194 results on '"Hersh, A."'
Search Results
2. Poset topology, moves, and Bruhat interval polytope lattices
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Gaetz, Christian and Hersh, Patricia
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Mathematics - Combinatorics ,05E45, 06A07 - Abstract
We study the poset topology of lattices arising from orientations of 1-skeleta of directionally simple polytopes, with Bruhat interval polytopes $Q_{e,w}$ as our main example. We show that the order complex $\Delta ((u,v)_w)$ of an interval therein is homotopy equivalent to a sphere if $Q_{u,v}$ is a face of $Q_{e,w}$ and is otherwise contractible. This significantly generalizes the known case of the permutahedron. We also show that saturated chains from $u$ to $v$ in such lattices are connected, and in fact highly connected, under moves corresponding to flipping across a 2-face. When $w$ is a Grassmannian permutation, this implies a strengthening of the restriction of Postnikov's move-equivalence theorem to the class of BCFW bridge decomposable plabic graphs., Comment: 14 pages, 1 figure
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- 2024
3. Evidence Is All You Need: Ordering Imaging Studies via Language Model Alignment with the ACR Appropriateness Criteria
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Yao, Michael S., Chae, Allison, Kahn Jr., Charles E., Witschey, Walter R., Gee, James C., Sagreiya, Hersh, and Bastani, Osbert
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Computer Science - Machine Learning ,Computer Science - Computation and Language ,Computer Science - Computers and Society - Abstract
Diagnostic imaging studies are an increasingly important component of the workup and management of acutely presenting patients. However, ordering appropriate imaging studies according to evidence-based medical guidelines is a challenging task with a high degree of variability between healthcare providers. To address this issue, recent work has investigated if generative AI and large language models can be leveraged to help clinicians order relevant imaging studies for patients. However, it is challenging to ensure that these tools are correctly aligned with medical guidelines, such as the American College of Radiology's Appropriateness Criteria (ACR AC). In this study, we introduce a framework to intelligently leverage language models by recommending imaging studies for patient cases that are aligned with evidence-based guidelines. We make available a novel dataset of patient "one-liner" scenarios to power our experiments, and optimize state-of-the-art language models to achieve an accuracy on par with clinicians in image ordering. Finally, we demonstrate that our language model-based pipeline can be used as intelligent assistants by clinicians to support image ordering workflows and improve the accuracy of imaging study ordering according to the ACR AC. Our work demonstrates and validates a strategy to leverage AI-based software to improve trustworthy clinical decision making in alignment with expert evidence-based guidelines., Comment: 15 pages main text, 4 figures, 1 table
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- 2024
4. A novel open-source ultrasound dataset with deep learning benchmarks for spinal cord injury localization and anatomical segmentation
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Kumar, Avisha, Kotkar, Kunal, Jiang, Kelly, Bhimreddy, Meghana, Davidar, Daniel, Weber-Levine, Carly, Krishnan, Siddharth, Kerensky, Max J., Liang, Ruixing, Leadingham, Kelley Kempski, Routkevitch, Denis, Hersh, Andrew M., Ashayeri, Kimberly, Tyler, Betty, Suk, Ian, Son, Jennifer, Theodore, Nicholas, Thakor, Nitish, and Manbachi, Amir
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
While deep learning has catalyzed breakthroughs across numerous domains, its broader adoption in clinical settings is inhibited by the costly and time-intensive nature of data acquisition and annotation. To further facilitate medical machine learning, we present an ultrasound dataset of 10,223 Brightness-mode (B-mode) images consisting of sagittal slices of porcine spinal cords (N=25) before and after a contusion injury. We additionally benchmark the performance metrics of several state-of-the-art object detection algorithms to localize the site of injury and semantic segmentation models to label the anatomy for comparison and creation of task-specific architectures. Finally, we evaluate the zero-shot generalization capabilities of the segmentation models on human ultrasound spinal cord images to determine whether training on our porcine dataset is sufficient for accurately interpreting human data. Our results show that the YOLOv8 detection model outperforms all evaluated models for injury localization, achieving a mean Average Precision (mAP50-95) score of 0.606. Segmentation metrics indicate that the DeepLabv3 segmentation model achieves the highest accuracy on unseen porcine anatomy, with a Mean Dice score of 0.587, while SAMed achieves the highest Mean Dice score generalizing to human anatomy (0.445). To the best of our knowledge, this is the largest annotated dataset of spinal cord ultrasound images made publicly available to researchers and medical professionals, as well as the first public report of object detection and segmentation architectures to assess anatomical markers in the spinal cord for methodology development and clinical applications.
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- 2024
5. Bi-capacity Choquet Integral for Sensor Fusion with Label Uncertainty
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Vakharia, Hersh and Du, Xiaoxiao
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Sensor fusion combines data from multiple sensor sources to improve reliability, robustness, and accuracy of data interpretation. The Fuzzy Integral (FI), in particular, the Choquet integral (ChI), is often used as a powerful nonlinear aggregator for fusion across multiple sensors. However, existing supervised ChI learning algorithms typically require precise training labels for each input data point, which can be difficult or impossible to obtain. Additionally, prior work on ChI fusion is often based only on the normalized fuzzy measures, which bounds the fuzzy measure values between [0, 1]. This can be limiting in cases where the underlying scales of input data sources are bipolar (i.e., between [-1, 1]). To address these challenges, this paper proposes a novel Choquet integral-based fusion framework, named Bi-MIChI (pronounced "bi-mi-kee"), which uses bi-capacities to represent the interactions between pairs of subsets of the input sensor sources on a bi-polar scale. This allows for extended non-linear interactions between the sensor sources and can lead to interesting fusion results. Bi-MIChI also addresses label uncertainty through Multiple Instance Learning, where training labels are applied to "bags" (sets) of data instead of per-instance. Our proposed Bi-MIChI framework shows effective classification and detection performance on both synthetic and real-world experiments for sensor fusion with label uncertainty. We also provide detailed analyses on the behavior of the fuzzy measures to demonstrate our fusion process., Comment: 10 pages, 7 figures, 7 tables; Accepted to 2024 FUZZ-IEEE and presented at 2024 IEEE WCCI; Code available at https://github.com/hvak/Bi-MIChI
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- 2024
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6. Machine learning-based algorithms for at-home respiratory disease monitoring and respiratory assessment
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Orangi-Fard, Negar, Bogdan, Alexandru, and Sagreiya, Hersh
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Computer Science - Machine Learning - Abstract
Respiratory diseases impose a significant burden on global health, with current diagnostic and management practices primarily reliant on specialist clinical testing. This work aims to develop machine learning-based algorithms to facilitate at-home respiratory disease monitoring and assessment for patients undergoing continuous positive airway pressure (CPAP) therapy. Data were collected from 30 healthy adults, encompassing respiratory pressure, flow, and dynamic thoraco-abdominal circumferential measurements under three breathing conditions: normal, panting, and deep breathing. Various machine learning models, including the random forest classifier, logistic regression, and support vector machine (SVM), were trained to predict breathing types. The random forest classifier demonstrated the highest accuracy, particularly when incorporating breathing rate as a feature. These findings support the potential of AI-driven respiratory monitoring systems to transition respiratory assessments from clinical settings to home environments, enhancing accessibility and patient autonomy. Future work involves validating these models with larger, more diverse populations and exploring additional machine learning techniques., Comment: 10 pages, 2 figures
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- 2024
7. Diameter bound for facet-ridge incidence graphs of geometric lattices
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Hersh, Patricia and Machacek, John
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Mathematics - Combinatorics ,05E45, 05B35, 06A07 - Abstract
This paper proves that the facet-ridge incidence graph of the order complex of any finite geometric lattice of rank $r$ has diameter at most ${r \choose 2}$. A key ingredient is the well-known fact that every ordering of the atoms of any finite geometric lattice gives rise to a lexicographic shelling of its order complex. The paper also gives results that provide some evidence that this bound ought to be sharp as well as examples indicating that the question of sharpness is quite subtle.
