1. An AI-powered blood test to detect cancer using nanoDSF
- Author
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Tsvetkov, Philipp O., Eyraud, Rémi, Ayache, Stéphane, Bougaev, Anton A., Malesinski, Soazig, Benazha, Hamed, Gorokhova, Svetlana, Buffat, Christophe, Dehais, Caroline, Sanson, Marc, Bielle, Franck, Figarella-Branger, Dominique, Chinot, Olivier, Tabouret, Emeline, and Devred, François
- Subjects
Quantitative Biology - Quantitative Methods ,Computer Science - Machine Learning ,Quantitative Biology - Tissues and Organs - Abstract
We describe a novel cancer diagnostic method based on plasma denaturation profiles obtained by a non-conventional use of Differential Scanning Fluorimetry. We show that 84 glioma patients and 63 healthy controls can be automatically classified using denaturation profiles with the help of machine learning algorithms with 92% accuracy. Proposed high throughput workflow can be applied to any type of cancer and could become a powerful pan-cancer diagnostic and monitoring tool from a simple blood test.
- Published
- 2020