Search

Español I, Romagosa V, Berlanga J, Domingo A, Losa F, Heras L, Janáriz J. Zoledronate-induced remission of acute panmyelosis with myelofibrosis. Eur J Haematol 2004: 73: 215–218. © Blackwell Munksgaard 2004. Acute panmyelosis with myelofibrosis is a rare and aggressive form of acute myeloid leukemia. We describe a new case with a huge proliferation of megakaryocytes, blast cells and reticulin fibers. The patient was treated with zoledronate, a third-generation bisphosphonate, and a gradual recovery from pancytopenia was observed. A new bone marrow biopsy performed 4 months later showed a surprising disappearance of the leukemic infiltration. Ten months after the diagnosis, the patient is still in healthy condition. This may support the recently described anti-tumor activity of zoledronate. [ABSTRACT FROM AUTHOR]

Breccia M, D'Elia GM, Girelli G, Vaglio S, Gentilini F, Chiara S, Alimena G. Paroxysmal cold haemoglobinuria as a tardive complication of idiopathic myelofibrosis. Eur J Haematol 2004: 73: 304–306. © Blackwell Munksgaard 2004. Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by the Donath–Landsteiner antibody. It is classically described in association with chronic syphilis or after acute viral infections. We describe the first case of PCH presented as a late manifestation of advanced myelofibrosis associated with antiphospholipid syndrome, that promptly responded to high dosage of prednisone. [ABSTRACT FROM AUTHOR]

Wong CC, Brown D, Howling SJ, Parker NE. Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure. Eur J Haematol 2003; 71: 388–390. © Blackwell Munksgaard 2003. We describe a 63-yr-old patient diagnosed with chronic idiopathic myelofibrosis whose disease was treated with hydroxyurea for 2 yr. He developed respiratory symptoms that were extensively investigated including lung biopsy. Clinical, radiological and histological features were compatible with a diagnosis of hydroxyurea-induced pneumonitis. Following drug withdrawal there was remarkable improvement in clinical and radiological findings. [ABSTRACT FROM AUTHOR]

The article reviews the book "Myelofibrosis and the Biology of Connective Tissue: Progress in Clinical and Biological Research," vol. 154, edited by P. D. Berk.