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- 2024
8. OCCAM: Online Continuous Controller Adaptation with Meta-Learned Models
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Sanghvi, Hersh, Folk, Spencer, and Taylor, Camillo Jose
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Computer Science - Robotics - Abstract
Control tuning and adaptation present a significant challenge to the usage of robots in diverse environments. It is often nontrivial to find a single set of control parameters by hand that work well across the broad array of environments and conditions that a robot might encounter. Automated adaptation approaches must utilize prior knowledge about the system while adapting to significant domain shifts to find new control parameters quickly. In this work, we present a general framework for online controller adaptation that deals with these challenges. We combine meta-learning with Bayesian recursive estimation to learn prior predictive models of system performance that quickly adapt to online data, even when there is significant domain shift. These predictive models can be used as cost functions within efficient sampling-based optimization routines to find new control parameters online that maximize system performance. Our framework is powerful and flexible enough to adapt controllers for four diverse systems: a simulated race car, a simulated quadrupedal robot, and a simulated and physical quadrotor. The video and code can be found at https://hersh500.github.io/occam., Comment: 8 pages, 4 figures. Accepted to Conference on Robot Learning (CoRL) 2024
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- 2024
9. An Evaluation of the Launching Elementary Academic Foundations (LEAF) to STEM Program
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Texas A&M University, Education Resource Center (ERC), Kayla Rollins, Adem Ekmekci, Xuan Zhao, and Hersh Waxman
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This report summarizes the results of kindergarten through fifth grade students' academic achievement outcomes in mathematics and science following four years of campus-level participation in the Launching Elementary Academic Foundations (LEAF) to STEM program. The LEAF to STEM Program consists of three key components that were adapted for K-5 teachers from a secondary STEM curricular intervention within the same charter system. The three key components were: 1) an elementary-focused project-based learning STEM curriculum, 2) ongoing professional development for participating teachers, and 3) peer-to-peer mentoring with secondary STEM teachers serving as mentors to elementary STEM teachers. The charter school system in which LEAF to STEM was implemented is ethnically and racially diverse, with a higher percentage of students of color than the state in which the system operates (86.1% vs. 71.9% students of color). The system serves a high population of students identified as at-risk, including 60% of students identified as eligible for Free and Reduced Lunch and 24% of students identified as English Language Learners. At the time of randomization, the charter system had a total of 14,572 grades K-5 students on 34 K-5 campuses. The cluster randomized-controlled trial assigned thirty-two K-5 campuses within a large charter system to a treatment/control (business-as-usual) condition using stratified sampling. Campuses were stratified into four groups based on whether a campus's total percentage of students classified as eligible for free-and-reduced price lunch (FRL) fell above or below the system-wide average percentage of FRL students. Within each of those levels, schools were further stratified into two additional groups, based on whether the percentage of a school's students meeting NWEA MAP Reading and Mathematics growth targets in the year prior to randomization to treatment was above or below the system-wide average. Student achievement in mathematics and science was measured using the NWEA MAP Rausch Interval Unit (RIT) scores for mathematics and science for all grades K through five students enrolled in campuses at the time of randomization. Mathematics baseline RIT scores, as well as RIT scores for years one (spring 2020), two (spring 2021), three (spring 2022), and four (spring 2023) of treatment were available for all students, whereas science RIT scores were only available for grades 4 and 5 students after one year (for both 4th and 5th grade students at the onset of the program) or two years of treatment (for 4th grade students only at the onset). Two-level hierarchical linear modeling (students nested in campuses) was employed to explore the impact of treatment on students' mathematics and science achievement (NWEA MAP scores) controlling for demographic background (i.e., ethnicity and gender) and prior achievement at the onset of the LEAF to STEM (beginning of year 1). Results indicated no statistically significant differences in mathematics and science achievement between students in the treatment and control conditions after four years of the exposure to the LEAF to STEM program. When broken down by the grade level, results still did not indicate any significant differences between treatment and control groups in mathematics and science achievement.
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- 2024
10. Chiral symmetry and Atiyah-Patodi-Singer index theorem for staggered fermions
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Nguyen, Mendel and Singh, Hersh
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High Energy Physics - Lattice ,Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory - Abstract
We consider the Atiyah-Patodi-Singer (APS) index theorem corresponding to the chiral symmetry of a continuum formulation of staggered fermions called K\"ahler-Dirac fermions, which have been recently investigated as an ingredient in lattice constructions of chiral gauge theories. We point out that there are two notions of chiral symmetry for K\"ahler-Dirac fermions, both having a mixed perturbative anomaly with gravity leading to index theorems on closed manifolds. By formulating these theories on a manifold with boundary, we find the APS index theorems corresponding to each of these symmetries, necessary for a complete picture of anomaly inflow, using a recently discovered physics-motivated proof. We comment on a fundamental difference between the nature of these two symmetries by showing that a sensible local, symmetric boundary condition only exists for one of the two symmetries. This sheds light on how these symmetries behave under lattice discretization, and in particular on their use for recent symmetric-mass generation proposals., Comment: 12 pages, 1 figure
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- 2024
11. CopilotCAD: Empowering Radiologists with Report Completion Models and Quantitative Evidence from Medical Image Foundation Models
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Wang, Sheng, Du, Tianming, Fischer, Katherine, Tasian, Gregory E, Ziemba, Justin, Garratt, Joanie M, Sagreiya, Hersh, and Fan, Yong
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Computer-aided diagnosis systems hold great promise to aid radiologists and clinicians in radiological clinical practice and enhance diagnostic accuracy and efficiency. However, the conventional systems primarily focus on delivering diagnostic results through text report generation or medical image classification, positioning them as standalone decision-makers rather than helpers and ignoring radiologists' expertise. This study introduces an innovative paradigm to create an assistive co-pilot system for empowering radiologists by leveraging Large Language Models (LLMs) and medical image analysis tools. Specifically, we develop a collaborative framework to integrate LLMs and quantitative medical image analysis results generated by foundation models with radiologists in the loop, achieving efficient and safe generation of radiology reports and effective utilization of computational power of AI and the expertise of medical professionals. This approach empowers radiologists to generate more precise and detailed diagnostic reports, enhancing patient outcomes while reducing the burnout of clinicians. Our methodology underscores the potential of AI as a supportive tool in medical diagnostics, promoting a harmonious integration of technology and human expertise to advance the field of radiology.
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- 2024
12. Efficient Multi-Resolution Fusion for Remote Sensing Data with Label Uncertainty
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Vakharia, Hersh and Du, Xiaoxiao
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Multi-modal sensor data fusion takes advantage of complementary or reinforcing information from each sensor and can boost overall performance in applications such as scene classification and target detection. This paper presents a new method for fusing multi-modal and multi-resolution remote sensor data without requiring pixel-level training labels, which can be difficult to obtain. Previously, we developed a Multiple Instance Multi-Resolution Fusion (MIMRF) framework that addresses label uncertainty for fusion, but it can be slow to train due to the large search space for the fuzzy measures used to integrate sensor data sources. We propose a new method based on binary fuzzy measures, which reduces the search space and significantly improves the efficiency of the MIMRF framework. We present experimental results on synthetic data and a real-world remote sensing detection task and show that the proposed MIMRF-BFM algorithm can effectively and efficiently perform multi-resolution fusion given remote sensing data with uncertainty., Comment: 4 pages, 3 figures, 2 tables; Accepted to International Geoscience and Remote Sensing Symposium (IGARSS) 2023; Code available at https://github.com/hvak/MIMRF-BFM
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- 2024
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13. Search Still Matters: Information Retrieval in the Era of Generative AI
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Hersh, William R.
