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National PERT Consortium, Inc. and University Medical Center Mainz

University Hospital of Cologne, Klinikum rechts der Isar, Technical University of Munich, RWTH Aachen University, University Hospital Tuebingen, Charite University, Berlin, Germany, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Sana Klinikum Offenbach, Goethe University, Klinikum Dortmund, KRH Klinikum Nordstadt, Asklepios Klinik Altona, Klinikum Altenburger Land, Klinikum Stadt Hanau, Klinikum Lüneburg, Ludwig-Maximilians - University of Munich, University of Göttingen, Krankenhaus Buchholz, Klinikum Osnabrück, Wuerzburg University Hospital, University of Giessen and Marburg, Sana Kliniken Lübeck, Mühlenkreiskliniken Minden, radprax MVZ Nordrhein, University Hospital Muenster, University Medical Center Rostock, Asklepios Klinik Wandsbek, Elbe Kliniken, Städtische Klinikum Braunschweig, Allgemeines Krankenhaus Celle, Bezirkskrankenhaus Günzburg, Klinikum Bremen-Mitte, gGmbH, University Medical Center Mainz, Klinikum Köln-Merheim, and University Hospital, Bonn

University Medical Center Mainz

University Medical Center Mainz and Motus GI Medical Technologies Ltd

Interdisciplinary Center for Clinical Trials, University Medical Center Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Department of Ophthalmology, and Sponsored by the German Federal Ministry of Education and Research (FKZ 13GW0732A)

Gilead Sciences, Barcelona Institute for Global Health, Harokopio University, University Medical Center Mainz, and Universitätsklinikum Düsseldorf

Hannover Medical School, Heinrich-Heine University, Duesseldorf, Klinikum Bamberg, Universitätsklinikum Kiel, University Medical Center Mainz, Uniklinikum Giessen und Marburg, University Hospital Ulm, Universitätsklinikum Leipzig, University Hospital Regensburg, Universitätsklinikum Hamburg-Eppendorf, and Klaus Michael Beier, Director, Institute for Sexual Research and Sexual Medicine

Newcastle University, University of Nottingham, University of Cambridge, University of Seville, Pinnacle Clinical Research, PLLC, ICAN Nutrition Education and Research, Assistance Publique - Hôpitaux de Paris, University of Angers, University of Palermo, University of Turin, Italy, University Medical Center Mainz, University of Helsinki, University of Bern, Linkoeping University, Perspectum, Antaros Medical, Resoundant Inc, Pfizer, Novartis, Takeda, Boehringer Ingelheim, Intercept Pharmaceuticals, and Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Hannover Medical School, University Hospital, Aachen, Allianz Chronischer Seltener Erkrankungen ACHSE e.V., Goethe University, Universität Münster, St. Josef Hospital Bochum, Otto-von-Guericke University Magdeburg, University Medical Center Mainz, University Hospital Regensburg, University Hospital Tuebingen, University Hospital Ulm, IKK gesund plus, Techniker Krankenkasse, University of Wuerzburg, Universitätsklinikum Hamburg-Eppendorf, AOK Hessen, and LWL-Universitätsklinikum der Ruhr-Universität Bochum

University Medicine Greifswald, Charite University, Berlin, Germany, German Heart Center, University of Mannheim, University Hospital Schleswig-Holstein, Medical University of Hannover, Goethe University, Universitätsklinikum Hamburg-Eppendorf, University Medical Center Mainz, University Medical Center Goettingen, Deutsches Herzzentrum Muenchen, Technical University of Munich, University Hospital Munich, Kerckhoff Klinik, and Benjamin Meder, Deputy Director - Clinic of Cardiology, Angiology and Pneumology

Otto Bock Healthcare Products GmbH, University Medical Center Mainz, and Johannes Schroeter, Director of Orthopaedic clinic

Sue Ryder House administered by Pallmed, Mutualista Asociación Hospital Evangélico, Pallium Latinoamérica N.G.O, University Medical Center Mainz, University of Campinas, Brazil, and University of Liverpool

