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Your search keyword '"Ulcerative Colitis"' showing total 28 results
Start Over Descriptor "Ulcerative Colitis" Publication Type Reviews
28 results on '"Ulcerative Colitis"'

1. Second Ustekinumab Biosimilar Gets FDA Approval.

Author

Hicks, Lucy

Subjects
*CROHN'S disease, *PSORIATIC arthritis, *ULCERATIVE colitis
Abstract

The US Food and Drug Administration (FDA) has approved the biosimilar ustekinumab-aekn (Selarsdi) for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis in adults and pediatric patients aged 6 years or older. This is the second ustekinumab biosimilar approved by the FDA and the second biosimilar approval in the United States for Alvotech in partnership with Teva Pharmaceuticals. Ustekinumab-aekn is expected to be marketed in the United States on or after February 21, 2025. [Extracted from the article]

Published
2024

2. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.

Author

Zhang, Xiao-Jun, Yuan, Zhong-Wen, Qu, Chang, Yu, Xiu-Ting, Huang, Tao, Chen, Ping Vicky, Su, Zi-Ren, Dou, Yao-Xing, Wu, Jia-Zhen, Zeng, Hui-Fang, Xie, Ying, and Chen, Jian-Nan

Subjects
*INFLAMMATORY bowel diseases, *CROHN'S disease, *GASTROINTESTINAL agents, *BIOCHEMISTRY, *PROTEOBACTERIA
Abstract

Graphical abstract Abstract Inflammatory bowel disease (IBD), majorly include Crohn's disease (CD) and ulcerative colitis (UC), is chronic and relapsing inflammatory disorders of the gastrointestinal tract, which treatment options remain limited. Here we examined the therapeutic effects of an isoquinoline alkaloid, Palmatine (Pal), on mice experimental colitis induced by dextran sulfate sodium (DSS) and explored underlying mechanisms. Colitis was induced in BALB/c mice by administering 3% DSS in drinking water for 7 days. Pal (50 and 100 mg kg−1) and the positive drug Sulfasalazine (SASP, 200 mg kg−1) were orally administered for 7 days. Disease activity index (DAI) was evaluated on day 8, and colonic tissues were collected for biochemistry analysis. The fecal microbiota was characterized by high-throughput Illumina MiSeq sequencing. And plasma metabolic changes were detected by UPLC-MS. Our results showed that Pal treatment significantly reduced DAI scores and ameliorated colonic injury in mice with DSS-induced colitis. Mucosal integrity was improved and cell apoptosis was inhibited. Moreover, gut microbiota analysis showed that mice received Pal-treatment have higher relative abundance of Bacteroidetes and Firmicutes, but reduced amount of Proteobacteria. Moreover, Pal not only suppressed tryptophan catabolism in plasma, but also decreased the protein expression of indoleamine 2,3-dioxygenase 1 (IDO-1, the rate-limiting enzyme of tryptophan catabolism) in colon tissue. This is consolidated by molecular docking, which suggested that Pal is a potent IDO-1 inhibitor. Taken together, our findings demonstrate that Pal ameliorated DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism, which indicated that Pal has great therapeutic potential for colitis. [ABSTRACT FROM AUTHOR]

Published
2018
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3. Close to the edge.

Subjects
*DRUG development, *ULCERATIVE colitis
Abstract

The article offers a review of the PRA023, a drug approaching the late-stage of clinical trials to treat ulcerative colitis, Crohn's disease and other nasty autoimmune conditions, developed by Prometheus.

Published
2023

4. GASTROHEPATIC DISORDERS.

Subjects
*OINTMENTS, *COLITIS treatment, *ULCERATIVE colitis, *DRUGS
Abstract

The article offers brief information on several drugs for gastrohepatic disorders including Azulfidine EN-tablets for ulcerative colitis from Pfizer Inc., Entocort EC budesonide for Crohn's disease from AstraZeneca PLC, and Preparation H Ointment for hemorrhoids from Wyeth Consumer Healthcare Inc.

Published
2013

5. Biogen and Samsung Bioepis Announce European Launch of IMRALDI ™ (adalimumab), Solidifying Leadership in European Anti-TNF Market.

Subjects
*METHOTREXATE, *PHARMACEUTICAL industry & economics, *ANKYLOSING spondylitis, *DOSE-effect relationship in pharmacology, *CROHN'S disease, *MARKETING, *PSORIASIS, *PSORIATIC arthritis, *RHEUMATOID arthritis, *JUVENILE idiopathic arthritis, *ULCERATIVE colitis, *UVEITIS, *DRUG approval, *TREATMENT effectiveness, *ADALIMUMAB, *HIDRADENITIS suppurativa, *THERAPEUTICS
Abstract

The article previews the IMRALDI (adalimumab) biosimilar drug from Samsung Bioepis Co., Ltd. and Biogen.

Published
2019
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6. Authors' reply.

Author

Grant, A., Go, P., and Collaboration, the Eu Hernia Trialists

Subjects
*ULCERATIVE colitis, *ANORECTAL function tests, *QUALITY of life
Abstract

Presents reply to a correspondence discussing the functional outcome after restorative panproctolectomy for ulcerative colitis. Differentiation of function from quality of life measures.

Published
2001
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7. GENERIC PRODUCTS.

