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23 results on '"inoko, Moriaki"'

1. External validation of the Pulmonary Embolism-Syncope, Anemia, and Renal Dysfunction bleeding score for early major bleeding in patients with acute pulmonary embolism: from the COMMAND VTE Registry-2

Author

Nishimoto, Yuji, Yamashita, Yugo, Morimoto, Takeshi, Chatani, Ryuki, Kaneda, Kazuhisa, Ikeda, Nobutaka, Kobayashi, Yohei, Ikeda, Satoshi, Kim, Kitae, Inoko, Moriaki, Takase, Toru, Tsuji, Shuhei, Oi, Maki, Takada, Takuma, Otsui, Kazunori, Sakamoto, Jiro, Ogihara, Yoshito, Inoue, Takeshi, Usami, Shunsuke, Chen, Po-Min, Togi, Kiyonori, Koitabashi, Norimichi, Hiramori, Seiichi, Doi, Kosuke, Mabuchi, Hiroshi, Tsuyuki, Yoshiaki, Murata, Koichiro, Takabayashi, Kensuke, Nakai, Hisato, Sueta, Daisuke, Shioyama, Wataru, Dohke, Tomohiro, Nishikawa, Ryusuke, Sato, Yukihito, Watanabe, Tetsuya, Yamada, Takahisa, Fukunami, Masatake, Kimura, Takeshi, Kaneda, Kazuhisa, Nishikawa, Ryusuke, Yamashita, Yugo, Chatani, Ryuki, Mushiake, Kazunori, Kadota, Kazushige, Nishimoto, Yuji, Sato, Yukihito, Ikeda, Nobutaka, Amemiya, Katsushi, Nakamura, Masato, Kobayashi, Yohei, Kimura, Ren, Inada, Tsukasa, Ikeda, Satoshi, Ueno, Yuki, Maemura, Koji, Kim, Kitae, Shigeno, Ryo, Furukawa, Yutaka, inoko, Moriaki, Ito, Shinya, Takase, Toru, Nakazawa, Gaku, Tsuji, Shuhei, Toyofuku, Mamoru, Oi, Maki, Kaitani, Kazuaki, Takada, Takuma, Jujo, Kentaro, Hagiwara, Nobuhisa, Otsui, Kazunori, Mori, Kenta, Sakamoto, Jiro, and Tamura, Toshihiro

Abstract

There is no established risk score for anticoagulant-related bleeding during the acute phase in patients with pulmonary embolism (PE). The PE-Syncope, Anemia, and Renal Dysfunction (PE-SARD) bleeding score was developed to predict early major bleeding but has not yet been fully externally validated.

Published
2024
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2. Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation

Author

Kanaoka, Koshiro, Onoue, Kenji, Terasaki, Satoshi, Nakano, Tomoya, Nakai, Michikazu, Sumita, Yoko, Hatakeyama, Kinta, Terasaki, Fumio, Kawakami, Rika, Iwanaga, Yoshitaka, Miyamoto, Yoshihiro, Saito, Yoshihiko, Yuda, Satoshi, Tanno, Masaya, Takahashi, Toru, Yokoshiki, Hisashi, Toba, Masahiro, Anzai, Toshihisa, Nagai, Toshiyuki, Sato, Takuma, Takenaka, Takashi, Yamazaki, Seiji, Katagiri, Yuki, Takeuchi, Toshiharu, Sugitatsu, Kazuya, Kakinoki, Shigeo, Matsumoto, Tomoaki, Urasawa, Kazushi, Tan, Michinao, Tsujino, Ichizo, Kamigaki, Mitsunori, Tomita, Hirofumi, Hanada, Kenji, Kushibiki, Motoi, Nakamura, Akihiro, Morino, Yoshihiro, Nasu, Takahito, Yasuda, Satoshi, Suzuki, Hideaki, Iwabuchi, Kaoru, Tsuji, Kanako, Namiuchi, Shigeto, Komaru, Tatsuya, Yagi, Masahiro, Uematsu, Shoko, Takahashi, Toshiaki, Takeda, Satoru, Nakanishi, Toru, Watanabe, Masafumi, Wanezaki, Masahiro, Matsui, Motoyuki, Sugawara, Shigeo, Takeishi, Yasuchika, Oikawa, Masayoshi, Komatsu, Nobuo, Suzuki, Satoshi, Okamoto, Hiroshi, Takeyasu, Noriyuki, Akiyama, Daiki, Eki, Yutaka, Kakuta, Tsunekazu, Sugiyama, Tomoyo, Koizumi, Tomomi, Ueno, Koji, Kario, Kazuomi, Taki, Mizuri, Matsumoto, Yuri, Yasu, Takanori, Nishioka, Osamu, Naito, Shigeto, Murata, Makoto, Tange, Shoichi, Kaneko, Katsumi, Muto, Makoto, Inagaki, Hiroshi, Hasegawa, Shuichi, Tachibana, Eizo, Atsumi, Wataru, Suzuki, Masahiro, Muramatsu, Toshihiro, Yamada, Yoshihiro, Taguchi, Isao, Fukuda, Yoshiaki, Matsui, Akihiro, Kanda, Junji, Hozawa, Koji, Matsumura, Akihiko, Shimizu, Wataru, Yamamoto, Takeshi, Komuro, Issei, Hatano, Masaru, Ikeda, Takanori, Kiuchi, Shunsuke, Chikamori, Taishiro, Takei, Yasuyoshi, Soejima, Kyoko, Minamishima, Toshinori, Tanaka, Hiroyuki, Shimizu, Shigeo, Kasao, Masashi, Kadohira, Tadayuki, Minamino, Tohru, Shimada, Kazunori, Iwata, Hiroshi, Momiyama, Yukihiko, Ashikaga, Takashi, Nozato, Toshihiro, Fujiwara, Yasumasa, Inoue, Kenji, Sasano, Tetsuo, Matsuda, Junji, Ishii, Yasuhiro, Ono, Yuichi, Tanabe, Kengo, Horiuchi, Yu, Shinke, Toshiro, Kodama, Yusuke, Moroi, Masao, Yazaki, Yoshiyuki, Mizumura, Taisuke, Ohta, Hiroshi, Akashi, Yoshihiro, Kotoku, Nozomi, Ikari, Yuji, Maruyama, Mitsunori, Sato, Yasuhiro, Tamura, Koichi, Konishi, Masaaki, Suzuki, Hiroshi, Ebato, Mio, Fukui, Kazuki, Yumoto, Kazuhiko, Iwasawa, Takamasa, Kashimura, Takeshi, Takahashi, Kazuyoshi, Okada, Yoshinobu, Kaku, Bunji, Usuda, Kazuo, Maruyama, Michiro, Kameyama, Tomoki, Higashikata, Toshinori, Hodatsu, Akihiko, Osato, Kazuo, Nagata, Yoji, Maeno, Koji, Satake, Kazuo, Sawanobori, Takao, Watanabe, Noboru, Kuwahara, Koichiro, Motoki, Hirohiko, Kitabayashi, Hiroshi, Otagiri, Kyuhachi, Kono, Tsunesuke, Yamagishi, Daisuke, Yazaki, Yoshikazu, Noda, Toshiyuki, Morishima, Itsuro, Watanabe, Naoki, Tanaka, Shinichiro, Onodera, Tomoya, Nawada, Ryuzo, Watanabe, Akinori, Matsunaga, Masaki, Suwa, Satoru, Sakamoto, Hiroshi, Sakamoto, Hiroki, Aoyama, Takeshi, Kanamori, Norio, Muto, Masahiro, Maekawa, Yuichiro, Ohtani, Hayato, Ozaki, Yukio, Naruse, Kenshin, Takemoto, Kenji, Kamiya, Haruo, Suzuki, Takeshi, Tomita, Yasushi, Suzuki, Susumu, Kametani, Ryosuke, Aoyama, Hidekazu, Osanai, Hiroyuki, Harada, Ken, Kada, Kenji, Saeki, Tomoaki, Kobayashi, Koichi, Ogawa, Yasuhiro, Terasawa, Akihiro, Shinoda, Masanori, Oguri, Mitsutoshi, Shimizu, Kiyokazu, Sawamura, Akinori, Sugiura, Atsushi, Hattori, Kosuke, Mokuno, Shinji, Kondo, Kazuhisa, Dohi, Kaoru, Moriwaki, Keishi, Kasai, Atsunobu, Nakakuki, Tetsuya, Kaitani, Kazuaki, Jinnai, Toshikazu, Yamamoto, Takashi, Kurata, Hiroyuki, Wada, Atsuyuki, Akao, Masaharu, Hamatani, Yasuhiro, Ishibashi, Kazuya, Akakabe, Yoshiki, Asaumi, Yasuhide, Matama, Hideo, Sakata, Yasushi, Kioka, Hidetaka, Takaishi, Hiroshi, Iwanaga, Yoshitaka, Takase, Toru, Matsuda, Mitsuo, Sato, Fumi, Hasegawa, Shinji, Ishigami, Kenichi, Ichikawa, Minoru, Takagi, Takashi, Inoko, Moriaki, Hoshiga, Masaaki, Fujita, Shuichi, Takeda, Yoshihiro, Kawarabayashi, Takahiko, Takaoka, Hideyuki, Nakajima, Kenji, Yuguchi, Tadashi, Kawasaki, Tatsuya, Shinoda, Yukinori, Sato, Yukihito, Ishihara, Masaharu, Matsumoto, Yuki, Kawai, Hiroya, Takaya, Tomofumi, Matsuo, Kouki, Mano, Toshiaki, Hirata, Kenichi, Hisamatsu, Eriko, Inoue, Nobutaka, Tamita, Koichi, Mukohara, Naoki, Shimoyama, Hisashi, Miyajima, Toru, Tamura, Toshihiro, Tamaki, Yodo, Suzuki, Megumi, Yokota, Ryoji, Horii, Manabu, Yamanaka, Kazuo, Kawata, Hiroyuki, Hashimoto, Yukihiro, Nakada, Yasuki, Nakagawa, Hitoshi, Ueda, Tomoya, Nishida, Taku, Seno, Ayako, Watanabe, Makoto, Akasaka, Takashi, Tanimoto, Takashi, Toyofuku, Mamoru, Yamamoto, Kazuhiro, Kinugasa, Yoshiharu, Hirai, Masayuki, Nasu, Hiroshi, Shirota, Kinya, Oda, Tsuyoshi, Oka, Takefumi, Kadota, Kazushige, Ohya, Masanobu, Ito, Hiroshi, Nakamura, Kazufumi, Ogura, Soichiro, Fuke, Soichiro, Uemura, Shiro, Matsubara, Hiromi, Watanabe, Atsuyuki, Morishima, Nobuyuki, Kihara, Yasuki, Hidaka, Takayuki, Ueda, Hironori, Ono, Yujiro, Muraoka, Yuji, Hatanari, Miyo, Miyamoto, Yoshinori, Dote, Keigo, Kato, Masaya, Yano, Masafumi, Mochizuki, Mamoru, Ikeda, Yasuhiro, Fujinaga, Hiroyuki, Hosokawa, Shinobu, Sata, Masataka, Yamaguchi, Koji, Aki, Naoko, Minamino, Tetsuo, Miyake, Yuichi, Takagi, Yuichiro, Doi, Masayuki, Taketani, Yoshio, Okayama, Hideki, Shigematsu, Tatsuya, Higaki, Akinori, Yamaguchi, Osamu, Inaba, Shinji, Ikeda, Shuntaro, Kawai, Kazuya, Kitaoka, Hiroaki, Kubo, Toru, Ando, Kenji, Inui, Kaoru, Fukumoto, Yoshihiro, Hori, Kensuke, Homma, Takehiro, Kawasaki, Tomohiro, Mohri, Masahiro, Fujiwara, Masaki, Tsutsui, Hiroyuki, Ide, Tomomi, Miura, Shin-Ichiro, Kuwano, Takashi, Shimomura, Hideki, Kadokami, Toshiaki, Taba, Masanao, Kondou, Katsuhiro, Kubota, Toru, Nagatomo, Daisuke, Mukai, Yasushi, Matsukawa, Ryuichi, Tashiro, Hideki, Shimomura, Mitsuhiro, Maemura, Koji, Kawano, Hiroaki, Oku, Koji, Yamasa, Toshihiko, Kizaki, Yoshihisa, Sakamoto, Tomohiro, Tamura, Yudai, Ito, Teruhiko, Fujimoto, Kazuteru, Tsujita, Kenichi, Takashio, Seiji, Kurokawa, Hirofumi, Takahashi, Naohiko, Saito, Shotaro, Arikawa, Masaya, Shibata, Yoshisato, Nishihira, Kensaku, Tsuruda, Toshihiro, Sonoda, Masahiro, Atsuchi, Nobuhiko, Ohishi, Mitsuru, Higuchi, Koji, Miyata, Masaaki, Oketani, Naoya, Akimoto, Yoshinori, Asahi, Tomohiro, and Wake, Minoru

