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A revolutionary new inline static mixer has been developed and specifically tailored to meet the exacting demands of HPLC and UHPLC systems. Poor mixing of two or more mobile phase solvents results in a high signal to noise ratio and, thus, decreased sensitivity. The test data presented demonstrates that superior mixing is achieved while minimizing the internal volume in various gradient test conditions, such as unparalleled mixing for trifluoroacetic acid (TFA) and water and acetonitrile gradients. [ABSTRACT FROM AUTHOR]

Shows the ability of Daicel's preparative columns operated at very high flow rates allow fast, high productivity separations to produce pure enantiomers. Experimental conditions; Productivity of guaiphenesin enantiomer.

Discusses the efforts of Duquesne University Center for Pharmaceutical Technology in Pennsylvania to develop and validate a process analytical technology using near infrared (NIR) spectroscopy as a tool. Use of NIR spectroscopy to predict tablet hardness and active pharmaceutical ingredient content; Precalibration operations; Calibration model optimization.