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1,330 results on '"Meyer-Lindenberg, Andreas"'

3. Predictors of adherence to exercise interventions in people with schizophrenia

Author

Schwaiger, Rebecca, Maurus, Isabel, Lembeck, Moritz, Papazova, Irina, Greska, David, Muenz, Susanne, Sykorova, Eliska, Thieme, Cristina E., Vogel, Bob O., Mohnke, Sebastian, Huppertz, Charlotte, Roeh, Astrid, Keller-Varady, Katriona, Malchow, Berend, Walter, Henrik, Wolfarth, Bernd, Wölwer, Wolfgang, Henkel, Karsten, Hirjak, Dusan, Schmitt, Andrea, Hasan, Alkomiet, Meyer-Lindenberg, Andreas, Falkai, Peter, and Roell, Lukas

Published
2024
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6. Diagnose- und Aufnahmezentrum: Etablierung und Evaluation einer integrierten translationalen Infrastruktur für die klinisch-psychiatrische Forschung

Author

Braun, Urs, Hennig, Oliver, Forstner, Johanna, Gerhardt, Sarah, Deffaa, Mirjam, Hirjak, Dusan, Deuschle, Michael, Koopmann, Anne, Wisch, Christian, Fritz, Melanie, Ende, Gabriele, Tost, Heike, Schöfer, Peter, Bischoff, Stefan, Janta, Matthias, Kiefer, Falk, Schmahl, Christian, Banaschewski, Tobias, and Meyer-Lindenberg, Andreas

Published
2024
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7. A primer on the use of machine learning to distil knowledge from data in biological psychiatry

Author

Quinn, Thomas P., Hess, Jonathan L., Marshe, Victoria S., Barnett, Michelle M., Hauschild, Anne-Christin, Maciukiewicz, Malgorzata, Elsheikh, Samar S. M., Men, Xiaoyu, Schwarz, Emanuel, Trakadis, Yannis J., Breen, Michael S., Barnett, Eric J., Zhang-James, Yanli, Ahsen, Mehmet Eren, Cao, Han, Chen, Junfang, Hou, Jiahui, Salekin, Asif, Lin, Ping-I, Nicodemus, Kristin K., Meyer-Lindenberg, Andreas, Bichindaritz, Isabelle, Faraone, Stephen V., Cairns, Murray J., Pandey, Gaurav, Müller, Daniel J., and Glatt, Stephen J.

Published
2024
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13. Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

Author

Solmi, Marco, Thompson, Trevor, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G, Hasler, Gregor, Conus, Philippe, Do Cuénod, Kim Q, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G, Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P, Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R, Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V, Valvassori, Samira S, Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, and Sand, Michael

Subjects
Clinical and Health Psychology, Health Sciences, Psychology, Mental Health, Behavioral and Social Science, Brain Disorders, Depression, Mental health, Good Health and Well Being, Humans, Adult, Reproducibility of Results, Pandemics, COVID-19, Surveys and Questionnaires, Outcome Assessment, Health Care, Factor Analysis, Statistical, Psychometrics, Covid-19, Pandemic, COH-FIT, Survey: P-factor: well-being: mental health: psychiatry: psychometric, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the internal validity of the co-primary outcome, a composite psychopathology "P-score".MethodsThe COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1-4 items ("COH-FIT items") were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r ≥ 0.5 with validated companion questionnaires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed.ResultsFrom >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (ω = 0.95). Factor structure was consistent across age and sex.ConclusionsCOH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health.

Published
2023

15. A stable and replicable neural signature of lifespan adversity in the adult brain

Author

Holz, Nathalie E., Zabihi, Mariam, Kia, Seyed Mostafa, Monninger, Maximillian, Aggensteiner, Pascal-M., Siehl, Sebastian, Floris, Dorothea L., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Meyer-Lindenberg, Andreas, Brandeis, Daniel, Buitelaar, Jan K., Nees, Frauke, Beckmann, Christian, Banaschewski, Tobias, and Marquand, Andre F.

