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2024 NOV 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 AUG 31 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on catecholamine receptors are presented in a new report. According [...]

2024 AUG 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Membrane Proteins - Catecholamine Receptors are presented in a [...]

2024 MAY 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Membrane Proteins - Biogenic Amine Receptors. According [...]

2024 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Membrane Proteins - Catecholamine Receptors. According to [...]

2024 APR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 NOV 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Membrane Proteins - Biogenic Amine Receptors. According [...]

2023 NOV 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 SEP 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Membrane Proteins - Catecholamine Receptors have been published. [...]

A recent study conducted at Guangdong Medical University in Dongguan, People's Republic of China, explored the potential benefits of using Achillea millefolium green-formulated zinc nanoparticles in mice with heart failure following myocardial infarction. The research focused on the synthesis of zinc nanoparticles using eco-friendly practices and their effects on myocardial infarction treatment. The study found that zinc nanoparticles exhibited cardioprotective characteristics by reducing inflammatory cytokines expression and myocardial injury markers, potentially improving cardiac function and reducing mortality rates in mice. The research concluded that zinc nanoparticles effectively prevented characteristic ST segment depression observed in animals with myocardial infarction. [Extracted from the article]

The article discusses the limitations of grouping subjects based on biological sex in substance use disorder research and proposes a new approach called the MISSING model. The study conducted experiments on Sprague Dawley rats to compare the effectiveness of grouping based on biological sex versus behavioral clustering in identifying distinct groups with regards to behavioral variables and confirming Nucleus Accumbens dopamine neurochemical expression/activity topography. The results suggest that grouping based on biological sex may not be the most effective method, highlighting the need for alternative approaches in research. [Extracted from the article]

A recent study by MIT researchers has identified two new pathways in the brain that connect to dopamine-producing neurons and modulate the effects of movement-initiating and movement-suppressing pathways. These pathways, located in the striatum, may influence decisions with strong emotional components. The findings suggest a need to revise the classical model of how the brain controls movement to include these newly discovered pathways. The research was funded by various organizations, including the National Institutes of Health and the Simons Foundation. [Extracted from the article]

A recent study conducted at Rush University Medical Center in Chicago, Illinois, focused on the epidemiology of headache presentations in United States Emergency Departments from 2016 to 2023. The study found that headaches are a common reason for ED visits, with approximately 4% of patients being admitted. Imaging, such as CT scans, is frequently performed, and medications like NSAIDs and dopamine antagonists are commonly administered, with opioid use declining over time. These findings can help inform health policy initiatives related to radiologic imaging and evidence-based medication administration. [Extracted from the article]

A recent study from the National Institute on Drug Abuse (NIDA) in Baltimore, Maryland, explored the role of dopamine D3 receptors in the rewarding effects of cocaine and opioids in mice. The research found that D3 receptors play distinct roles in cocaine versus opioid reward, with D3 receptors being critically involved in the actions of opioids but not cocaine. The study utilized various techniques to investigate the function of presynaptic versus postsynaptic D3 receptors in the mesolimbic dopamine system. This peer-reviewed research provides valuable insights into the neural mechanisms underlying the rewarding effects of these substances. [Extracted from the article]

A study conducted by Geneva University Hospitals evaluated the economic impact of the PedAMINES app in reducing medication errors in pediatric emergency care. The app automates dose calculations for drugs like epinephrine, norepinephrine, dopamine, and midazolam, aiming to prevent adverse drug events. The research found that the app could potentially reduce errors and be cost-effective, with the primary factors influencing cost per error being app maintenance, likelihood of adverse events, and underdosing frequency. The study advocates for widespread adoption of the app to benefit pediatric emergency care in Switzerland. [Extracted from the article]

A patent has been issued for the use of reboxetine to treat narcolepsy with cataplexy by Axsome Therapeutics Inc. The patent describes methods of administering antidepressants, such as selective norepinephrine inhibitors, to individuals with narcolepsy. The treatment aims to reduce daytime sleepiness, cataplexy attacks, and improve overall quality of life for those affected by this neurological condition. This development addresses the limited treatment options available for narcolepsy and highlights the potential benefits of using reboxetine in managing the symptoms associated with this disorder. [Extracted from the article]

Researchers at Michigan State University have conducted a study on the role of midbrain dopamine cells projecting to the insular cortex in mediated performance, with implications for animal models of reality testing in schizophrenia. The study found that perturbations in the DISC-1 genetic locus led to a reduction in the number of cells in the VTA -> IC circuit, affecting behavior during mediated performance testing. Inactivation of this circuit predisposed wild-type mice to impaired reality testing, highlighting the importance of dopamine-insular cortex connections in schizophrenia research. The study was supported by the National Institutes of Health (NIH) in the United States and has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at AIMST University explored the relationship between the gut microbiome and neurotransmitter levels in schizophrenia patients. The study found that specific bacteria were enriched in schizophrenia patients compared to healthy controls, and certain bacteria were negatively correlated with dopamine, serotonin, and BDNF levels. The research suggests that gut microbiome-targeted therapies could potentially help rebalance neurotransmitter levels in individuals with schizophrenia, offering new possibilities for treatment. For more information, the full study can be accessed in The Egyptian Journal of Neurology, Psychiatry and Neurosurgery. [Extracted from the article]

