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Photonic hooks (PHs) are non-evanescent light beams with a highly concentrated curved optical fields. Since their discovery, PHs always have one single inflection point and thus have a hook-like structure. In this work, a new type of PHs with two inflection points and S-shaped structures (S-PHs) were reported for the first time. We theoretically studied the effects of various physical parameters on the generation of S-PHs. Furthermore, we showed that decorating particles with multiple patches can significantly enhance the curvature and length of the S-PHs. The S-PHs may have potential applications in super-resolution imaging, sub-wavelength micromachining, particle and cell manipulation, etc., Comment: 8 pages, 6 figures

Web search heavily relies on click-through behavior as an essential feedback signal for performance improvement and evaluation. Traditionally, click is usually treated as a positive implicit feedback signal of relevance or usefulness, while non-click (especially non-click after examination) is regarded as a signal of irrelevance or uselessness. However, there are many cases where users do not click on any search results but still satisfy their information need with the contents of the results shown on the Search Engine Result Page (SERP). This raises the problem of measuring result usefulness and modeling user satisfaction in "Zero-click" search scenarios. Previous works have solved this issue by (1) detecting user satisfaction for abandoned SERP with context information and (2) considering result-level click necessity with external assessors' annotations. However, few works have investigated the reason behind non-click behavior and estimated the usefulness of non-click results. A challenge for this research question is how to collect valuable feedback for non-click results. With neuroimaging technologies, we design a lab-based user study and reveal differences in brain signals while examining non-click search results with different usefulness levels. The findings in significant brain regions and electroencephalogram~(EEG) spectrum also suggest that the process of usefulness judgment might involve similar cognitive functions of relevance perception and satisfaction decoding. Inspired by these findings, we conduct supervised learning tasks to estimate the usefulness of non-click results with brain signals and conventional information (i.e., content and context factors). Results show that it is feasible to utilize brain signals to improve usefulness estimation performance and enhancing human-computer interactions in "Zero-click" search scenarios.

We report a computational 3D microscopy technique, termed Fourier ptychographic diffraction tomography (FPDT), that iteratively stitches together numerous variably illuminated, low-resolution images acquired with a low-numerical aperture (NA) objective in 3D Fourier space to create a wide field-of-view (FOV), high-resolution, depth-resolved complex refractive index (RI) image across large volumes. Unlike conventional optical diffraction tomography (ODT) approaches that rely on controlled bright-field illumination, holographic phase measurement, and high-NA objective detection, FPDT employs tomographic RI reconstruction from low-NA intensity-only measurements. In addition, FPDT incorporates high-angle dark-field illuminations beyond the NA of the objective, significantly expanding the accessible object frequency. With FPDT, we present the highest-throughput ODT results with 390nm lateral resolution and 899nm axial resolution across a 10X FOV of 1.77mm2 and a depth of focus of ~20{\mu}m. Billion-voxel 3D tomographic imaging results of biological samples establish FPDT as a powerful non-invasive and label-free tool for high-throughput 3D microscopy applications.

We demonstrate a label-free, scan-free {\it intensity} diffraction tomography technique utilizing annular illumination (aIDT) to rapidly characterize large-volume 3D refractive index distributions in vitro. By optimally matching the illumination geometry to the microscope pupil, our technique reduces the data requirement by 60$\times$ to achieve high-speed 10 Hz volume rates. Using 8 intensity images, we recover $\sim350\times100\times20\mu$m$^3$ volumes with near diffraction-limited lateral resolution of 487 nm and axial resolution of 3.4 $\mu$m. Our technique's large volume rate and high resolution enables 3D quantitative phase imaging of complex living biological samples across multiple length scales. We demonstrate aIDT's capabilities on unicellular diatom microalgae, epithelial buccal cell clusters with native bacteria, and live \emph{Caenorhabditis elegans} specimens. Within these samples, we recover macro-scale cellular structures, subcellular organelles, and dynamic micro-organism tissues with minimal motion artifacts. Quantifying such features has significant utility in oncology, immunology, and cellular pathophysiology, where these morphological features are evaluated for changes in the presence of disease, parasites, and new drug treatments. Finally, we simulate our aIDT system to highlight the accuracy and sensitivity of our technique. aIDT shows promise as a powerful high-speed, label-free computational microscopy technique applications where natural imaging is required to evaluate environmental effects on a sample in real-time. We provide example datasets and an open source implementation of aIDT at \href{https://github.com/bu-cisl/IDT-using-Annular-Illumination}{https://github.com/bu-cisl/IDT-using-Annular-Illumination}.