Published
2023
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16. Towards a youth mental health paradigm: a perspective and roadmap

Author

Uhlhaas, Peter J., Davey, Christopher G., Mehta, Urvakhsh Meherwan, Shah, Jai, Torous, John, Allen, Nicholas B., Avenevoli, Shelli, Bella-Awusah, Tolulope, Chanen, Andrew, Chen, Eric Y. H., Correll, Christoph U., Do, Kim Q., Fisher, Helen L., Frangou, Sophia, Hickie, Ian B., Keshavan, Matcheri S., Konrad, Kerstin, Lee, Francis S., Liu, Cindy H., Luna, Beatriz, McGorry, Patrick D., Meyer-Lindenberg, Andreas, Nordentoft, Merete, Öngür, Dost, Patton, George C., Paus, Tomáš, Reininghaus, Ulrich, Sawa, Akira, Schoenbaum, Michael, Schumann, Gunter, Srihari, Vinod H., Susser, Ezra, Verma, Swapna K., Woo, T. Wilson, Yang, Lawrence H., Yung, Alison R., and Wood, Stephen J.

Published
2023
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20. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Author

Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, and Pariante, Carmine M

Subjects
Clinical Trials and Supportive Activities, Depression, Clinical Research, Mental Health, Brain Disorders, Serious Mental Illness, Major Depressive Disorder, Good Health and Well Being, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Humans, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD.

Published
2022

24. Intelligence, educational attainment, and brain structure in those at familial high‐risk for schizophrenia or bipolar disorder

Author

Zwarte, Sonja MC, Brouwer, Rachel M, Agartz, Ingrid, Alda, Martin, Alonso‐Lana, Silvia, Bearden, Carrie E, Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth EL, Cahn, Wiepke, Canales‐Rodríguez, Erick J, Cannon, Dara M, Cannon, Tyrone D, Caseras, Xavier, Castro‐Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, Bonnin, Caterina Mar, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E, Eker, Mehmet Cagdas, Erk, Susanne, Fatjó‐Vilas, Mar, Fears, Scott C, Foley, Sonya F, Frangou, Sophia, Fullerton, Janice M, Glahn, David C, Goghari, Vina M, Goikolea, Jose M, Goldman, Aaron L, Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L, Heinz, Andreas, Ongun, Ceren Hidiroglu, Hillegers, Manon HJ, Houenou, Josselin, Pol, Hilleke E Hulshoff, Hultman, Christina M, Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G, Kane, Fergus, Kempton, Matthew J, Koenis, Marinka MG, Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M, Lenroot, Rhoshel K, Marcelis, Machteld, Mattay, Venkata S, McDonald, Colm, Meyer‐Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B, Moreno, Dolores, Murray, Robin M, Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A, Os, Jim, Overs, Bronwyn J, Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M, Piguet, Camille, Pomarol‐Clotet, Edith, Radua, Joaquim, Ramsay, Ian S, Richter, Anja, Roberts, Gloria, Salvador, Raymond, Aydogan, Aybala Saricicek, Sarró, Salvador, Schofield, Peter R, Simsek, Esma M, Simsek, Fatma, Soares, Jair C, Sponheim, Scott R, Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R, Whalley, Heather C, Wu, Mon‐Ju, Yalin, Nefize, Andreassen, Ole A, Ching, Christopher RK, Thomopoulos, Sophia I, Erp, Theo GM, Jahanshad, Neda, and Thompson, Paul M

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Bipolar Disorder, Clinical Research, Serious Mental Illness, Neurosciences, Schizophrenia, Mental Health, Aetiology, 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, Mental health, Cognitive Dysfunction, Educational Status, Family, Genetic Predisposition to Disease, Humans, Intelligence, Magnetic Resonance Imaging, Neuroimaging, bipolar disorder, education, intelligence, neuroimaging, relatives, schizophrenia, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

Published
2022

25. Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis

Author

Förstner, Bernd R., Tschorn, Mira, Reinoso-Schiller, Nicolas, Maričić, Lea Mascarell, Röcher, Erik, Kalman, Janos L., Stroth, Sanna, Mayer, Annalina V., Schwarz, Kristina, Kaiser, Anna, Pfennig, Andrea, Manook, André, Ising, Marcus, Heinig, Ingmar, Pittig, Andre, Heinz, Andreas, Mathiak, Klaus, Schulze, Thomas G., Schneider, Frank, Kamp-Becker, Inge, Meyer-Lindenberg, Andreas, Padberg, Frank, Banaschewski, Tobias, Bauer, Michael, Rupprecht, Rainer, Wittchen, Hans-Ulrich, and Rapp, Michael A.

