1. Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.
- Author
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Mitoma, Hiroshi, Adhikari, Keya, Aeschlimann, Daniel, Chattopadhyay, Partha, Hadjivassiliou, Marios, Hampe, Christiane, Honnorat, Jérôme, Joubert, Bastien, Kakei, Shinji, Lee, Jongho, Manto, Mario, Matsunaga, Akiko, Mizusawa, Hidehiro, Nanri, Kazunori, Shanmugarajah, Priya, Yoneda, Makoto, and Yuki, Nobuhiro
- Subjects
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CEREBELLAR ataxia , *AUTOIMMUNE thyroiditis , *MILLER Fisher syndrome , *PARANEOPLASTIC syndromes , *CELLULAR immunity , *GLUTAMATE decarboxylase - Abstract
In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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