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Computer Science - Information Retrieval ,Computer Science - Artificial Intelligence ,H.3 - Abstract
Objective: Information retrieval (IR, also known as search) systems are ubiquitous in modern times. How does the emergence of generative artificial intelligence (AI), based on large language models (LLMs), fit into the IR process? Process: This perspective explores the use of generative AI in the context of the motivations, considerations, and outcomes of the IR process with a focus on the academic use of such systems. Conclusions: There are many information needs, from simple to complex, that motivate use of IR. Users of such systems, particularly academics, have concerns for authoritativeness, timeliness, and contextualization of search. While LLMs may provide functionality that aids the IR process, the continued need for search systems, and research into their improvement, remains essential., Comment: 7 pages, no figures
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- 2023
14. Contrastive Self-Supervised Learning for Spatio-Temporal Analysis of Lung Ultrasound Videos
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Chen, Li, Rubin, Jonathan, Ouyang, Jiahong, Balaraju, Naveen, Patil, Shubham, Mehanian, Courosh, Kulhare, Sourabh, Millin, Rachel, Gregory, Kenton W, Gregory, Cynthia R, Zhu, Meihua, Kessler, David O, Malia, Laurie, Dessie, Almaz, Rabiner, Joni, Coneybeare, Di, Shopsin, Bo, Hersh, Andrew, Madar, Cristian, Shupp, Jeffrey, Johnson, Laura S, Avila, Jacob, Dwyer, Kristin, Weimersheimer, Peter, Raju, Balasundar, Kruecker, Jochen, and Chen, Alvin
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Self-supervised learning (SSL) methods have shown promise for medical imaging applications by learning meaningful visual representations, even when the amount of labeled data is limited. Here, we extend state-of-the-art contrastive learning SSL methods to 2D+time medical ultrasound video data by introducing a modified encoder and augmentation method capable of learning meaningful spatio-temporal representations, without requiring constraints on the input data. We evaluate our method on the challenging clinical task of identifying lung consolidations (an important pathological feature) in ultrasound videos. Using a multi-center dataset of over 27k lung ultrasound videos acquired from over 500 patients, we show that our method can significantly improve performance on downstream localization and classification of lung consolidation. Comparisons against baseline models trained without SSL show that the proposed methods are particularly advantageous when the size of labeled training data is limited (e.g., as little as 5% of the training set)., Comment: ISBI 2023, 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI)
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- 2023
- Full Text
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15. Extensions of Heterogeneity in Integration and Prediction (HIP) with R Shiny Application
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Butts, J., Wendt, C., Bowler, R., Hersh, C. P., Long, Q., Eberly, L., and Safo, S. E.
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Statistics - Methodology ,Statistics - Applications ,Statistics - Computation ,Statistics - Machine Learning - Abstract
Multiple data views measured on the same set of participants is becoming more common and has the potential to deepen our understanding of many complex diseases by analyzing these different views simultaneously. Equally important, many of these complex diseases show evidence of subgroup heterogeneity (e.g., by sex or race). HIP (Heterogeneity in Integration and Prediction) is among the first methods proposed to integrate multiple data views while also accounting for subgroup heterogeneity to identify common and subgroup-specific markers of a particular disease. However, HIP is applicable to continuous outcomes and requires programming expertise by the user. Here we propose extensions to HIP that accommodate multi-class, Poisson, and Zero-Inflated Poisson outcomes while retaining the benefits of HIP. Additionally, we introduce an R Shiny application, accessible on shinyapps.io at https://multi-viewlearn.shinyapps.io/HIP_ShinyApp/, that provides an interface with the Python implementation of HIP to allow more researchers to use the method anywhere and on any device. We applied HIP to identify genes and proteins common and specific to males and females that are associated with exacerbation frequency. Although some of the identified genes and proteins show evidence of a relationship with chronic obstructive pulmonary disease (COPD) in existing literature, others may be candidates for future research investigating their relationship with COPD. We demonstrate the use of the Shiny application with a publicly available data. An R-package for HIP would be made available at https://github.com/lasandrall/HIP.
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- 2023
16. Topological terms with qubit regularization and relativistic quantum circuits
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Bhattacharya, Tanmoy, Chandrasekharan, Shailesh, Gupta, Rajan, Richardson, Thomas R., and Singh, Hersh
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High Energy Physics - Lattice ,Quantum Physics - Abstract
Qubit regularization provides a rich framework to explore quantum field theories. The freedom to choose how the important symmetries of the theory are embedded in the qubit regularization scheme allows us to construct new lattice models with rich phase diagrams. Some of the phases can contain topological terms which lead to critical phases. In this work we introduce and study the SU(3)-F qubit regularization scheme to embed the SO(3) spin-symmetry. We argue that qubit models in this regularization scheme contain several phases including a critical phase which describes the k = 1 Wess-Zumino-Witten (WZW) conformal field theory (CFT) at long distances, and two massive phases one of which is trvially gapped and the other which breaks the lattice translation symmetry. We construct a simple space-time Euclidean lattice model with a single coupling U and study it using the Monte Carlo method. We show the model has a critical phase at small U and a trivially massive phase at large U with a first order transition separating the two. Another feature of our model is that it is symmetric under space-time rotations, which means the temporal and spatial lattice spacing are connected to each other. The unitary time evolution operator obtained by a Wick rotation of the transfer matrix of our model can help us compute the physics of the k = 1 WZW CFT in real time without the need for tuning the temporal lattice spacing to zero. We use this idea to introduce the concept of a relativistic quantum circuit on a discrete space-time lattice., Comment: 15 pages
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- 2023
17. Generalized Ginsparg-Wilson relations
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Clancy, Michael, Kaplan, David B., and Singh, Hersh
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High Energy Physics - Lattice ,Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory - Abstract
We give a general derivation of Ginsparg-Wilson relations for both Dirac and Majorana fermions in any dimension. These relations encode continuous and discrete chiral, parity and time reversal anomalies and will apply to the various classes of free fermion topological insulators and superconductors (in the framework of a relativistic quantum field theory in Euclidean spacetime). We show how to formulate the exact symmetries of the lattice action and the relevant index theorems for the anomalies., Comment: 14 pages. Submitted Version. Section III.D revised, and other minor improvements
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- 2023
18. Neural Network Solutions of Bosonic Quantum Systems in One Dimension
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Bedaque, Paulo F., Kumar, Hersh, and Sheng, Andy
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Nuclear Theory ,Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Quantum Gases ,Quantum Physics - Abstract
Neural networks have been proposed as efficient numerical wavefunction ansatze which can be used to variationally search a wide range of functional forms for ground state solutions. These neural network methods are also advantageous in that more variational parameters and system degrees of freedom can be easily added. We benchmark the methodology by using neural networks to study several different integrable bosonic quantum systems in one dimension and compare our results to the exact solutions. While testing the scalability of the procedure to systems with many particles, we also introduce using symmetric function inputs to the neural network to enforce exchange symmetries of indistinguishable particles., Comment: 12 pages, 8 figures
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- 2023
19. Dallas 2K: A Natural History Study of Depression (D2K)
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The Hersh Foundation and Madhukar H. Trivedi, MD, Professor
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- 2024
20. Coping Power -- Rural: Iterative Adaptation of an Evidence-Based Preventive Intervention for Rural Upper Elementary and Middle Schools
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Amanda J. Nguyen, Jacqueline Hersh, Lydia Beahm, Lora Henderson Smith, Courtney Newman, Katelyn Birchfield, Kurt Michael, and Catherine P. Bradshaw
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Background: Educators in rural schools are uniquely situated to address youth mental health disparities, yet often face challenges in delivering mental health supports. This paper describes the process of adapting the evidence-based Coping Power program, a small group prevention program for youth with aggressive behavior problems, to be a two-tiered (Tier 1 and Tier 2), transdiagnostic intervention to improve fit and feasibility for rural upper-elementary and middle schools. Method: Identified challenges with the Coping Power program for rural areas included program length, substantial staffing and resource requirements, lack of universal programming, low caregiver engagement, and co-occurring problems. Initial adaptations included a classroom and small group format implemented by school staff, teacher consultations integrated into coaching and co-facilitation, and a technology-supported caregiver component. Implementer feedback forms, coaching notes, and individual interviews informed the iterative development and feasibility testing process. Results: Between 2019-2023, thirteen schools across six rural districts implemented the program. Student curriculum revisions included order and relative emphasis of content, classroom and small group overlap, necessary simplification of concepts, improved contextualization to the rural setting, and the addition of student workbooks. Supports for implementers included fully developed lesson plans and slides, a comprehensive implementation manual, video lesson overviews, action-focused training, and a 3-session coaching model to support implementer preparation and sustain motivation. Teacher and caregiver infographic text "nudges" were improved to promote generalization of concepts across settings. Discussion: By partnering with school-based implementers, the adapted program holds promise to be more feasible and appealing for rural schools than the original model. This fully developed program is now ready for larger-scale testing in rural schools. [This paper was published in "School Mental Health."]
