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Chronic heart failure is a common and complex clinical syndrome that results from impaired cardiac relaxation or contraction. Patients with chronic heart failure may experience multiple debilitating symptoms, such as fatigue, pain, and peripheral oedema. However, breathlessness may be considered the most debilitating symptom. This is the first of two articles on chronic heart failure, and outlines the pathophysiology of the condition, its causes, assessment, and signs and symptoms. Part 2 will discuss the treatment and management of the condition, including pharmacological strategies, device implantation, lifestyle modification, cardiac rehabilitation and palliative care. [ABSTRACT FROM AUTHOR]

The article discusses a study being conducted by University of South Florida (USF) which examined whether a combination of supplements for the hormone aldosterone and anti-inflammatory medications can slow hearing loss. Topics include the grant awarded to the research, decline in aldosterone experienced by untreated aging mice compared to young adult mice, and the plan of the team to conduct four levels of human clinical trials once a license is received for the patent.

The article describes the case of a 39-year-old woman who was referred to a hospital for the evaluation of primary aldosterone with a history of hypertension and hypokalemia.

The article suggest the higher risk among hypertensive patients with an adrenal incidentaloma to have autonomous aldosterone secretion than normotensive counterparts, according to results of a research study.