A recent study from Jiangsu University in China has developed a nonenzymatic electrochemical sensor for detecting both ascorbic acid (AA) and dopamine (DA) simultaneously. The sensor utilizes a Co-modified MCM-41 mesoporous molecular sieve with superior electrocatalytic activity, allowing for a wider peak potential difference in the oxidation of AA and DA. The research demonstrated successful detection of AA in orange juice and DA in madopar pill samples, showing promise for practical applications in food analysis. For more information, the full article can be accessed for free online. [Extracted from the article]

Researchers at the First Affiliated Hospital of Zhengzhou University have reported a case of anti-dopamine receptor 2 (D2R) antibody encephalitis in an adult patient, a subtype of autoimmune encephalitis. The patient presented with various symptoms including insomnia, memory impairment, and movement disorders, with positive D2R antibodies in both serum and cerebrospinal fluid. Treatment with immunotherapy led to significant improvement and full recovery over a 6-month follow-up period. This study highlights the importance of recognizing D2R encephalitis in adults and the effectiveness of immunotherapy in treating this condition. [Extracted from the article]

A study conducted at University Hospital Munster in Germany analyzed the use of Angiotensin II (ANGII) in patients with catecholamine-resistant vasodilatory shock and acute kidney injury (AKI). The study found that ANGII was associated with lower 28-day mortality, increased likelihood of mean arterial pressure (MAP) response, and more days alive and free from renal replacement therapy (RRT) in patients with stage 3 AKI. These results suggest the potential benefits of ANGII in treating patients with severe AKI and shock. [Extracted from the article]

Orexo AB has initiated a new study, OX640-002, to investigate the absorption of epinephrine from OX640 in participants with allergic rhinitis. The study aims to understand the effectiveness of OX640 in treating severe allergic reactions, including anaphylaxis, in the presence of nasal allergic symptoms. The study involves 30 participants with allergic rhinitis and will cost SEK 11 million, with results expected in early 2025. This research is crucial for advancing the development of OX640 and meeting regulatory requirements for potential approval. [Extracted from the article]

The article discusses a study on catecholaminergic polymorphic ventricular tachycardia (CPVT) conducted by researchers at Pirogov Russian National Research Medical University. CPVT is a primary electrical heart disease that can lead to polymorphic ventricular tachycardia in response to adrenergic stimulation, with syncope being a common symptom. The main treatment approach for CPVT is drug therapy with beta-blockers, but there is increasing evidence suggesting their lack of efficacy, leading to the exploration of combination therapy and interventional methods like cardioverter defibrillator implantation and left side sympathectomy. The research provides insights into the efficacy, safety, and indications for managing CPVT in patients. [Extracted from the article]

Researchers at the University of North Dakota have conducted a study on the regulation of norepinephrine transporter (NET) in relation to postural orthostatic tachycardia syndrome (POTS). The study found that palmitoylation, a post-translational modification, plays a crucial role in the regulation of NET expression and function. The research suggests that dysregulation of palmitoylation may contribute to the pathogenesis of adrenergic disorders like POTS. This study provides novel insights into potential avenues for the development of treatments for NET-based adrenergic disorders. [Extracted from the article]

A study conducted at the Cleveland Clinic focused on the relationship between plasma catecholamines and hemodynamic parameters in patients undergoing invasive cardiopulmonary exercise testing for exercise intolerance, specifically preload insufficiency. The research found that patients with preload insufficiency had higher heart rates and epinephrine levels at rest, indicating increased sympathetic activity. However, there were no strong associations between catecholamines and cardiac filling pressures, suggesting that catecholamine levels are primarily influenced by peak workload. This peer-reviewed study provides valuable insights into the physiological mechanisms underlying exercise intolerance in patients with preload insufficiency. [Extracted from the article]

Researchers from Pirogov Russian National Research Medical University have conducted a study on Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), a primary electrical heart disease that can lead to ventricular tachycardia in response to stress. The study highlights the challenges in diagnosing CPVT early and emphasizes the importance of analyzing genetic causes and associated disorders for effective management. Future research aims to improve diagnostic quality and reduce mortality rates among CPVT patients. For more information, readers can access the full article titled "Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia" in the journal Voprosy sovremennoj pediatrii. [Extracted from the article]

A recent study conducted in Tokyo, Japan, explored the associations between cerebrospinal fluid monoamine metabolites and striatal dopamine transporter binding in Parkinson's disease patients. The research found that lower levels of 5-hydroxyindole acetic acid (5-HIAA) were significantly associated with abnormalities in cardiac I-123-meta-iodobenzylguanidine (MIBG) imaging. Additionally, the study confirmed direct associations between 5-HIAA and cardiac MIBG, as well as between homovanillic acid (HVA) and striatal dopamine transporter binding. This research provides valuable insights into the neurochemical mechanisms underlying Parkinson's disease. [Extracted from the article]

The article discusses a study on the early disruption of entorhinal dopamine in a knock-in model of Alzheimer's disease. Researchers found that dopamine neurons projecting to the lateral entorhinal cortex become dysfunctional in early stages of Alzheimer's, leading to memory impairments. Reactivation of these dopamine fibers or treatment with L-DOPA improved associative learning behavior, suggesting a potential target for clinical investigation in Alzheimer's patients. The study highlights the importance of understanding the role of dopamine in memory impairment in Alzheimer's disease. [Extracted from the article]