Published
2023
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28. Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder

Author

Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, D’ardhuy, Xavier Liogier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Bast, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Leyhausen, Johanna, Schäfer, Tim, Gurr, Caroline, Berg, Lisa M., Seelemeyer, Hanna, Pretzsch, Charlotte M., Floris, Dorothea L., Chatham, Chris, and Murphy, Declan G.

Published
2024
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29. Multimodal Associations of FKBP5 Methylation With Emotion-Regulatory Brain Circuits

Author

Kremer, Thomas L., Chen, Junfang, Buhl, Anais, Berhe, Oksana, Bilek, Edda, Geiger, Lena S., Ma, Ren, Moessnang, Carolin, Reichert, Markus, Reinhard, Iris, Schwarz, Kristina, Schweiger, Janina I., Streit, Fabian, Witt, Stephanie H., Zang, Zhenxiang, Zhang, Xiaolong, Nöthen, Markus M., Rietschel, Marcella, Ebner-Priemer, Ulrich W., Schwarz, Emanuel, Meyer-Lindenberg, Andreas, Braun, Urs, and Tost, Heike

Published
2024
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34. Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology

Author

Buitelaar, Jan K., Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier d’Ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Rausch, Annika, Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Ilioska, Iva, Mei, Ting, Zwiers, Marcel P., Forde, Natalie J., Floris, Dorothea L., Stones, Richard, Holt, Rosemary J., and Llera, Alberto

Published
2023
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35. Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits

Author

O’Leary, Aet, Fernàndez-Castillo, Noèlia, Gan, Gabriela, Yang, Yunbo, Yotova, Anna Y., Kranz, Thorsten M., Grünewald, Lena, Freudenberg, Florian, Antón-Galindo, Ester, Cabana-Domínguez, Judit, Harneit, Anais, Schweiger, Janina I., Schwarz, Kristina, Ma, Ren, Chen, Junfang, Schwarz, Emanuel, Rietschel, Marcella, Tost, Heike, Meyer-Lindenberg, Andreas, Pané-Farré, Christiane A., Kircher, Tilo, Hamm, Alfons O., Burguera, Demian, Mota, Nina Roth, Franke, Barbara, Schweiger, Susann, Winter, Jennifer, Heinz, Andreas, Erk, Susanne, Romanczuk-Seiferth, Nina, Walter, Henrik, Ströhle, Andreas, Fehm, Lydia, Fydrich, Thomas, Lueken, Ulrike, Weber, Heike, Lang, Thomas, Gerlach, Alexander L., Nöthen, Markus M., Alpers, Georg W., Arolt, Volker, Witt, Stephanie, Richter, Jan, Straube, Benjamin, Cormand, Bru, Slattery, David A., and Reif, Andreas

Published
2022
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36. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans.

Author

Sønderby, Ida E, van der Meer, Dennis, Moreau, Clara, Kaufmann, Tobias, Walters, G Bragi, Ellegaard, Maria, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Micael, Armstrong, Nicola J, Bernard, Manon, Blackburn, Nicholas B, Blangero, John, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Bülow, Robin, Bøen, Rune, Cahn, Wiepke, Calhoun, Vince D, Caspers, Svenja, Ching, Christopher RK, Cichon, Sven, Ciufolini, Simone, Crespo-Facorro, Benedicto, Curran, Joanne E, Dale, Anders M, Dalvie, Shareefa, Dazzan, Paola, de Geus, Eco JC, de Zubicaray, Greig I, de Zwarte, Sonja MC, Desrivieres, Sylvane, Doherty, Joanne L, Donohoe, Gary, Draganski, Bogdan, Ehrlich, Stefan, Eising, Else, Espeseth, Thomas, Fejgin, Kim, Fisher, Simon E, Fladby, Tormod, Frei, Oleksandr, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Ge, Tian, Glahn, David C, Grabe, Hans J, Groenewold, Nynke A, Gústafsson, Ómar, Haavik, Jan, Haberg, Asta K, Hall, Jeremy, Hashimoto, Ryota, Hehir-Kwa, Jayne Y, Hibar, Derrek P, Hillegers, Manon HJ, Hoffmann, Per, Holleran, Laurena, Holmes, Avram J, Homuth, Georg, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E, Ikeda, Masashi, Jahanshad, Neda, Jockwitz, Christiane, Johansson, Stefan, Jönsson, Erik G, Jørgensen, Niklas R, Kikuchi, Masataka, Knowles, Emma EM, Kumar, Kuldeep, Le Hellard, Stephanie, Leu, Costin, Linden, David EJ, Liu, Jingyu, Lundervold, Arvid, Lundervold, Astri Johansen, Maillard, Anne M, Martin, Nicholas G, Martin-Brevet, Sandra, Mather, Karen A, Mathias, Samuel R, McMahon, Katie L, McRae, Allan F, Medland, Sarah E, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Modenato, Claudia, Sánchez, Jennifer Monereo, Morris, Derek W, Mühleisen, Thomas W, Murray, Robin M, Nielsen, Jacob, Nordvik, Jan E, Nyberg, Lars, Loohuis, Loes M Olde, and Ophoff, Roel A