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- 2024
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21. Weakly Semi-Supervised Detection in Lung Ultrasound Videos
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Ouyang, Jiahong, Chen, Li, Li, Gary Y., Balaraju, Naveen, Patil, Shubham, Mehanian, Courosh, Kulhare, Sourabh, Millin, Rachel, Gregory, Kenton W., Gregory, Cynthia R., Zhu, Meihua, Kessler, David O., Malia, Laurie, Dessie, Almaz, Rabiner, Joni, Coneybeare, Di, Shopsin, Bo, Hersh, Andrew, Madar, Cristian, Shupp, Jeffrey, Johnson, Laura S., Avila, Jacob, Dwyer, Kristin, Weimersheimer, Peter, Raju, Balasundar, Kruecker, Jochen, and Chen, Alvin
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Frame-by-frame annotation of bounding boxes by clinical experts is often required to train fully supervised object detection models on medical video data. We propose a method for improving object detection in medical videos through weak supervision from video-level labels. More concretely, we aggregate individual detection predictions into video-level predictions and extend a teacher-student training strategy to provide additional supervision via a video-level loss. We also introduce improvements to the underlying teacher-student framework, including methods to improve the quality of pseudo-labels based on weak supervision and adaptive schemes to optimize knowledge transfer between the student and teacher networks. We apply this approach to the clinically important task of detecting lung consolidations (seen in respiratory infections such as COVID-19 pneumonia) in medical ultrasound videos. Experiments reveal that our framework improves detection accuracy and robustness compared to baseline semi-supervised models, and improves efficiency in data and annotation usage., Comment: IPMI 2023
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- 2023
22. Evidence of social learning across symbolic cultural barriers in sperm whales
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Leitão, António, Lucas, Maxime, Poetto, Simone, Hersh, Taylor A., Gero, Shane, Gruber, David, Bronstein, Michael, and Petri, Giovanni
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Computer Science - Social and Information Networks ,Statistics - Applications - Abstract
We provide quantitative evidence suggesting social learning in sperm whales across socio-cultural boundaries, using acoustic data from the Pacific and Atlantic Oceans. Traditionally, sperm whale populations are categorized into clans based on their vocal repertoire: the rhythmically patterned click sequences (codas) that they use. Among these codas, identity codas function as symbolic markers for each clan, accounting for 35-60% of codas they produce. We introduce a computational method to model whale speech, which encodes rhythmic micro-variations within codas, capturing their vocal style. We find that vocal style-clans closely align with repertoire-clans. However, contrary to vocal repertoire, we show that sympatry increases vocal style similarity between clans for non-identity codas, i.e. most codas, suggesting social learning across cultural boundaries. More broadly, this subcoda structure model offers a framework for comparing communication systems in other species, with potential implications for deeper understanding of vocal and cultural transmission within animal societies.
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- 2023
23. FastMRI Prostate: A Publicly Available, Biparametric MRI Dataset to Advance Machine Learning for Prostate Cancer Imaging
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Tibrewala, Radhika, Dutt, Tarun, Tong, Angela, Ginocchio, Luke, Keerthivasan, Mahesh B, Baete, Steven H, Chopra, Sumit, Lui, Yvonne W, Sodickson, Daniel K, Chandarana, Hersh, and Johnson, Patricia M
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Physics - Medical Physics ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
The fastMRI brain and knee dataset has enabled significant advances in exploring reconstruction methods for improving speed and image quality for Magnetic Resonance Imaging (MRI) via novel, clinically relevant reconstruction approaches. In this study, we describe the April 2023 expansion of the fastMRI dataset to include biparametric prostate MRI data acquired on a clinical population. The dataset consists of raw k-space and reconstructed images for T2-weighted and diffusion-weighted sequences along with slice-level labels that indicate the presence and grade of prostate cancer. As has been the case with fastMRI, increasing accessibility to raw prostate MRI data will further facilitate research in MR image reconstruction and evaluation with the larger goal of improving the utility of MRI for prostate cancer detection and evaluation. The dataset is available at https://fastmri.med.nyu.edu., Comment: 4 pages, 1 figure
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- 2023
24. Explanations of Black-Box Models based on Directional Feature Interactions
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Masoomi, Aria, Hill, Davin, Xu, Zhonghui, Hersh, Craig P, Silverman, Edwin K., Castaldi, Peter J., Ioannidis, Stratis, and Dy, Jennifer
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Computer Science - Machine Learning - Abstract
As machine learning algorithms are deployed ubiquitously to a variety of domains, it is imperative to make these often black-box models transparent. Several recent works explain black-box models by capturing the most influential features for prediction per instance; such explanation methods are univariate, as they characterize importance per feature. We extend univariate explanation to a higher-order; this enhances explainability, as bivariate methods can capture feature interactions in black-box models, represented as a directed graph. Analyzing this graph enables us to discover groups of features that are equally important (i.e., interchangeable), while the notion of directionality allows us to identify the most influential features. We apply our bivariate method on Shapley value explanations, and experimentally demonstrate the ability of directional explanations to discover feature interactions. We show the superiority of our method against state-of-the-art on CIFAR10, IMDB, Census, Divorce, Drug, and gene data.
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- 2023
25. Quantum Information Science and Technology for Nuclear Physics. Input into U.S. Long-Range Planning, 2023
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Beck, Douglas, Carlson, Joseph, Davoudi, Zohreh, Formaggio, Joseph, Quaglioni, Sofia, Savage, Martin, Barata, Joao, Bhattacharya, Tanmoy, Bishof, Michael, Cloet, Ian, Delgado, Andrea, DeMarco, Michael, Fink, Caleb, Florio, Adrien, Francois, Marianne, Grabowska, Dorota, Hoogerheide, Shannon, Huang, Mengyao, Ikeda, Kazuki, Illa, Marc, Joo, Kyungseon, Kharzeev, Dmitri, Kowalski, Karol, Lai, Wai Kin, Leach, Kyle, Loer, Ben, Low, Ian, Martin, Joshua, Moore, David, Mehen, Thomas, Mueller, Niklas, Mulligan, James, Mumm, Pieter, Pederiva, Francesco, Pisarski, Rob, Ploskon, Mateusz, Reddy, Sanjay, Rupak, Gautam, Singh, Hersh, Singh, Maninder, Stetcu, Ionel, Stryker, Jesse, Szypryt, Paul, Valgushev, Semeon, VanDevender, Brent, Watkins, Samuel, Wilson, Christopher, Yao, Xiaojun, Afanasev, Andrei, Balantekin, Akif Baha, Baroni, Alessandro, Bunker, Raymond, Chakraborty, Bipasha, Chernyshev, Ivan, Cirigliano, Vincenzo, Clark, Benjamin, Dhiman, Shashi Kumar, Du, Weijie, Dutta, Dipangkar, Edwards, Robert, Flores, Abraham, Galindo-Uribarri, Alfredo, Ruiz, Ronald Fernando Garcia, Gueorguiev, Vesselin, Guo, Fanqing, Hansen, Erin, Hernandez, Hector, Hattori, Koichi, Hauke, Philipp, Hjorth-Jensen, Morten, Jankowski, Keith, Johnson, Calvin, Lacroix, Denis, Lee, Dean, Lin, Huey-Wen, Liu, Xiaohui, Llanes-Estrada, Felipe J., Looney, John, Lukin, Misha, Mercenne, Alexis, Miller, Jeff, Mottola, Emil, Mueller, Berndt, Nachman, Benjamin, Negele, John, Orrell, John, Patwardhan, Amol, Phillips, Daniel, Poole, Stephen, Qualters, Irene, Rumore, Mike, Schaefer, Thomas, Scott, Jeremy, Singh, Rajeev, Vary, James, Galvez-Viruet, Juan-Jose, Wendt, Kyle, Xing, Hongxi, Yang, Liang, Young, Glenn, and Zhao, Fanyi
