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Alzheimer's Disease (AD) and related dementia are a growing global health challenge due to the aging population. In this paper, we present ADMarker, the first end-to-end system that integrates multi-modal sensors and new federated learning algorithms for detecting multidimensional AD digital biomarkers in natural living environments. ADMarker features a novel three-stage multi-modal federated learning architecture that can accurately detect digital biomarkers in a privacy-preserving manner. Our approach collectively addresses several major real-world challenges, such as limited data labels, data heterogeneity, and limited computing resources. We built a compact multi-modality hardware system and deployed it in a four-week clinical trial involving 91 elderly participants. The results indicate that ADMarker can accurately detect a comprehensive set of digital biomarkers with up to 93.8% accuracy and identify early AD with an average of 88.9% accuracy. ADMarker offers a new platform that can allow AD clinicians to characterize and track the complex correlation between multidimensional interpretable digital biomarkers, demographic factors of patients, and AD diagnosis in a longitudinal manner.

Ellipsoid fitting is of general interest in machine vision, such as object detection and shape approximation. Most existing approaches rely on the least-squares fitting of quadrics, minimizing the algebraic or geometric distances, with additional constraints to enforce the quadric as an ellipsoid. However, they are susceptible to outliers and non-ellipsoid or biased results when the axis ratio exceeds certain thresholds. To address these problems, we propose a novel and robust method for ellipsoid fitting in a noisy, outlier-contaminated 3D environment. We explicitly model the ellipsoid by kernel density estimation (KDE) of the input data. The ellipsoid fitting is cast as a maximum likelihood estimation (MLE) problem without extra constraints, where a weighting term is added to depress outliers, and then effectively solved via the Expectation-Maximization (EM) framework. Furthermore, we introduce the vector {\epsilon} technique to accelerate the convergence of the original EM. The proposed method is compared with representative state-of-the-art approaches by extensive experiments, and results show that our method is ellipsoid-specific, parameter free, and more robust against noise, outliers, and the large axis ratio. Our implementation is available at https://zikai1.github.io/.

Federated meta-learning (FML) has emerged as a promising paradigm to cope with the data limitation and heterogeneity challenges in today's edge learning arena. However, its performance is often limited by slow convergence and corresponding low communication efficiency. In addition, since the available radio spectrum and IoT devices' energy capacity are usually insufficient, it is crucial to control the resource allocation and energy consumption when deploying FML in practical wireless networks. To overcome the challenges, in this paper, we rigorously analyze each device's contribution to the global loss reduction in each round and develop an FML algorithm (called NUFM) with a non-uniform device selection scheme to accelerate the convergence. After that, we formulate a resource allocation problem integrating NUFM in multi-access wireless systems to jointly improve the convergence rate and minimize the wall-clock time along with energy cost. By deconstructing the original problem step by step, we devise a joint device selection and resource allocation strategy to solve the problem with theoretical guarantees. Further, we show that the computational complexity of NUFM can be reduced from $O(d^2)$ to $O(d)$ (with the model dimension $d$) via combining two first-order approximation techniques. Extensive simulation results demonstrate the effectiveness and superiority of the proposed methods in comparison with existing baselines.

In order to meet the requirements for performance, safety, and latency in many IoT applications, intelligent decisions must be made right here right now at the network edge. However, the constrained resources and limited local data amount pose significant challenges to the development of edge AI. To overcome these challenges, we explore continual edge learning capable of leveraging the knowledge transfer from previous tasks. Aiming to achieve fast and continual edge learning, we propose a platform-aided federated meta-learning architecture where edge nodes collaboratively learn a meta-model, aided by the knowledge transfer from prior tasks. The edge learning problem is cast as a regularized optimization problem, where the valuable knowledge learned from previous tasks is extracted as regularization. Then, we devise an ADMM based federated meta-learning algorithm, namely ADMM-FedMeta, where ADMM offers a natural mechanism to decompose the original problem into many subproblems which can be solved in parallel across edge nodes and the platform. Further, a variant of inexact-ADMM method is employed where the subproblems are `solved' via linear approximation as well as Hessian estimation to reduce the computational cost per round to $\mathcal{O}(n)$. We provide a comprehensive analysis of ADMM-FedMeta, in terms of the convergence properties, the rapid adaptation performance, and the forgetting effect of prior knowledge transfer, for the general non-convex case. Extensive experimental studies demonstrate the effectiveness and efficiency of ADMM-FedMeta, and showcase that it substantially outperforms the existing baselines.