Subjects
ENIGMA-CNV working group, Clinical Sciences, Public Health and Health Services, Psychology
Abstract

Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers display a high prevalence of micro- and macrocephaly in deletion and duplication carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs in 38 cohorts from the large-scale ENIGMA-CNV collaboration and the UK Biobank and identified 28 1q21.1 distal deletion and 22 duplication carriers and 37,088 non-carriers (48% male) derived from 15 distinct magnetic resonance imaging scanner sites. With standardized methods, we compared subcortical and cortical brain measures (all) and cognitive performance (UK Biobank only) between carrier groups also testing for mediation of brain structure on cognition. We identified positive dosage effects of copy number on intracranial volume (ICV) and total cortical surface area, with the largest effects in frontal and cingulate cortices, and negative dosage effects on caudate and hippocampal volumes. The carriers displayed distinct cognitive deficit profiles in cognitive tasks from the UK Biobank with intermediate decreases in duplication carriers and somewhat larger in deletion carriers-the latter potentially mediated by ICV or cortical surface area. These results shed light on pathobiological mechanisms of neurodevelopmental disorders, by demonstrating gene dose effect on specific brain structures and effect on cognitive function.

Published
2021

37. Exercise as an add-on treatment in individuals with schizophrenia: Results from a large multicenter randomized controlled trial

Author

Maurus, Isabel, Roell, Lukas, Lembeck, Moritz, Papazova, Irina, Greska, David, Muenz, Susanne, Wagner, Elias, Campana, Mattia, Schwaiger, Rebecca, Schneider-Axmann, Thomas, Rosenberger, Kerstin, Hellmich, Martin, Sykorova, Eliska, Thieme, Cristina E., Vogel, Bob O., Harder, Carolin, Mohnke, Sebastian, Huppertz, Charlotte, Roeh, Astrid, Keller-Varady, Katriona, Malchow, Berend, Walter, Henrik, Wolfarth, Bernd, Wölwer, Wolfgang, Henkel, Karsten, Hirjak, Dusan, Schmitt, Andrea, Hasan, Alkomiet, Meyer-Lindenberg, Andreas, and Falkai, Peter

Published
2023
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40. Trees for brains: Current residential tree cover density and its association with brain structure in young adults

Author

Kühn, Simone, Banaschewski, Tobias, Bokde, Arun L.W., Büchel, Christian, Burke Quinlan, Erin, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie Laure, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Vaidya, Nilakshi, Meyer-Lindenberg, Andreas, and Gallinat, Jürgen

Published
2023
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44. Climate Change and Mental Health: Position Paper of the European Psychiatric Association

Author

Brandt, Lasse, primary, Adorjan, Kristina, additional, Catthoor, Kirsten, additional, Chkonia, Eka, additional, Falkai, Peter, additional, Fiorillo, Andrea, additional, Gondek, Tomasz M., additional, Le Vay, Jessica Newberry, additional, Rojnic, Martina, additional, Meyer-Lindenberg, Andreas, additional, Heinz, Andreas, additional, Dom, Geert, additional, and Luykx, Jurjen J., additional

Published
2024
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45. Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