The transport-of-intensity equation (TIE) is a well-established non-interferometric phase retrieval approach, which enables quantitative phase imaging (QPI) of transparent sample simply by measuring the intensities at multiple axially displaced planes. Nevertheless, it still suffers from two fundamentally limitations. First, it is quite susceptible to low-frequency errors (such as \cloudy" artifacts), which results from the poor contrast of the phase transfer function (PTF) near the zero frequency. Second, the reconstructed phase tends to blur under spatially low-coherent illumination, especially when the defocus distance is beyond the near Fresnel region. Recent studies have shown that the shape of the illumination aperture has a significant impact on the resolution and phase reconstruction quality, and by simply replacing the conventional circular illumination aperture with an annular one, these two limitations can be addressed, or at least significantly alleviated. However, the annular aperture was previously empirically designed based on intuitive criteria related to the shape of PTF, which does not guarantee optimality. In this work, we optimize the illumination pattern to maximize TIE's performance based on a combined quantitative criterion for evaluating the \goodness" of an aperture. In order to make the size of the solution search space tractable, we restrict our attention to binary coded axis-symmetric illumination patterns only, which are easier to implement and can generate isotropic TIE PTFs. We test the obtained optimal illumination by imaging both a phase resolution target and HeLa cells based on a small-pitch LED array, suggesting superior performance over other suboptimal patterns in terms of both signal-to-noise ratio (SNR) and spatial resolution., Comment: 15 pages, 8 figures

We demonstrate a three-dimensional (3D) optical diffraction tomographic technique with optimal frequency combination (OFC-ODT) for the 3D quantitative phase imaging of unlabeled specimens. Three sets of through-focus intensity images are captured under an annular aperture and two circular apertures with different coherence parameters. The 3D phase optical transfer functions (POTF) corresponding to different illumination apertures are combined to obtain an optimally synthesized frequency response, achieving high-quality, low-noise 3D reconstructions with imaging resolution up to the incoherent diffraction limit. Besides, the 3D imaging performance of annular illumination is explored and the expression of 3D POTF for arbitrary illumination pupils is derived and analyzed. It is shown that the phase-contrast washout effect in high-NA circular apertures can be effectively addressed by introducing a complementary annular aperture, which strongly boosts the phase contrast and improves the practical imaging resolution. To test the feasibility of the proposed OFC-ODT technique, the 3D refractive index reconstruction results based on a simulated 3D resolution target and experimental investigations of micro polystyrene bead and unstained biological samples are presented. Due to its capability of high-resolution 3D phase imaging as well as the compatibility with widely available commercial microscope, the OFC-ODT is expected to find versatile applications in biological and biomedical research.

In this work, we present a highly efficient quantitative phase imaging (QPI) approach using programmable annular LED illumination based on traditional bright-field microscope. As a new type of coded illumination, the LED array provides a flexible and compatible way to realize QPI. The proposed method modulates the transfer function of system by changing the LED illumination pattern, which achieves twice resolution of objective NA and gives noise-robust response of transfer function. The phase of a sample could be recovered from the intensity images with the inversion of transfer function. Moreover, the weak object transfer function (WOTF) of axisymmetric oblique source is derived, and the noise-free and noisy simulation results sufficiently validate the applicability of discrete annular source. The quantitative phase measurements of micro polystyrene bead and visible blazed transmission grating demonstrate the accuracy of proposed method. Finally, the experimental investigations of unstained human cancer cells using different types objective are presented, and these results show the possibility of widespread adoption of QPI in the morphology study of cellular processes and biomedical community., Comment: 18 page, 8 figures

