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1. Carbon nanotube substrates enhance SARS-CoV-2 spike protein ion yields in matrix assisted laser desorption-ionization mass spectrometry

Author

Schenkel, T., Snijders, A. M., Nakamura, K., Seidl, P. A., Mak, B., Obst-Huebl, L., Knobel, H., Pong, I., Persaud, A., van Tilborg, J., Ostermayr, T., Steinke, S., Blakely, E. A., Ji, Q., Javey, A., Kapadia, R., Geddes, C. G. R., and Esarey, E.

Subjects
Physics - Biological Physics, Physics - Applied Physics
Abstract

Nanostructured surfaces enhance ion yields in matrix assisted laser desorption-ionization mass spectrometry (MALDI-MS). The spike protein complex, S1, is one fingerprint signature of Sars-CoV-2 with a mass of 75 kDa. Here, we show that MALDI-MS yields of Sars-CoV-2 spike protein ions in the 100 kDa range are enhanced 50-fold when the matrix-analyte solution is placed on substrates that are coated with a dense forest of multi-walled carbon nanotubes, compared to yields from uncoated substrates. Nanostructured substrates can support the development of mass spectrometry techniques for sensitive pathogen detection and environmental monitoring.

Published
2022
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