Published
2022
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3. Edoxaban, Rivaroxaban, or Apixaban for Cancer-Associated Venous Thromboembolism in the Real World: Insights from the COMMAND VTE Registry-2

Author

Sueta, Daisuke, Yamashita, Yugo, Morimoto, Takeshi, Chatani, Ryuki, Nishimoto, Yuji, Kaneda, Kazuhisa, Ikeda, Nobutaka, Kobayashi, Yohei, Ikeda, Satoshi, Kim, Kitae, Inoko, Moriaki, Takase, Toru, Tsuji, Shuhei, Oi, Maki, Takada, Takuma, Otsui, Kazunori, Sakamoto, Jiro, Ogihara, Yoshito, Inoue, Takeshi, Usami, Shunsuke, Chen, Po-Min, Togi, Kiyonori, Koitabashi, Norimichi, Hiramori, Seiichi, Doi, Kosuke, Mabuchi, Hiroshi, Tsuyuki, Yoshiaki, Murata, Koichiro, Takabayashi, Kensuke, Nakai, Hisato, Shioyama, Wataru, Dohke, Tomohiro, Nishikawa, Ryusuke, Kimura, Takeshi, and Tsujita, Kenichi

Published
2024
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4. B-type natriuretic peptide in patients with asymptomatic severe aortic stenosis

Author

Nakatsuma, Kenji, Taniguchi, Tomohiko, Morimoto, Takeshi, Shiomi, Hiroki, Ando, Kenji, Kanamori, Norio, Murata, Koichiro, Kitai, Takeshi, Kawase, Yuichi, Izumi, Chisato, Miyake, Makoto, Mitsuoka, Hirokazu, Kato, Masashi, Hirano, Yutaka, Matsuda, Shintaro, Inada, Tsukasa, Nagao, Kazuya, Mabuchi, Hiroshi, Takeuchi, Yasuyo, Yamane, Keiichiro, Toyofuku, Mamoru, Ishii, Mitsuru, Minamino-Muta, Eri, Kato, Takao, Inoko, Moriaki, Ikeda, Tomoyuki, Komasa, Akihiro, Ishii, Katsuhisa, Hotta, Kozo, Higashitani, Nobuya, Kato, Yoshihiro, Inuzuka, Yasutaka, Maeda, Chiyo, Jinnai, Toshikazu, Morikami, Yuko, Saito, Naritatsu, Minatoya, Kenji, and Kimura, Takeshi

Abstract

ObjectivesWe sought to evaluate the prognostic impact of the B-type natriuretic peptide (BNP) levels in patients with asymptomatic severe aortic stenosis (AS), who were not referred for aortic valve replacement (AVR).MethodsWe used data from a Japanese multicentre registry, the Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis Registry, which enrolled 3815 consecutive patients with severe AS. Of those, 387 asymptomatic patients who were not referred for AVR without left ventricular dysfunction and very severe AS were subdivided into four groups based on their BNP levels (BNP<100 pg/mL, n=201; 100≤BNP<200 pg/mL, n=94; 200≤BNP<300 pg/mL, n=42 and BNP>300 pg/mL, n=50).ResultsThe cumulative 5-year incidence of AS-related events (aortic valve-related death or heart failure hospitalisation) was incrementally higher with increasing BNP level (14.2%, 29.6%, 46.3% and 47.0%, p<0.001). After adjusting for confounders, the risk for AS-related events was incrementally greater with increasing BNP levels (HR: 1.97, 95% CI: 0.97 to 3.98, p=0.06; HR: 3.59, 95% CI: 1.55 to 8.32, p=0.03 and HR: 7.38, 95% CI: 3.21 to 16.9, p<0.001, respectively). Notably, asymptomatic patients with BNPlevels of <100 pg/mL had an event rate of only 2.1% at 1 year.ConclusionsIncreased BNP level was associated with a higher risk for AS-related adverse events in patients with asymptomatic severe AS with normal left ventricular ejection fraction who were not referred for AVR. Asymptomatic patients with BNP levels of <100 pg/mL had relatively low event rate, who might be safely followed with watchful waiting strategy.Trail registration numberUMIN000012140.

Published
2019
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5. Malignant disease as a comorbidity in patients with severe aortic stenosis: clinical presentation, outcomes, and management.

Author

Minamino-Muta, Eri, Kato, Takao, Morimoto, Takeshi, Taniguchi, Tomohiko, Nakatsuma, Kenji, Kimura, Yuki, Inoko, Moriaki, Shirai, Shinichi, Kanamori, Norio, Murata, Koichiro, Kitai, Takeshi, Kawase, Yuichi, Miyake, Makoto, Izumi, Chisato, Mitsuoka, Hirokazu, Hirano, Yutaka, Sasa, Tomoki, Nagao, Kazuya, Inada, Tsukasa, Nishikawa, Ryusuke, Takeuchi, Yasuyo, Yamagami, Shintaro, Yamane, Keiichiro, Su, Kanae, Komasa, Akihiro, Ishii, Katsuhisa, Yamashita, Yugo, Kato, Yoshihiro, Takabayashi, Kensuke, Saito, Naritatsu, Minatoya, Kenji, and Kimura, Takeshi

Abstract

To investigate the effect of malignancy on the outcomes of patients with severe aortic stenosis (AS) and the management strategy for AS with malignancy.