Newcastle-upon-Tyne Hospitals NHS Trust, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Institute of Cardiometabolism and Nutrition, France, University of Cambridge, Örebro University, Sweden, University of Bern, University of Oxford, University of Turin, Italy, University of Angers, University Hospital, Antwerp, Linkoeping University, University of Helsinki, UMC Utrecht, National and Kapodistrian University of Athens, University of Lisbon, University of Milan, University of Palermo, Catholic University of the Sacred Heart, Wuerzburg University Hospital, RWTH Aachen University, University of Nottingham, Medical University of Vienna, University of Birmingham, University of Florence, Assistance Publique - Hôpitaux de Paris, and University Medical Center Mainz

Ludwig-Maximilians - University of Munich, Universitätsklinikum Hamburg-Eppendorf, University Medical Center Mainz, Max Planck Institute for Human Development, Federal Joint Committee, and Odette Wegwarth, Prof. Dr.

Interdisciplinary Center Clinical Trials (IZKS), University Medical Center Mainz

Heart and Diabetes Center North Rhine-Westphalia, University Medical Center Mainz, Heart Center Leipzig - University Hospital, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), University of Leipzig, and Thomas Stocker, MD

Macquarie University, Australia, University of Melbourne, Kepler University Hospital, Medical University Innsbruck, General University Hospital, Prague, Universitätsklinikum Köln, Goethe University, University Medical Center Mainz, University of Göttingen, University Hospital Dresden, Charite University, Berlin, Germany, Heinrich-Heine University, Duesseldorf, University of Roma La Sapienza, University of Padova, University of Florence, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, University of Messina, Universita di Verona, Uniuversity of Genua, Italy, Leiden University Medical Center, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht, Burdenko Neurosurgery Institute, Sahlgrenska University Hospital, Sweden, University of Bern, Barrow Neurological Institute, Stanford University, Emory University, University of Wisconsin, Madison, University of California, San Francisco, University of Illinois at Chicago, Brigham and Women's Hospital, Mayo Clinic, University of California, Los Angeles, NorthShore University HealthSystem, and Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Interdisciplinary Center Clinical Trials (IZKS), University Medical Center Mainz and Georg Bartsch, Assistant Medical Director of Department of Urology and Pediatric Urology

Leiden University Medical Center, The Netherlands Cancer Institute, St Mark's Hospital Foundation, Hospital Clinic of Barcelona, Hôpital Edouard Herriot, Maria Sklodowska-Curie National Research Institute of Oncology, Hospital General Universitario de Alicante, University Medical Center Mainz, IRCCS Azienda Ospedaliero-Universitaria di Bologna, and Prof. Evelien Dekker, MD, PhD, Prof. dr. Evelien Dekker, MD, PhD

Leiden University Medical Center, The Netherlands Cancer Institute, St Mark's Hospital Foundation, Hospital Clinic of Barcelona, Hôpital Edouard Herriot, Maria Sklodowska-Curie National Research Institute of Oncology, Hospital General Universitario de Alicante, University Medical Center Mainz, IRCCS Azienda Ospedaliero-Universitaria di Bologna, and Prof. Evelien Dekker, MD, PhD, Prof. dr. Evelien Dekker, MD, PhD

Interdisciplinary Center Clinical Trials (IZKS), University Medical Center Mainz and Marcus-Alexander Wörns, Senior consultant, Department of Internal Medicine I

KKS Dresden, Zentrum für Klinische Studien Leipzig, and University Medical Center Mainz

Department of Psychiatry and Psychotherapy, University Medical Center, Mainz and Prof. Dr. Dr. Perikles Simon, Professor for Sports Medicine MD PHD

European Georges Pompidou Hospital and Prof. Stavros Konstantinides, MD, Medical Director of Center for Thrombosis and Hemostasis, University Medical Center Mainz