Author

Solmi, Marco, primary, Thompson, Trevor, additional, Estradé, Andrés, additional, Agorastos, Agorastos, additional, Radua, Joaquim, additional, Cortese, Samuele, additional, Dragioti, Elena, additional, Leisch, Friedrich, additional, Vancampfort, Davy, additional, Thygesen, Lau Caspar, additional, Aschauer, Harald, additional, Schlögelhofer, Monika, additional, Aschauer, Elena, additional, Schneeberger, Andres, additional, Huber, Christian G., additional, Hasler, Gregor, additional, Conus, Philippe, additional, Cuénod, Kim Q. Do, additional, von Känel, Roland, additional, Arrondo, Gonzalo, additional, Fusar-Poli, Paolo, additional, Gorwood, Philip, additional, Llorca, Pierre-Michel, additional, Krebs, Marie-Odile, additional, Scanferla, Elisabetta, additional, Kishimoto, Taishiro, additional, Rabbani, Golam, additional, Skonieczna-Żydecka, Karolina, additional, Brambilla, Paolo, additional, Favaro, Angela, additional, Takamiya, Akihiro, additional, Zoccante, Leonardo, additional, Colizzi, Marco, additional, Bourgin, Julie, additional, Kamiński, Karol, additional, Moghadasin, Maryam, additional, Seedat, Soraya, additional, Matthews, Evan, additional, Wells, John, additional, Vassilopoulou, Emilia, additional, Gadelha, Ary, additional, Su, Kuan-Pin, additional, Kwon, Jun Soo, additional, Kim, Minah, additional, Lee, Tae Young, additional, Papsuev, Oleg, additional, Manková, Denisa, additional, Boscutti, Andrea, additional, Gerunda, Cristiano, additional, Saccon, Diego, additional, Righi, Elena, additional, Monaco, Francesco, additional, Croatto, Giovanni, additional, Cereda, Guido, additional, Demurtas, Jacopo, additional, Brondino, Natascia, additional, Veronese, Nicola, additional, Enrico, Paolo, additional, Politi, Pierluigi, additional, Ciappolino, Valentina, additional, Pfennig, Andrea, additional, Bechdolf, Andreas, additional, Meyer-Lindenberg, Andreas, additional, Kahl, Kai G., additional, Domschke, Katharina, additional, Bauer, Michael, additional, Koutsouleris, Nikolaos, additional, Winter, Sibylle, additional, Borgwardt, Stefan, additional, Bitter, Istvan, additional, Balazs, Judit, additional, Czobor, Pál, additional, Unoka, Zsolt, additional, Mavridis, Dimitris, additional, Tsamakis, Konstantinos, additional, Bozikas, Vasilios P., additional, Tunvirachaisakul, Chavit, additional, Maes, Michael, additional, Rungnirundorn, Teerayuth, additional, Supasitthumrong, Thitiporn, additional, Haque, Ariful, additional, Brunoni, Andre R., additional, Costardi, Carlos Gustavo, additional, Schuch, Felipe Barreto, additional, Polanczyk, Guilherme, additional, Luiz, Jhoanne Merlyn, additional, Fonseca, Lais, additional, Aparicio, Luana V., additional, Valvassori, Samira S., additional, Nordentoft, Merete, additional, Vendsborg, Per, additional, Hoffmann, Sofie Have, additional, Sehli, Jihed, additional, Sartorius, Norman, additional, Heuss, Sabina, additional, Guinart, Daniel, additional, Hamilton, Jane, additional, Kane, John, additional, Rubio, Jose, additional, Sand, Michael, additional, Koyanagi, Ai, additional, Solanes, Aleix, additional, Andreu-Bernabeu, Alvaro, additional, Cáceres, Antonia San José, additional, Arango, Celso, additional, Díaz-Caneja, Covadonga M., additional, Hidalgo-Mazzei, Diego, additional, Vieta, Eduard, additional, Gonzalez-Peñas, Javier, additional, Fortea, Lydia, additional, Parellada, Mara, additional, Fullana, Miquel A., additional, Verdolini, Norma, additional, Andrlíková, Eva, additional, Janků, Karolina, additional, Millan, Mark