Published
2018
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7. Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial

Author

Connolly, Stuart J, Eikelboom, John W, Bosch, Jackie, Dagenais, Gilles, Dyal, Leanne, Lanas, Fernando, Metsarinne, Kaj, O'Donnell, Martin, Dans, Anthony L, Ha, Jong-Won, Parkhomenko, Alexandr N, Avezum, Alvaro A, Lonn, Eva, Lisheng, Liu, Torp-Pedersen, Christian, Widimsky, Petr, Maggioni, Aldo P, Felix, Camilo, Keltai, Katalin, Hori, Masatsugu, Yusoff, Khalid, Guzik, Tomasz J, Bhatt, Deepak L, Branch, Kelley R H, Cook Bruns, Nancy, Berkowitz, Scott D, Anand, Sonia S, Varigos, John D, Fox, Keith A A, Yusuf, Salim, SALA, JORGELINA, CARTASEGNA, LUIS, VICO, MARISA, HOMINAL, MIGUEL ANGEL, HASBANI, EDUARDO, CACCAVO, ALBERTO, ZAIDMAN, CESAR, VOGEL, DANIEL, HRABAR, ADRIAN, SCHYGIEL, PABLO OMAR, CUNEO, CARLOS, LUQUEZ, HUGO, MACKINNON, IGNACIO J., AHUAD GUERRERO, RODOLFO ANDRES, COSTABEL, JUAN PABLO, BARTOLACCI, INES PALMIRA, MONTANA, OSCAR, BARBIERI, MARIA, GOMEZ VILAMAJO, OSCAR, GARCIA DURAN, RUBEN OMAR, SCHIAVI, LILIA BEATRIZ, GARRIDO, MARCELO, INGARAMO, ADRIAN, BORDONAVA, ANSELMO PAULINO, PELAGAGGE, MARIA JOSE, NOVARETTO, LEONARDO, ALBISU DI GENNERO, JUAN PABLO, IBANEZ SAGGIA, LUZ MARIA, ALVAREZ, MOIRA, VITA, NESTOR ALEJANDRO, MACIN, STELLA MARIS, DRAN, RICARDO DARIO, CARDONA, MARCELO, GUZMAN, LUIS, SARJANOVICH, RODOLFO JUAN, CUADRADO, JESUS, NANI, SEBASTIAN, LITVAK BRUNO, MARCOS RAUL, CHACON, CAROLINA, MAFFEI, LAURA ELENA, GRINFELD, DIEGO, VENSENTINI, NATALIA, MAJUL, CLAUDIO RODOLFO, LUCIARDI, HECTOR LUCAS, GONZALEZ COLASO, PATRICIA DEL CARMEN, FERRE PACORA, FREDY ANTONI, VAN DEN HEUVEL, PAUL, VERHAMME, PETER, ECTOR, BAVO, DEBONNAIRE, PHILIPPE, VAN DE BORNE, PHILIPPE, LEROY, JEAN, SCHROE, HERMAN, VRANCKX, PASCAL, ELEGEERT, IVAN, HOFFER, ETIENNE, DUJARDIN, KARL, INDIO DO BRASIL, CLARISSE, PRECOMA, DALTON, ABRANTES, JOSE ANTONIO, MANENTI, EULER, REIS, GILMAR, SARAIVA, JOSE, MAIA, LILIA, HERNANDES, MAURO, ROSSI, PAULO, ROSSI DOS SANTOS, FABIO, ZIMMERMANN, SERGIO LUIZ, RECH, RAFAEL, ABIB JR, EDUARDO, LEAES, PAULO, BOTELHO, ROBERTO, DUTRA, OSCAR, SOUZA, WEIMAR, BRAILE, MARIA, IZUKAWA, NILO, NICOLAU, JOSE CARLOS, TANAJURA, LUIZ FERNANDO, SERRANO JUNIOR, CARLOS VICENTE, MINELLI, CESAR, NASI, LUIZ ANTONIO, OLIVEIRA, LIVIA, DE CARVALHO CANTARELLI, MARCELO JOSE, TYTUS, RICHARD, PANDEY, SHEKHAR, LONN, EVA, CHA, JAMES, VIZEL, SAUL, BABAPULLE, MOHAN, LAMY, ANDRE, SAUNDERS, KEVIN, BERLINGIERI, JOSEPH, KIAII, BOB, BHARGAVA, RAKESH, MEHTA, PRAVINSAGAR, HILL, LAURIE, FELL, DAVID, LAM, ANDY, AL-QOOFI, FAISAL, BROWN, CRAIG, PETRELLA, ROBERT, RICCI, JOSEPH A, GLANZ, ANTHONY, NOISEUX, NICOLAS, BAINEY, KEVIN, MERALI, FATIMA, HEFFERNAN, MICHAEL, DELLA SIEGA, ANTHONY, DAGENAIS, GILLES R, DAGENAIS, FRANCOIS, BRULOTTE, STEEVE, NGUYEN, MICHEL, HARTLEIB, MICHAEL, GUZMAN, RANDOLPH, BOURGEOIS, RONALD, RUPKA, DENNIS, KHAYKIN, YAARIV, GOSSELIN, GILBERT, HUYNH, THAO, PILON, CLAUDE, CAMPEAU, JEAN, PICHETTE, FRANCIS, DIAZ, ARIEL, JOHNSTON, JAMES, SHUKLE, PRAVIN, HIRSCH, GREGORY, RHEAULT, PAUL, CZARNECKI, WLODZIMIERZ, ROY, ANNIE, NAWAZ, SHAH, FREMES, STEPHEN, SHUKLA, DINKAR, JANO, GABRIEL, COBOS, JORGE LEONARDO, CORBALAN, RAMON, MEDINA, MARCELO, NAHUELPAN, LEONARDO, RAFFO, CARLOS, PEREZ, LUIS, POTTHOFF, SERGIO, STOCKINS, BENJAMIN, SEPULVEDA, PABLO, PINCETTI, CHRISTIAN, VEJAR, MARGARITA, TIAN, HONGYAN, WU, XUESI, KE, YUANNAN, JIA, KAIYING, YIN, PENGFEI, WANG, ZHAOHUI, YU, LITIAN, WU, SHULIN, WU, ZONGQUI, LIU, SHAO WEN, BAI, XIAO JUAN, ZHENG, YANG, YANG, PING, YANG, YUN MEI, ZHANG, JIWEI, GE, JUNBO, CHEN, XIAO PING, LI, JUNXIA, HU, TAO HONG, ZHANG, RUIYAN, ZHENG, ZHE, CHEN, XIN, TAO, LIANG, LI, JIANPING, HUANG, WEIJIAN, FU, GUOSHENG, LI, CHUNJIAN, DONG, YUGANG, WANG, CHUNSHENG, ZHOU, XINMIN, KONG, YE, SOTOMAYOR, ARISTIDES, ACCINI MENDOZA, JOSE LUIS, CASTILLO, HENRY, URINA, MIGUEL, AROCA, GUSTAVO, PEREZ, MARITZA, MOLINA DE SALAZAR, DORA INES, SANCHEZ VALLEJO, GREGORIO, FERNANDO, MANZUR J, GARCIA, HENRY, GARCIA, LUIS HERNANDO, ARCOS, EDGAR, GOMEZ, JUAN, CUERVO MILLAN, FRANCISCO, TRUJILLO DADA, FREDY ALBERTO, VESGA, BORIS, MORENO SILGADO, GUSTAVO ADOLFO, ZIDKOVA, EVA, LUBANDA, JEAN-CLAUDE, KALETOVA, MARKETA, KRYZA, RADIM, MARCINEK, GABRIEL, RICHTER, MAREK, SPINAR, JINDRICH, MATUSKA, JIRI, TESAK, MARTIN, MOTOVSKA, ZUZANA, BRANNY, MARIAN, MALY, JIRI, MALY, MARTIN, WIENDL, MARTIN, FOLTYNOVA CAISOVA, LENKA, SLABY, JOSEF, VOJTISEK, PETR, PIRK, JAN, SPINAROVA, LENKA, BENESOVA, MIROSLAVA, CANADYOVA, JULIA, HOMZA, MIROSLAV, FLORIAN, JINDRICH, POLASEK, ROSTISLAV, COUFAL, ZDENEK, SKALNIKOVA, VLADIMIRA, BRAT, RADIM, BRTKO, MIROSLAV, JANSKY, PETR, LINDNER, JAROSLAV, MARCIAN, PAVEL, STRAKA, ZBYNEK, TRETINA, MARTIN, DUARTE, YAN CARLOS, POW CHON LONG, FREDDY, SANCHEZ, MAYRA, LOPEZ, JOSE, PERUGACHI, CARMITA, MARMOL, RICARDO, TRUJILLO, FREDDY, TERAN, PABLO, TUOMILEHTO, JAAKKO, TUOMILEHTO, HENRI, TUOMINEN, MARJA-LEENA, TUOMILEHTO, HENRI, KANTOLA, ILKKA, STEG, GABRIEL, ABOYANS, VICTOR, LECLERCQ, FLORENCE, FERRARI, EMILE, BOCCARA, FRANCK, MESSAS, EMMANUEL, MISMETTI, PATRICK, SEVESTRE, MARIE ANTOINETTE, CAYLA, GUILLAUME, MOTREFF, PASCAL, STOERK, STEFAN, DUENGEN, HANS-DIRK, STELLBRINK, CHRISTOPH, GUEROCAK, OSMAN, KADEL, CHRISTOPH, BRAUN-DULLAEUS, RUEDIGER, JESERICH, MICHAEL, OPITZ, CHRISTIAN, VOEHRINGER, HANS-FRIEDRICH, APPEL, KARL-FRIEDRICH, WINKELMANN, BERNHARD, DORSEL, THOMAS, NIKOL, SIGRID, DARIUS, HARALD, RANFT, JURGEN, SCHELLONG, SEBASTIAN, JUNGMAIR, WOLFGANG, DAVIERWALA, PIROZE, VORPAHL, MARC, BAJNOK, LASZLO, LASZLO, ZOLTAN, NOORI, EBRAHIM, VERESS, GABOR, VERTES, ANDRAS, ZSARY, ANDRAS, KIS, ERNO, KORANYI, LASZLO, BAKAI, JUDIT, BODA, ZOLTAN, POOR, FERENC, JARAI, ZOLTAN, KEMENY, VENDEL, BARTON, JOHN, MCADAM, BRENDAN, MURPHY, ANDREW, CREAN, PETER, MAHON, NIALL, CURTIN, RONAN, MACNEILL, BRIAIN, DINNEEN, SEAN, HALABI, MAJDI, ZIMLICHMAN, REUVEN, ZELTSER, DAVID, TURGEMAN, YOAV, KLAINMAN, ELIEZER, LEWIS, BASIL, KATZ, AMOS, ATAR, SHAUL, ZIMLICHMAN, REUVEN, NIKOLSKY, EUGENIA, BOSI, STEFANO, NALDI, MONICA, FAGGIANO, POMPILIO, ROBBA, DEBORA, MOS, LUCIO, SINAGRA, GIANFRANCO, COSMI, FRANCO, OLTRONA VISCONTI, LUIGI, CARMINE, DE MATTEIS, DI PASQUALE, 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GLENN, BLACK, ROBERT, LADER, ELLIS, KOSTIS, JOHN B., BITTNER, VERA, MCGUINN, WILLIAM, BRANCH, KELLEY, MALHOTRA, VINAY, MICHAELSON, STEPHEN, VACANTE, MICHAEL, MCCORMICK, MATTHEW, ARIMIE, RALUCA, CAMP, ALAN, DAGHER, GEORGE, KOSHY, N. MATHEW, THEW, STEPHEN, COSTELLO, FREDERICK, HEIMAN, MARK, CHILTON, ROBERT, MORAN, MICHAEL, ADLER, FREDRIC, COMEROTA, ANTHONY, SEIWERT, ANDREW, FRENCH, WILLIAM, SEROTA, HARVEY, HARRISON, ROBERT, BAKAEEN, FAISAL, OMER, SHUAB, CHANDRA, LOKESH, WHELAN, ALAN, BOYLE, ANDREW, ROBERTS-THOMSON, PHILIP, ROGERS, JAMES, CARROLL, PATRICK, COLQUHOUN, DAVID, SHAW, JAMES, BLOMBERY, PETER, AMERENA, JOHN, HII, CHRIS, ROYSE, ALISTAIR, SINGH, BHUWAN, SELVANAYAGAM, JOSEPH, JANSEN, SHIRLEY, LO, WINGCHI, HAMMETT, CHRISTOPHER, POULTER, ROHAN, NARASIMHAN, SESHASAYEE, WIGGERS, HENRIK, NIELSEN, HENRIK, GISLASON, GUNNAR, KOBER, LARS, HOULIND, KIM, BOENELYKKE SOERENSEN, VIBEKE, DIXEN, ULRIK, REFSGAARD, JENS, ZEUTHEN, ELISABETH, SOEGAARD, PETER, HRANAI, MARIAN, GASPAR, LUDOVIT, PELLA, DANIEL, HATALOVA, KATARINA, DROZDAKOVA, ERIKA, COMAN, IOAN, DIMULESCU, DOINA, VINEREANU, DRAGOS, CINTEZA, MIRCEA, SINESCU, CRINA, ARSENESCU, CATALINA, BENEDEK, IMRE, BOBESCU, ELENA, DOBREANU, DAN, GAITA, DAN, IANCU, ADRIAN, ILIESIU, ADRIANA, LIGHEZAN, DANIEL, PETRESCU, LUCIAN, PIRVU, OCTAVIAN, TEODORESCU, IULIA, TESLOIANU, DAN, VINTILA, MARIUS MARCIAN, and CHIONCEL, OVIDIU