- Subjects
Nuclear Experiment ,Nuclear Theory ,Quantum Physics - Abstract
In preparation for the 2023 NSAC Long Range Plan (LRP), members of the Nuclear Science community gathered to discuss the current state of, and plans for further leveraging opportunities in, QIST in NP research at the Quantum Information Science for U.S. Nuclear Physics Long Range Planning workshop, held in Santa Fe, New Mexico on January 31 - February 1, 2023. The workshop included 45 in-person participants and 53 remote attendees. The outcome of the workshop identified strategic plans and requirements for the next 5-10 years to advance quantum sensing and quantum simulations within NP, and to develop a diverse quantum-ready workforce. The plans include resolutions endorsed by the participants to address the compelling scientific opportunities at the intersections of NP and QIST. These endorsements are aligned with similar affirmations by the LRP Computational Nuclear Physics and AI/ML Workshop, the Nuclear Structure, Reactions, and Astrophysics LRP Town Hall, and the Fundamental Symmetries, Neutrons, and Neutrinos LRP Town Hall communities., Comment: A white paper for the 2023 nuclear physics long-range planning activity, emerging from the workshop "Quantum Information Science for U.S. Nuclear Physics Long Range Planning'', held in Santa Fe, New Mexico on January 31 - February 1, 2023. 26 pages with 7 figures
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- 2023
26. Vacuum Entanglement Harvesting in the Ising Model
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Singh, Hersh, Bhattacharya, Tanmoy, Chandrasekharan, Shailesh, and Gupta, Rajan
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High Energy Physics - Lattice ,Quantum Physics - Abstract
The low-energy states of quantum many body systems, such as spin chains, are entangled. Using tensor network computations, we demonstrate a protocol that distills Bell pairs out of the ground state of the prototypical transverse-field Ising model. We explore the behavior of rate of entanglement distillation in various phases, and possible optimizations of the protocol. Finally, we comment on the protocol as we approach quantum criticality defining a continuum field theory., Comment: 21 pages, 8 figures, 5 tables
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- 2023
27. On the Feasibility of Machine Learning Augmented Magnetic Resonance for Point-of-Care Identification of Disease
- Author
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Singhal, Raghav, Sudarshan, Mukund, Mahishi, Anish, Kaushik, Sri, Ginocchio, Luke, Tong, Angela, Chandarana, Hersh, Sodickson, Daniel K., Ranganath, Rajesh, and Chopra, Sumit
- Subjects
Computer Science - Machine Learning - Abstract
Early detection of many life-threatening diseases (e.g., prostate and breast cancer) within at-risk population can improve clinical outcomes and reduce cost of care. While numerous disease-specific "screening" tests that are closer to Point-of-Care (POC) are in use for this task, their low specificity results in unnecessary biopsies, leading to avoidable patient trauma and wasteful healthcare spending. On the other hand, despite the high accuracy of Magnetic Resonance (MR) imaging in disease diagnosis, it is not used as a POC disease identification tool because of poor accessibility. The root cause of poor accessibility of MR stems from the requirement to reconstruct high-fidelity images, as it necessitates a lengthy and complex process of acquiring large quantities of high-quality k-space measurements. In this study we explore the feasibility of an ML-augmented MR pipeline that directly infers the disease sidestepping the image reconstruction process. We hypothesise that the disease classification task can be solved using a very small tailored subset of k-space data, compared to image reconstruction. Towards that end, we propose a method that performs two tasks: 1) identifies a subset of the k-space that maximizes disease identification accuracy, and 2) infers the disease directly using the identified k-space subset, bypassing the image reconstruction step. We validate our hypothesis by measuring the performance of the proposed system across multiple diseases and anatomies. We show that comparable performance to image-based classifiers, trained on images reconstructed with full k-space data, can be achieved using small quantities of data: 8% of the data for detecting multiple abnormalities in prostate and brain scans, and 5% of the data for knee abnormalities. To better understand the proposed approach and instigate future research, we provide an extensive analysis and release code.
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- 2023
28. A Topic Modeling Approach to Classifying Open Street Map Health Clinics and Schools in Sub-Saharan Africa
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Anderson, Joshua W., Encina, Luis Iñaki Alberro, Karippacheril, Tina George, Hersh, Jonathan, and Stringer, Cadence
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Computer Science - Machine Learning - Abstract
Data deprivation, or the lack of easily available and actionable information on the well-being of individuals, is a significant challenge for the developing world and an impediment to the design and operationalization of policies intended to alleviate poverty. In this paper we explore the suitability of data derived from OpenStreetMap to proxy for the location of two crucial public services: schools and health clinics. Thanks to the efforts of thousands of digital humanitarians, online mapping repositories such as OpenStreetMap contain millions of records on buildings and other structures, delineating both their location and often their use. Unfortunately much of this data is locked in complex, unstructured text rendering it seemingly unsuitable for classifying schools or clinics. We apply a scalable, unsupervised learning method to unlabeled OpenStreetMap building data to extract the location of schools and health clinics in ten countries in Africa. We find the topic modeling approach greatly improves performance versus reliance on structured keys alone. We validate our results by comparing schools and clinics identified by our OSM method versus those identified by the WHO, and describe OSM coverage gaps more broadly.
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- 2022
29. Generalized recursive atom ordering and equivalence to CL-shellability
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Hersh, Patricia and Stadnyk, Grace
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Mathematics - Combinatorics ,05E45, 06A07 - Abstract
Bj\"orner and Wachs introduced CL-shellability as a technique for studying the topological structure of order complexes of partially ordered sets (posets). They also introduced the notion of recursive atom ordering, and they proved that a finite bounded poset is CL-shellable if and only if it admits a recursive atom ordering. In this paper, a generalization of the notion of recursive atom ordering is introduced. A finite bounded poset is proven to admit such a generalized recursive atom ordering if and only if it admits a traditional recursive atom ordering. This is also proven equivalent to admitting a CC-shelling (a type of shelling introduced by Kozlov) with a further property called self-consistency. Thus, CL-shellability is proven equivalent to self-consistent CC-shellability. As an application, the uncrossing posets, namely the face posets for stratified spaces of planar electrical networks, are proven to be dual CL-shellable., Comment: Significant revisions, version accepted to Combinatorial Theory
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- 2022
30. Preparation for Quantum Simulation of the 1+1D O(3) Non-linear {\sigma}-Model using Cold Atoms
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Ciavarella, Anthony N., Caspar, Stephan, Singh, Hersh, and Savage, Martin J.
