulder joint function. However, modified anterolateral acromioplasty significantly reduced the CSA value and decreased the incidence of rotator cuff re-tears. [ABSTRACT FROM AUTHOR]

Forkhead box O1 (FOXO1) is a key regulator of osteogenesis. The aim of this study was to identify the mechanisms of microRNAs (miRNAs) targeting FOXO1 in osteogenic differentiation of human bone marrow mesenchymal stem cells (hMSCs). Three miRNA target prediction programs were used to search for potential miRNAs that target FOXO1. Quantitative real‐time polymerase chain reaction was conducted to detect the expression of miR‐1271‐5p and FOXO1 during osteogenic differentiation. Target gene prediction and screening, luciferase reporter assay was used to verify the downstream target gene of miR‐1271‐5p. The expression levels of FOXO1 and Runx2 were detected by RT‐qPCR and Western blot analysis. Alkaline phosphatase (ALP) activity and matrix mineralization were detected by biochemical methods. The expression levels of Runx2, ALP, and osteocalcin were detected by RT‐qPCR. Our results showed that miR‐1271‐5p was downregulated during osteogenic induction. And the expression levels of miR‐1271‐5p were higher in osteoporotic tissues than that in adjacent nonosteoporotic tissues. The expression levels of FOXO1 were lower in osteoporotic tissues than that in adjacent nonosteoporotic tissues. And a negative correlation was found between miR‐1271‐5p and FOXO1 in osteoporotic tissues. Overexpression of miR‐1271‐5p downregulated FOXO1 and inhibited osteogenic differentiation in hMSCs. Overexpression of miR‐1271‐5p downregulated the expression of osteogenic markers and reduced ALP activity. In addition, ectopic expression of FOXO1 reversed the effect of miR‐1271‐5p on osteogenic differentiation. In conclusion, miR‐1271‐5p functioned as a therapeutic target of osteogenic differentiation in hMSCs by inhibiting FOXO1, which provides valuable insights into the use of miR‐1271‐5p as a target in the treatment of osteoporosis and other bone metabolic diseases. [ABSTRACT FROM AUTHOR]

Background: Most of the studies assessing the corrective posterior total hip arthroplasty (THA) mainly focused on the mini-incision approach. Studies exploring the short external rotator sparing approach are rare. Therefore, this study aimed to compare the effectiveness of standard posterior approach and short external rotator sparing approach. Methods: This prospective observational study included 126 patients who underwent THA in June 2017–June 2018. Patients were assigned to standard (standard posterior approach) and corrective (short external rotator sparing approach) groups based on the surgical method. Surgical data were recorded postoperatively. Postoperative hip joint recovery was assessed using the times to ambulation and independent stair use, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, Harris score, and Oxford hip score (OHS) at 2 and 8 postoperative weeks. The visual analog scale (VAS) was used for postoperative pain assessment. Results: Postoperative changes of creatine kinase (CK), myoglobin, CRP, and prosthesis position were similar in both groups (P > 0.05). However, intraoperative blood loss (P < 0.001) and postoperative 6-h drainage volume (P = 0.03), hospital stay, blood transfusion rate, and times to ambulation and independent stair use were significantly reduced in the corrective group. Postoperatively, Oxford, and WOMAC scores significantly decreased in both groups. After surgery, the VAS score was more overtly decreased in the corrective group compared with the standard group. Conclusions: This study concluded that the less invasive short external rotator sparing approach for THA caused less damage, reducing perioperative blood loss, shortening functional recovery time, maintaining prosthesis stability, and improving postoperative pain. [ABSTRACT FROM AUTHOR]

• The soil fauna community at Pinus tabuliformis forest with different restoration ages was studied. • Soil fauna community diversity and soil food web were highest and the most stable in 6-year-old Pinus tabuliformis forest. • SOM, NCP and NHS were the main factors affecting the composition of the soil fauna community. • The undergrowth herb community drive the evolution of soil fauna community and regulated the soil food web. This study aimed to examine the characteristics and regulatory mechanisms of the soil fauna community in Pinus tabuliformis plantations at different restoration ages. The study was conducted on the soil fauna of Pinus tabuliformis in different restoration ages (6a, 11a, 18a, and 22a) in Wuqi County. Soil fauna, soil samples, understory herb biomass were collected in the spring, summer, autumn and winter of 2021. The relationship between the soil fauna community characteristics and environmental factors were studied. The results are as follows: (1) The density increased and the number of species decreased in the soil fauna community with an increase in restoration ages, and the composition and structure of the soil fauna community were significantly different at different restoration ages. (2) The diversity of the soil fauna community was highest and the soil food web was the most stable in 6-year-old Pinus tabuliformis plantations. Followed by a 22-year-old Pinus tabuliformis plantation. The lowest soil fauna diversity and the least stable food webs were found at 11- and 18-years-old of Pinus tabuliformis plantations. (3) The understory herb community had the greatest impact on the composition and structure of soil fauna community. SOM, NCP and NHS were the main factors affecting the composition of the soil fauna community. (4) During the restoration of Pinus tabuliformis plantations, the soil fauna community is mainly controlled by the top-down food resources, and the understory herb community driven the evolution process of the soil fauna community, thereby regulating the soil food web. Our research results emphasize the importance of sub-forest herbaceous vegetation to soil animals, which is essential for the formulation of sustainable biodiversity conservation policies for planted forest ecosystems. [ABSTRACT FROM AUTHOR]