Abstract

Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease.

Published
2018
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8. Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial

Author

Anand, Sonia S, Bosch, Jackie, Eikelboom, John W, Connolly, Stuart J, Diaz, Rafael, Widimsky, Peter, Aboyans, Victor, Alings, Marco, Kakkar, Ajay K, Keltai, Katalin, Maggioni, Aldo P, Lewis, Basil S, Störk, Stefan, Zhu, Jun, Lopez-Jaramillo, Patricio, O'Donnell, Martin, Commerford, Patrick J, Vinereanu, Dragos, Pogosova, Nana, Ryden, Lars, Fox, Keith A A, Bhatt, Deepak L, Misselwitz, Frank, Varigos, John D, Vanassche, Thomas, Avezum, Alvaro A, Chen, Edmond, Branch, Kelley, Leong, Darryl P, Bangdiwala, Shrikant I, Hart, Robert G, Yusuf, Salim, SALA, JORGELINA, CARTASEGNA, LUIS, VICO, MARISA, HOMINAL, MIGUEL ANGEL, HASBANI, EDUARDO, CACCAVO, ALBERTO, ZAIDMAN, CESAR, VOGEL, DANIEL, HRABAR, ADRIAN, SCHYGIEL, PABLO OMAR, CUNEO, CARLOS, LUQUEZ, HUGO, MACKINNON, IGNACIO J., AHUAD GUERRERO, RODOLFO ANDRES, COSTABEL, JUAN PABLO, BARTOLACCI, INES PALMIRA, MONTANA, OSCAR, BARBIERI, MARIA, GOMEZ VILAMAJO, OSCAR, GARCIA DURAN, RUBEN OMAR, SCHIAVI, LILIA BEATRIZ, GARRIDO, MARCELO, INGARAMO, ADRIAN, BORDONAVA, ANSELMO PAULINO, PELAGAGGE, MARIA JOSE, NOVARETTO, LEONARDO, ALBISU DI GENNERO, JUAN PABLO, IBANEZ SAGGIA, LUZ MARIA, ALVAREZ, MOIRA, VITA, NESTOR ALEJANDRO, MACIN, STELLA MARIS, DRAN, RICARDO DARIO, CARDONA, MARCELO, GUZMAN, LUIS, SARJANOVICH, RODOLFO JUAN, CUADRADO, JESUS, NANI, SEBASTIAN, LITVAK BRUNO, MARCOS RAUL, CHACON, CAROLINA, MAFFEI, LAURA ELENA, GRINFELD, DIEGO, VENSENTINI, NATALIA, MAJUL, CLAUDIO RODOLFO, LUCIARDI, HECTOR LUCAS, GONZALEZ COLASO, PATRICIA DEL CARMEN, FERRE PACORA, FREDY ANTONI, VAN DEN HEUVEL, PAUL, VERHAMME, PETER, ECTOR, BAVO, DEBONNAIRE, PHILIPPE, VAN DE BORNE, PHILIPPE, LEROY, JEAN, SCHROE, HERMAN, VRANCKX, PASCAL, ELEGEERT, IVAN, HOFFER, ETIENNE, DUJARDIN, KARL, INDIO DO BRASIL, CLARISSE, PRECOMA, DALTON, ABRANTES, JOSE ANTONIO, MANENTI, EULER, REIS, GILMAR, SARAIVA, JOSE, MAIA, LILIA, HERNANDES, MAURO, ROSSI, PAULO, ROSSI DOS SANTOS, FABIO, ZIMMERMANN, SERGIO LUIZ, RECH, RAFAEL, ABIB JR, EDUARDO, LEAES, PAULO, BOTELHO, ROBERTO, DUTRA, OSCAR, SOUZA, WEIMAR, BRAILE, MARIA, IZUKAWA, NILO, NICOLAU, JOSE CARLOS, TANAJURA, LUIZ FERNANDO, SERRANO JUNIOR, CARLOS VICENTE, MINELLI, CESAR, NASI, LUIZ ANTONIO, OLIVEIRA, LIVIA, DE CARVALHO CANTARELLI, MARCELO JOSE, TYTUS, RICHARD, PANDEY, SHEKHAR, LONN, EVA, CHA, JAMES, VIZEL, SAUL, BABAPULLE, MOHAN, LAMY, ANDRE, SAUNDERS, KEVIN, BERLINGIERI, JOSEPH, KIAII, BOB, BHARGAVA, RAKESH, MEHTA, PRAVINSAGAR, HILL, LAURIE, FELL, DAVID, LAM, ANDY, AL-QOOFI, FAISAL, BROWN, CRAIG, PETRELLA, ROBERT, RICCI, JOSEPH A, GLANZ, ANTHONY, NOISEUX, NICOLAS, BAINEY, KEVIN, MERALI, FATIMA, HEFFERNAN, MICHAEL, DELLA SIEGA, ANTHONY, DAGENAIS, GILLES R, DAGENAIS, FRANCOIS, BRULOTTE, STEEVE, NGUYEN, MICHEL, HARTLEIB, MICHAEL, GUZMAN, RANDOLPH, BOURGEOIS, RONALD, RUPKA, DENNIS, KHAYKIN, YAARIV, GOSSELIN, GILBERT, HUYNH, THAO, PILON, CLAUDE, CAMPEAU, JEAN, PICHETTE, FRANCIS, DIAZ, ARIEL, JOHNSTON, JAMES, SHUKLE, PRAVIN, HIRSCH, GREGORY, RHEAULT, PAUL, CZARNECKI, WLODZIMIERZ, ROY, ANNIE, NAWAZ, SHAH, FREMES, STEPHEN, SHUKLA, DINKAR, JANO, GABRIEL, COBOS, JORGE LEONARDO, CORBALAN, RAMON, MEDINA, MARCELO, NAHUELPAN, LEONARDO, RAFFO, CARLOS, PEREZ, LUIS, POTTHOFF, SERGIO, STOCKINS, BENJAMIN, SEPULVEDA, PABLO, PINCETTI, CHRISTIAN, VEJAR, MARGARITA, TIAN, HONGYAN, WU, XUESI, KE, YUANNAN, JIA, KAIYING, YIN, PENGFEI, WANG, ZHAOHUI, YU, LITIAN, WU, SHULIN, WU, ZONGQUI, LIU, SHAO WEN, BAI, XIAO JUAN, ZHENG, YANG, YANG, PING, YANG, YUN MEI, ZHANG, JIWEI, GE, JUNBO, CHEN, XIAO PING, LI, JUNXIA, HU, TAO HONG, ZHANG, RUIYAN, ZHENG, ZHE, CHEN, XIN, TAO, LIANG, LI, JIANPING, HUANG, WEIJIAN, FU, GUOSHENG, LI, CHUNJIAN, DONG, YUGANG, WANG, CHUNSHENG, ZHOU, XINMIN, KONG, YE, SOTOMAYOR, ARISTIDES, ACCINI MENDOZA, JOSE LUIS, CASTILLO, HENRY, URINA, MIGUEL, AROCA, GUSTAVO, PEREZ, MARITZA, MOLINA DE SALAZAR, DORA INES, SANCHEZ VALLEJO, GREGORIO, FERNANDO, MANZUR J, GARCIA, HENRY, GARCIA, LUIS HERNANDO, ARCOS, EDGAR, GOMEZ, JUAN, CUERVO MILLAN, FRANCISCO, TRUJILLO DADA, FREDY ALBERTO, VESGA, BORIS, MORENO SILGADO, GUSTAVO ADOLFO, ZIDKOVA, EVA, LUBANDA, JEAN-CLAUDE, KALETOVA, MARKETA, KRYZA, RADIM, MARCINEK, GABRIEL, RICHTER, MAREK, SPINAR, JINDRICH, MATUSKA, JIRI, TESAK, MARTIN, MOTOVSKA, ZUZANA, BRANNY, MARIAN, MALY, JIRI, MALY, MARTIN, WIENDL, MARTIN, FOLTYNOVA CAISOVA, LENKA, SLABY, JOSEF, VOJTISEK, PETR, PIRK, JAN, SPINAROVA, LENKA, BENESOVA, MIROSLAVA, CANADYOVA, JULIA, HOMZA, MIROSLAV, FLORIAN, JINDRICH, POLASEK, ROSTISLAV, COUFAL, ZDENEK, SKALNIKOVA, VLADIMIRA, BRAT, RADIM, BRTKO, MIROSLAV, JANSKY, PETR, LINDNER, JAROSLAV, MARCIAN, PAVEL, STRAKA, ZBYNEK, TRETINA, MARTIN, DUARTE, YAN CARLOS, POW CHON LONG, FREDDY, SANCHEZ, MAYRA, LOPEZ, JOSE, PERUGACHI, CARMITA, MARMOL, RICARDO, TRUJILLO, FREDDY, TERAN, PABLO, TUOMILEHTO, JAAKKO, TUOMILEHTO, HENRI, TUOMINEN, MARJA-LEENA, TUOMILEHTO, HENRI, KANTOLA, ILKKA, STEG, GABRIEL, ABOYANS, VICTOR, LECLERCQ, FLORENCE, FERRARI, EMILE, BOCCARA, FRANCK, MESSAS, EMMANUEL, MISMETTI, PATRICK, SEVESTRE, MARIE ANTOINETTE, CAYLA, GUILLAUME, MOTREFF, PASCAL, STOERK, STEFAN, DUENGEN, HANS-DIRK, STELLBRINK, CHRISTOPH, GUEROCAK, OSMAN, KADEL, CHRISTOPH, BRAUN-DULLAEUS, RUEDIGER, JESERICH, MICHAEL, OPITZ, CHRISTIAN, VOEHRINGER, HANS-FRIEDRICH, APPEL, KARL-FRIEDRICH, WINKELMANN, BERNHARD, DORSEL, THOMAS, NIKOL, SIGRID, DARIUS, HARALD, RANFT, JURGEN, SCHELLONG, SEBASTIAN, JUNGMAIR, WOLFGANG, DAVIERWALA, PIROZE, VORPAHL, MARC, BAJNOK, LASZLO, LASZLO, ZOLTAN, NOORI, EBRAHIM, VERESS, GABOR, VERTES, ANDRAS, ZSARY, ANDRAS, KIS, ERNO, KORANYI, LASZLO, BAKAI, JUDIT, BODA, ZOLTAN, POOR, FERENC, JARAI, ZOLTAN, KEMENY, VENDEL, BARTON, JOHN, MCADAM, BRENDAN, MURPHY, ANDREW, CREAN, PETER, MAHON, NIALL, CURTIN, RONAN, MACNEILL, BRIAIN, DINNEEN, SEAN, HALABI, MAJDI, ZIMLICHMAN, REUVEN, ZELTSER, DAVID, TURGEMAN, YOAV, KLAINMAN, ELIEZER, LEWIS, BASIL, KATZ, AMOS, ATAR, SHAUL, ZIMLICHMAN, REUVEN, NIKOLSKY, EUGENIA, BOSI, STEFANO, NALDI, MONICA, FAGGIANO, POMPILIO, ROBBA, DEBORA, MOS, LUCIO, SINAGRA, GIANFRANCO, COSMI, FRANCO, OLTRONA