Subjects
*ULCERATIVE colitis, *DOSAGE forms of drugs
Published
2018

9. WARRIOR BRAVE PROTECTOR.

Subjects
*ULCERATIVE colitis, *INFERTILITY, *NONFICTION
Abstract

A debut memoir details the struggles of a wife with ulcerative colitis and infertility. [ABSTRACT FROM AUTHOR]

Published
2017

10. WARRIOR BRAVE PROTECTOR.

Subjects
*ULCERATIVE colitis, *NONFICTION
Abstract

A debut memoir details the struggles of a wife with ulcerative colitis and infertility. [ABSTRACT FROM AUTHOR]

Published
2017

11. WARRIOR BRAVE PROTECTOR.

Subjects
*COLITIS treatment, *ULCERATIVE colitis, *NONFICTION
Abstract

A debut memoir details the struggles of a wife with ulcerative colitis and infertility. [ABSTRACT FROM AUTHOR]

Published
2017

12. WARRIOR BRAVE PROTECTOR.

Subjects
*MEMOIRS, *ULCERATIVE colitis, *FEMALE infertility, *NONFICTION
Abstract

A debut memoir details the struggles of a wife with ulcerative colitis and infertility. [ABSTRACT FROM AUTHOR]

Published
2017

14. WARRIOR BRAVE PROTECTOR.

Subjects
*ULCERATIVE colitis, *NONFICTION, *PATIENTS
Abstract

A debut memoir details the struggles of a wife with ulcerative colitis and infertility. [ABSTRACT FROM AUTHOR]

Published
2017

15. WARRIOR BRAVE PROTECTOR.

Subjects
*ULCERATIVE colitis, *MEMOIRS, *NONFICTION, *PATIENTS
Abstract

A review of the book "Warrior Brave Protector," by Kim Mills, is presented.

Published
2017

17. Pyoderma gangrenosum as a cause of spontaneous vulvovaginal ulceration.

Author

Langeland, Tor and Rokkones, Erik

Subjects
*VAGINAL diseases, *VULVAR diseases, *DISEASES in women, *BIOPSY, *ULCERATIVE colitis, *NEUTROPHILS, *VASCULITIS
Abstract

The article presents a case study regarding Pyoderma gangrenosum as a cause of spontaneous vulvovaginal ulceration. A 55-year-old woman was admitted to the hospital with spontaneous ulcerations of the vulva, vagina and the right gluteal region that had developed during the preceding week. The ulcerations developed rapidly as painful redness and infiltrations of the skin, followed by necrotization. She stated that "pieces of the skin fell off," resulting in deep and very painful ulcerations. Biopsies from the ulcer margin showed nonspecific changes with ulceration and neutrophilic infiltration without certain signs of vasculitis.

Published
2004
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19. Ulcerative Colitis (Book).

Subjects
ULCERATIVE colitis, NONFICTION
Abstract

Reviews the book 'Ulcerative Colitis,' by J. C. Goligher.

Published
1970

20. ULCERATIVE COLITIS.

Subjects
ULCERATIVE colitis, NONFICTION
Abstract

Reviews the book "Ulcerative Colitis," by Harry E. Bacon.

Published
1959

21. THE SURGICAL MANAGEMENT OF ULCERATIVE COLITIS.

Author

Dreiling, David A.

Subjects
ULCERATIVE colitis, NONFICTION
Abstract

Reviews the book "The Surgical Management of Ulcerative Colitis," by Frank Couper Walker.

Published
1970

22. Histopathological Variation in UC.

Author

Wisecarver, J. L. and Thompson, Jon S.

Subjects
ULCERATIVE colitis, INFLAMMATORY bowel diseases, COLON (Anatomy), BIOPSY, MUCOUS membranes
Abstract

Provides an overview of the study "Ulcerative Colitis: Patterns of Involvement in Colo-Rectal Biopsies and Changes With Time," by C. G. Kleer and H. D. Appelman. Importance of mucosa biopsy; Occurrence of rectal sparing in ulcerative colitis.

Published
1999

23. American view of colitis.

Author

Long, R.G.

Subjects
*ULCERATIVE colitis, *NONFICTION
Abstract

Reviews the book 'Mucosal Ulcerative Colitis,' edited by G. Jagelman.

Published
1986

24. Ulcer Disease: New Aspects of Pathogenesis and Pharmacology.

Author

Sinar, Dennis R. and Achord, James L.

Subjects
ULCERATIVE colitis, NONFICTION
Abstract

Reviews the book "Ulcer Disease: New Aspects of Pathogenesis and Pharmacology," edited by Sandor Szabo and Carl J. Pfeiffer.

Published
1990

25. Ulcerative Colitis.

Author

Greenstein, Adrian J.

Subjects
ULCERATIVE colitis, NONFICTION
Abstract

Reviews the book "Ulcerative Colitis," by Michael J. Goodman and Marshall Sparberg, M. D.

Published
1980

26. Diet Management for Ulcerative Colitis:.

Author

Greenstein, Adrian J.

Subjects
ULCERATIVE colitis, NONFICTION
Abstract

Reviews the book "Diet Management for Ulcerative Colitis," by Map Hanson.

Published
1974

28. ULCERATIVE COLITIS:.

Author

Dreiling, David A.

Subjects
ULCERATIVE colitis, NONFICTION
Abstract

Reviews the book "Ulcerative Colitis," by J. C. Goligher, F. T. de Dombal, G. Watkinson, and B. C. Morson.

Published
1970

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