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3. National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022

Author

Abeysekera, Kush, Marjot, Tom, Brennan, Paul, Mahgoub, Sara, Cacciottolo, Tessa, Hydes, Theresa, Hardy, Tim, McGinty, Gio, Tavabie, Oliver, Cathcart, Jennifer, Premathilaka, Chirantha, Mukhopadhya, Ashis, Bhat, Arshiya, Begum, Shahnaz, Abushaban, Bashar, Bhuva, Meha, Sinclair, Sophie, Leith, Damien, McCulloch, Cullen, Leithead, Joanna, Fox, Richard, Shah, Muhammad Haris, Campbell, Eugene, Brown, Edward, Mansour, Dina, Shah, Fatma, Allison, Michael, Chan, Jonathan, Roberts, Victoria, Appanna, Gautham, Mandour, Mandour Omer, Slee, Georgina, Wong, Vicki, Kotha, Sreelakshmi, Pekarska, Katrina, Parker, Richard, Sieberhagen, Cyril, Ngan, Thomas, Asilmaz, Esra, Miller, Hamish, Cobbold, Jeremy, Crocombe, Dom, Tsochatzis, Manolis, Tanwar, Sudeep, Dias, Aruna, Singh, Gurmit, Agrawal, Swastik, Chhabra, Puneet, Gurung, Amrita, Veettil, Rajesh, Abeles, Robin Daniel, Chatterjee, Devnandan, Carbonell, Michael, Mohamed, Zameer, El-Sayed, Ahmed, Johnson, Amy, Barclay, Stephen, Kelly, Katherine, Munonye, Joshua, Coates, Dominic, Bamidele, Opeyemi, Johnston, Thomas, Samuel, David, Ball, Belinda, Arscott-Samuel, Rebecca, Hams, Pamela, Armstrong, Matthew, Elkhol, Ayman, Shailesh, Karanth, Bains, Vikram, Manousou, Pinelopi, Gupta, Tarun, Than, Sophia, Unitt, Esther, Gordon, Victoria, Wakefield, Alice, Gilchrist, Sian, Cozma, Ioana, Saeed, Sohaib, Umrani, Salman, Olsen, Kathryn, Li, Wenhao, Sheridan, David, McPherson, Stuart, and Alazawi, William

Published
2023
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4. Addressing the Pediatric Mental Health Crisis in Emergency Departments in the US: Findings of a National Pediatric Boarding Consensus Panel

Author

Aggarwal, Arpit, Behere, Aniruddh P., Brahmbhatt, Khyati, Burns, Beech, Carubia, Beau, Fabbro, Anilla Del, Dell, Mary Lynn, Donise, Kathleen, Duffy, Susan, Giles, Lisa, Johnson, Kyle, Kalapatapu, Raj K., Lardizabal, Marybeth, Moreno, Claudia, Pergjika, Alba, Pierce, Donald, Rogers, Steven, Schott, Meghan, Shaw, Richard J., Sheridan, David, Zablan, Kashmeer, Feuer, Vera, Mooneyham, GenaLynne C., and Malas, Nasuh M.

Published
2023
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10. The Role of Nonclassroom Spaces in Living-Learning Communities

Author

Altimare, Emily and Sheridan, David M.

Abstract

A body of research suggests that learning communities provide a range of academic benefits by increasing social connectedness. Researchers have also hypothesized that informal learning spaces--nonclassroom spaces (NCSs)--can facilitate learning by supporting social connectedness. This study uses qualitative methods to explore the way nonclassroom spaces facilitate learning-related activities within a recently established learning community at Michigan State University. Our findings suggest that NCSs function as social hubs, help make intellectual and creative work visible to the larger learning community, and provide access to important resources. More generally, NCSs help to facilitate community formation and identity.

Published
2016

11. Urinary Catheterization in Infants: When It’s Knot so Simple

Author

Sheridan, David C., Burns, Beech, and Mickley, Megan

Abstract

Pediatric fever is one of the most common presenting complaints to emergency departments (ED). While often due to a viral illness, in young children without a source the most common bacterial infection is pyelonephritis. For this reason, when no focal source can be identified a urinary specimen is recommended. In young children who are unable to urinate on demand, a straight catheter is required to obtain a sterile specimen. This is generally a benign procedure and is performed frequently in EDs. We report a case of a young girl who underwent straight bladder catheterization and was subsequently found to have a retained catheter that had become knotted in the bladder. This case report highlights a rare complication of this common procedure and describes the technique required to remove the catheter. An understanding of these issues may avoid the need for transfer to a pediatric facility or for subspecialty consultation.