VISCONTI, LUIGI, CARMINE, DE MATTEIS, DI PASQUALE, GIUSEPPE, DI BIASE, MATTEO, MANDORLA, SARA, BERNARDINANGELI, MARINO, PICCINNI, GIOVANNI CARLO, GULIZIA, MICHELE MASSIMO, GALVANI, MARCELLO, VENTURI, FLAVIO, MOROCUTTI, GIORGIO, BALDIN, MARIA GRAZIA, OLIVIERI, CARLO, PERNA, GIAN PIERO, CIRRINCIONE, VINCENZO, KANNO, TAKAYASU, DAIDA, HIROYUKI, OZAKI, YUKIO, MIYAMOTO, NAOMASA, HIGASHIUE, SHINICHI, DOMAE, HIROSHI, HOSOKAWA, SHINOBU, KOBAYASHI, HIROO, KURAMOCHI, TAKEHIKO, FUJII, KENSHI, MIZUTOMI, KAZUAKI, SAKU, KEIJIRO, KIMURA, KAZUO, HIGUCHI, YOSHIHARU, ABE, MITSUNORI, OKUDA, HARUHITO, NODA, TOSHIYUKI, MITA, TERUAKI, HIRAYAMA, ATSUSHI, ONAKA, HARUHIKO, INOKO, MORIAKI, HIROKAMI, MITSUGU, OKUBO, MUNENORI, AKATSUKA, YUTAKA, IMAMAKI, MIZUHO, KAMIYA, HARUO, MANITA, MAMORU, HIMI, TOSHIHARU, UENO, HIDEKI, HISAMATSU, YUJI, AKO, JUNYA, NISHINO, YASUHIRO, KAWAKAMI, HIDEO, YAMADA, YUTAKA, KORETSUNE, YUKIHIRO, YAMADA, TAKAHISA, YOSHIDA, TETSURO, SHIMOMURA, HIDEKI, KINOSHITA, NORIYUKI, TAKAHASHI, AKIHIKO, YUSOFF, KHALID, WAN AHMAD, WAN AZMAN, ABU HASSAN, MUHAMMAD RADZI, KASIM, SAZZLI, ABDUL RAHIM, AIZAI AZAN, MOHD ZAMRIN, DIMON, MACHIDA, MASAHARU, HIGASHINO, YORIHIKO, UTSU, NORIAKI, NAKANO, AKIHIKO, NAKAMURA, SHIGERU, HASHIMOTO, TETSUO, ANDO, KENJI, SAKAMOTO, TOMOHIRO, PRINS, F.J., LOK, DIRK, MILHOUS, JOHANNES GERT-JAN, VIERGEVER, ERIC, WILLEMS, FRANK, SWART, HENK, ALINGS, MARCO, BREEDVELD, ROB, DE VRIES, KEES-JAN, VAN DER BORGH, ROGER, OEI, FANNY, ZOET-NUGTEREN, STIENEKE, KRAGTEN, HANS, HERRMAN, JEAN PAUL, VAN BERGEN, PAUL, GOSSELINK, MARCEL, HOEKSTRA, EDUARD, ZEGERS, ERWIN, RONNER, EELKO, DEN HARTOG, FRANK, BARTELS, GERARD, NIEROP, PETER, VAN DER ZWAAN, COEN, VAN ECK, JACOB, VAN GORSELEN, EDWIN, GROENEMEIJER, BJORN, HOOGSLAG, PIETER, DE GROOT, MARC ROBERT, LOYOLA, ALDRIN, SULIT, DENNIS JOSE, REY, NANNETTE, ABOLA, MARIA TERESA, MORALES, DANTE, PALOMARES, ELLEN, ABAT, MARC EVANS, ROGELIO, GREGORIO, CHUA, PHILIP, DEL PILAR, JOSE CARLO, ALCARAZ, JOHN DENNIS, EBO, GERALDINE, TIRADOR, LOUIE, CRUZ, JOSEFINA, ANONUEVO, JOHN, PITARGUE, ARTHUR, JANION, MARIANNA, GUZIK, TOMASZ, GAJOS, GRZEGORZ, ZABOWKA, MACIEJ, RYNKIEWICZ, ANDRZEJ, BRONCEL, MARLENA, SZUBA, ANDRZEJ, CZARNECKA, DANUTA, MAGA, PAWEL, STRAZHESKO, IRINA, VASYUK, YURY, SIZOVA, ZHANNA, POZDNYAKOV, YURY, BARBARASH, OLGA, VOEVODA, MIKHAIL, POPONINA, TATIANA, REPIN, ALEXEY, OSIPOVA, IRINA, EFREMUSHKINA, ANNA, NOVIKOVA, NINA, AVERKOV, OLEG, ZATEYSHCHIKOV, DMITRY, VERTKIN, ARKADIY, AUSHEVA, AZA, COMMERFORD, PATRICK, SEEDAT, SAADIYA, VAN ZYL, LOUIS, ENGELBRECHT, JAN, MAKOTOKO, ELLEN MAKONLI, PRETORIUS, CATHARINA ELIZABETH, MOHAMED, ZAID, HORAK, ADRIAN, MABIN, THOMAS, KLUG, ERIC, BAE, JANG-HO, KIM, CHEOLHO, KIM, CHONG-JIN, KIM, DONG-SOO, KIM, YONG JIN, JOO, SEUNGJAE, HA, JONG-WON, PARK, CHUL SOO, KIM, JANG YOUNG, KIM, YOUNG-KWON, JARNERT, CHRISTINA, MOOE, THOMAS, DELLBORG, MIKAEL, TORSTENSSON, INGEMAR, ALBERTSSON, PER, JOHANSSON, LARS, AL-KHALILI, FARIS, ALMROTH, HENRIK, ANDERSSON, TOMMY, PANTEV, EMIL, TENGMARK, BENGT-OLOV, LIU, BO, RASMANIS, GUNDARS, WAHLGREN, CARL-MAGNUS, MOCCETTI, TIZIANO, PARKHOMENKO, ALEXANDER, TSELUYKO, VIRA, VOLKOV, VOLODYMYR, KOVAL, OLENA, KONONENKO, LYUDMYLA, PROKHOROV, OLEKSANDR, VDOVYCHENKO, VALERIY, BAZYLEVYCH, ANDRIY, RUDENKO, LEONID, VIZIR, VADYM, KARPENKO, OLEKSANDR, MALYNOVSKY, YAROSLAV, KOVAL, VALENTYNA, STOROZHUK, BORYS, COTTON, JAMES, VENKATARAMAN, ASOK, MORIARTY, ANDREW, CONNOLLY, DEREK, DAVEY, PATRICK, SENIOR, ROXY, BIRDI, INDERPAUL, CALVERT, JOHN, DONNELLY, PATRICK, TREVELYAN, JASPER, CARTER, JUSTIN, PEACE, AARON, AUSTIN, DAVID, KUKREJA, NEVILLE, HILTON, THOMAS, SRIVASTAVA, SUNNY, WALSH, RONALD, FIELDS, RONALD, HAKAS, JOSEPH, PORTNAY, EDWARD, GOGIA, HARINDER, SALACATA, ABRAHAM, HUNTER, JOHN J., BACHARACH, J MICHAEL, SHAMMAS, NICOLAS, SURESH, DAMODHAR, SCHNEIDER, RICKY, GURBEL, PAUL, BANERJEE, SUBHASH, GRENA, PAUL, BEDWELL, NOEL, SLOAN, STEPHEN, LUPOVITCH, STEVEN, SONI, ANAND, GIBSON, KATHLEEN, SANGRIGOLI, RENEE, MEHTA, RAJENDRA, I-HSUAN TSAI, PETER, GILLESPIE, EVE, DEMPSEY, STEPHEN, HAMROFF, GLENN, BLACK, ROBERT, LADER, ELLIS, KOSTIS, JOHN B., BITTNER, VERA, MCGUINN, WILLIAM, BRANCH, KELLEY, MALHOTRA, VINAY, MICHAELSON, STEPHEN, VACANTE, MICHAEL, MCCORMICK, MATTHEW, ARIMIE, RALUCA, CAMP, ALAN, DAGHER, GEORGE, KOSHY, N. MATHEW, THEW, STEPHEN, COSTELLO, FREDERICK, HEIMAN, MARK, CHILTON, ROBERT, MORAN, MICHAEL, ADLER, FREDRIC, COMEROTA, ANTHONY, SEIWERT, ANDREW, FRENCH, WILLIAM, SEROTA, HARVEY, HARRISON, ROBERT, BAKAEEN, FAISAL, OMER, SHUAB, CHANDRA, LOKESH, WHELAN, ALAN, BOYLE, ANDREW, ROBERTS-THOMSON, PHILIP, ROGERS, JAMES, CARROLL, PATRICK, COLQUHOUN, DAVID, SHAW, JAMES, BLOMBERY, PETER, AMERENA, JOHN, HII, CHRIS, ROYSE, ALISTAIR, SINGH, BHUWAN, SELVANAYAGAM, JOSEPH, JANSEN, SHIRLEY, LO, WINGCHI, HAMMETT, CHRISTOPHER, POULTER, ROHAN, NARASIMHAN, SESHASAYEE, WIGGERS, HENRIK, NIELSEN, HENRIK, GISLASON, GUNNAR, KOBER, LARS, HOULIND, KIM, BOENELYKKE SOERENSEN, VIBEKE, DIXEN, ULRIK, REFSGAARD, JENS, ZEUTHEN, ELISABETH, SOEGAARD, PETER, HRANAI, MARIAN, GASPAR, LUDOVIT, PELLA, DANIEL, HATALOVA, KATARINA, DROZDAKOVA, ERIKA, COMAN, IOAN, DIMULESCU, DOINA, VINEREANU, DRAGOS, CINTEZA, MIRCEA, SINESCU, CRINA, ARSENESCU, CATALINA, BENEDEK, IMRE, BOBESCU, ELENA, DOBREANU, DAN, GAITA, DAN, IANCU, ADRIAN, ILIESIU, ADRIANA, LIGHEZAN, DANIEL, PETRESCU, LUCIAN, PIRVU, OCTAVIAN, TEODORESCU, IULIA, TESLOIANU, DAN, VINTILA, MARIUS MARCIAN, and CHIONCEL, OVIDIU

