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Accurate drug target affinity prediction can improve drug candidate selection, accelerate the drug discovery process, and reduce drug production costs. Previous work focused on traditional fingerprints or used features extracted based on the amino acid sequence in the protein, ignoring its 3D structure which affects its binding affinity. In this work, we propose GraphPrint: a framework for incorporating 3D protein structure features for drug target affinity prediction. We generate graph representations for protein 3D structures using amino acid residue location coordinates and combine them with drug graph representation and traditional features to jointly learn drug target affinity. Our model achieves a mean square error of 0.1378 and a concordance index of 0.8929 on the KIBA dataset and improves over using traditional protein features alone. Our ablation study shows that the 3D protein structure-based features provide information complementary to traditional features., Comment: Accepted: The NeurIPS 2023 Workshop on New Frontiers of AI for Drug Discovery and Development (AI4D3 2023), New Orleans, LA, USA, 2023

A closed electromagnetic resonant chamber (RC) is a highly favorable artificial environment for wireless communication. A pair of antennas within the chamber constitutes a two-port network described by an impedance matrix. We analyze communication between the two antennas when the RC has perfectly conducting walls and the impedance matrix is imaginary-valued. The transmit antenna is driven by a current source, and the receive antenna is connected to a load resistor whose voltage is measured by an infinite-impedance amplifier. There are a countably infinite number of poles in the channel, associated with resonance in the RC, which migrate towards the real frequency axis as the load resistance increases. There are two sources of receiver noise: the Johnson noise of the load resistor, and the internal amplifier noise. An application of Shannon theory yields the capacity of the link, subject to bandwidth and power constraints on the transmit current. For a constant transmit power, capacity increases without bound as the load resistance increases. Surprisingly, the capacity-attaining allocation of transmit power versus frequency avoids placing power close to the resonant frequencies., Comment: 10 pages, 13 figures. To be published in IEEE Journal on Selected Areas in Communications Special Issue on Electromagnetic Signal and Information Theory

Healthcare clinics regularly encounter dynamic data that changes due to variations in patient populations, treatment policies, medical devices, and emerging disease patterns. Deep learning models can suffer from catastrophic forgetting when fine-tuned in such scenarios, causing poor performance on previously learned tasks. Continual learning allows learning on new tasks without performance drop on previous tasks. In this work, we investigate the performance of continual learning models on four different medical imaging scenarios involving ten classification datasets from diverse modalities, clinical specialties, and hospitals. We implement various continual learning approaches and evaluate their performance in these scenarios. Our results demonstrate that a single model can sequentially learn new tasks from different specialties and achieve comparable performance to naive methods. These findings indicate the feasibility of recycling or sharing models across the same or different medical specialties, offering another step towards the development of general-purpose medical imaging AI that can be shared across institutions., Comment: 4 pages, 1 Figure. Accepted in NeurIPS 2023 (Medical Imaging meets NeurIPS Workshop)

In the context of surgery, robots can provide substantial assistance by performing small, repetitive tasks such as suturing, needle exchange, and tissue retraction, thereby enabling surgeons to concentrate on more complex aspects of the procedure. However, existing surgical task learning mainly pertains to rigid body interactions, whereas the advancement towards more sophisticated surgical robots necessitates the manipulation of soft bodies. Previous work focused on tissue phantoms for soft tissue task learning, which can be expensive and can be an entry barrier to research. Simulation environments present a safe and efficient way to learn surgical tasks before their application to actual tissue. In this study, we create a Robot Operating System (ROS)-compatible physics simulation environment with support for both rigid and soft body interactions within surgical tasks. Furthermore, we investigate the soft tissue interactions facilitated by the patient-side manipulator of the DaVinci surgical robot. Leveraging the pybullet physics engine, we simulate kinematics and establish anchor points to guide the robotic arm when manipulating soft tissue. Using demonstration-guided reinforcement learning (RL) algorithms, we investigate their performance in comparison to traditional reinforcement learning algorithms. Our in silico trials demonstrate a proof-of-concept for autonomous surgical soft tissue retraction. The results corroborate the feasibility of learning soft body manipulation through the application of reinforcement learning agents. This work lays the foundation for future research into the development and refinement of surgical robots capable of managing both rigid and soft tissue interactions. Code is available at https://github.com/amritpal-001/tissue_retract., Comment: 10 Pages, 5 figures, MICCAI 2023 conference (AECAI workshop)

Tree fruit breeding is a long-term activity involving repeated measurements of various fruit quality traits on a large number of samples. These traits are traditionally measured by manually counting the fruits, weighing to indirectly measure the fruit size, and fruit colour is classified subjectively into different color categories using visual comparison to colour charts. These processes are slow, expensive and subject to evaluators' bias and fatigue. Recent advancements in deep learning can help automate this process. A method was developed to automatically count the number of sweet cherry fruits in a camera's field of view in real time using YOLOv3. A system capable of analyzing the image data for other traits such as size and color was also developed using Python. The YOLO model obtained close to 99% accuracy in object detection and counting of cherries and 90% on the Intersection over Union metric for object localization when extracting size and colour information. The model surpasses human performance and offers a significant improvement compared to manual counting., Comment: Published in 25th International Conference on Image Processing, Computer Vision, & Pattern Recognition (IPCV'21)

Robotic surgery has increased the domain of surgeries possible. Several examples of partial surgical automation have been seen in the past decade. We break down the path of automation tasks into features required and provide a checklist that can help reach higher levels of surgical automation. Finally, we discuss the current challenges and advances required to make this happen., Comment: 6 Pages, 4 figures, 2 Tables

Bounds on the frequency domain behavior of electrically small antennas are adapted to assess the time domain distortion or fidelity achievable by simple linear time-invariant (LTI) systems. Rigorous expressions for a TM$_{01}$ spherical shell are used as a direct analog to the well known Chu limit on an antenna's bandwidth-efficiency product. These expressions are shown to agree with results obtained using narrowband single resonance approximations, allowing for the analysis of arbitrary small dipole-like structures through bounds on their single frequency Q-factor and efficiency. The resulting expressions are used as a basis for assessing the performance gains of electrically small non-LTI (e.g., direct antenna modulation) transmitters for which Q-factor and impedance bandwidth are not defined but which can be analyzed directly in the time domain via distortion., Comment: 8 pages, 8 figures

The paper aims to show how an application can be developed that converts the English language into the Punjabi Language, and the same application can convert the Text to Speech(TTS) i.e. pronounce the text. This application can be really beneficial for those with special needs., Comment: 5 pages, 8 figures, 3 tables

Privacy Security of data in Cloud Storage is one of the main issues. Many Frameworks and Technologies are used to preserve data security in cloud storage. [1] Proposes a framework which includes the design of data organization structure, the generation and management of keys, the treatment of change of user's access right and dynamic operations of data, and the interaction between participants. It also design an interactive protocol and an extirpation-based key derivation algorithm, which are combined with lazy revocation, it uses multi-tree structure and symmetric encryption to form a privacy-preserving, efficient framework for cloud storage. [2] Proposes a framework which design a privacy-preserving cloud storage framework in which he designed an interaction protocol among participants, use key derivation algorithm to generate and manage keys, use both symmetric and asymmetric encryption to hide the sensitive data of users, and apply Bloom filter for cipher text retrieval. A system based on this framework is realized. This paper analyzes both the frameworks in terms of the feasibility of the frameworks, running overhead of the system and the privacy security of the frameworks.