Published
2018

13. Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study

Author

Miller, Hamish, primary, Harman, David, additional, Aithal, Guruprasad Padur, additional, Manousou, Pinelopi, additional, Cobbold, Jeremy F, additional, Parker, Richard, additional, Sheridan, David, additional, Newsome, Philip N, additional, Karpe, Fredrik, additional, Neville, Matthew, additional, Arlt, Wiebke, additional, Sitch, Alice J, additional, Korbonits, Marta, additional, Biehl, Michael, additional, Alazawi, William, additional, and Tomlinson, Jeremy W, additional

Published
2024
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14. National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022

Author

Li, Wenhao, primary, Sheridan, David, additional, McPherson, Stuart, additional, Alazawi, William, additional, Abeysekera, Kush, additional, Marjot, Tom, additional, Brennan, Paul, additional, Mahgoub, Sara, additional, Cacciottolo, Tessa, additional, Hydes, Theresa, additional, Hardy, Tim, additional, McGinty, Gio, additional, Tavabie, Oliver, additional, Cathcart, Jennifer, additional, Premathilaka, Chirantha, additional, Mukhopadhya, Ashis, additional, Bhat, Arshiya, additional, Begum, Shahnaz, additional, Abushaban, Bashar, additional, Bhuva, Meha, additional, Sinclair, Sophie, additional, Leith, Damien, additional, McCulloch, Cullen, additional, Leithead, Joanna, additional, Fox, Richard, additional, Shah, Muhammad Haris, additional, Campbell, Eugene, additional, Brown, Edward, additional, Mansour, Dina, additional, Shah, Fatma, additional, Allison, Michael, additional, Chan, Jonathan, additional, Roberts, Victoria, additional, Appanna, Gautham, additional, Mandour, Mandour Omer, additional, Slee, Georgina, additional, Wong, Vicki, additional, Kotha, Sreelakshmi, additional, Pekarska, Katrina, additional, Parker, Richard, additional, Sieberhagen, Cyril, additional, Ngan, Thomas, additional, Asilmaz, Esra, additional, Miller, Hamish, additional, Cobbold, Jeremy, additional, Crocombe, Dom, additional, Tsochatzis, Manolis, additional, Tanwar, Sudeep, additional, Dias, Aruna, additional, Singh, Gurmit, additional, Agrawal, Swastik, additional, Chhabra, Puneet, additional, Gurung, Amrita, additional, Veettil, Rajesh, additional, Abeles, Robin Daniel, additional, Chatterjee, Devnandan, additional, Carbonell, Michael, additional, Mohamed, Zameer, additional, El-Sayed, Ahmed, additional, Johnson, Amy, additional, Barclay, Stephen, additional, Kelly, Katherine, additional, Munonye, Joshua, additional, Coates, Dominic, additional, Bamidele, Opeyemi, additional, Johnston, Thomas, additional, Samuel, David, additional, Ball, Belinda, additional, Arscott-Samuel, Rebecca, additional, Hams, Pamela, additional, Armstrong, Matthew, additional, Elkhol, Ayman, additional, Shailesh, Karanth, additional, Bains, Vikram, additional, Manousou, Pinelopi, additional, Gupta, Tarun, additional, Than, Sophia, additional, Unitt, Esther, additional, Gordon, Victoria, additional, Wakefield, Alice, additional, Gilchrist, Sian, additional, Cozma, Ioana, additional, Saeed, Sohaib, additional, Umrani, Salman, additional, and Olsen, Kathryn, additional

Published
2023
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15. Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis

Author

Petroff, David, Blank, Valentin, Newsome, Philip N, Shalimar, Voican, Cosmin Sebastian, Thiele, Maja, de Lédinghen, Victor, Baumeler, Stephan, Chan, Wah Kheong, Perlemuter, Gabriel, Cardoso, Ana-Carolina, Aggarwal, Sandeep, Sasso, Magali, Eddowes, Peter J, Allison, Michael, Tsochatzis, Emmanuel, Anstee, Quentin M, Sheridan, David, Cobbold, Jeremy F, Naveau, Sylvie, Lupsor-Platon, Monica, Mueller, Sebastian, Krag, Aleksander, Irles-Depe, Marie, Semela, David, Wong, Grace Lai-Hung, Wong, Vincent Wai-Sun, Villela-Nogueira, Cristiane A, Garg, Harshit, Chazouillères, Olivier, Wiegand, Johannes, and Karlas, Thomas