Abstract

Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.

Published
2018
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9. Impact of the left ventricular mass index on the outcomes of severe aortic stenosis

Author

Minamino-Muta, Eri, Kato, Takao, Morimoto, Takeshi, Taniguchi, Tomohiko, Inoko, Moriaki, Haruna, Tetsuya, Izumi, Toshiaki, Miyamoto, Shoichi, Nakane, Eisaku, Sasaki, Kenichi, Funasako, Moritoshi, Ueyama, Koji, Shirai, Shinichi, Kitai, Takeshi, Izumi, Chisato, Nagao, Kazuya, Inada, Tsukasa, Tada, Eiji, Komasa, Akihiro, Ishii, Katsuhisa, Saito, Naritatsu, Sakata, Ryuzo, Minatoya, Kenji, and Kimura, Takeshi

Abstract

ObjectiveTo elucidate the factors associated with high left ventricular mass index (LVMI) and to test the hypothesis that high LVMI is associated with worse outcome in severe aortic stenosis (AS).MethodsWe analysed 3282 patients with LVMI data in a retrospective multicentre registry enrolling consecutive patients with severe AS in Japan. The management strategy, conservative or initial aortic valve replacement (AVR), was decided by the attending physician. High LVMI was defined as LVMI >115 g/m2for males and >95 g/m2for females. We compared the risk between normal and high LVMI in the primary outcome measures compromising aortic valve-related death and heart failure hospitalisation.ResultsAge was mean 77 (SD 9.6) years and peak aortic jet velocity (Vmax) was 4.1 (0.9) m/s. The factors associated with high LVMI (n=2374) included female, body mass index ≥22, absence of dyslipidemia, left ventricular ejection fraction <50%, Vmax ≥4 m/s, regurgitant valvular disease, hypertension, anaemia and end-stage renal disease. In the conservative management cohort (normal LVMI: n=691, high LVMI: n=1480), the excess adjusted 5-year risk of high LVMI was significant (HR: 1.53, 95% CI 1.26 to 1.85, p<0.001). In the initial AVR cohort (normal LVMI: n=217, high LVMI: n=894), the risk did not differ significantly between the two groups (HR: 0.96, 95% CI 0.60 to 1.55, p=0.88). There was a significant interaction between the initial treatment strategy and the risk of high LVMI (p=0.016).ConclusionsThe deleterious impact of high LVMI on outcome was observed in patients managed conservatively, but not observed in patients managed with initial AVR.Trial registration numberUMIN000012140; Post-results.

