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Neurodegenerative diseases are frequently associated with structural changes in the brain. Magnetic Resonance Imaging (MRI) scans can show these variations and therefore be used as a supportive feature for a number of neurodegenerative diseases. The hippocampus has been known to be a biomarker for Alzheimer disease and other neurological and psychiatric diseases. However, it requires accurate, robust and reproducible delineation of hippocampal structures. Fully automatic methods are usually the voxel based approach, for each voxel a number of local features were calculated. In this paper we compared four different techniques for feature selection from a set of 315 features extracted for each voxel: (i) filter method based on the Kolmogorov-Smirnov test; two wrapper methods, respectively, (ii) Sequential Forward Selection and (iii) Sequential Backward Elimination; and (iv) embedded method based on the Random Forest Classifier on a set of 10 T1-weighted brain MRIs and tested on an independent set of 25 subjects. The resulting segmentations were compared with manual reference labelling. By using only 23 features for each voxel (sequential backward elimination) we obtained comparable state of-the-art performances with respect to the standard tool FreeSurfer., Comment: To appear on "Computational and Mathematical Methods in Medicine", Hindawi Publishing Corporation. 19 pages, 7 figures