Published
2021
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16. Willingness to Vaccinate Children against Influenza after the Coronavirus Disease 2019 Pandemic

Author

Ahmed, Sarah, Ali, Samina, Brown, Julie C., Craig, Simon, Davis, Adrienne L., Gaucher, Nathalie, Gianluca, Gualco, Goldman, Ran, Griffiths, Mark, Hall, Jeanine E., Hansen, Matt, Hurt, Thomas L., Kelly, Christopher, Klein, Eileen J., Kozer, Eran, Marneni, Shashidhar, Mater, Ahmed, Mistry, Rakesh, Parra, Cristina, Poonai, Naveen, Rao, Arjun, Sheridan, David, Shimizu, Naoki, Yue, Esther L., Goldman, Ran D., McGregor, Sophie, Marneni, Shashidhar R., Katsuta, Tomohiro, Griffiths, Mark A., Seiler, Michelle, Cotanda, Cristina Parra, Gelernter, Renana, Hoeffe, Julia, Gualco, Gianluca, Manzano, Sergio, Thompson, Graham C., and Ahmed, Sara

Published
2021
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17. Impact of social media "challenges" on poison center case volume for intentional ingestions among school-aged children: an observational study.

Author

Marshall, Rebecca D., Bailey, Jessica, Lin, Amber, Sheridan, David C., Hendrickson, Robert G., Hughes, Adrienne, and Horowitz, B. Zane

Subjects
POISON control centers, SOCIAL media, INGESTION, SCHOOL children, SCIENTIFIC observation, ATTEMPTED suicide, AT-risk youth
Abstract

Mental health problems among youth have escalated over the past decade, with increased rates of self-harm, including suicide attempts by ingestion. Social media use has been linked to youth mental health, including "challenges" urging youth to ingest substances for recreational and other purposes. We hypothesized that social media challenges for particular substances would temporally correspond with increased ingestions of these substances. We identified peak Google Trends search times for social media ingestion challenges involving diphenhydramine, laundry pods, nutmeg, and cinnamon, and used data from America's Poison Centers National Poison Data System to plot reported ingestions 3 months before and after peak searches in school-aged children. There were 2,169 individuals in the analysis. Diphenhydramine was the most frequently reported ingestion for misuse/abuse and suicidal purposes (n = 266 and 1,609, respectively). For all ingestions together, 45 percent (n = 979) had a moderate health effect, and 6.35 percent (n = 137) had a major health effect. Time of peak searches corresponded with increased ingestions for each substance. We found a temporal relationship between peak Google Trends searches for ingestion challenges and ingestions of that substance reported to United States poison centers. Compared to misuse/abuse ingestions, most suicidal ingestions peaked 1–2 months later, suggesting a public health opportunity for intervention. This retrospective observational study does not establish causal effect. All data are a result of self-reporting of the exposures, which may lead to a reporting bias. Google Trends is not the only search engine and likely underestimates the true incidence of social media posts. Additional research is needed on the relationship between social media and youth mental health, particularly around "challenges" that place youths' health at risk. There may be opportunities for intervention to decrease medical and mental health sequelae of these challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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19. FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study

Author

Newsome, Philip N, Sasso, Magali, Deeks, Jonathan J, Paredes, Angelo, Boursier, Jérôme, Chan, Wah-Kheong, Yilmaz, Yusuf, Czernichow, Sébastien, Zheng, Ming-Hua, Wong, Vincent Wai-Sun, Allison, Michael, Tsochatzis, Emmanuel, Anstee, Quentin M, Sheridan, David A, Eddowes, Peter J, Guha, Indra N, Cobbold, Jeremy F, Paradis, Valérie, Bedossa, Pierre, Miette, Véronique, Fournier-Poizat, Céline, Sandrin, Laurent, and Harrison, Stephen A

Published
2020
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24. (Re)Mediating (Un)Heard Resonances: Tracing the Rhythms of Aurality in a Residential College Community

Author

Brownell, Cassie J., Sheridan, David M., and Scales, Christopher A.