Published
2017
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10. AV Nodal Reentrant Tachycardia in a Patient with Persistent Left Superior Vena Cava: Distinction between AV Nodal Versus Atrial Reentry

Author

Fukuda, Terunobu, Haruna, Tetsuya, Ito, Hidehiro, Sasaki, Kenichi, Abe, Tomomi, Nakane, Eisaku, Miyamoto, Shouichi, Uehara, Kyoukun, Ooba, Muneo, Ueyama, Kouji, Inoko, Moriaki, and Nohara, Ryuji

Abstract

A 75-year-old male presented with palpitation on exertion. He suffered from frequent tachycardia attacks. His 12-leads electrocardiogram showed irregular cycle lengths (400–550 ms) of tachycardia with occasional 2:1 atrioventricular conduction (thus AV reentry was excluded). He had a complex anatomy of persistent left superior vena cava (PLSVC)/ enlarged coronary sinus (CS). The activation map in a 3-dimensional CARTO system (Biosense-Webster, USA) was merged with the multi-detector computed tomography image and revealed that the tachycardia spread centrifugally from the junction between the PLSVC and enlarged CS. However, delivery of radio frequency (RF) energy to the earliest atrial activation site did not affect the tachycardia. Finally, the tachycardia was diagnosed as a fast/ slow type atrioventricular nodal reentrant tachycardia (AVNRT) because the tachycardia was cured only after the anterograde/retrograde AV conduction was disturbed by the application of RF energy to the posteroseptal perimitral area, possibly due to the injury to the AV node.

Published
2010
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11. AV Nodal Reentrant Tachycardia in a Patient with Persistent Left Superior Vena Cava: Distinction between AV Nodal Versus Atrial Reentry

Author

Fukuda, Terunobu, Haruna, Tetsuya, Ito, Hidehiro, Sasaki, Kenichi, Abe, Tomomi, Nakane, Eisaku, Miyamoto, Shouichi, Uehara, Kyoukun, Ooba, Muneo, Ueyama, Kouji, Inoko, Moriaki, and Nohara, Ryuji

Abstract

A 75-year-old male presented with palpitation on exertion. He suffered from frequent tachycardia attacks. His 12-leads electrocardiogram showed irregular cycle lengths (400–550 ms) of tachycardia with occasional 2:1 atrioventricular conduction (thus AV reentry was excluded). He had a complex anatomy of persistent left superior vena cava (PLSVC)/ enlarged coronary sinus (CS). The activation map in a 3-dimensional CARTO system (Biosense-Webster, USA) was merged with the multi-detector computed tomography image and revealed that the tachycardia spread centrifugally from the junction between the PLSVC and enlarged CS. However, delivery of radio frequency (RF) energy to the earliest atrial activation site did not affect the tachycardia. Finally, the tachycardia was diagnosed as a fast/ slow type atrioventricular nodal reentrant tachycardia (AVNRT) because the tachycardia was cured only after the anterograde/retrograde AV conduction was disturbed by the application of RF energy to the posteroseptal perimitral area, possibly due to the injury to the AV node.

Published
2010
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12. Mechanisms of Negative Inotropic Effects of Class Ic Antiarrhythmic Agents: Comparative Study of the Effects of Flecainide and Pilsicainide on Intracellular Calcium Handling in Dog Ventricular Myocardium

Author

Kihara, Yasuki, Inoko, Moriaki, Hatakeyama*, Noboru, Momose*, Yasunori, and Sasayama, Shigetake

Abstract

We studied the subcellular mechanisms responsible for the negative inotropic effects of the two Ic drugs flecainide and pilsicainide. Aequorin luminescence (Ca2+i) and isometric tension were recorded simultaneously in isolated trabeculae from the dog ventricle. In isolated myocytes from the same ventricle, the slow inward current (ICa) was recorded. Both flecainide and pilsicainide decreased peak Ca2+i, peak tension, and peak ICaconcentration dependently. Each effect with flecainide was more marked than that with pilsicainide; however, Ca2+iand ICaparalleled each other in changes in tension, and the tension-Ca2+i-ICarelationship showed the same curve for each drug. We conclude that the difference in negative inotropic effects of these class Ic drugs are primarily related to their effects on L-type Ca2+channels and the subsequent decreases in the amount of Ca2+released from the sarcoplasmic reticulum (SR) during each cardiac cycle. Therefore, their negative inotropic effects may not be directly correlated with the essential mechanisms responsible for their antiarrhythmic action.

Published
1996

14. Early Changes in the Functions of Cardiac Sarcoplasmic Reticulum in Volume-overloaded Cardiac Hypertrophy in Rats

Author

Hisamatsu, Yuji, Ohkusa, Tomoko, Kihara, Yasuki, Inoko, Moriaki, Ueyama, Takeshi, Yano, Masafumi, Sasayama, Shigetake, and Matsuzaki, Masunori

Abstract

By sequestering activator calcium, the sarcoplasmic reticulum (SR) plays the central role in the excitation–contraction (E–C) cycle of cardiac muscle. Hence, functional changes in the SR in diseased myocardium might critically determine its mechanical characteristics. Previously, we demonstrated that both Ca2+release and uptake were increased in SR isolated from hearts showing compensatory left ventricular (LV) hypertrophy taken from pressure-overloaded rats. However, it has not been elucidated whether such alterations also occur in the volume-overloaded myocardium. Rats in which volume-overloaded hypertrophy had been induced by aortocaval shunt 12 weeks prior to the investigation were compared to sham-operated controls in terms of SR Ca2+uptake and release, and density of Ca2+releasing channels (ryanodine receptors, RyR). Isometric tension and intracellular Ca2+transients were also measured using the bioluminescent Ca2+indicator, aequorin, in isolated LV papillary muscles. The extent of hypertrophy was verified by measuring the ratio of biventricular weight to body weight.In vivo, the aortocaval shunt rats showed normal LV contractility and slightly depressed LV relaxation, indicating a compensatory (adaptive) stage of LV function. In contrast, Ca2+release, uptake, and maximal number of [3H]-ryanodine binding sites were all significantly lower in aortocaval shunt rats than in controls. Both the Ca2+transients and isometric relaxation of the isolated myocardium were significantly prolonged in aortocaval shunt rats, though their amplitudes were similar in the two groups. Thus, the volume-overloaded cardiac hypertropy, even at its hemodynamically compensatory (adaptive) stage, (i) was accompanied by abnormal Ca2+handling, as indicated by prolonged intracellular Ca2+transients and isometric tension traces, (ii) seems to involve subcellular mechanisms related to decreases in SR Ca2+release and uptake functions, as well as to a decrease in the number of RyR. Therefore, changes in the intracellular processes underlying cardiac E–C coupling, including SR function, precede the development of this type of heart disease.

Published
1997
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16. Abstract 12827: Impact of Concomitant Deep Vein Thrombosis on Clinical Outcomes in Patients With Acute Pulmonary Embolism

Author

Nishiwaki, Shushi, Yamashita, Yugo, Morita, Yusuke, Inoko, Moriaki, Morimoto, Takeshi, Amano, Hidewo, takase, toru, Hiramori, Seiichi, Kim, Kitae, Oi, Maki, Kato, Takao, and Kimura, Takeshi

Abstract

Introduction:For patients with acute pulmonary embolism (PE), risk stratification is important for decision-making regarding PE therapy. An increased thrombus burden such as concomitant deep venous thrombosis (DVT) might have a poor prognosis. Impact of concomitant DVT on short-term adverse events in acute PE patients has not been fully evaluated.Methods:The COMMAND VTE Registry was a retrospective multicenter registry enrolling consecutive 3027 patients with acute symptomatic venous thromboembolism (VTE) among 29 centers in Japan between 2010 and 2014. After excluding 1312 patients with DVT only and 1029 patients who did not undergo lower extremities ultrasound examination, the current study population consisted of 664 PE patients who underwent lower extremities ultrasound examination at diagnosis. There were 430 (64.8%) proximal DVT patients, 163 (24.5%) distal DVT patients, and 71 (10.7%) no-DVT patients. Outcome measures were compared among the 3 groups.Results:The cumulative 90-day incidence of all-cause death was higher in proximal DVT patients than those in distal DVT and no-DVT patients (proximal DVT: 7.8%, distal DVT: 2.5%, no-DVT: 2.8%, P=0.03). By multivariate analysis, the risk for all-cause death in proximal DVT patients tended to be higher than that in no-DVT patients (adjusted hazard ratio [HR], 2.28; 95% confidence interval [CI], 0.54-9.7, P=0.26), whereas the risk for all-cause death between distal DVT and no-DVT patients was comparable (adjusted HR, 0.88; 95% CI, 0.16-4.84, P=0.88). There was no significant difference for PE-related death, recurrent VTE, and major ISTH bleeding.Conclusions:The presence of concomitant proximal DVT was associated with a higher risk for short-term mortality in patients with acute PE. The examination of residual lower extremities thrombus could offer the advantages of further risk stratification and decision-making for acute PE.

Published
2019
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17. Abstract 13318: Clinical Outcomes of Perioperative Takotsubo Cardiomyopathy Associated With Noncardiac Surgery

Author

Morita, Yusuke, Yamaji, Yuhei, Nakane, Eisaku, Haruna, Yoshisumi, Haruna, Tetsuya, Hanyu, Michiya, and Inoko, Moriaki

Abstract

Introductions:Takotsubo cardiomyopathy (TC) is triggered by acute medical illness and intensive stress. There is minimal data on perioperative TC in patients undergoing major noncardiac surgery.Methods:Patients who underwent major noncardiac surgery during index hospitalizations were identified using 2014 National Readmission Database. Patients were stratified by the presence of TC diagnosis using previously validated administrative code. Outcome measures were 30-day readmission, in in-hospital mortality, and resource utilization.Results:Among estimated 5.1 million patients who underwent noncardiac surgery, TC was diagnosed in 2393 (0.047%) cases. TC was identified more commonly in patients with females (58.5% vs. 83.0%; p<0.001) and older patients (median [interquartile], 61 [47-72] vs. 68 [59-77] years; p<0.001). Perioperative TC was significantly associated with increased mortality (1.3% vs. 13.1%; p<0.001), increased readmission within 30 days (9.5% vs. 17.6%; p <0.001), and medical costs for index hospitalizations ($14010 [$9323-21704] vs. $55213 [$1814-64357]; p<0.001). Several independent predictors of clinical characteristics were identified for the diagnosis of perioperative TC, in hospital mortality, and 30-day readmission.Conclusions:Among patients undergoing noncardiac surgery who develop a perioperative TC, almost 1 in 3 suffer from in-hospital mortality or nonelective hospital readmission within 30 days. Our study emphasized that perioperative TC should be considered as differential diagnosis in patients who are decompensated during the perioperative period.