High-resolution wide field-of-view (FOV) microscopic imaging plays an essential role in various fields of biomedicine, engineering, and physical sciences. As an alternative to conventional lens-based scanning techniques, lensfree holography provides a new way to effectively bypass the intrinsical trade-off between the spatial resolution and FOV of conventional microscopes. Unfortunately, due to the limited sensor pixel-size, unpredictable disturbance during image acquisition, and sub-optimum solution to the phase retrieval problem, typical lensfree microscopes only produce compromised imaging quality in terms of lateral resolution and signal-to-noise ratio (SNR). Here, we propose an adaptive pixel-super-resolved lensfree imaging (APLI) method which can solve, or at least partially alleviate these limitations. Our approach addresses the pixel aliasing problem by Z-scanning only, without resorting to subpixel shifting or beam-angle manipulation. Automatic positional error correction algorithm and adaptive relaxation strategy are introduced to enhance the robustness and SNR of reconstruction significantly. Based on APLI, we perform full-FOV reconstruction of a USAF resolution target ($\sim$29.85 $m{m^2}$) and achieve half-pitch lateral resolution of 770 $nm$, surpassing 2.17 times of the theoretical Nyquist-Shannon sampling resolution limit imposed by the sensor pixel-size (1.67 $\mu m$). Full-FOV imaging result of a typical dicot root is also provided to demonstrate its promising potential applications in biologic imaging.

For quantitative phase imaging (QPI) based on transport-of-intensity equation (TIE), partially coherent illumination provides speckle-free imaging, compatibility with brightfield microscopy, and transverse resolution beyond coherent diffraction limit. Unfortunately, in a conventional microscope with circular illumination aperture, partial coherence tends to diminish the phase contrast, exacerbating the inherent noise-to-resolution tradeoff in TIE imaging, resulting in strong low-frequency artifacts and compromised imaging resolution. Here, we demonstrate how these issues can be effectively addressed by replacing the conventional circular illumination aperture with an annular one. The matched annular illumination not only strongly boosts the phase contrast for low spatial frequencies, but significantly improves the practical imaging resolution to near the incoherent diffraction limit. By incorporating high-numerical aperture (NA) illumination as well as high-NA objective, it is shown, for the first time, that TIE phase imaging can achieve a transverse resolution up to 208 nm, corresponding to an effective NA of 2.66. Time-lapse imaging of in vitro Hela cells revealing cellular morphology and subcellular dynamics during cells mitosis and apoptosis is exemplified. Given its capability for high-resolution QPI as well as the compatibility with widely available brightfield microscopy hardware, the proposed approach is expected to be adopted by the wider biology and medicine community., Comment: This manuscript was originally submitted on 20 Feb. 2017

Applications and systems are constantly faced with decisions that require picking from a set of actions based on contextual information. Reinforcement-based learning algorithms such as contextual bandits can be very effective in these settings, but applying them in practice is fraught with technical debt, and no general system exists that supports them completely. We address this and create the first general system for contextual learning, called the Decision Service. Existing systems often suffer from technical debt that arises from issues like incorrect data collection and weak debuggability, issues we systematically address through our ML methodology and system abstractions. The Decision Service enables all aspects of contextual bandit learning using four system abstractions which connect together in a loop: explore (the decision space), log, learn, and deploy. Notably, our new explore and log abstractions ensure the system produces correct, unbiased data, which our learner uses for online learning and to enable real-time safeguards, all in a fully reproducible manner. The Decision Service has a simple user interface and works with a variety of applications: we present two live production deployments for content recommendation that achieved click-through improvements of 25-30%, another with 18% revenue lift in the landing page, and ongoing applications in tech support and machine failure handling. The service makes real-time decisions and learns continuously and scalably, while significantly lowering technical debt.