Abstract

Although other disciplines have explored sound as more than oral language, music, or noise, educational scholarship exploring everyday soundscapes still has room to grow. In this article, a team of transdisciplinary scholars from education, writing and rhetoric, and ethnomusicology explore new possibilities for sound in research and teaching by examining a cross-course assignment grounded in the sonic experiences of a residential, living-learning college community. Through examining student-produced compositions, we introduce a number of relevant insights into the relationships between space, community, and a pedagogy of aurality.

Published
2018
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27. Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis.

Author

Mayo, Marlyn J., Vierling, John M., Bowlus, Christopher L., Levy, Cynthia, Hirschfield, Gideon M., Neff, Guy W., Galambos, Michael R., Gordon, Stuart C., Borg, Brian B., Harrison, Stephen A., Thuluvath, Paul J., Goel, Aparna, Shiffman, Mitchell L., Swain, Mark G., Jones, David E. J., Trivedi, Palak, Kremer, Andreas E., Aspinall, Richard J., Sheridan, David A., and Dörffel, Yvonne

Subjects
CHOLANGITIS, CLINICAL trials, ADVERSE health care events, NON-alcoholic fatty liver disease, BIOMARKERS
Abstract

Summary: Background: Seladelpar is a potent and selective peroxisome proliferator‐activated receptor‐δ agonist that targets multiple cell types involved in primary biliary cholangitis (PBC), leading to anti‐cholestatic, anti‐inflammatory and anti‐pruritic effects. Aims: To evaluate the long‐term safety and efficacy of seladelpar in patients with PBC. Methods: In an open‐label, international, long‐term extension study, patients with PBC completing seladelpar lead‐in studies continued treatment. Seladelpar was taken orally once daily at doses of 5 or 10 mg with dose adjustment permitted for safety or tolerability. The primary analysis was for safety and the secondary efficacy analysis examined biochemical markers of cholestasis and liver injury. The study was terminated early due to the unexpected histological findings in a concurrent study for non‐alcoholic steatohepatitis, which were subsequently found to predate treatment. Safety and efficacy data were analysed through 2 years. Results: There were no serious treatment‐related adverse events observed among 106 patients treated with seladelpar for up to 2 years. There were four discontinuations for safety, one possibly related to seladelpar. Among 53 patients who completed 2 years of seladelpar, response rates increased from years 1 to 2 for the composite endpoint (alkaline phosphatase [ALP] <1.67 × ULN, ≥15% decrease in ALP, and total bilirubin ≤ULN) and ALP normalisation from 66% to 79% and from 26% to 42%, respectively. In those with elevated bilirubin at baseline, 43% achieved normalisation at year 2. Conclusions: Seladelpar was safe, and markedly improved biochemical markers of cholestasis and liver injury in patients with PBC. These effects were maintained or improved throughout the second year. Clinicaltrials.gov: NCT03301506; Clinicaltrialsregister.eu: 2017‐003910‐16. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Addressing the Pediatric Mental Health Crisis in Emergency Departments in US: Findings of a National Pediatric Boarding Consensus Panel

Author

Feuer, Vera, primary, Mooneyham, GenaLynne C., additional, Malas, Nasuh M., additional, Aggarwal, Arpit, additional, Behere, Aniruddh P., additional, Brahmbhatt, Khyati, additional, Burns, Beech, additional, Carubia, Beau, additional, Fabbro, Anilla Del, additional, Dell, Mary Lynn, additional, Donise, Kathleen, additional, Duffy, Susan, additional, Giles, Lisa, additional, Johnson, Kyle, additional, Kalapatapu, Raj K., additional, Lardizabal, Marybeth, additional, Moreno, Claudia, additional, Pergjika, Alba, additional, Pierce, Donald, additional, Rogers, Steven, additional, Schott, Meghan, additional, Shaw, Richard J., additional, Sheridan, David, additional, and Zablan, Kashmeer, additional

Published
2023
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31. Developing a risk stratification tool for advanced NAFLD fibrosis using routinely measured clinical variables in a diabetes clinic annual review

Author

Miller, Hamish, primary, Colosimo, Santo, additional, Li, Wenhao, additional, Cobbold, Jeremy, additional, Alazawi, William, additional, Harman, David, additional, Aithal, Guruprasad, additional, Manousou, Pinelopi, additional, Parker, Richard, additional, Newsome, Philip N, additional, Sheridan, David, additional, Devalia, Kalpana, additional, Loy, John, additional, and Tomlinson, Jeremy, additional

