Problem: Patients who are treated in the dental practice often do not associate oral health with systemic health. Incomplete health history self-reporting confirms the lack of knowledge of current or existing health conditions. Periodontal disease can affect all individuals, although there is a higher prevalence among those living below the federal poverty level. In the southern Illinois region, approximately 1/3 of the population is covered under the medical assistance program. Purpose: The purpose of this study was to identify the correlation between systemic health issues and periodontal disease and determine if consistencies exist with data from southern Illinois and national trends. Methods: A convenience sample of current patients in the advanced periodontics clinic at Southern Illinois University Carbondale (SIUC) agreed to participate in this IRB approved study. An Excel data sheet was used to gather demographic information in addition to health issues and dental concerns from June 2019 to February 2020. Medical information included conditions that affect the nervous system, respiratory system, endocrine system, bone/muscle disorders, digestive system, urinary system, heart/blood vessel disorders and 'other' conditions. Patients received a periodontal screening to determine calculus deposit levels and the overall periodontal condition. Chi-square test of independence was calculated to test the relationship between systemic health issues and periodontal disease. Results: High blood pressure was the most reported systemic health issue among all patients and among those ages 50 and older. Statistically significant relationships were found between periodontal disease and high blood pressure, joint pain, and arthritis among all patients (n=927). No statistically significant relationships (p<0.05) were identified among those age 50 and older (n=348) however, not all patients completed all portions of the health history. Conclusion: Oral-systemic relationships between perio-dontal disease, hypertension and joint conditions were identified from the data collected at the dental hygiene clinic at SIUC, an access point for patients who lack health care in the region. The dental hygiene clinic is the access point for patients who lack healthcare in the region. Future research should focus on educating this vulnerable population on oral-systemic health and overall risk reduction. [ABSTRACT FROM AUTHOR]