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LONDON, April 12, 2016 /PRNewswire/ -- Biosimilars are highly-similar versions of biological drugs that are indicated for cancer, kidney disorders and a wide range of autoimmune diseases. Originator biologics are [...]

NEW YORK, Feb. 11, 2016 /PRNewswire/ -- Biosimilars are highly-similar versions of biological drugs that are indicated for cancer, kidney disorders and a wide range of autoimmune diseases. Originator biologics [...]

2015 JUN 17 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Cirrhosis are presented in a new report. According to news reporting out [...]

'Granulocyte colony-stimulating factor (G-CSF) is a member of the cytokine family of growth factors that can protect the neurons from focal cerebral ischemia-induced injuries. The intracerebral hemorrhage (ICH) has been [...]

Fresh data on life sciences are presented in the report '15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292).' '15-Deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), a major prostanoid [...]

New investigation results, 'Interferon-alpha and viral triggers promote functional maturation of human monocyte-derived dendritic cells,' are detailed in a study published in British Journal of Dermatology. 'Type I interferons (IFNs) [...]

Research findings, 'Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF,' are discussed in a new report. 'Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays an important role in the pathogenesis of acute [...]

Researchers detail in 'Contribution of GM-CSF on the enhancement of the T cell-stimulating activity of macrophages,' new data in life sciences. According to recent research from Tokyo, Japan, 'Mycobacterium leprae [...]

Current study results from the report, 'PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection,' have been published. 'Adenovirus is endocytosed and efficiently destroyed by human and [...]

Data detailed in 'Treatment with granulocyte-colony stimulating factor in patients with acute myocardial infarction. Evidence for a stimulation of neovascularization and improvement of myocardial perfusion' have been presented. 'Stem cell [...]

Investigators in South Korea, Germany and France have published new leukemia data. Study 1: Remission of acute myelogenous leukemia (AML) with AML1/ETO rearrangement should be confirmed by FISH because granulocyte-colony [...]

The rate of infectious complications during interferon-based therapy for hepatitis C virus infection is not related to neutropenia. 'The relationship between infectious complications and neutropenia was evaluated in recipients of [...]

Scientists have developed a mesothelioma vaccine using recombinant GM-CSF plus autologous tumor cells. According to a report from Australia, 'Treatments evaluated for malignant mesothelioma (MM), including chemotherapy, radiotherapy, and surgery [...]

Antitumor effector cells were generated from cultured dendritic cells and tumor mRNA from gastric cancer cells. According to recent research from Japan, 'Antitumor effector cells were generated by stimulating peripheral [...]

According to recent research from Germany, Tyr phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of P27(Kip1) in the acute promyelocytic leukemia cell line NB4. 'We have investigated [...]

Monocyte chemotactic protein-1 levels provide prognostic information in breast cancer patients. 'We studied serum monocyte chemotactic protein-1 (MCP-1) levels in breast cancer patients in relationship to their clinicopathologic variables and [...]

Research from the United States has demonstrated that low-dose outpatient chemobiotherapy with temozolomide, granulocyte-macrophage colony stimulating factor, interferon-alpha 2b, and recombinant interleukin-2 is effective in treatment of metastatic melanoma. R.W. [...]

Mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. 'Bone marrow (BM) cells are reported to contribute to the process of regeneration following myocardial infarction. The [...]

Granulocyte-colony stimulating factor (G-CSF) augments bone marrow-induced neovascularization. 'Because G-CSF mobilizes bone marrow cells including endothelial progenitor cells, we examined whether G-CSF augments angiogenesis and collateral vessel formation induced by [...]

Circulating CD34+ cells increase 10 hours after G-CSF administration. According to recent research from Germany, 'In order to increase the CD34+ cell yield in children undergoing autologous stem cell transplantation, [...]

Docetaxel and vinorelbine plus granulocyte-macrophage colony-stimulating factor (GM-CSF) was used to treat malignant melanoma. 'Patients having locoregional or metastatic melanoma have a poor prognosis, with 50% to 100% of patients [...]

Docetaxel was used as a single-agent treatment in elderly patients with breast cancer. In a recent report, researchers in Spain conducted a study 'to assess the efficacy and safety profile [...]

BioVex, Ltd., has submitted an Investigational New Drug application (IND) to the U.S. Food and Drug Administration (FDA) to initiate a clinical trial in malignant melanoma of OncoVEX GM-CSF, its [...]

Granulocyte-colony stimulating factor affects serum levels of soluble interleukin-2 receptors following allogeneic stem cell transplantation. 'Soluble interleukin-2 receptor (sIL-2R) levels were analyzed in 127 stem-cell transplant recipients. Granulocyte-colony stimulating factor [...]

Flt3+CD11b+ progenitors develop into the main conventional dendritic cell subtypes. According to recently published research from Germany, 'Dendritic cells (DC) represent key regulators of the immune system, yet their development [...]

Researchers have investigated the relationship of granulocyte colony stimulating factor with other acute phase reactants in man. According to scientists in England, 'The nonspecific acute phase response in mice is [...]

Stat3 negatively regulates G-CSF signaling by inducing SOCS3 expression. 'G-CSF specifically stimulates the proliferation and differentiation of cells that are committed to the neutrophil-granulocyte lineage. 'Although Stat3 was thought to [...]

Hematopoietic stem cells are identified from dermal papillae of hair follicles. According to recent research from China, 'Hematopoietic stem cell (HSC) activity has been identified from the hair follicles (HFs) [...]

Data on schistosomiasis are outlined in reports from Brazil, Egypt and Australia. Study 1: GM-CSF and TNF-alpha synergize to increase in vitro granuloma size of peripheral blood mononuclear cells from [...]

Mayne Group Limited (MAY) announced that its Mayne Pharma business unit has entered into a strategic collaboration with PLIVA d.d. (PLIVA). The purpose of this collaboration is to develop and [...]

GM-CSF and TNF-alpha synergize to increase in vitro granuloma size of peripheral blood mononuclear cells from humans induced by Schistosoma mansoni recombinant 28-kDa glutathione S-transferase. 'The 28-kDa glutathione S-transferase of [...]

Fusion transgene elicits a robust immunological response to tumor cells. 'Genetic engineering of tumor cells to express both granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-2 can induce synergistic immune antitumor [...]

A study from Germany has reported that interleukin-5, interleukin-3 and granulocyte-macrophage colony-stimulating factor prime actin-polymerization in human eosinophils. 'Characteristic features of atopic diseases (AD) are immigration and local activation of [...]

According to researchers from England, infusion of granulocyte-colony stimulating factor may reduce the duration and severity of neutropenia. S.P. Robinson and coauthors wrote, 'The efficacy of granulocytes transfusions (GTX) in [...]

Research from Japan published recently in the Journal of Leukocyte Biology, described the short-term delay of Fas-stimulated apoptosis by granulocyte/macrophage colony-stimulating factor GM-CSF as a result of temporary suppression of [...]

Stem cells expressing homing receptors are expanded from cryopreserved and unselected cord blood. According to published research from South Korea, 'We assessed the cytokine combinations that are best for ex [...]