Search

Raman backscattering facilitates measurements in systems with limited optical access. In such experiments, spatial filtering is of paramount importance to collect signals only from a welldefined probe volume. In the present work, a straightforward numerical approach is presented to estimate the performance of a spatial filter in a given application. A systematic investigation is carried out for an experimental system using a metallic mirror with a hole acting as a spatial filter. In this configuration, a small hole results in poor spatial resolution but high signal intensity whereas a large hole yields good spatial resolution but low signal. It is shown that the approach allows the optimal hole diameter to be determined that offers a compromise between spatial resolution and signal intensity. Spatially filtered Raman backscattering measurements in a fed-batch stirred tank reactor are presented, where the conversion of citric acid is monitored. [ABSTRACT FROM AUTHOR]

The article presents a retrospective analysis, conducted by Dr. Florian M. Heussen and colleagues at the Doheny Eye Institute, on features in eyes with early age-related macular degeneration (AMD). According to Heussen, hyper-reflective foci discovered on optical coherence tomography (OCT) scans were related to a higher transition to neovascular disease from early AMD. He adds that they need to closely examine at OCT scans and inspect them for any new factors that have not been distinguished. INSET: Take-Home Message.