InGaAs/InP single-photon detectors (SPDs) are widely used for near-infrared photon counting in practical applications. Photon detection efficiency (PDE) is one of the most important parameters for SPD characterization, and therefore increasing PDE consistently plays a central role in both industrial development and academic research. Here we present the implementation of high-frequency gating InGaAs/InP SPD with a PDE as high as 60% at 1550 nm. On one hand, we optimize the structure design and device fabrication of InGaAs/InP single-photon avalanche diode with an additional dielectric-metal reflection layer to relatively increase the absorption efficiency of incident photons by ~ 20%. On the other hand, we develop a monolithic readout circuit of weak avalanche extraction to minimize the parasitic capacitance for the suppression of the afterpulsing effect. With 1.25 GHz sine wave gating and optimized gate amplitude and operation temperature, the SPD is characterized to reach a PDE of 60% with a dark count rate (DCR) of 340 kcps. For practical use, given 3 kcps DCR as a reference the PDE reaches ~ 40% PDE with an afterpulse probability of 5.5%, which can significantly improve the performance for the near-infrared SPD based applications., Comment: 5 pages, 4 figures. Accepted for publication in Review of Scientific Instruments

Under mean-variance-utility framework, we propose a new portfolio selection model, which allows wealth and time both have influences on risk aversion in the process of investment. We solved the model under a game theoretic framework and analytically derived the equilibrium investment (consumption) policy. The results conform with the facts that optimal investment strategy heavily depends on the investor's wealth and future income-consumption balance as well as the continuous optimally consumption process is highly dependent on the consumption preference of the investor., Comment: arXiv admin note: substantial text overlap with arXiv:2005.06782

In this paper, we propose a new class of optimization problems, which maximize the terminal wealth and accumulated consumption utility subject to a mean variance criterion controlling the final risk of the portfolio. The multiple-objective optimization problem is firstly transformed into a single-objective one by introducing the concept of overall "happiness" of an investor defined as the aggregation of the terminal wealth under the mean-variance criterion and the expected accumulated utility, and then solved under a game theoretic framework. We have managed to maintain analytical tractability; the closed-form solutions found for a set of special utility functions enable us to discuss some interesting optimal investment strategies that have not been revealed before in literature.

High-frequency gating InGaAs/InP single-photon detectors (SPDs) are widely used for applications requiring single-photon detection in the near-infrared region such as quantum key distribution. Reducing SPD size is highly desired for practical use, which is favorable to the implementation of further system integration. Here we present, to the best of our knowledge, the most compact high-frequency sine wave gating (SWG) InGaAs/InP SPD. We design and fabricate an InGaAs/InP single-photon avalanche diode (SPAD) with optimized semiconductor structure, and then encapsulate the SPAD chip and a mini-thermoelectric cooler inside a butterfly package with a size of 12.5 mm $\times$ 22 mm $\times$ 10 mm. Moreover, we implement a monolithic readout circuit for the SWG SPD in order to replace the quenching electronics that is previously designed with board-level integration. Finally, the components of SPAD, monolithic readout circuit and the affiliated circuits are integrated into a single module with a size of 13 cm $\times$ 8 cm $\times$ 4 cm. Compared with the 1.25 GHz SWG InGaAs/InP SPD module (25 cm $\times$ 10 cm $\times$ 33 cm) designed in 2012, the volume of our miniaturized SPD is reduced by 95\%. After the characterization, the SPD exhibits excellent performance with a photon detection efficiency of 30\%, a dark count rate of 2.0 kcps and an afterpulse probability of 8.8\% under the conditions of 1.25 GHz gating rate, 100 ns hold-off time and 243 K. Also, we perform the stability test over one week, and the results show the high reliability of the miniaturized SPD module., Comment: 5 pages, 6 figures. Accepted for publication in Review of Scientific Instruments