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Quantum Physics ,Condensed Matter - Quantum Gases ,High Energy Physics - Lattice ,Nuclear Theory - Abstract
The 1+1D O(3) non-linear {\sigma}-model is a model system for future quantum lattice simulations of other asymptotically-free theories, such as non-Abelian gauge theories. We find that utilizing dimensional reduction can make efficient use of two-dimensional layouts presently available on cold atom quantum simulators. A new definition of the renormalized coupling is introduced, which is applicable to systems with open boundary conditions and can be measured using analog quantum simulators. Monte Carlo and tensor network calculations are performed to determine the quantum resources required to reproduce perturbative short-distance observables. In particular, we show that a rectangular array of 48 Rydberg atoms with existing quantum hardware capabilities should be able to adiabatically prepare low-energy states of the perturbatively-matched theory. These states can then be used to simulate non-perturbative observables in the continuum limit that lie beyond the reach of classical computers., Comment: 12 pages, 5 figures, 2 tables, published version
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- 2022
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31. Cold Neutron-Deuteron Capture and Wigner-SU(4) Symmetry
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Lin, Xincheng, Singh, Hersh, Springer, Roxanne P., and Vanasse, Jared
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Nuclear Theory - Abstract
We calculate the cold neutron-deuteron ($nd$) capture cross section, $\sigma_{nd}$, to next-to-next-to leading order (NNLO) using the model-independent approach of pionless effective field theory (EFT($\pi\!\!\!/$)). At leading order we find $\sigma_{nd} = 0.315 \pm 0.217$ mb, while the experimental result is 0.508(15) mb [Jurney, Bendt and Browne in Phys. Rev. C 25, 2810 (1982)] for a laboratory neutron velocity of 2200 m/s. At next-to-leading-order (NLO), we show that $\sigma_{nd}$ is sensitive to the low energy constant (LEC), $L_1^{(0)}$, of the two-nucleon isovector current appearing at NLO. A fit of $L_1^{(0)}$ at NLO to the triton magnetic moment yields a NLO prediction of $\sigma_{nd}=0.393 \pm 0.164$ mb, where the error comes from propagating the error from the $L_1^{(0)}$ fit. At next-to-next-to-leading-order (NNLO), we find that a new three-nucleon magnetic moment counterterm is required for renormalization group invariance of both $\sigma_{nd}$ and the triton magnetic moment. Fitting the NNLO correction to $L_1^{(0)}$ (denoted $L_1^{(1)}$) to cold neutron-proton capture ($\sigma_{np}$) yields a NNLO prediction of $\sigma_{nd}=0.447 \pm 0.130$ mb, where the error comes from propagating the error from the $L_1^{(1)}$ fit. We also study different fittings of $L_1^{(0)}$ and $L_1^{(1)}$ to $\sigma_{np}$, $\sigma_{nd}$, and/or the triton magnetic moment. For example, fitting $L_1^{(0)}$ simultaneously to $\sigma_{np}$, $\sigma_{nd}$, and the triton magnetic moment at NLO, and fitting $L_1^{(1)}$ simultaneously to $\sigma_{np}$ and $\sigma_{nd}$ at NNLO, yields $\sigma_{nd} = 0.480 \pm 0.114$ mb and $0.511 \pm 0.042$ mb, respectively, where errors are naively estimated from EFT($\pi\!\!\!/$) power counting. In addition, we discuss how Wigner-SU(4) symmetry may alter the naive EFT($\pi\!\!\!/$) expansion of $\sigma_{nd}$., Comment: 61 pages, 10 figures, version published in PRC. Some typos and errors in numerical results are fixed compared to the previous version
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- 2022
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32. Lattice regularizations of $\theta$ vacua: Anomalies and qubit models
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Nguyen, Mendel and Singh, Hersh
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High Energy Physics - Lattice ,Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Nuclear Theory ,Quantum Physics - Abstract
Anomalies are a powerful way to gain insight into possible lattice regularizations of a quantum field theory. In this work, we argue that the continuum anomaly for a given symmetry can be matched by a manifestly-symmetric, local, lattice regularization in the same spacetime dimensionality only if (i) the symmetry action is offsite, or (ii) if the continuum anomaly is reproduced exactly on the lattice. We consider lattice regularizations of a class of prototype models of QCD: the (1+1)-dimensional asymptotically-free Grassmannian nonlinear sigma models (NLSMs) with a $\theta$ term. Using the Grassmannian NLSMs as a case study, we provide examples of lattice regularizations in which both possibilities are realized. For possibility (i), we argue that Grassmannian NLSMs can be obtained from $\mathrm{SU}(N)$ antiferromagnets with a well-defined continuum limit, reproducing both the infrared physics of $\theta$ vacua and the ultraviolet physics of asymptotic freedom. These results enable the application of new classical algorithms to lattice Monte Carlo studies of these quantum field theories, and provide a viable realization suited for their quantum simulation. On the other hand, we show that, perhaps surprisingly, the conventional lattice regularization of $\theta$ vacua due to Berg and L\"uscher reproduces the anomaly exactly on the lattice, providing a realization of the second possibility., Comment: 10 pages + appendices
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- 2022
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33. Recent Approaches for Perceptive Legged Locomotion
- Author
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Sanghvi, Hersh
- Subjects
Computer Science - Robotics - Abstract
As both legged robots and embedded compute have become more capable, researchers have started to focus on field deployment of these robots. Robust autonomy in unstructured environments requires perception of the world around the robot in order to avoid hazards. However, incorporating perception online while maintaining agile motion is more challenging for legged robots than other mobile robots due to the complex planners and controllers required to handle the dynamics of locomotion. This report will compare three recent approaches for perceptive locomotion and discuss the different ways in which vision can be used to enable legged autonomy., Comment: 40 pages, 11 figures
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- 2022
34. SynthA1c: Towards Clinically Interpretable Patient Representations for Diabetes Risk Stratification
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Yao, Michael S., Chae, Allison, MacLean, Matthew T., Verma, Anurag, Duda, Jeffrey, Gee, James, Torigian, Drew A., Rader, Daniel, Kahn, Charles, Witschey, Walter R., and Sagreiya, Hersh
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Image and Video Processing ,Quantitative Biology - Quantitative Methods - Abstract
Early diagnosis of Type 2 Diabetes Mellitus (T2DM) is crucial to enable timely therapeutic interventions and lifestyle modifications. As the time available for clinical office visits shortens and medical imaging data become more widely available, patient image data could be used to opportunistically identify patients for additional T2DM diagnostic workup by physicians. We investigated whether image-derived phenotypic data could be leveraged in tabular learning classifier models to predict T2DM risk in an automated fashion to flag high-risk patients without the need for additional blood laboratory measurements. In contrast to traditional binary classifiers, we leverage neural networks and decision tree models to represent patient data as 'SynthA1c' latent variables, which mimic blood hemoglobin A1c empirical lab measurements, that achieve sensitivities as high as 87.6%. To evaluate how SynthA1c models may generalize to other patient populations, we introduce a novel generalizable metric that uses vanilla data augmentation techniques to predict model performance on input out-of-domain covariates. We show that image-derived phenotypes and physical examination data together can accurately predict diabetes risk as a means of opportunistic risk stratification enabled by artificial intelligence and medical imaging. Our code is available at https://github.com/allisonjchae/DMT2RiskAssessment., Comment: 12 pages. Accepted to PRIME MICCAI 2023
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- 2022
35. How many quantum gates do gauge theories require?
- Author
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Murairi, Edison M., Cervia, Michael J., Kumar, Hersh, Bedaque, Paulo F., and Alexandru, Andrei
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High Energy Physics - Lattice ,Nuclear Theory ,Quantum Physics - Abstract
We discuss the implementation of lattice gauge theories on digital quantum computers, focusing primarily on the number of quantum gates required to simulate their time evolution. We find that to compile quantum circuits, using available state-of-the-art methods with our own augmentations, the cost of a single time step of an elementary plaquette is beyond what is reasonably practical in the current era of quantum hardware. However, we observe that such costs are highly sensitive to the truncation scheme used to derive different Hamiltonian formulations of non-Abelian gauge theories, emphasizing the need for low-dimensional truncations of such models in the same universality class as the desired theories., Comment: 14 pages of RevTeX, 7 figures
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- 2022
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36. Simulating Heisenberg Interactions in the Ising Model with Strong Drive Fields
- Author
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Ciavarella, Anthony N., Caspar, Stephan, Singh, Hersh, Savage, Martin J., and Lougovski, Pavel
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Quantum Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Lattice - Abstract
The time-evolution of an Ising model with large driving fields over discrete time intervals is shown to be reproduced by an effective XXZ-Heisenberg model at leading order in the inverse field strength. For specific orientations of the drive field, the dynamics of the XXX-Heisenberg model is reproduced. These approximate equivalences, valid above a critical driving field strength set by dynamical phase transitions in the Ising model, are expected to enable quantum devices that natively evolve qubits according to the Ising model to simulate more complex systems., Comment: 10 pages, 5 figures, accepted version
- Published
- 2022
37. Evaluating a Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, or Conduct Problems (MATCH) in School-Based Mental Health Care: Study Protocol for a Randomized Controlled Trial
- Author
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Harmon, Sherelle L., Price, Maggi A., Corteselli, Katherine A., Lee, Erica H., Metz, Kristina, Bonadio, F. Tony, Hersh, Jacqueline, Marchette, Lauren K., Rodríguez, Gabriela M., Raftery-Helmer, Jacquelyn, Thomassin, Kristel, Bearman, Sarah Kate, Jensen-Doss, Amanda, Evans, Spencer C., and Weisz, John R.
- Abstract
Introduction: Schools have become a primary setting for providing mental health care to youths in the U.S. School-based interventions have proliferated, but their effects on mental health and academic outcomes remain understudied. In this study we will implement and evaluate the effects of a flexible multidiagnostic treatment called Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, or Conduct Problems (MATCH) on students' mental health and academic outcomes. Methods and Analysis: This is an assessor-blind randomized controlled effectiveness trial conducted across five school districts. School clinicians are randomized to either MATCH or usual care (UC) treatment conditions. The target sample includes 168 youths (ages 7-14) referred for mental health services and presenting with elevated symptoms of anxiety, depression, trauma, and/or conduct problems. Clinicians randomly assigned to MATCH or UC treat the youths who are assigned to them through normal school referral procedures. The project will evaluate the effectiveness of MATCH compared to UC on youths' mental health and school related outcomes and assess whether changes in school outcomes are mediated by changes in youth mental health.
