1. Tomographic phase and attenuation extraction for a sample composed of unknown materials using X-ray propagation-based phase-contrast imaging
- Author
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Alloo, Samantha J., Paganin, David M., Morgan, Kaye S., Gureyev, Timur E., Mayo, Sherry C., Mohammadi, Sara, Lockie, Darren, Menk, Ralf Hendrik, Arfelli, Fulvia, Zanconati, Fabrizio, Tromba, Giuliana, and Pavlov, Konstantin M.
- Subjects
Physics - Medical Physics ,Electrical Engineering and Systems Science - Image and Video Processing ,Physics - Optics - Abstract
Propagation-based phase-contrast X-ray imaging (PB-PCXI) generates image contrast by utilizing sample-imposed phase-shifts. This has proven useful when imaging weakly-attenuating samples, as conventional attenuation-based imaging does not always provide adequate contrast. We present a PB-PCXI algorithm capable of extracting the X-ray attenuation, $\beta$, and refraction, $\delta$, components of the complex refractive index of distinct materials within an unknown sample. The method involves curve-fitting an error-function-based model to a phase-retrieved interface in a PB-PCXI tomographic reconstruction, which is obtained when Paganin-type phase-retrieval is applied with incorrect values of $\delta$ and $\beta$. The fit parameters can then be used to calculate true $\delta$ and $\beta$ values for composite materials. This approach requires no a priori sample information, making it broadly applicable. Our PB-PCXI reconstruction is single distance, requiring only one exposure per tomographic angle, which is important for radiosensitive samples. We apply this approach to a breast-tissue sample, recovering the refraction component, $\delta$, with 0.6 - 2.4\% accuracy compared to theoretical values., Comment: 8 pages, 4 figures and 1 table
- Published
- 2021
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