Online monitoring of critical quality attributes (CQAs) directly within the bioreactor can provide the basis for advanced processing of therapeutics production, including automated real-time monitoring, feedback control process intensification, smart manufacturing, and real-time release testing. This paper presents recent developments in online high performance liquid chromatography– high-resolution mass spectrometry (HPLC–HRMS) platforms as a promising process analytical technology (PAT) tool for real-time monitoring of antibody quality attributes (QAs) in biopharmaceutical processes. This technology can be used to monitor multiple CQAs and process parameters during cell culture production, enabling real-time decisions. [ABSTRACT FROM AUTHOR]
The author discusses his vision for the development of a low-cost paper-based diagnostic tool for testing blood types. He shares a research conducted at Monash University wherein two series of experiments were performed to study transportation of blood/antibody solution on paper and transportation of blood on antibody-treated paper. The researchers hoped to develop an inexpensive, reliable paper-based product for instantaneous blood typing.
Published
2011
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