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Your search keyword '"Ren, Guolian"' showing total 35 results
Start Over Author "Ren, Guolian" Publication Type Periodicals
35 results on '"Ren, Guolian"'

5. Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Author

Ren, Guolian, primary, Wang, Geng, additional, Jin, Qiuyue, additional, Niu, Xiaomin, additional, Wang, Rongrong, additional, Ping, Canqi, additional, Qiang, Jihong, additional, Li, Qingxia, additional, Han, Jingjing, additional, Wang, Ruili, additional, Zhang, Guoshun, additional, and Zhang, Shuqiu, additional

Published
2024
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8. Simultaneous Improvements of Physicochemical Properties and Anti‐Microbial Activity of Berberine via Forming Salt with Gallic Acid.

Author

Chen, Yi, Yang, Xirui, Ren, Guolian, Zhang, Shuqiu, and Zhang, Guoshun

Abstract

Implementing combination medication through crystal engineering technology receives increasing attention from researchers due to improvements in the clinical treatment effects as well as the physicochemical properties of the drug. Berberine (BER) is commonly used to treat gastroenteritis and bacterial diarrhea, with the problems of poor solubility and low oral bioavailability. Recently, it is found that gallic acid (GA) also has anti‐inflammatory and anti‐bacterial activities. Therefore, if the above‐mentioned two ingredients can be combined, it is possible to enhance the therapeutic effects and physicochemical properties of BER. Inspired by this, 8‐hydroxy‐7,8‐dihydroberberine (8H‐HBER) in this study is employed to react with gallic acid to yield BER gallate dihydrate (2BER‐2GA‐2 W). Furthermore, dissolution experiments demonstrate that the maximum apparent solubility (MAS) of 2BER‐2GA‐2 W in dilute hydrochloric acid solution medium (pH 1.2) has increased by 7 times compared to the commercial form of BER, because of avoiding the common‐ion effect. Moreover, 2BER‐2GA‐2 W has also obviously enhanced stability relative to the commercial form of BER. In addition, 2BER‐2GA‐2 W has a better inhibitory effect on Staphylococcus aureus (S. aureus) relative to the commercial form of BER. Hence, 2BER‐2GA‐2 W will be a promising solid‐state form of BER for its further development. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Docetaxel prodrug and hematoporphyrin co-assembled nanoparticles for anti-tumor combination of chemotherapy and photodynamic therapy

Author

Ren, Guolian, primary, Li, Yujie, additional, Ping, Canqi, additional, Duan, Danyu, additional, Li, Ning, additional, Tang, Jiaqi, additional, Wang, Rongrong, additional, Guo, Wenju, additional, Niu, Xiaomin, additional, Ji, Qiuyue, additional, Zhang, Guoshun, additional, Wang, Ruili, additional, and Zhang, Shuqiu, additional

Published
2022
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15. Targeting metabotropic glutamate receptor 4 for cancer immunotherapy

Author

Wan, Zhuoya, primary, Sun, Runzi, additional, Liu, Yang-Wuyue, additional, Li, Sihan, additional, Sun, Jingjing, additional, Li, Jiang, additional, Zhu, Junjie, additional, Moharil, Pearl, additional, Zhang, Bei, additional, Ren, Pengfei, additional, Ren, Guolian, additional, Zhang, Min, additional, Ma, Xiaochao, additional, Dai, Shuangshuang, additional, Yang, Da, additional, Lu, Binfeng, additional, and Li, Song, additional

Published
2021
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26. In vivo antimalarial activity and pharmacokinetics of artelinic acid-choline derivative liposomes in rodents.

