1. Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum.
- Author
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Basnet, Buddha Bahadur, Chen, Baosong, Suleimen, Yerlan Melsuly, Ma, Ke, Guo, Shouyu, Bao, Li, Huang, Ying, and Liu, Hongwei
- Subjects
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FUNGAL metabolism , *ORGANIC compound analysis , *BACILLUS (Bacteria) , *CANDIDA albicans , *CELL death , *CELL lines , *EPITHELIAL cells , *ESCHERICHIA coli , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *POLYENES , *STAPHYLOCOCCUS aureus , *TERPENES , *PLANT extracts - Abstract
As part of our search for new cytotoxic and antimicrobial natural products from endolichenic fungi, 19 compounds including 1 new 10-member lactone (2), 1 new polyacetylene glycoside (3), 1 new brasilane-type sesquiterpenoid glycoside (4), and 2 isobenzofuran-1(3H)-one derivatives (5 and 6) were isolated from the solid culture of the endolichenic fungus Hypoxylon fuscum. Their structures were unambiguously elucidated by NMR spectroscopic data, MS, ECD (electronic circular dichroism) calculation, and chemical methods. The cytotoxic effects on K562, SW480, and HEPG2 cell lines and the antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli , and Candida albicans were assessed. Compounds 1, 2 , and 5 exhibited moderate cytotoxicity against K562, SW480, and HEPG2 cell lines while compounds 1, 9 , and 11 displayed weak antibacterial activity against S. aureus. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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