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The article presents updates relating to antibiotics as of September 2016. Topics covered include the problem posed by the development of bacterial resistance to antibiotic drugs, the use by Paratek Pharmaceuticals of structure-activity relationships to make substituent changes on a minocycline core and the attempt by pharmaceutical company Entasis Therapeutics to restore the usefulness ofß-lactam antibiotics.

The article offers information on tetracyclines and their mechanism in the treatment of noninfectious disease-related disease like inflammation. Topics discussed include management of inflammation through tetracyclines, recommendation by the 2007 American Academy of Dermatology on the use of minocycline in severe acne and recommendations by the 2014 American Acne and Rosacea Society on the use of low-dose doxycycline in rosacea.