1. Long-term alpha interferon treatment is effective on anaemia and significantly reduces iron overload in congenital dyserythropoiesis type I.
- Author
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Lavabre-Bertrand, Thierry, Ramos, Jeanne, Delfour, Christophe, Henry, Laurent, Guiraud, Isabelle, Carillo, Serge, Wagner, Andr, Bureau, Jean Paul, and Blanc, Pierre
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INTERFERONS ,ANEMIA ,IRON ,THERAPEUTICS ,FERRITIN ,IRON in the body ,HEMATOLOGY - Abstract
Lavabre-Bertrand T, Ramos J, Delfour C, Henry L, Guiraud I, Carillo S, Wagner A, Bureau JP, Blanc P. Long-term alpha interferon treatment is effective on anaemia and significantly reduces iron overload in congenital dyserythropoiesis type I.Eur J Haematol 2004: 73: 380–383.© Blackwell Munksgaard 2004.Interferon has been shown to be an effective treatment of congenital dyserythropoiesis type I (CDA-I), but the optimal dose and the feasibility of this treatment remains to be determined. Here, in a 9-yr follow-up of a single patient, we show that interferon remains active during such a long period. The optimal dose of conventional alpha interferon could be evaluated at 2 million units twice a week. Pegylated interferon could be used as well at a dose of 30 μg/wk. During interferon treatment, serum and erythrocyte ferritin levels decreased progressively, and remained inversely correlated with haemoglobin levels. On repeated liver biopsies, iron overload could be normalized. Low dose interferon is a long-term treatment of CDA-I, and allows a significant decrease in iron overload, that could be interesting even in patients who are only moderately anaemic. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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