Published
2023
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34. Investigation of hepatitis C virus (HCV) interactions with host lipid metabolism : a translational research study

Author

Sheridan, David Anthony

Subjects
616.9
Abstract

Research into chronic hepatitis C virus (HCV) infection (CHC) is needed because only ~50% of patients with CHC are cured with existing treatments. HCV interacts with metabolism of cholesterol and very low density lipoproteins (VLDL) for replication, assembly, secretion and entry. Patients with CHC exhibit a dyslipidemia characterised by low LDL cholesterol (LDL-C) and insulin resistance. This translational study characterised the dyslipidemia apparent in CHC in retrospective and prospective HCV cohorts. Distinct metabolic phenotypes were defined between HCV genotypes 1 and 3. LDL-C was markedly reduced in HCV-G3, which exerted a greater effect than apoE genotype on LDL-C levels. Prospective analysis of non-cholesterol sterol intermediates established that disordered cholesterol synthesis in HCV was mediated predominantly via the lathosterol pathway. In HCV-G3, levels of Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) were low compared to healthy controls, suggesting increased LDL clearance. Low LDL-C and high triglyceride/HDL ratio were found to be predictive of poor response to anti-viral therapy. Collaboration in a genome wide association study revealed that SNPs in IL28B rather than in lipid regulating genes are the major host genetic determinants of treatment response. Analysis of HCV lipoviral particles (LVP) by iodixanol density gradient ultracentrifugation revealed correlations between insulin resistance and triglycerides (TG) with LVP in HCV-G1. Determination of apoB in VLDL1, VLDL2, IDL and LDL fractions confirmed fasting TG are predominately in the VLDL1 fraction, implying that HCV-G1 preferentially associates with the VLDL1 pathway. Interferon γ inducible protein 10 (IP10), a marker of hepatic interferon stimulated gene expression correlated with LDL-C and HCV LVP ratio in HCV-G1, explaining the association between low LDL-C and poor treatment response. A randomised pilot trial in 60 CHC non-responders indicated that 12 weeks of treatment with Fluvastatin can lower total viral load in HCV-G1 & G4 and that low dose n3 PUFAs improved IP10 levels.

Published
2010

36. Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study

Author

Jones, David, Boudes, Pol F, Swain, Mark G, Bowlus, Christopher L, Galambos, Michael R, Bacon, Bruce R, Doerffel, Yvonne, Gitlin, Norman, Gordon, Stuart C, Odin, Joseph A, Sheridan, David, Wörns, Markus-Alexander, Clark, Virginia, Corless, Linsey, Hartmann, Heinz, Jonas, Mark E, Kremer, Andreas E, Mells, George F, Buggisch, Peter, Freilich, Bradley L, Levy, Cynthia, Vierling, John M, Bernstein, David E, Hartleb, Marek, Janczewska, Ewa, Rochling, Fedja, Shah, Hemant, Shiffman, Mitchell L, Smith, John H, Choi, Yun-Jung, Steinberg, Alexandra, Varga, Monika, Chera, Harinder, Martin, Robert, McWherter, Charles A, and Hirschfield, Gideon M

Published
2017
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39. Study of the development of crystalline Proteus mirabilis biofilms on urinary catheters

