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Cardiovascular disease (CVD) is highly prevalent in an ageing society. The increased incidence and mortality rates of CVD are global issues endangering human health. There is an urgent requirement for understanding the aetiology and pathogenesis of CVD and developing possible interventions for preventing CVD in ageing hearts. It is necessary to select appropriate models and treatment methods. The D‐galactose‐induced cardiac ageing model possesses the advantages of low mortality, short time and low cost and has been increasingly used in the study of cardiovascular diseases in recent years. Therefore, understanding the latest progress in D‐galactose‐induced cardiac ageing is valuable. This review highlights the recent progress and potential therapeutic interventions used in D‐galactose‐induced cardiac ageing in recent years by providing a comprehensive summary of D‐galactose‐induced cardiac ageing in vivo and in vitro. This review may serve as reference literature for future research on age‐related heart diseases. [ABSTRACT FROM AUTHOR]

Background: Peritoneal metastasis often occurs in patients with colorectal cancer peritoneal metastasis, and the prognosis is poor. A large body of evidence highlights the beneficial effects of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on survival, but to date, there is little consensus on the optimal treatment strategy for patients with colorectal cancer peritoneal metastasis. The purpose of this study is to evaluate the impact of CRS + HIPEC on survival and provide reference for the treatment of patients with colorectal cancer peritoneal metastasis. Methods: This systematic review and meta-analysis is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The PubMed, Embase, Cochrane, Web of Knowledge, and ClinicalTrials.gov databases were screened from inception of the review to March 11, 2022. Ten studies were included in qualitative and quantitative analysis. Results: A total of 3200 patients were enrolled in the study, including 788 patients in the CRS and HIPEC groups and 2412 patients in the control group, of which 3 were randomized controlled trials and 7 were cohort studies. The 3 randomized controlled studies were of high quality, and the quality scores of the 7 cohort studies were all 7 or above, indicating high quality. The results showed that the OS of CRS + HIPEC group was higher than that of control group (HR: 0.53, 95% CI: 0.38–0.73; P < 0.00001, I2 = 82.9%); the heterogeneity of the studies was large. The subgroup analysis showed that the OS of CRS and HIPEC group was higher than that of PC group (HR: 0.37, 95% CI: 0.30–0.47; P = 0.215, I2 = 31%) and higher than that in CRS group (HR: 0.73, 95% CI: 0.49–1.07; P = 0.163, I2 = 44.8%); the heterogeneity of the studies was low. In the OPEN group, the OS of THE CRS and HIPEC groups was higher than that in the control group (HR: 0.51, 95% CI: 0.38–0.70; P = 0.353, I2 = 3.9%); OPEN group showed lower heterogeneity. The OS of 60–100-min group was higher than that in the control group (HR: 0.65, 95% CI: 0.49–0.88; P = 0.172, I2 = 37.4%); the heterogeneity of the studies was low. Sensitivity analysis showed that there was no significant difference in the results of the combined analysis after each study was deleted. The results of publication bias showed that the P-value of Egger and Begg tests was 0.078 > 0.05, indicating that there is no publication bias. Conclusions: CRS + HIPEC can improve the survival rate of patients with colorectal cancer peritoneal metastasis [ABSTRACT FROM AUTHOR]

Purpose: To evaluate and compare the implant survival rates, marginal bone loss, and mechanical complications of prostheses supported by splinted and nonsplinted short implants (≤8.5 mm). Material and Methods: Electronic database (MEDLINE, CENTRAL, Web of Science, and EMBASE) and manual searches up to May 2021 were conducted to identify studies comparing splinted and nonsplinted short implants (≤8.5 mm). The primary outcome was implant survival rate. Secondary outcomes were marginal bone loss and mechanical complications. The quality of included studies and risk‐of‐bias were assessed according to the Newcastle‐Ottawa Scale. A random‐effects model was used to analyze the data. Results: Twelve studies fulfilled the inclusion criteria and featured 1506 short implants (596 nonsplinted and 910 splinted) with a follow‐up time ranging from 1 to 16 years. Quantitative analysis found no statistically significant differences between splinted and nonsplinted short implants (≤8.5 mm) for survival rate (RR = 0.98; 95% CI 0.96, 1.01; p = 0.26)) and marginal bone loss (SMD = –0.08; 95% CI – 0.23, 0.07; p = 0.28). Veneer chipping, abutment screw breakage, screw loosening, and loss of retention were reported in the selected studies as common complications. However, no statistically significant difference was found between splinted and nonsplinted short implants (RR = 0.56; 95% CI 0.20, 1.54; p = 0.26). Conclusions: Within the limitations of the present meta‐analysis, it might be concluded that splinted short implants (≤8.5 mm) do not present superior performance in survival rate, marginal bone maintenance and prevention of mechanical complications compared with single‐unit prostheses. [ABSTRACT FROM AUTHOR]

Reviews the book "The Noodle Maker," by Ma Jian and translated by Flora Drew.

With increasing potential for environmental volatility in the wake of increasing atmospheric pollutants, the need for sustainable approaches towards renewable energy and pollution reduction is ever-expanding. In recent years, research has geared towards utilizing carbon dioxide, which is seen as the largest threat of climate change, to produce various other useful chemicals while decreasing carbon dioxide levels. Considering this recent research, covalent organic frameworks (COFs) have jumped into the spotlight as promising and exciting new catalysts development to drive efforts towards easing climate change. As a relatively new class of materials, COFs are high surface area crystalline networks with a large degree of fine-tunable chemistry and the capability of metallic hybridization and functional group modifications. This review is a comprehensive and detailed discussion of the recent research accomplishments and goals of both photocatalytic and electrocatalytic carbon dioxide reduction using COFs as catalysts. Recent COF electrochemical catalysis is thoroughly discussed through different metal-based and pristine COFs along with the material design principles necessary to reduce carbon dioxide effectively and selectively. COF photocatalysis is discussed namely on the remarkable ability of irradiation-induced carbon dioxide reduction for pristine metal-free, metalated, and hybrid COFs along with the ability of photocoupled electrocatalytic reduction. Additionally, final conclusions on the state of COF research are provided along with future suggestions towards expanding and improving the investigation and application of COFs for CO 2 reduction. [Display omitted] • Covalent organic frameworks (COFs) materials are introduced. • COFs catalysts for photo- and electro- catalysis of CO 2 reduction are reviewed. • Future development of COFs catalysts in carbon dioxide reductions is provided. [ABSTRACT FROM AUTHOR]