Published
2019
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18. High- Versus Low-Gradient Severe Aortic Stenosis

Author

Taniguchi, Tomohiko, Morimoto, Takeshi, Shiomi, Hiroki, Ando, Kenji, Kanamori, Norio, Murata, Koichiro, Kitai, Takeshi, Kawase, Yuichi, Izumi, Chisato, Miyake, Makoto, Mitsuoka, Hirokazu, Kato, Masashi, Hirano, Yutaka, Matsuda, Shintaro, Inada, Tsukasa, Nagao, Kazuya, Murakami, Tomoyuki, Takeuchi, Yasuyo, Yamane, Keiichiro, Toyofuku, Mamoru, Ishii, Mitsuru, Minamino-Muta, Eri, Kato, Takao, Inoko, Moriaki, Ikeda, Tomoyuki, Komasa, Akihiro, Ishii, Katsuhisa, Hotta, Kozo, Higashitani, Nobuya, Kato, Yoshihiro, Inuzuka, Yasutaka, Maeda, Chiyo, Jinnai, Toshikazu, Morikami, Yuko, Saito, Naritatsu, Minatoya, Kenji, and Kimura, Takeshi

Abstract

Supplemental Digital Content is available in the text.

Published
2017
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20. A Rare Case of Hypertrophic Cardiomyopathy with Subendocardial Late Gadolinium Enhancement in an Apical Aneurysm with Thrombus

Author

Morita, Yusuke, Kato, Takao, Okano, Mitsumasa, Su, Kanae, Kimura, Masahiro, Minamino, Eri, Nakane, Eisaku, Izumi, Toshiaki, Miyamoto, Shoichi, Haruna, Tetsuya, and Inoko, Moriaki

Abstract

The mechanisms responsible for the development of apical aneurysms in cases of hypertrophic cardiomyopathy (HCM) are currently unclear but likely involve multiple factors. Here, we present a case of HCM with marked subendocardial fibrosis involving the apical and proximal portions of the left ventricle. A 71-year-old man with left ventricular hypertrophy presented with signs and symptoms of heart failure. The presence of asymmetrical left ventricular hypertrophy and bilateral, thickened ventricular walls with an apical aneurysm on transthoracic echocardiography suggested a diagnosis of HCM with ventricular dysfunction. No intraventricular pressure gradients with obstruction were identified. Late gadolinium enhancement (LGE) with cardiac magnetic resonance imaging and endomyocardial biopsies showed subendocardial fibrosis involving the apical aneurysm and proximal portion. Whereas LGE in a transmural pattern is commonly observed in HCM apical aneurysms, subendocardial LGE, as noted in the present case, is a relatively rare occurrence. Thus, the present case may provide unique insights into the adverse remodeling process and formation of apical aneurysms in cases of HCM.

Published
2014
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21. 718-4 Lack of Positive Inotropic Effect by p-Adrenoceptor Stimulation in the Failing Myocardium is not Due to Inability to Supply Intracellular Ca2+nor cAMP: Studies in Dahl Rat Heart Failure Model

Author

Inoko, Moriaki, Kihara, Yasuki, and Sasayama, Shigetake

Abstract

We recently reported that the Dahl salt-sensitive rat (DS) fed with a highsalt diet presents the transition from compensatory LV hypertrophy at the age of 11 weeks (LVH) to the decompensated LV dilatation at the age of 1622 weeks (CHF). To investigate the mechanisms of decreased positive inotropic effects of β-adrenoceptor stimulation in the failing myocardium, we observed the effects of isoproterenol (ISO) (10–9–10–6M) and forskolin (FOR) (10–7-10–5M) on the isometric tension (T) and the corresponding intracellular calcium transients (Cai2+) in the aequorin-Ioaded LV papillary muscles from this animal. Control studies were performed in 18-week-old Dahl saltresistant rats (DR). In LVH, OS showed a significant prolongation in the time course of T without changes in that of Cai2+. In CHF, peak T was depressed and the time course of T was further prolonged, which was accompanied by a reduced amplitude and a prolonged time course of Cai2+. The positive inotropic effect (increase in peak T) by ISO was decreased in LVH and disappeared in CHF despite preserved augmentation of peak Cai2+in both stages. In contrast, FOR increased both peak T and peak Cai2+in either stage.nISO (10–5M) %peakTISO (10–5M) %peakCai2+FOR(10–5M) %peakTFOR(10–5M) %peakCai2+DR6189±34202±36284±72301±69LVH DS6146±21*182±32196±17*282±43CHF DS683±24**158±21*173±52*248±44means±S.D.; %peakT: %change in peakT; %peakCai2+: %change in peakCai2+*p&lt;005**p&lt;001 vs. DR. †P&lt;0.05, ‡p&lt;0.01 vs. LVH DS

Published
1995
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22. 932-87 Non-Mechanical Energy Expenditure is Preserved During the Transition from Compensatory Hypertrophy to Failure of the Left Ventricle in Dahl Salt-Sensitive Rats

Author

Morii, Isao, Kihara, Yasuki, Inoko, Moriaki, Kambayashi, Masashi, and Sasayama, Shigetake

Abstract

Dahl salt-sensitive rats fed with a high-salt diet (8% NaCI) progressively develop concentric LV hypertrophy (LVH, 11 weeks), which is followed by LV dilatation with pulmonary congestion (CHF, 18 weeks). To clarify modulation in cardiac energetics during the transition from LVH to CHF, we measured LV pressure-volume area (PVA) and myocardial oxygen consumption (MVO2) in isolated, isovolumically contracting hearts from this animal model. Hearts were coronary-perfused with Tyrode's solution at 37°C and were paced at 3.33 Hz (perfusate Ca2+: 1 mM or 2 mM). The perfusion pressure was kept constant at 140 mmHg throughout the experiment. PO2in the perfusate and in the coronary effluent were continuously monitored with oxygen electrodes. The end-systolic pressure-volume relation (ESPVR) determined during the stepwise changes of the LV volume were fit by a binomial regression analysis, which provided a slope (Ees) and a volume intercept (V0). Linear regression analysis of the MVO2-PVA relation determined a slope (A) and a MVO2intercept (B).Ca2+EesV0ABmMmmHg.g.ml–1mlxl0–2mlO2.mmHg–1·ml–1x 10–2mlO2.beat–1.g–1LVH11352±l251.97±1.233.27±1.451.80±0.14In=5)21853±110*1.59±0.982.10±0.872.27±0.20*CHF1458±98†7.33±2.00†4.05±1151.18±0.06†(n=4)2649±148*,†5.60±1.56†3.47±0.861.52±0.l5*,†mean±SEM.*p&lt;0.05 vs. Ca2+ 1 mM, paired t-test†p&lt;0.05 vs. LVH, unpaired t-test

Published
1995
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23. 932-87 Non-Mechanical Energy Expenditure is Preserved During the Transition from Compensatory Hypertrophy to Failure of the Left Ventricle in Dahl Salt-Sensitive Rats

Author

Morii, Isao, Kihara, Yasuki, Inoko, Moriaki, Kambayashi, Masashi, and Sasayama, Shigetake

Abstract

Dahl salt-sensitive rats fed with a high-salt diet (8% NaCI) progressively develop concentric LV hypertrophy (LVH, 11 weeks), which is followed by LV dilatation with pulmonary congestion (CHF, 18 weeks). To clarify modulation in cardiac energetics during the transition from LVH to CHF, we measured LV pressure-volume area (PVA) and myocardial oxygen consumption (MVO2) in isolated, isovolumically contracting hearts from this animal model. Hearts were coronary-perfused with Tyrode's solution at 37°C and were paced at 3.33Hz (perfusate Ca2+: 1mM or 2mM). The perfusion pressure was kept constant at 140mmHg throughout the experiment. po2in the perfusate and in the coronary effluent were continuously monitored with oxygen electrodes. The end-systolic pressure-volume relation (ESPVR) determined during the stepwise changes of the LV volume were fit by a binomial regression analysis, which provided a slope (Ees) and a volume intercept (V0). Linear regression analysis of the MVO2-PVA relation determined a slope (A) and a MVO2intercept (B)Ca2+EesV0ABmMmmHg.g.ml–1mlxl0–2mlO2.mmHg–1·ml–1x 10–2mlO2.beat–1.g–1LVH11352±l251.97±1.233.27±1.451.80±0.14(n=5)21853±110*1.59±0.982.10±0.872.27±0.20*CHF1458±98†7.33±2.00†4.05±1.151.18±0.06†(n=4)2649±148*†5.60±1.56†3.47±0.861.52±0.l5*†mean±SEM.*p&lt;0.05 vs. Ca2+ 1mM, paired t-test†p&lt;0.05 vs. LVH, unpaired t-test

Published
1995
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