Search

Researchers at Seoul National University have discovered a new synthetic method for incorporating functional groups into the meta position of pyridine, an essential structure in drug development. This method allows for the synthesis of di-meta-substituted pyridines without ortho and para substitutions, which are typically challenging to achieve. The researchers also uncovered the requirement for resonance-assisted hydrogen bonding in the generation of key intermediates for this transformation. The developed methodology has wide applications, including core remodeling of natural products, drug-natural product conjugation, late-stage functionalization of drug molecules, and synthesis of regioisomeric compounds. Additionally, the researchers identified anti-inflammatory agents through the functional evaluation of synthesized analogs, demonstrating the utility of this methodology. [Extracted from the article]

A recent report from Ain Shams University in Cairo, Egypt discusses research on the chemical reactivity of certain compounds called 6,8-dimethylchromones with heterocyclic enamines. The researchers synthesized various compounds and conducted molecular analysis to determine their properties. The compounds showed potential inhibitory effects against microbes and cancer cells, and also exhibited good drug-like properties. The study provides valuable insights into the reactivity and potential applications of these compounds. [Extracted from the article]

Keywords: Cancer; Cancer Therapy; Drugs and Therapies; Health and Medicine; Oncology EN Cancer Cancer Therapy Drugs and Therapies Health and Medicine Oncology 685 685 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in cancer therapy. The potato disc tumor assay was used to assess Agrobacterium tumefaciens -induced tumors to evaluate the anti-tumor activities of compounds (4a - 4i), using Vinblastine as a standard drug. Cancer, Cancer Therapy, Drugs and Therapies, Health and Medicine, Oncology. [Extracted from the article]