J., additional, Honciuc, Mihaela, additional, Moniuszko-Malinowska, Anna, additional, Łoniewski, Igor, additional, Samochowiec, Jerzy, additional, Kiszkiel, Łukasz, additional, Marlicz, Maria, additional, Sowa, Paweł, additional, Marlicz, Wojciech, additional, Spies, Georgina, additional, Stubbs, Brendon, additional, Firth, Joseph, additional, Sullivan, Sarah, additional, Darcin, Asli Enez, additional, Aksu, Hatice, additional, Dilbaz, Nesrin, additional, Noyan, Onur, additional, Kitazawa, Momoko, additional, Kurokawa, Shunya, additional, Tazawa, Yuki, additional, Anselmi, Alejandro, additional, Cracco, Cecilia, additional, Machado, Ana Inés, additional, Estrade, Natalia, additional, De Leo, Diego, additional, Curtis, Jackie, additional, Berk, Michael, additional, Carvalho, Andre F., additional, Ward, Philip, additional, Teasdale, Scott, additional, Rosenbaum, Simon, additional, Marx, Wolfgang, additional, Horodnic, Adrian Vasile, additional, Oprea, Liviu, additional, Alexinschi, Ovidiu, additional, Ifteni, Petru, additional, Turliuc, Serban, additional, Ciuhodaru, Tudor, additional, Bolos, Alexandra, additional, Matei, Valentin, additional, Nieman, Dorien H., additional, Sommer, Iris, additional, van Os, Jim, additional, van Amelsvoort, Therese, additional, Sun, Ching-Fang, additional, Guu, Ta-wei, additional, Jiao, Can, additional, Zhang, Jieting, additional, Fan, Jialin, additional, Zou, Liye, additional, Yu, Xin, additional, Chi, Xinli, additional, de Timary, Philippe, additional, van Winkel, Ruud, additional, Ng, Bernardo, additional, Pena, Edilberto, additional, Arellano, Ramon, additional, Roman, Raquel, additional, Sanchez, Thelma, additional, Movina, Larisa, additional, Morgado, Pedro, additional, Brissos, Sofia, additional, Aizberg, Oleg, additional, Mosina, Anna, additional, Krinitski, Damir, additional, Mugisha, James, additional, Sadeghi-Bahmani, Dena, additional, Sheybani, Farshad, additional, Sadeghi, Masoud, additional, Hadi, Samira, additional, Brand, Serge, additional, Errazuriz, Antonia, additional, Crossley, Nicolas, additional, Ristic, Dragana Ignjatovic, additional, López-Jaramillo, Carlos, additional, Efthymiou, Dimitris, additional, Kuttichira, Praveenlal, additional, Kallivayalil, Roy Abraham, additional, Javed, Afzal, additional, Afridi, Muhammad Iqbal, additional, James, Bawo, additional, Seb-Akahomen, Omonefe Joy, additional, Fiedorowicz, Jess, additional, Daskalakis, Jeff, additional, Yatham, Lakshmi N., additional, Yang, Lin, additional, Okasha, Tarek, additional, Dahdouh, Aïcha, additional, Gerdle, Björn, additional, Tiihonen, Jari, additional, Shin, Jae Il, additional, Lee, Jinhee, additional, Mhalla, Ahmed, additional, Gaha, Lotfi, additional, Brahim, Takoua, additional, Altynbekov, Kuanysh, additional, Negay, Nikolay, additional, Nurmagambetova, Saltanat, additional, Jamei, Yasser Abu, additional, Weiser, Mark, additional, and Correll, Christoph U., additional

Published
2024
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47. Association between aerobic fitness and the functional connectome in patients with schizophrenia

Author

Roell, Lukas, Maurus, Isabel, Keeser, Daniel, Karali, Temmuz, Papazov, Boris, Hasan, Alkomiet, Schmitt, Andrea, Papazova, Irina, Lembeck, Moritz, Hirjak, Dusan, Sykorova, Eliska, Thieme, Cristina E., Muenz, Susanne, Seitz, Valentina, Greska, David, Campana, Mattia, Wagner, Elias, Loehrs, Lisa, Stoecklein, Sophia, Ertl-Wagner, Birgit, Poemsl, Johannes, Roeh, Astrid, Malchow, Berend, Keller-Varady, Katriona, Meyer-Lindenberg, Andreas, and Falkai, Peter

Published
2022
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