- Published
- 2021
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38. From asymptotic freedom to $\theta$ vacua: Qubit embeddings of the O(3) nonlinear $\sigma$ model
- Author
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Caspar, Stephan and Singh, Hersh
- Subjects
High Energy Physics - Lattice ,Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Quantum Physics - Abstract
Conventional lattice formulations of $\theta$ vacua in the $1+1$-dimensional $\text{O}(3)$ nonlinear sigma model suffer from a sign problem. Here, we construct the first sign-problem-free regularization for arbitrary $\theta$. Using efficient lattice Monte Carlo algorithms, we demonstrate how a Hamiltonian model of spin-$\tfrac12$ degrees of freedom on a 2-dimensional spatial lattice reproduces both the infrared sector for arbitrary $\theta$, as well as the ultraviolet physics of asymptotic freedom. Furthermore, as a model of qubits on a two-dimensional square lattice with only nearest-neighbor interactions, it is naturally suited for studying the physics of $\theta$ vacua and asymptotic freedom on near-term quantum devices. Our construction generalizes to $\theta$ vacua in all $\text{CP}(N-1)$ models, solving a long standing sign problem., Comment: 7 pages, 4 figures
- Published
- 2022
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39. Large-charge conformal dimensions at the $O(N)$ Wilson-Fisher fixed point
- Author
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Singh, Hersh
- Subjects
High Energy Physics - Lattice - Abstract
Recent work using a large-charge expansion for the $O(N)$ Wilson-Fisher conformal field theory has shown that the anomalous dimensions of large-charge operators can be expressed in terms of a few low-energy constants (LECs) of a large-charge effective field theory (EFT). By performing lattice Monte Carlo computations at the $O(N)$ Wilson-Fisher fixed point, we compute the anomalous dimensions of large-charge operators up to $N=8$ and charge $Q=10$, and extract the leading and subleading LECs of the $O(N)$ large-charge EFT. To alleviate the signal-to-noise ratio problem present in the large-charge sector of conventional lattice formulations of the $O(N)$ theory, we employ a recently developed qubit formulation of the $O(N)$ nonlinear sigma models with a worm algorithm. This enables us to test the validity of the large-charge expansion and the recent large-$N$ predictions for the coefficients of the large-charge EFT., Comment: 12 pages, 9 figures
- Published
- 2022
40. Fast Footstep Planning on Uneven Terrain Using Deep Sequential Models
- Author
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Sanghvi, Hersh and Taylor, Camillo Jose
- Subjects
Computer Science - Robotics - Abstract
One of the fundamental challenges in realizing the potential of legged robots is generating plans to traverse challenging terrains. Control actions must be carefully selected so the robot will not crash or slip. The high dimensionality of the joint space makes directly planning low-level actions from onboard perception difficult, and control stacks that do not consider the low-level mechanisms of the robot in planning are ill-suited to handle fine-grained obstacles. One method for dealing with this is selecting footstep locations based on terrain characteristics. However, incorporating robot dynamics into footstep planning requires significant computation, much more than in the quasi-static case. In this work, we present an LSTM-based planning framework that learns probability distributions over likely footstep locations using both terrain lookahead and the robot's dynamics, and leverages the LSTM's sequential nature to find footsteps in linear time. Our framework can also be used as a module to speed up sampling-based planners. We validate our approach on a simulated one-legged hopper over a variety of uneven terrains., Comment: 6 pages, 4 figures, accepted to ICRA 2022
- Published
- 2021
41. Space-time symmetric qubit regularization of the asymptotically free two-dimensional O(4) model
- Author
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Zhou, Junzhe, Singh, Hersh, Bhattacharya, Tanmoy, Chandrasekharan, Shailesh, and Gupta, Rajan
- Subjects
High Energy Physics - Lattice ,Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Nuclear Theory ,Quantum Physics - Abstract
We explore if space-time symmetric lattice field theory models with a finite Hilbert space per lattice site can reproduce asymptotic freedom in the two-dimensional $O(4)$ model. We focus on a simple class of such models with a five dimensional local Hilbert space. We demonstrate how even the simplest model reproduces asymptotic freedom within the D-theory formalism but at the cost of increasing the size of the Hilbert space through coupling several layers of a two-dimensional lattice. We then argue that qubit regularization can be viewed as an effective field theory (EFT) even if the continuum limit cannot be reached, as long as we can tune the model close enough to the continuum limit where perturbation theory, or other analytical techniques, become viable. We construct a simple lattice model on a single layer with a four dimensional local Hilbert space that acts like an excellent EFT of the original theory., Comment: 11 pages, 6 figures
- Published
- 2021
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42. Accounting for data heterogeneity in integrative analysis and prediction methods: An application to Chronic Obstructive Pulmonary Disease
- Author
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Butts, J., Wendt, C., Bowler, R., Hersh, C. P., Long, Q., Eberly, L., and Safo, S. E.
- Subjects
Statistics - Methodology - Abstract
Epidemiologic and genetic studies in chronic obstructive pulmonary disease (COPD) and many complex diseases suggest subgroup disparities (e.g., by sex). We consider this problem from the standpoint of integrative analysis where we combine information from different views (e.g., genomics, proteomics, clinical data). Existing integrative analysis methods ignore the heterogeneity in subgroups, and stacking the views and accounting for subgroup heterogeneity does not model the association among the views. To address analytical challenges in the problem of our interest, we propose a statistical approach for joint association and prediction that leverages the strengths in each view to identify molecular signatures that are shared by and specific to males and females and that contribute to the variation in COPD, measured by airway wall thickness. HIP (Heterogeneity in Integration and Prediction) accounts for subgroup heterogeneity, allows for sparsity in variable selection, is applicable to multi-class and to univariate or multivariate continuous outcomes, and incorporates covariate adjustment. We develop efficient algorithms in PyTorch. Our COPD findings have identified several proteins, genes, and pathways that are common and specific to males and females, some of which have been implicated in COPD, while others could lead to new insights into sex differences in COPD mechanisms.
- Published
- 2021
43. Robust Integrative Biclustering for Multi-view Data
- Author
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Zhang, W., Wendt, C., Bowler, R., Hersh, C. P., and Safo, S. E.
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Statistics - Methodology - Abstract
In many biomedical research, multiple views of data (e.g., genomics, proteomics) are available, and a particular interest might be the detection of sample subgroups characterized by specific groups of variables. Biclustering methods are well-suited for this problem as they assume that specific groups of variables might be relevant only to specific groups of samples. Many biclustering methods exist for identifying row-column clusters in a view but few methods exist for data from multiple views. The few existing algorithms are heavily dependent on regularization parameters for getting row-column clusters, and they impose unnecessary burden on users thus limiting their use in practice. We extend an existing biclustering method based on sparse singular value decomposition for single-view data to data from multiple views. Our method, integrative sparse singular value decomposition (iSSVD), incorporates stability selection to control Type I error rates, estimates the probability of samples and variables to belong to a bicluster, finds stable biclusters, and results in interpretable row-column associations. Simulations and real data analyses show that iSSVD outperforms several other single- and multi-view biclustering methods and is able to detect meaningful biclusters. iSSVD is a user-friendly, computationally efficient algorithm that will be useful in many disease subtyping applications.
- Published
- 2021
44. Searching for Scientific Evidence in a Pandemic: An Overview of TREC-COVID
- Author
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Roberts, Kirk, Alam, Tasmeer, Bedrick, Steven, Demner-Fushman, Dina, Lo, Kyle, Soboroff, Ian, Voorhees, Ellen, Wang, Lucy Lu, and Hersh, William R
- Subjects
Computer Science - Information Retrieval - Abstract
We present an overview of the TREC-COVID Challenge, an information retrieval (IR) shared task to evaluate search on scientific literature related to COVID-19. The goals of TREC-COVID include the construction of a pandemic search test collection and the evaluation of IR methods for COVID-19. The challenge was conducted over five rounds from April to July, 2020, with participation from 92 unique teams and 556 individual submissions. A total of 50 topics (sets of related queries) were used in the evaluation, starting at 30 topics for Round 1 and adding 5 new topics per round to target emerging topics at that state of the still-emerging pandemic. This paper provides a comprehensive overview of the structure and results of TREC-COVID. Specifically, the paper provides details on the background, task structure, topic structure, corpus, participation, pooling, assessment, judgments, results, top-performing systems, lessons learned, and benchmark datasets.