Author

Duan, Shuai, Wang, Ruili, Wang, Rongrong, Tang, Jiaqi, Xiao, Xiaoyang, Li, Ning, Guo, Wenju, Yang, Qingshan, Ren, Guolian, and Zhang, Shuqiu

Subjects
LIPOSOMES, PLASMODIUM yoelii, PHARMACOKINETICS, DEHYDRATION reactions, DRUG resistance, TREATMENT effectiveness
Abstract

It is urgent to develop new antimalarial drugs with good therapeutic effects to address the emergence of drug resistance. Here, the artelinic acid-choline derivative (AD) was synthesized by dehydration reaction and esterification reaction, aimed to avoid the emergence of drug resistance by synergistic effect of artemisinins and choline derivative, which could compete with choline for rate-limiting enzymes in the phosphatidylcholine (PC) biosynthetic pathway. AD was formulated into liposomes (ADLs) by the thin-film hydration method. Efficacy of ADLs was evaluated by Peters 4-day suppression test. The suppression percentage against Plasmodium yoelii BY265 (Py BY265) in ADLs group was higher than those of positive control groups (dihydroartemisinin liposomes, P < 0.05) and other control groups (P ⩽ 0.05) at the doses of 4.4, 8.8, 17.6 µ mol (kg·d)−1, respectively. The negative conversion fraction, recrudescence fraction and survival fraction of ADLs group were superior to other control groups. Pharmacokinetics in rats after intravenous injection suggested that ADLs exhibited higher exposure levels (indexed by area under concentration-time curve) than that of AD solution, artelinic acid liposomes or artelinic acid solution (P < 0.01). Taken together, ADLs exhibited promising antimalarial efficacy and pharmacokinetic characteristics. [ABSTRACT FROM AUTHOR]

Published
2020
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30. Construction and cellular uptake evaluation of redox-responsive docetaxel prodrug self-assembled nanoparticles.

Author

Ren, Guolian, Chen, Pei, Tang, Jiaqi, Wang, Rongrong, Duan, Shuai, Wang, Ruili, Xie, Yin, and Zhang, Shuqiu

Subjects
OXIDATION-reduction reaction, DOCETAXEL, MOLECULAR self-assembly, NANOPARTICLES, DRUG side effects
Abstract

Docetaxel (DTX) solution has some serious adverse side effects. A redox-responsive DTX prodrug synthesized in our laboratory was used to prepare DTX prodrug self-assembled nanoparticles (DSNPs) with the method of nanoprecipitation. This study aimed at optimizing the formulation to develop stable preparation for the delivery of DTX. Single-factor test was used to evaluate the effects of the preparation concentration of DTX prodrug, stirring speed, the types of stabilizers and temperature on the prescription process of DSNPs. The particle size and polydispersity index were selected as the evaluation indexes. The entrapment efficiency, drug-loading, size distribution and zeta potential were characterized by UPLC and Zetasizer, respectively. The stability and cellular behavior of DSNPs were investigated by Zetasizer, LC–MS/MS and confocal laser scanning microscope, respectively. The particle size, entrapment efficiency and drug-loading of DSNPs were 173.8 ± 1.4 nm, 98.8% ± 0.1%, and 47.8% ± 0.9%, respectively. DSNPs showed good stability during the storage of 30 days, and were taken into the cells in a time-dependent and concentration-dependent manner. The method of nanoprecipitation could be used to entrap DTX. The preparation method was simple, and the quality of DSNPs was stable and reliable. Through the optimization of the formulation, we obtained uniform and stable DSNPs, which could escape from lysosomes of tumor cells. The optimized formulations were stable for intravenous administration. This study could provide scientific support for the development of nano-drug delivery system of small anti-tumor drug. [ABSTRACT FROM AUTHOR]

Published
2018
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31. Construction and cellular uptake behavior of redox-sensitive docetaxel prodrug-loaded liposomes.