Author

Morgan, Sheridan David

Subjects
616.9
Abstract

Infection by Proteus mirabilis can seriously complicate the care of patients undergoing long-term indwelling bladder catheterisation. The urease-producing bacteria colonize the catheter surfaces forming extensive biofilm communities and are capable of generating ammonia from urea and elevating the pH of the urine and biofilm. Under these conditions crystals of calcium and magnesium phosphates form in the urine and within the bacterial biofilm on the indwelling device leading to its encrustation and blockage. Urine can leak around the outside of the blocked catheter and patients become incontinent. Alternatively, urine is retained within the bladder, causing painful distension of the bladder. Reflux of infected urine to the kidneys can lead to serious symptomatic episodes such as pyelonephritis, septicaemia and endotoxic shock. All available types of indwelling catheter are vulnerable to this problem and currently there are no effective procedures available for its control. While the basic mechanism has been established for catheter encrustation we still need to know more about some of the fundamental aspects of the process. Little is known about the early events and the precise mechanisms which P. mirabilis uses to colonize catheter surfaces. The factors that control the rate at which crystalline biofilm forms on the catheters are also unknown. The aims of this study were to establish the sequence of events in the early stages of crystalline P. mirabilis biofilm formation on the range of currently available catheters for use with patients to determine the role of Mannose-Resistant Proteus-hkc fimbriae (MR/P fimbriae) in P. mirabilis crystalline biofilm formation on catheters to investigate how the pH at which calcium and magnesium phosphates precipitate from urine, the nucleation pH (pHn) can be manipulated and to determine the effect of this parameter on the rate of catheter encrustation. Using a laboratory model of the catheterised bladder, scanning electron microscopy and X-ray microanalysis, the initial stages of P. mirabilis crystalline biofilm development was observed on catheter surfaces. All-silicone, silicone-coated latex, hydrogel-coated latex and hydrogel/silver-coated latex catheters rapidly acquired a microcrystalline 'foundation layer' comprised predominantly of calcium phosphate, upon which, P. mirabilis crystalline biofilm subsequently developed. A similar 'foundation layer' was observed on the encrusted surfaces of hydrogel/silver-coated catheters removed from long-term catheterised patients. The catheters impregnated with nitrofurazone briefly delayed the onset of crystalline biofilm formation, while all-silicone and hydrogel-coated latex catheters inflated with triclosan (3 mg/ml in Na2C03) were able to maintain acidic urine pH and prevent crystalline biofilm development for the 7 day experimental period. There is evidence that MR/P fimbriae are involved in initiating infection in non-catheterised urinary tracts. The role of these adhesins in crystalline biofilm formation on indwelling catheters however, has not been investigated. Using bladder models infected with a wild type P. mirabilis strain able to express MR/P fimbriae and its derived MR/P-negative mutant, time to catheter blockage experiments and scanning electron microscopy revealed that MR/P fimbriae were not essential for P. mirabilis colonization of catheter surfaces or the development of crystalline P. mirabilis biofilm. Although the wild type and mutant strain initiated biofilm formation in different ways both rapidly blocked all-silicone catheters with crystalline material. The overriding factor in catheter blockage was the generation of alkaline urine, raising the pH above that at which crystalline formations develop. Previously it has been demonstrated that the pHn of human urine can be elevated by dilution and by increasing its citrate content. In the present study the effect of dilution and adding citrate on the pHn of artificial was assessed. Furthermore, the effect on the rate of encrustation on all-silicone catheters was examined in laboratory models supplied with these urines and infected with urease-positive P. mirabilis, Providencia rettgeri and Proteus vulgaris. The pHn of urine could be elevated from pH 6.7 in neat urine to pH 8.4 in urine diluted to 1:6. When neat, 1:1, 1:2 and 1:3 diluted urines were supplied to bladder models significant increases in catheter lifespan were recorded at each ascending dilution. Increasing the citrate content of the 1:1 diluted urine from 0 to 3.0 g/L citrate elevated the pHn from pH 7 to pH 9.1. Scanning electron microscopy of catheter sections revealed crystalline material in the biofilms could be virtually eliminated for at least 7 days in models supplied with urine with pHns of >pH 8.5. Time to catheter blockage experiments showed the rate of catheter encrustation became significantly reduced as the pHn of urine increased. Catheters in models supplied with urine containing citrate concentrations of 1.5 mg/ml (pHn >8.4) or more drained freely for the whole 7-day experimental period.

Published
2007

45. A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms

Author

Sharkawy, Rasha El, Bayoumi, Ali, Metwally, Mayada, Mangia, Alessandra, Berg, Thomas, Romero-Gomez, Manuel, Abate, Maria Lorena, Irving, William L., Sheridan, David, Dore, Gregory J., Spengler, Ulrich, Lampertico, Pietro, Bugianesi, Elisabetta, Weltman, Martin, Mollison, Lindsay, Cheng, Wendy, Riordan, Stephen, Santoro, Rosanna, Gallego-Durán, Rocío, Fischer, Janett, Nattermann, Jacob, D’Ambrosio, Roberta, McLeod, Duncan, Powell, Elizabeth, latchoumanin, Olivier, Thabet, Khaled, Najim, Mustafa A. M., Douglas, Mark W., Liddle, Christopher, Qiao, Liang, George, Jacob, Eslam, Mohammed, and International Liver Disease Genetics Consortium (ILDGC)

Published
2019
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