- Published
- 2021
45. sJIVE: Supervised Joint and Individual Variation Explained
- Author
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Palzer, Elise F., Wendt, Christine, Bowler, Russell, Hersh, Craig P., Safo, Sandra E., and Lock, Eric F.
- Subjects
Statistics - Machine Learning ,Computer Science - Machine Learning ,Quantitative Biology - Quantitative Methods ,Statistics - Methodology - Abstract
Analyzing multi-source data, which are multiple views of data on the same subjects, has become increasingly common in molecular biomedical research. Recent methods have sought to uncover underlying structure and relationships within and/or between the data sources, and other methods have sought to build a predictive model for an outcome using all sources. However, existing methods that do both are presently limited because they either (1) only consider data structure shared by all datasets while ignoring structures unique to each source, or (2) they extract underlying structures first without consideration to the outcome. We propose a method called supervised joint and individual variation explained (sJIVE) that can simultaneously (1) identify shared (joint) and source-specific (individual) underlying structure and (2) build a linear prediction model for an outcome using these structures. These two components are weighted to compromise between explaining variation in the multi-source data and in the outcome. Simulations show sJIVE to outperform existing methods when large amounts of noise are present in the multi-source data. An application to data from the COPDGene study reveals gene expression and proteomic patterns that are predictive of lung function. Functions to perform sJIVE are included in the R.JIVE package, available online at http://github.com/lockEF/r.jive ., Comment: 23 pages, 8 tables, 3 figures
- Published
- 2021
46. Qubit regularization of asymptotic freedom
- Author
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Bhattacharya, Tanmoy, Buser, Alexander J., Chandrasekharan, Shailesh, Gupta, Rajan, and Singh, Hersh
- Subjects
High Energy Physics - Lattice ,Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Nuclear Theory ,Quantum Physics - Abstract
We provide strong evidence that the asymptotically free (1+1)-dimensional non-linear O(3) sigma model can be regularized using a quantum lattice Hamiltonian, referred to as the "Heisenberg-comb", that acts on a Hilbert space with only two qubits per spatial lattice site. The Heisenberg-comb consists of a spin-half anti-ferromagnetic Heisenberg-chain coupled anti-ferromagnetically to a second local spin-half particle at every lattice site. Using a world-line Monte Carlo method we show that the model reproduces the universal step-scaling function of the traditional model up to correlation lengths of 200,000 in lattice units and argue how the continuum limit could emerge. We provide a quantum circuit description of time-evolution of the model and argue that near-term quantum computers may suffice to demonstrate asymptotic freedom., Comment: 6 pages, 4 figures. Published version
- Published
- 2020
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47. Monitoring War Destruction from Space: A Machine Learning Approach
- Author
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Mueller, Hannes, Groger, Andre, Hersh, Jonathan, Matranga, Andrea, and Serrat, Joan
- Subjects
Economics - General Economics ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Existing data on building destruction in conflict zones rely on eyewitness reports or manual detection, which makes it generally scarce, incomplete and potentially biased. This lack of reliable data imposes severe limitations for media reporting, humanitarian relief efforts, human rights monitoring, reconstruction initiatives, and academic studies of violent conflict. This article introduces an automated method of measuring destruction in high-resolution satellite images using deep learning techniques combined with data augmentation to expand training samples. We apply this method to the Syrian civil war and reconstruct the evolution of damage in major cities across the country. The approach allows generating destruction data with unprecedented scope, resolution, and frequency - only limited by the available satellite imagery - which can alleviate data limitations decisively.
- Published
- 2020
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48. Characterizing Hirability via Personality and Behavior
- Author
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Malik, Harshit, Dhillon, Hersh, Goecke, Roland, and Subramanian, Ramanathan
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
While personality traits have been extensively modeled as behavioral constructs, we model \textbf{\textit{job hirability}} as a \emph{personality construct}. On the {\emph{First Impressions Candidate Screening}} (FICS) dataset, we examine relationships among personality and hirability measures. Modeling hirability as a discrete/continuous variable with the \emph{big-five} personality traits as predictors, we utilize (a) apparent personality annotations, and (b) personality estimates obtained via audio, visual and textual cues for hirability prediction (HP). We also examine the efficacy of a two-step HP process involving (1) personality estimation from multimodal behavioral cues, followed by (2) HP from personality estimates. Interesting results from experiments performed on $\approx$~5000 FICS videos are as follows. (1) For each of the \emph{text}, \emph{audio} and \emph{visual} modalities, HP via the above two-step process is more effective than directly predicting from behavioral cues. Superior results are achieved when hirability is modeled as a continuous vis-\'a-vis categorical variable. (2) Among visual cues, eye and bodily information achieve performance comparable to face cues for predicting personality and hirability. (3) Explanatory analyses reveal the impact of multimodal behavior on personality impressions; \eg, Conscientiousness impressions are impacted by the use of \emph{cuss words} (verbal behavior), and \emph{eye movements} (non-verbal behavior), confirming prior observations., Comment: 9 pages
- Published
- 2020
49. Optimization of MR Fingerprinting for Free-Breathing Quantitative Abdominal Imaging
- Author
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van Riel, Max H. C., Yu, Zidan, Hodono, Shota, Xia, Ding, Chandarana, Hersh, Fujimoto, Koji, and Cloos, Martijn A.
- Subjects
Physics - Medical Physics ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
In this work, we propose a free-breathing magnetic resonance fingerprinting method that can be used to obtain $B_1^+$-robust quantitative maps of the abdomen in a clinically acceptable time. A three-dimensional MR fingerprinting sequence with a radial stack-of-stars trajectory was implemented for quantitative abdominal imaging. The k-space acquisition ordering was adjusted to improve motion-robustness. The flip angle pattern was optimized using the Cram\'er-Rao Lower Bound, and the encoding efficiency of sequences with 300, 600, 900, and 1800 flip angles was evaluated. To validate the sequence, a movable multicompartment phantom was developed. Reference multiparametric maps were acquired under stationary conditions using a previously validated MRF method. Periodic motion of the phantom was used to investigate the motion-robustness of the proposed sequence. The best performing sequence length (600 flip angles) was used to image the abdomen during a free-breathing volunteer scan. When using a series of 600 or more flip angles, the estimated $T_1$ values in the stationary phantom showed good agreement with the reference scan. Phantom experiments revealed that motion-related artefacts can appear in the quantitative maps, and confirmed that a motion-robust k-space ordering is essential in preventing these artefacts. The in vivo scan demonstrated that the proposed sequence can produce clean parameter maps while the subject breathes freely. Using this sequence, it is possible to generate $B_1^+$-robust quantitative maps of proton density, $T_1$, and $B_1^+$ under free-breathing conditions at a clinically usable resolution within 5 minutes., Comment: 14 pages, 7 figures, 9 supplementary figures
- Published
- 2020
50. TREC-COVID: Constructing a Pandemic Information Retrieval Test Collection
- Author
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Voorhees, Ellen, Alam, Tasmeer, Bedrick, Steven, Demner-Fushman, Dina, Hersh, William R, Lo, Kyle, Roberts, Kirk, Soboroff, Ian, and Wang, Lucy Lu
- Subjects
Computer Science - Information Retrieval ,H.3.0 - Abstract
TREC-COVID is a community evaluation designed to build a test collection that captures the information needs of biomedical researchers using the scientific literature during a pandemic. One of the key characteristics of pandemic search is the accelerated rate of change: the topics of interest evolve as the pandemic progresses and the scientific literature in the area explodes. The COVID-19 pandemic provides an opportunity to capture this progression as it happens. TREC-COVID, in creating a test collection around COVID-19 literature, is building infrastructure to support new research and technologies in pandemic search., Comment: 10 pages, 5 figures. TREC-COVID web site: http://ir.nist.gov/covidSubmit/ Will also appear in June 2020 issue of ACM SIGIR Forum
- Published
- 2020
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