Author

Ren, Guolian, Jiang, Mengjuan, Guo, Weiling, Sun, Bingjun, Lian, He, Wang, Yongjun, and He, Zhonggui

Subjects
DOCETAXEL, LIPOSOMES, VITAMIN E, LIQUID chromatography, SONICATION
Abstract

A redox-responsive docetaxel (DTX) prodrug consisting of a disulfide linkage between DTX and vitamin E (DTX-SS-VE) was synthesized in our laboratory and was successfully formulated into liposomes. The aim of this study was to optimize the formulation and investigate the cellular uptake of DTX prodrug-loaded liposomes (DPLs). The content of DTX-SS-VE was determined by ultrahigh-performance liquid chromatography (UPLC). The formulation and process were optimized using entrapment efficiency (EE), drug-loading (DL), particle size and polydispersity index (PDI) as the evaluation indices. The optimal formulation was as follows: drug/lipid ratio of 1:12, cholesterol/lipid ratio of 1:10, hydration temperature of 40 °C, sonication power and time of 400 W and 5 min. The EE, DL and particle size of the optimized DPLs were 97.60 ± 0.03%, 7.09 ± 0.22% and 93.06 ± 0.72 nm, respectively. DPLs had good dilution stability under the physiological conditions over 24 h. In addition, DPLs were found to enter tumor cells via different pathways and released DTX from the prodrug to induce apoptosis. Taken together, the optimized formulation and process were found to be a simple, stable and applicable method for the preparation of DPLs that could successfully escape from lysosomes. [ABSTRACT FROM PUBLISHER]

Published
2018
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32. Hydrates and Solvates of Acotiamide Hydrochloride: Crystallization, Structure, Stability, and Solubility

Author

Zhang, Guoshun, Xiao, Xiaoyang, Zhang, Lifeng, Ren, Guolian, and Zhang, Shuqiu

Abstract

This paper elucidated eight crystal structures of acotiamide hydrochloride (AH) via single-crystal X-ray diffraction (SCXRD) with water (1AH-1W-I, 1AH-3W), methanol (1AH-1M), methanol and water (1AH-1W-1M-I, 1AH-1W-1M-II), ethanol (1AH-1E), ethanol and water (1AH-1W-1E), and n-propanol (1AH-1P). Two influencing factors, water content and solvent type, were investigated for their effects on the formation of distinct hydrates and solvates. In addition, the stability and solubility of these solid phase forms were analyzed based on their structures. The results of SCXRD revealed that AH tends to crystallize together with a solvent as both a hydrogen bond donor and acceptor. The control experiments in methanol–water, ethanol–water, n-propanol–water, and acetone–water systems showed that the final crystal form varied with an increase in the water content. The eight crystals fall into three types based on their spatial stacking, corresponding interestingly to different stability and solubility. Furthermore, the relationship between changes in solubility curves and the solid phase forms of the undissolved samples was preliminarily elucidated.

Published
2019
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33. Star-Shape Redox-Responsive PEG-Sheddable Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Triggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison

Author

Ai, Xiaoyu, primary, Sun, Jin, additional, Zhong, Lu, additional, Wu, Chunnuan, additional, Niu, Handong, additional, Xu, Tao, additional, Lian, He, additional, Han, Xiaopeng, additional, Ren, Guolian, additional, Ding, Wenya, additional, Wang, Jia, additional, Pu, Xiaohui, additional, and He, Zhonggui, additional

Published
2014
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34. Enhanced Oral Delivery of Paclitaxel Using Acetylcysteine Functionalized Chitosan-Vitamin E Succinate Nanomicelles Based on a Mucus Bioadhesion and Penetration Mechanism

Author

Lian, He, primary, Zhang, Tianhong, additional, Sun, Jin, additional, Liu, Xiaohong, additional, Ren, Guolian, additional, Kou, Longfa, additional, Zhang, Youxi, additional, Han, Xiaopeng, additional, Ding, Wenya, additional, Ai, Xiaoyu, additional, Wu, Chunnuan, additional, Li, Lin, additional, Wang, Yongjun, additional, Sun, Yinghua, additional, Wang, Siling, additional, and He, Zhonggui, additional

Published
2013
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