1. Fatal pulmonary thromboembolism after a second course of high-dose chemotherapy with autologous peripheral blood stem cell transplantation.
- Author
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Kounami, Shinji, Aoyagi, Noriyuki, Nakayama, Keiko, Yoshiyama, Megumi, Boshi, H., Sakiyama, Michiyo, Takeuchi, Takeshi, and Yoshikawa, Norishige
- Subjects
THROMBOEMBOLISM in children ,DRUG therapy ,TUMORS in children ,STEM cell transplantation - Abstract
Kounami S, Aoyagi N, Nakayama K, Yoshiyama M, Boshi H, Sakiyama M, Takeuchi T, Yoshikawa N. Fatal pulmonary thromboembolism after a second course of high-dose chemotherapy with autologous peripheral blood stem cell transplantation. Pediatr Transplantation 2003: 7: 400–403. © 2003 Blackwell Munksgaard We describe a 4-yr-old boy with an occult primitive neuroectodermal tumor, who suffered fatal PTE after a second course of HDC with autologous PBSCT. On day +52 after a second PBSCT, he was admitted because of respiratory distress. Respiratory failure rapidly progressed and he died within 4 days. The diagnosis of PTE was confirmed by a lung perfusion study with technetium-99m macroaggregated albumin, but too late to allow treatment. Although rare, PTE must be recognized as an important differential diagnosis when respiratory symptoms are observed after HDC with PBSCT. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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