Faced with the problems of low production efficiency and unreasonable industrial organization exist in the development of agriculture, this paper studied the multi-objective optimization of sustainable agricultural industrial structure based on genetic algorithm in order to optimize the allocation of agricultural industrial structure. First of all, this paper expounded the current agricultural development background, and then put forward the research status of multi-objective optimization algorithm, based on which points out the advantages of genetic algorithm. Then, establish the model system that is based on the optimal allocation of industrial structure. Use the improved genetic algorithm to solve the problem, and modify the operator design to obtain the optimal algorithm for the sustainable agricultural optimization sequence. The results of the algorithm evaluation show that the optimized industrial structure benefit value and sustainability both have been improved. [ABSTRACT FROM AUTHOR]

The article focuses on a research regarding the effect of the S-PT84, a strain of heat-killed Lactobacillus pentosus, on hypertriacylglycerolemia in rats. According to the research, in vitro analysis has revealed that administration of S-PT84 inhibited the hydrolysis of triacylglycerols by pancreatic lipase. It also mentions that administration of fat emulsion with or without S-PT84 resulted in the increase of plasma triacylglycerol concentration in rats.

In the context of global climate change and increasing population, transitioning to resource-efficient, environmentally friendly agricultural technologies is essential for sustainability. In this context, the present study is anchored in the theories of information asymmetry and bounded rationality. It constructs a tripartite evolutionary game model under market mechanisms and government guidance, facing the challenges of promoting green agricultural technologies among multiple actors. This model explores the strategic choices and dynamic evolution of these actors under economic incentives and risk perception. The objective of the research is to reveal the dynamic evolutionary trends of stakeholder behavior under different policy intervention conditions and how governments can propel the promotion of green agricultural production technologies through policy instruments. To encompass the impact of historical decisions on the evolutionary process of green technology dissemination, this study employs a Delay Differential Equations (DDE) algorithm that considers historical time lags in its numerical simulations. Through stability analysis and DDE numerical simulations, the research identifies factors influencing the promotion of green agricultural production technologies. The findings indicate that under market mechanisms, there is a risk of "market failure" in the dissemination model of green agricultural technologies. Government participation can provide external incentive support, effectively enhancing the stability and efficiency of the evolutionary game system for promoting green technologies. Simulation results further suggest that government intervention can significantly improve the stability and efficiency of technology promotion. Economies of scale, initial willingness, risk perception, and subsidy intensity are decisive factors in technology adoption. Consequently, policymakers are advised to formulate precise and multifaceted subsidy strategies based on the varying needs of different actors, to stimulate engagement, reduce risk, and encourage widespread adoption of green technologies. This study lays a theoretical groundwork for smallholders and family farms to overcome technology adoption barriers, crucial for sustainable agricultural development. It provides a framework for understanding and addressing these challenges, guiding policymakers in crafting effective green agriculture policies to improve farming efficiency and sustainability. [Display omitted] • This research investigates the impact of policy interventions on the adoption of green agricultural technologies. • We employ a tripartite game model and the DDE algorithm to analyze strategy evolution. • The study demonstrates that government involvement enhances the promotion of green technologies. • Implement a variety of subsidies to promote green technologies and support sustainable agriculture. [ABSTRACT FROM AUTHOR]

Up-regulated HIF-2α (hypoxia induced factor 2) had been demonstrated to contribute to Osteoarthritis (OA) development via inducing the expression of matrix-degrading enzymes. However, the HIF-2α also could promote primary cilia loss through HIF-2α/AURKA (Aurora kinase A)/NEDD9 pathway. And the primary cilia dysfunction is another characteristic of the OA. Thus, we investigated here whether the HIF-2α also contributes the OA development through mediating the primary cilia loss. The primary chondrocytes were isolated from the experimental OA mice induced by destabilization of the medial meniscus (DMM). Chondrocytes were cultured under normoxia (21% O 2) or hypoxia (2% O 2) conditions. The HIF-1α and HIF-2α expressions were assessed by western blot. The cilia formation was counted by immuno-staining the acetylated tubulin. The contribution of HIF-1α or HIF-2α to the primary cilia loss was assessed by knocking-down the HIF-1α or HIF-2α individually. The HIF-2α/AURKA/NEDD9 pathway was validated through over-expressing or knocking-down specific components of the pathway and then counting the primary cilia number. Finally, the pathway was further confirmed in the OA mice. Hypoxia could induce the expression of both HIF-1α and HIF-2α, and also reduce the number of primary cilia on the chondrocytes isolated from the experimental OA mice. Knocking-down or over-expressing HIF-1α or HIF-2α individually showed that the HIF-2α could induce the primary cilia reduction rather than the HIF-1α. Manipulating the HIF-2α expression could positively affect the AURKA and NEDD9 expression. Manipulating the AURKA and NEDD9 expressions could reverse the function of HIF-2α on primary cilia. In the mice, knocking-down both AURKA and NEDD9 could alleviate the OA development significantly. Up-regulated HIF-2α contributes to the Osteoarthritis development through mediating the primary cilia loss, which might be developed as therapeutic targets for OA treatment. • Up-regulated HIF-2α contributes to the Osteoarthritis development • HIF-2α induces primary cilia loss in OA through HIF2α/AURKA/ NEDD9 pathway • HIF-1α does not involve into the primary cilia regulation under hypoxia in OA [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to determine the functional and radiological outcomes of arthroscopic treatment of anterior ankle impingement (AAI) in patients with chronic lateral ankle instability (CAI).Methods: All patients with CAI between June 2012 and May 2015 were invited to participate in this investigation. All of them accepted open modified Broström repair of lateral ankle ligaments and were divided into two groups: AAI group (with anterior ankle impingement) and pure CAI group (without anterior ankle impingement). All of them were followed up using American Orthopaedic Foot and Ankle Society Score (AOFAS), Karlsson Ankle Functional Score and Tegner activity score. Ankle dorsiflexion was also examined. X-ray examination was applied to investigate anterior tibiotalar osteophytes.Results: Finally, a total of 60 patients were followed up at a mean of 37 ± 10 months, including 22 patients in the AAI group and 38 patients in the pure CAI group. Preoperatively, the AAI group had significant lower AOFAS score (62.9 ± 11.7 vs 72.9 ± 11.1; p = 0.002) and Tegner activity score (1.5 ± 0.8 vs 2.1 ± 1.0; p = 0.04) respectively when compared with the pure CAI group. The ankle dorsiflexion of the AAI group (13 ± 2.1) was also significantly lower than that of the pure CAI group (26.2 ± 2.1) (p = 0.001). However, there was no significant difference in the AOFAS score or the Karlsson score or the Tegner score or the Ankle dorsiflexion between the two groups postoperatively. The postoperative X-ray images demonstrated complete osteophyte resection in all patients, and no recurrence of osteophyte.Conclusion: The functional outcome scores and dorsiflexion had significantly improved postoperatively. Combined treatment of chronic ankle instability and anterior ankle impingement produced satisfactory surgical outcomes in patients with CAI accompanied by anterior ankle impingement symptom. [ABSTRACT FROM AUTHOR]

The embedded controller is small in size and powerful in computing power, and can quickly complete the related processing and calculation of flight attitude and track planning data. Wireless data transmission can realize a long-distance data transmission between the aircraft command center and the airborne control platform. Based on the data fusion algorithm of the Kalmánz filter, the data collected by multiple sensors can be integrated, which can effectively reduce the measurement noise amplitude. At the same time, the cumulative error of a single sensor is reduced. In order to solve the problems of ant colony algorithm in case it is easy to fall into the local extremum and the convergence speed is slow, an improved ant colony algorithm for 3D navigation of unmanned aerial vehicles is proposed for trace planning. This study divides the three-dimensional track planning into two parts based on the improved ant colony algorithm for two-dimensional plane planning and height planning. Geometric optimization methods to enhance the guidance of ant search are used. According to the distance and height constraints between the track point and the threat source, the altitude of the track points to plan the 3D track of the drone is calculated and adjusted. At the same time, the adaptive parameter adjustment method is used to improve the ant colony search ability and the interaction ability between individuals, and effectively get rid of the situation to avoid to falling into a local optimum. In addition, the index function is established and the path is smoothed. Simulation results show that the proposed improved algorithm cannot only safely avoid threats in the three-dimensional environment, but also has the ability to find the optimal solution and the convergence speed is better than the original algorithm. [ABSTRACT FROM AUTHOR]

Systemic lupus erythematosus (SLE) is a severe autoimmune disorder, the pathogenesis of which remains largely unknown. The present study aimed to investigate the role and mechanism of circular RNAs in the etiopathogenesis of SLE. CD4+ T cells in patients with SLE expressed higher levels of hsa_circ_0010957 compared with healthy individuals and was a good differentiator of the active from inactive SLE disease. It was also determined that hsa_circ_0010957 mediated microRNA (miR)-125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)-18, IL-6 and IL-17, which are important factors in the process of SLE. Hsa_circ_0010957 abrogated the proinflammatory effect of IL-6 via the blockade of STAT3 signaling. In conclusion, increased hsa_circ_0010957 may be involved in SLE pathogenesis via miR-125b/STAT3 signaling. Hsa_circ_0010957 promises to be a potential biomarker and therapeutic target for SLE. [ABSTRACT FROM AUTHOR]